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The map label for this gene is dctA [H]

Identifier: 158316190

GI number: 158316190

Start: 5269209

End: 5270615

Strand: Reverse

Name: dctA [H]

Synonym: Franean1_4413

Alternate gene names: 158316190

Gene position: 5270615-5269209 (Counterclockwise)

Preceding gene: 158316193

Following gene: 158316189

Centisome position: 58.68

GC content: 62.76

Gene sequence:

>1407_bases
ATGACCACGTTATCGGCCCCGTCGCGGACGGGATCCGCACGCCGACGCTGGTACCGGCAGCTTTACGTCTGGGTGCTGGC
GGGGATCGTCGCCGGAATCTTAGTGGGCCACTTCTCCCCAGGAGTCGGTGTCGACCTTCAGCCACTCGGCACTACTTTCG
TCGACGCCATCAAAATGATCATCGCTCCCATCGTGTTCTGCACAGTGGTCGGCGGCATCGCGCAGGTCGACAACCTGCGC
AAGGTAGGCCGGGTGGGGCTGAAGGCGTTCACCTACTTTGAGCTCGTCACCACCGCCGCGCTGGTGCTCGGGCTCATCGT
GATGAACGTGCTGCGTCCCGGTGACGGCGTCAACGCCGACCCGGACACGCTGTCGGTCAATGAGACCGTCGGCGGGTACA
TCGCACAGGGCGAGTCAAAGGGCTGGGGCGATCACCTGGCAGACGTTGTACCGGATAGCGTGGTCGGCGCGTTCGCCGAG
GGCAAGGTGCTCCAGGTACTGTTCTTCGCCGTACTATTCGGCATCGCGCTGAACCTCACCGGCAAGCAAGGTGCCGCAAT
CGCCGGCGGGATAGAGCGGGTCGGTCGCACCATGTTCCAGGTACTCCGGTTCGTCATGTACGCGGCACCAGTCGGCGCGT
TCGGCGCCATGGCCTTCACCATAGGCAAGTACGGAATCGACACCCTAACCAGCCTCGGAAAGCTTGTCGCGGTCTTCTAC
GGCACGTCGTTGTTCTTCGTCGTCGTTGTGCTCGGCGCGATTGCTGCAACCATCGGCGTAAACATCTTCAAGCTGCTGCG
ATACATCCGAGAAGAACTCCTGATCGTTCTTGGGACATCGTCCTCCGAATCCGTCCTTCCGCAAATCATGACAAAACTGG
AGAGACTCGGGGCGCCACGCCAGGTCGTGGGTCTCACAGTTCCTACCGGATACTCTTTCAACCTGGACGGGACCTGCATC
TACCTGACGCTCGCCAGCCTGTACCTCGCCCAGGCGGTCGGCGTCGACCTCTCCCTCGGCGAACAGCTCACCATCATCGG
TGTGCTGCTACTGACCTCCAAAGGCGCTGCCGGGGTCACCGGCTCCGGCTTCATCGTGCTCGCGGCGACGCTGTCGACCG
TCGGGACAATTCCGGTCGCCGCCATCATGCTGATCTTCGGGGTCGACAAGTTTATGTCGGAGTGCCGGGCGCTCACCAAC
GTCTGTGGCAACACCCTCGCCACCCTCGTCGTCGCGAACTGGGAAGGCGTCCTCGACAAGGAGCAGATGCGAAAGGCGCT
GAACGCGGGTCCGGACTACACACCGGACGTCACCGACAGGCTCGACGTGCCGGAGACGATCGAGACCGGGGAGCTACTTG
AGGCACCGGCGCAGGCCCAACCCACTCTGATCGGCGGTAACCGCTAG

Upstream 100 bases:

>100_bases
TGAACAGTACGACCAAAACCGTGACCATGATCGTGAACGCAGTCACTGTAACGCCACCACACGGGGCGGGCACACGGAAC
CGCCCGGCTAGGAGGCTCGC

Downstream 100 bases:

>100_bases
CCGACAGGCCGGGCGGGAGACGTAGCCGTGCGTCGGCAGCGGCACCGTTGCGTCGATGGGTCCGACGCGGCGCTGACCAT
CACACTCACCGCCCTCGCAG

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTTLSAPSRTGSARRRWYRQLYVWVLAGIVAGILVGHFSPGVGVDLQPLGTTFVDAIKMIIAPIVFCTVVGGIAQVDNLR
KVGRVGLKAFTYFELVTTAALVLGLIVMNVLRPGDGVNADPDTLSVNETVGGYIAQGESKGWGDHLADVVPDSVVGAFAE
GKVLQVLFFAVLFGIALNLTGKQGAAIAGGIERVGRTMFQVLRFVMYAAPVGAFGAMAFTIGKYGIDTLTSLGKLVAVFY
GTSLFFVVVVLGAIAATIGVNIFKLLRYIREELLIVLGTSSSESVLPQIMTKLERLGAPRQVVGLTVPTGYSFNLDGTCI
YLTLASLYLAQAVGVDLSLGEQLTIIGVLLLTSKGAAGVTGSGFIVLAATLSTVGTIPVAAIMLIFGVDKFMSECRALTN
VCGNTLATLVVANWEGVLDKEQMRKALNAGPDYTPDVTDRLDVPETIETGELLEAPAQAQPTLIGGNR

Sequences:

>Translated_468_residues
MTTLSAPSRTGSARRRWYRQLYVWVLAGIVAGILVGHFSPGVGVDLQPLGTTFVDAIKMIIAPIVFCTVVGGIAQVDNLR
KVGRVGLKAFTYFELVTTAALVLGLIVMNVLRPGDGVNADPDTLSVNETVGGYIAQGESKGWGDHLADVVPDSVVGAFAE
GKVLQVLFFAVLFGIALNLTGKQGAAIAGGIERVGRTMFQVLRFVMYAAPVGAFGAMAFTIGKYGIDTLTSLGKLVAVFY
GTSLFFVVVVLGAIAATIGVNIFKLLRYIREELLIVLGTSSSESVLPQIMTKLERLGAPRQVVGLTVPTGYSFNLDGTCI
YLTLASLYLAQAVGVDLSLGEQLTIIGVLLLTSKGAAGVTGSGFIVLAATLSTVGTIPVAAIMLIFGVDKFMSECRALTN
VCGNTLATLVVANWEGVLDKEQMRKALNAGPDYTPDVTDRLDVPETIETGELLEAPAQAQPTLIGGNR
>Mature_467_residues
TTLSAPSRTGSARRRWYRQLYVWVLAGIVAGILVGHFSPGVGVDLQPLGTTFVDAIKMIIAPIVFCTVVGGIAQVDNLRK
VGRVGLKAFTYFELVTTAALVLGLIVMNVLRPGDGVNADPDTLSVNETVGGYIAQGESKGWGDHLADVVPDSVVGAFAEG
KVLQVLFFAVLFGIALNLTGKQGAAIAGGIERVGRTMFQVLRFVMYAAPVGAFGAMAFTIGKYGIDTLTSLGKLVAVFYG
TSLFFVVVVLGAIAATIGVNIFKLLRYIREELLIVLGTSSSESVLPQIMTKLERLGAPRQVVGLTVPTGYSFNLDGTCIY
LTLASLYLAQAVGVDLSLGEQLTIIGVLLLTSKGAAGVTGSGFIVLAATLSTVGTIPVAAIMLIFGVDKFMSECRALTNV
CGNTLATLVVANWEGVLDKEQMRKALNAGPDYTPDVTDRLDVPETIETGELLEAPAQAQPTLIGGNR

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI194239697, Length=463, Percent_Identity=23.7580993520518, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI169790839, Length=421, Percent_Identity=25.41567695962, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI21314632, Length=403, Percent_Identity=25.3101736972705, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI66773030, Length=525, Percent_Identity=23.047619047619, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4827012, Length=275, Percent_Identity=28.3636363636364, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI5032093, Length=399, Percent_Identity=25.8145363408521, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI223468566, Length=276, Percent_Identity=27.1739130434783, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI223468564, Length=268, Percent_Identity=26.4925373134328, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI40254478, Length=264, Percent_Identity=26.5151515151515, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI262359914, Length=373, Percent_Identity=23.5924932975871, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1789947, Length=423, Percent_Identity=54.8463356973995, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1790514, Length=402, Percent_Identity=40.2985074626866, Blast_Score=291, Evalue=7e-80,
Organism=Escherichia coli, GI1788024, Length=398, Percent_Identity=21.105527638191, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789473, Length=371, Percent_Identity=25.0673854447439, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17537407, Length=451, Percent_Identity=25.7206208425721, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71983099, Length=453, Percent_Identity=25.8278145695364, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=453, Percent_Identity=25.8278145695364, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71996953, Length=465, Percent_Identity=23.4408602150538, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193206505, Length=455, Percent_Identity=21.978021978022, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI193206654, Length=520, Percent_Identity=22.5, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17541374, Length=400, Percent_Identity=22.5, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24583025, Length=426, Percent_Identity=24.8826291079812, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137668, Length=426, Percent_Identity=24.8826291079812, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24583023, Length=426, Percent_Identity=24.8826291079812, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281360483, Length=482, Percent_Identity=24.0663900414938, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17137666, Length=482, Percent_Identity=24.0663900414938, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281360481, Length=482, Percent_Identity=24.0663900414938, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 49211; Mature: 49080

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTLSAPSRTGSARRRWYRQLYVWVLAGIVAGILVGHFSPGVGVDLQPLGTTFVDAIKMI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH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HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA