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The map label for this gene is cusS [H]

Identifier: 158315648

GI number: 158315648

Start: 4586246

End: 4587676

Strand: Reverse

Name: cusS [H]

Synonym: Franean1_3858

Alternate gene names: 158315648

Gene position: 4587676-4586246 (Counterclockwise)

Preceding gene: 158315649

Following gene: 158315647

Centisome position: 51.08

GC content: 77.36

Gene sequence:

>1431_bases
GTGCCGCTGCGGGTACGACTGACCCTGCTGTTCGTCCTGGGCACCACGCTGGTGCTCGCGGCCGCCGGCGTGCTGTTCTA
CGCGCTGCTGCGCACCAACCTGCGGAACTCCGTCGACGCGAACCTGCGCACCCGGATGGCCGTGCTCGCCGCGCAGGTCC
CCGCCGCGGCGGACCCGGCCGCGCAGCTGCGGGCCTACGGCGCCGGGCCCGCCCAGCTGCTGCGCCCCGACGGCTCCGTC
GCCGCCTCGAACGACAGCGCCGGTCCCGAGCCGCTGCTCGAGCCCGCCCAGGTGGCCACGGCGCTCGCCCGCTCGGAGTC
GCTCACGTCCGGCGAGCTGCGGGAGCCGGGCGGCGACGATGACGACGCGCGCGCGCTGGCCGTCCCGGTGCGGACCGGGG
CGCGGGACGGGGTTTTGGTCGTCGCGACGAGCACCGATCTGACCGACTCGGCCGAGGACCGCGTCCGCAACATCATGGTC
AGCGCGACGGCGCCGATGGTCGCGCTCTCCGGGCTCGCGGCCTGGCTGCTGTCGGGCGCCGCCCTGCGCCCGGTCGATCG
CATGCGCCGGCAGACCGCCGCCATCAGCGAGTCGGACAGCTCCGCCGAGCTGGACGTGCCCCCGACCCGCGACGAGATCG
CCGCCCTGGCCGCCACGATGAACAACCTGCTGCGCCGGCTGCACGCCGCCCGCGCCCGCGACCGGGCGTTCGTCGCAGAC
GCCGGGCACGAGCTGCGGACCCCGCTCACCAACCTCAAGGCCGAGCTCGAGCTCGCCGGCCGCCCGGCCCGCACCCGCGA
CGAGCTCGTCGACGCGGTCGCGGGCGCGGCGGAGGAGACCGAGCGGCTGATCCGGCTCTCCGAGTCACTGCTCACGCTCG
CCCGGATGGACAGCGGCATCACCGCCCCGCGGCGGCTGGACGCCGGCGACCTCCTCGAGCGGGCCGCCCGCGCCGCGACC
GGCCACGCCGAGACCAGGCAGGTCCGCCTCCACCTGGACGCCGACCCGGGCCTCGCCGTGGACGCGGACCCCGACATGCT
CCGCCAGGCGGTCGACAACCTGGTGGCCAACGCCATCCGTCACGCGCCGCCCGGCACCGCCGTGGACGTCCGGGCCGGGC
CGGGTGAGGCCGGGAGGACCGTCGTCGTGCGGGTGCGTGACCGCGGCCCGGGGTTCCCCCCGGACTTCCTGCCGCGTGCC
TTCGAACGTTTCAGCCGCGCCGACGCCGCGCGCACCCGCGACCACGGCGGCACCGGCACCAGCGGAAACAGCAGCGGGAC
GGGCCTTGGTGGCACCGGGCTCGGGCTCGCCATCGCCGCGGCGGTGGCGCGGGCCCACCAGGGGACCGCCACCGCCGCCA
ACCATCCCGACGGCGGCGCCGTCGTCACGCTCACGCTGCCCGCCGCGGGCGGTCTCCCGCCGGACCGGTAG

Upstream 100 bases:

>100_bases
ACGGCCTGTCGCGCATCGAGACGGTCCGCGGCGCCGGCTACCGCCTCCGCACCGAGACCACCGACACAGCCGACACAGCC
GAGACGGGGACGTAGCGCCC

Downstream 100 bases:

>100_bases
AACCTGGAAGAGTCCCACGTCCGCGCCGGACGGTGATGTCGGGAAGCCGGCGGCAACGCCCTGACCAGGCGGCCACAGGC
GGACGGCAAAATCGTGGGAT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MPLRVRLTLLFVLGTTLVLAAAGVLFYALLRTNLRNSVDANLRTRMAVLAAQVPAAADPAAQLRAYGAGPAQLLRPDGSV
AASNDSAGPEPLLEPAQVATALARSESLTSGELREPGGDDDDARALAVPVRTGARDGVLVVATSTDLTDSAEDRVRNIMV
SATAPMVALSGLAAWLLSGAALRPVDRMRRQTAAISESDSSAELDVPPTRDEIAALAATMNNLLRRLHAARARDRAFVAD
AGHELRTPLTNLKAELELAGRPARTRDELVDAVAGAAEETERLIRLSESLLTLARMDSGITAPRRLDAGDLLERAARAAT
GHAETRQVRLHLDADPGLAVDADPDMLRQAVDNLVANAIRHAPPGTAVDVRAGPGEAGRTVVVRVRDRGPGFPPDFLPRA
FERFSRADAARTRDHGGTGTSGNSSGTGLGGTGLGLAIAAAVARAHQGTATAANHPDGGAVVTLTLPAAGGLPPDR

Sequences:

>Translated_476_residues
MPLRVRLTLLFVLGTTLVLAAAGVLFYALLRTNLRNSVDANLRTRMAVLAAQVPAAADPAAQLRAYGAGPAQLLRPDGSV
AASNDSAGPEPLLEPAQVATALARSESLTSGELREPGGDDDDARALAVPVRTGARDGVLVVATSTDLTDSAEDRVRNIMV
SATAPMVALSGLAAWLLSGAALRPVDRMRRQTAAISESDSSAELDVPPTRDEIAALAATMNNLLRRLHAARARDRAFVAD
AGHELRTPLTNLKAELELAGRPARTRDELVDAVAGAAEETERLIRLSESLLTLARMDSGITAPRRLDAGDLLERAARAAT
GHAETRQVRLHLDADPGLAVDADPDMLRQAVDNLVANAIRHAPPGTAVDVRAGPGEAGRTVVVRVRDRGPGFPPDFLPRA
FERFSRADAARTRDHGGTGTSGNSSGTGLGGTGLGLAIAAAVARAHQGTATAANHPDGGAVVTLTLPAAGGLPPDR
>Mature_475_residues
PLRVRLTLLFVLGTTLVLAAAGVLFYALLRTNLRNSVDANLRTRMAVLAAQVPAAADPAAQLRAYGAGPAQLLRPDGSVA
ASNDSAGPEPLLEPAQVATALARSESLTSGELREPGGDDDDARALAVPVRTGARDGVLVVATSTDLTDSAEDRVRNIMVS
ATAPMVALSGLAAWLLSGAALRPVDRMRRQTAAISESDSSAELDVPPTRDEIAALAATMNNLLRRLHAARARDRAFVADA
GHELRTPLTNLKAELELAGRPARTRDELVDAVAGAAEETERLIRLSESLLTLARMDSGITAPRRLDAGDLLERAARAATG
HAETRQVRLHLDADPGLAVDADPDMLRQAVDNLVANAIRHAPPGTAVDVRAGPGEAGRTVVVRVRDRGPGFPPDFLPRAF
ERFSRADAARTRDHGGTGTSGNSSGTGLGGTGLGLAIAAAVARAHQGTATAANHPDGGAVVTLTLPAAGGLPPDR

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=344, Percent_Identity=29.9418604651163, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788393, Length=288, Percent_Identity=32.2916666666667, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1786600, Length=264, Percent_Identity=31.0606060606061, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1789403, Length=481, Percent_Identity=27.027027027027, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788279, Length=323, Percent_Identity=24.7678018575851, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788713, Length=271, Percent_Identity=24.3542435424354, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=29.2134831460674, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=27.5303643724696, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790551, Length=310, Percent_Identity=24.8387096774194, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790861, Length=368, Percent_Identity=26.0869565217391, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=254, Percent_Identity=29.9212598425197, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787374, Length=372, Percent_Identity=22.8494623655914, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081816, Length=245, Percent_Identity=28.9795918367347, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789149, Length=250, Percent_Identity=27.2, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=262, Percent_Identity=28.6259541984733, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=272, Percent_Identity=26.4705882352941, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49348; Mature: 49217

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRVRLTLLFVLGTTLVLAAAGVLFYALLRTNLRNSVDANLRTRMAVLAAQVPAAADPA
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCH
AQLRAYGAGPAQLLRPDGSVAASNDSAGPEPLLEPAQVATALARSESLTSGELREPGGDD
HHHHHCCCCHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
DDARALAVPVRTGARDGVLVVATSTDLTDSAEDRVRNIMVSATAPMVALSGLAAWLLSGA
CCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ALRPVDRMRRQTAAISESDSSAELDVPPTRDEIAALAATMNNLLRRLHAARARDRAFVAD
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
AGHELRTPLTNLKAELELAGRPARTRDELVDAVAGAAEETERLIRLSESLLTLARMDSGI
CCCHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
TAPRRLDAGDLLERAARAATGHAETRQVRLHLDADPGLAVDADPDMLRQAVDNLVANAIR
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEECCCHHHHHHHHHHHHHHHHH
HAPPGTAVDVRAGPGEAGRTVVVRVRDRGPGFPPDFLPRAFERFSRADAARTRDHGGTGT
CCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
SGNSSGTGLGGTGLGLAIAAAVARAHQGTATAANHPDGGAVVTLTLPAAGGLPPDR
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
PLRVRLTLLFVLGTTLVLAAAGVLFYALLRTNLRNSVDANLRTRMAVLAAQVPAAADPA
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCH
AQLRAYGAGPAQLLRPDGSVAASNDSAGPEPLLEPAQVATALARSESLTSGELREPGGDD
HHHHHCCCCHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
DDARALAVPVRTGARDGVLVVATSTDLTDSAEDRVRNIMVSATAPMVALSGLAAWLLSGA
CCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ALRPVDRMRRQTAAISESDSSAELDVPPTRDEIAALAATMNNLLRRLHAARARDRAFVAD
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
AGHELRTPLTNLKAELELAGRPARTRDELVDAVAGAAEETERLIRLSESLLTLARMDSGI
CCCHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
TAPRRLDAGDLLERAARAATGHAETRQVRLHLDADPGLAVDADPDMLRQAVDNLVANAIR
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEECCCHHHHHHHHHHHHHHHHH
HAPPGTAVDVRAGPGEAGRTVVVRVRDRGPGFPPDFLPRAFERFSRADAARTRDHGGTGT
CCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
SGNSSGTGLGGTGLGLAIAAAVARAHQGTATAANHPDGGAVVTLTLPAAGGLPPDR
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]