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The map label for this gene is yngJ [H]

Identifier: 158315485

GI number: 158315485

Start: 4367633

End: 4368769

Strand: Reverse

Name: yngJ [H]

Synonym: Franean1_3690

Alternate gene names: 158315485

Gene position: 4368769-4367633 (Counterclockwise)

Preceding gene: 158315486

Following gene: 158315484

Centisome position: 48.64

GC content: 75.02

Gene sequence:

>1137_bases
GTGCTGCTGGAGTTGAGTCCCGACCAGGAGGTCCTCAGGGAGGCGACCGCGAGATACCTCGCGGACCGGGTCCCGGCCGA
GGCGGTCCGCCGCCTGCGCCACGACCCCGCCGGCTTCGAGGCCGACTACTGGCAGGGCGGAGCCGAGCTGGGGTGGACGT
CCCTGCTGGTCGGTGAGGAGCAGGGCGGCGGGTCGATCAGCGGGTCCGCCCTGGTCGACCTGACGCTGGTCGCCCACGAG
TTCGGCCTGCGTGCCGCGCCCGGGCCGCTGGCCGCCACCAACGTCGTCGCCGCCGCGCTGGGCGCGGCGGGCCCGGCGCA
CTCCGAGGTCCTGGCCGACATCCTGTCGGGTGCCACGGTGGCGGCGTGGTGCCTCGGCGGGCCGCCGCCGCTGGACCGGC
TCGACAGCGTCGGCCTCGCCCTGCGGGTCGACGGCGACGACCTCGTCCTCGACGGGGTCAGCCGCCCGGTCGAGTCGGCC
GCCCAGGCCGGGCACCTGCTCGTCGCCGCCCGCGGCGAGGAGGGGCTCACCCAGCTGCTGGTGCCCGCGGCCACGCCCGG
GGTGACGGTGGAGCCGCTGCGCACGGTCGACCTGACCCGGCGCTTCTTCGCTGTCCGGATGGACGGCGTCCGGGTGCCGC
GCGCCGCCGCCGTCGGCGAGGTCGGCGCGGCGGCCGACCAGATCGAGCGCCAGCTCCAGCGCGCGATCGTGATCCTCAAC
GCCGAGACTGTCGGCGCGATGCAGGCCGCCTTCGACATGACCGTCCGCTGGGCCTTCGAGCGTTACTCCTTCGGCCGGCC
GCTCGCGTCCTACCAGGCGCTCAAGCACCGTTTCGCCGACATGAAGACCTGGCTGGAAGGCGCGCACGCCGTCAACGACA
GCGCCGCGGCGGCCGTCGACGCCGGCTCGCCCGACGCCGGGGAGCTGGTGAGCGCGGCGAAGTCCTTCATCGGCGACTAC
GGGACGGAGCTGCTGCAGGACTGCGTCCAGCTGCACGGCGGGATCGGCGTGACCTACGAGCACGACCTGCACCTGTACCT
GCGCCGCGTCACCGTGAACCGGGCGCTGTGCGGCACGCCGGCCGAGCACCGCCAGCGCGTCGCCGCCGTCGTCGAGCACC
TCAAGGAGCGGGCATGA

Upstream 100 bases:

>100_bases
ACCGCCCCGTGCGGCCGCGGTCGGACGGGAGCCCACGCGGCGCGACCCGAGCCGCGGCAGGCGTCGGGCAAGGGAGCCGA
ATGACGCGAGGTGACGGATC

Downstream 100 bases:

>100_bases
CGTCCGACATCAGCACCGGCACCGGCTCGGCCGCCGGCGCGGCGAACGCGGAAGCCACGGAGAGCGTCGCGGACTTCCGC
CGGCGGGCGCGGACGTGGAT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MLLELSPDQEVLREATARYLADRVPAEAVRRLRHDPAGFEADYWQGGAELGWTSLLVGEEQGGGSISGSALVDLTLVAHE
FGLRAAPGPLAATNVVAAALGAAGPAHSEVLADILSGATVAAWCLGGPPPLDRLDSVGLALRVDGDDLVLDGVSRPVESA
AQAGHLLVAARGEEGLTQLLVPAATPGVTVEPLRTVDLTRRFFAVRMDGVRVPRAAAVGEVGAAADQIERQLQRAIVILN
AETVGAMQAAFDMTVRWAFERYSFGRPLASYQALKHRFADMKTWLEGAHAVNDSAAAAVDAGSPDAGELVSAAKSFIGDY
GTELLQDCVQLHGGIGVTYEHDLHLYLRRVTVNRALCGTPAEHRQRVAAVVEHLKERA

Sequences:

>Translated_378_residues
MLLELSPDQEVLREATARYLADRVPAEAVRRLRHDPAGFEADYWQGGAELGWTSLLVGEEQGGGSISGSALVDLTLVAHE
FGLRAAPGPLAATNVVAAALGAAGPAHSEVLADILSGATVAAWCLGGPPPLDRLDSVGLALRVDGDDLVLDGVSRPVESA
AQAGHLLVAARGEEGLTQLLVPAATPGVTVEPLRTVDLTRRFFAVRMDGVRVPRAAAVGEVGAAADQIERQLQRAIVILN
AETVGAMQAAFDMTVRWAFERYSFGRPLASYQALKHRFADMKTWLEGAHAVNDSAAAAVDAGSPDAGELVSAAKSFIGDY
GTELLQDCVQLHGGIGVTYEHDLHLYLRRVTVNRALCGTPAEHRQRVAAVVEHLKERA
>Mature_378_residues
MLLELSPDQEVLREATARYLADRVPAEAVRRLRHDPAGFEADYWQGGAELGWTSLLVGEEQGGGSISGSALVDLTLVAHE
FGLRAAPGPLAATNVVAAALGAAGPAHSEVLADILSGATVAAWCLGGPPPLDRLDSVGLALRVDGDDLVLDGVSRPVESA
AQAGHLLVAARGEEGLTQLLVPAATPGVTVEPLRTVDLTRRFFAVRMDGVRVPRAAAVGEVGAAADQIERQLQRAIVILN
AETVGAMQAAFDMTVRWAFERYSFGRPLASYQALKHRFADMKTWLEGAHAVNDSAAAAVDAGSPDAGELVSAAKSFIGDY
GTELLQDCVQLHGGIGVTYEHDLHLYLRRVTVNRALCGTPAEHRQRVAAVVEHLKERA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=363, Percent_Identity=25.6198347107438, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI7656849, Length=340, Percent_Identity=24.4117647058824, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4557231, Length=341, Percent_Identity=23.4604105571848, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI187960098, Length=341, Percent_Identity=23.4604105571848, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI76496475, Length=389, Percent_Identity=23.9074550128535, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4557235, Length=389, Percent_Identity=23.9074550128535, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4501857, Length=358, Percent_Identity=20.6703910614525, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4557233, Length=264, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=21.4285714285714, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786223, Length=326, Percent_Identity=22.0858895705521, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081958, Length=369, Percent_Identity=21.680216802168, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17506239, Length=383, Percent_Identity=24.0208877284595, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508101, Length=385, Percent_Identity=24.9350649350649, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=24.21875, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17570075, Length=395, Percent_Identity=23.0379746835443, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=383, Percent_Identity=23.2375979112272, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17533517, Length=344, Percent_Identity=20.6395348837209, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569725, Length=256, Percent_Identity=23.828125, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71990804, Length=174, Percent_Identity=26.4367816091954, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646207, Length=357, Percent_Identity=25.2100840336134, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24666513, Length=404, Percent_Identity=24.009900990099, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24660351, Length=270, Percent_Identity=24.4444444444444, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=23.015873015873, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21356377, Length=245, Percent_Identity=25.3061224489796, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 39933; Mature: 39933

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLELSPDQEVLREATARYLADRVPAEAVRRLRHDPAGFEADYWQGGAELGWTSLLVGEE
CEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEEEECC
QGGGSISGSALVDLTLVAHEFGLRAAPGPLAATNVVAAALGAAGPAHSEVLADILSGATV
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHH
AAWCLGGPPPLDRLDSVGLALRVDGDDLVLDGVSRPVESAAQAGHLLVAARGEEGLTQLL
HHHCCCCCCCHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHCCEEEEEECCCCCHHHHH
VPAATPGVTVEPLRTVDLTRRFFAVRMDGVRVPRAAAVGEVGAAADQIERQLQRAIVILN
HCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEC
AETVGAMQAAFDMTVRWAFERYSFGRPLASYQALKHRFADMKTWLEGAHAVNDSAAAAVD
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEC
AGSPDAGELVSAAKSFIGDYGTELLQDCVQLHGGIGVTYEHDLHLYLRRVTVNRALCGTP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCC
AEHRQRVAAVVEHLKERA
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLELSPDQEVLREATARYLADRVPAEAVRRLRHDPAGFEADYWQGGAELGWTSLLVGEE
CEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEEEECC
QGGGSISGSALVDLTLVAHEFGLRAAPGPLAATNVVAAALGAAGPAHSEVLADILSGATV
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHH
AAWCLGGPPPLDRLDSVGLALRVDGDDLVLDGVSRPVESAAQAGHLLVAARGEEGLTQLL
HHHCCCCCCCHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHCCEEEEEECCCCCHHHHH
VPAATPGVTVEPLRTVDLTRRFFAVRMDGVRVPRAAAVGEVGAAADQIERQLQRAIVILN
HCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEC
AETVGAMQAAFDMTVRWAFERYSFGRPLASYQALKHRFADMKTWLEGAHAVNDSAAAAVD
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEC
AGSPDAGELVSAAKSFIGDYGTELLQDCVQLHGGIGVTYEHDLHLYLRRVTVNRALCGTP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCC
AEHRQRVAAVVEHLKERA
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]