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The map label for this gene is yhcA [H]

Identifier: 158315197

GI number: 158315197

Start: 4026654

End: 4028168

Strand: Direct

Name: yhcA [H]

Synonym: Franean1_3397

Alternate gene names: 158315197

Gene position: 4026654-4028168 (Clockwise)

Preceding gene: 158315196

Following gene: 158315203

Centisome position: 44.83

GC content: 71.09

Gene sequence:

>1515_bases
ATGGCCTCCAGTGCCGACAGTGGCGGTTCCGCCCCGGTCGCTACCCGTCGTGTGGACGAGTCGCGCGTCAACGCGATCAT
CGCTGTCCTGGGCGGGATAGGCGTCGTCGTCGCGATGATGCAGACGTTGATGGTGCCGCTACTGCCGACGCTGCCATCGC
TGCTGCACACCAGCTCGGCGAACGCCTCGTGGGCGATCACGGCCACGCTGCTCACCGCGTCCGTCGCCAACCCGGTGTAC
GGGCGGCTCGGTGACCTCTACGGCAAGCGGCGCATGGTCTTCGTCGCCGGCACCGCGCTCGCCTGCGGCTCGGTGGTGTG
CGCCCTGAGCAGCTCGCTCGTGCCGTTGCTGGTGGGCCGGTCGATGCAGGGCCTCGGCATGGCGATCATCCCGCTGGGCA
TCAGCATCATGCGTGACCTGCTGCCGGCGAAGCGGCTGATCCCCGCCATGGCGCTGATGAGCTCCTCGCTCGGGATCGGG
AGCGCGCTGGGCCTGCCGATCGCGGCGGCGGTCGCCCAGCAGGCCAACTGGCACGTGCTGTTCTGGGGCTCGGCTGTCGC
CGTCGTCGCCCTGATGGTGCTGATCTGGCGGGTCGTTCCCGAGTCGCCGGTCCGCGGCACGGGCCGGTTCGACCTGCCGG
GGGCGATCCTGCTCTCCGGAGGGCTCGTCGCGCTGCTGCTCGCCGTGTCGAAGGGAAGCACCTGGGGCTGGACCAGCACC
ACGACCCTCGGCCTGGGCATGGTGGCCGCCGCCCTCCTCGTCGCCTGGACCTGGTGGGAGGCCCGCGCCGAGGCCCCCCT
CGTGGACCTGCGCACCACCATCCGGCGCCCGGTGCTGCTGACGAACACCGCTTCCGTTGCACTGGGCTTCGCGATGTACG
CGAACTCGCTGATCAACCCCCAGCTGCTGCAGCTGCCGAAGGCCACCGGGCACGGGCTCGGCCAGTCGTTGCTCGCCACA
GGCCTGTGGATGGCCCCCGTGGGGCTGGTGATGATGGCCGTGTCGCCCATCGCCGGCAGGCTGATCACGGCACGCGGACC
GAGGACCTCGCTCATCGCCGGCTCGGTCGTGATCGCCGGTGGCTACTGCCTCGCACTTGGGCTCACCAGCAGCCCGCCGG
GAGTCCTTCTCGTCAGCTGCGTGATCAGCACCGGCGTCGCACTGGCTTACGCGTCCATGCCCACTCTGATCATGCAGTCC
GTGCCGGCCTCCGAGGGCGCCGCGGCGAACGGCCTCAACACCCTCATGCGCTCCATCGGAACCACGGGGGCGAGCGCGGT
GATCGGCGTGGTCCTGGCGAACATGACCATCCCGTTCGGATCGACCCGGGTGCCCTCCCTCGCCGGCCTGCACGTCGGAT
ACCTGATCGGCGCCGGTGCCGCGCTGATCGCCGGCCTGCTGGCCCTCGGCATCCCCGGCCGCGCGGCGTCGAAGTCGACC
GTCACGCTCCCGGAACCACGCCGGACGTCGCCGCAGGCGGCCCAGCCCGCGGCGACATCCACCTCAAGCGTCTGA

Upstream 100 bases:

>100_bases
GGCGCGGCAAGTGTGACCGGTTCCGCTCCGTCGTGCACTGACATTCGGGAGGTATGCATGATACATATGTATGTATAGTA
CAAGGAAGTGAGGAGGGGAC

Downstream 100 bases:

>100_bases
GGTCAGGTCATGGCTGGAGCCACAGGGGCTCGGGCAGGAGTGATCCGAGGCCGTACTGGGTGACGCCGCCGACGTTCCTG
GCGGCCATGACGCTCGGGTT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MASSADSGGSAPVATRRVDESRVNAIIAVLGGIGVVVAMMQTLMVPLLPTLPSLLHTSSANASWAITATLLTASVANPVY
GRLGDLYGKRRMVFVAGTALACGSVVCALSSSLVPLLVGRSMQGLGMAIIPLGISIMRDLLPAKRLIPAMALMSSSLGIG
SALGLPIAAAVAQQANWHVLFWGSAVAVVALMVLIWRVVPESPVRGTGRFDLPGAILLSGGLVALLLAVSKGSTWGWTST
TTLGLGMVAAALLVAWTWWEARAEAPLVDLRTTIRRPVLLTNTASVALGFAMYANSLINPQLLQLPKATGHGLGQSLLAT
GLWMAPVGLVMMAVSPIAGRLITARGPRTSLIAGSVVIAGGYCLALGLTSSPPGVLLVSCVISTGVALAYASMPTLIMQS
VPASEGAAANGLNTLMRSIGTTGASAVIGVVLANMTIPFGSTRVPSLAGLHVGYLIGAGAALIAGLLALGIPGRAASKST
VTLPEPRRTSPQAAQPAATSTSSV

Sequences:

>Translated_504_residues
MASSADSGGSAPVATRRVDESRVNAIIAVLGGIGVVVAMMQTLMVPLLPTLPSLLHTSSANASWAITATLLTASVANPVY
GRLGDLYGKRRMVFVAGTALACGSVVCALSSSLVPLLVGRSMQGLGMAIIPLGISIMRDLLPAKRLIPAMALMSSSLGIG
SALGLPIAAAVAQQANWHVLFWGSAVAVVALMVLIWRVVPESPVRGTGRFDLPGAILLSGGLVALLLAVSKGSTWGWTST
TTLGLGMVAAALLVAWTWWEARAEAPLVDLRTTIRRPVLLTNTASVALGFAMYANSLINPQLLQLPKATGHGLGQSLLAT
GLWMAPVGLVMMAVSPIAGRLITARGPRTSLIAGSVVIAGGYCLALGLTSSPPGVLLVSCVISTGVALAYASMPTLIMQS
VPASEGAAANGLNTLMRSIGTTGASAVIGVVLANMTIPFGSTRVPSLAGLHVGYLIGAGAALIAGLLALGIPGRAASKST
VTLPEPRRTSPQAAQPAATSTSSV
>Mature_503_residues
ASSADSGGSAPVATRRVDESRVNAIIAVLGGIGVVVAMMQTLMVPLLPTLPSLLHTSSANASWAITATLLTASVANPVYG
RLGDLYGKRRMVFVAGTALACGSVVCALSSSLVPLLVGRSMQGLGMAIIPLGISIMRDLLPAKRLIPAMALMSSSLGIGS
ALGLPIAAAVAQQANWHVLFWGSAVAVVALMVLIWRVVPESPVRGTGRFDLPGAILLSGGLVALLLAVSKGSTWGWTSTT
TLGLGMVAAALLVAWTWWEARAEAPLVDLRTTIRRPVLLTNTASVALGFAMYANSLINPQLLQLPKATGHGLGQSLLATG
LWMAPVGLVMMAVSPIAGRLITARGPRTSLIAGSVVIAGGYCLALGLTSSPPGVLLVSCVISTGVALAYASMPTLIMQSV
PASEGAAANGLNTLMRSIGTTGASAVIGVVLANMTIPFGSTRVPSLAGLHVGYLIGAGAALIAGLLALGIPGRAASKSTV
TLPEPRRTSPQAAQPAATSTSSV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=392, Percent_Identity=27.2959183673469, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081983, Length=394, Percent_Identity=25.6345177664975, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788392, Length=422, Percent_Identity=27.2511848341232, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789042, Length=392, Percent_Identity=25.5102040816327, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790195, Length=337, Percent_Identity=25.2225519287834, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324954, Length=224, Percent_Identity=28.125, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50960; Mature: 50829

Theoretical pI: Translated: 11.48; Mature: 11.48

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSADSGGSAPVATRRVDESRVNAIIAVLGGIGVVVAMMQTLMVPLLPTLPSLLHTSSA
CCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NASWAITATLLTASVANPVYGRLGDLYGKRRMVFVAGTALACGSVVCALSSSLVPLLVGR
CCCEEEHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCHHHHHHCC
SMQGLGMAIIPLGISIMRDLLPAKRLIPAMALMSSSLGIGSALGLPIAAAVAQQANWHVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEE
FWGSAVAVVALMVLIWRVVPESPVRGTGRFDLPGAILLSGGLVALLLAVSKGSTWGWTST
EECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
TTLGLGMVAAALLVAWTWWEARAEAPLVDLRTTIRRPVLLTNTASVALGFAMYANSLINP
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCH
QLLQLPKATGHGLGQSLLATGLWMAPVGLVMMAVSPIAGRLITARGPRTSLIAGSVVIAG
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHEECCCEEEC
GYCLALGLTSSPPGVLLVSCVISTGVALAYASMPTLIMQSVPASEGAAANGLNTLMRSIG
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
TTGASAVIGVVLANMTIPFGSTRVPSLAGLHVGYLIGAGAALIAGLLALGIPGRAASKST
CCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
VTLPEPRRTSPQAAQPAATSTSSV
EECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASSADSGGSAPVATRRVDESRVNAIIAVLGGIGVVVAMMQTLMVPLLPTLPSLLHTSSA
CCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NASWAITATLLTASVANPVYGRLGDLYGKRRMVFVAGTALACGSVVCALSSSLVPLLVGR
CCCEEEHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCHHHHHHCC
SMQGLGMAIIPLGISIMRDLLPAKRLIPAMALMSSSLGIGSALGLPIAAAVAQQANWHVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEE
FWGSAVAVVALMVLIWRVVPESPVRGTGRFDLPGAILLSGGLVALLLAVSKGSTWGWTST
EECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
TTLGLGMVAAALLVAWTWWEARAEAPLVDLRTTIRRPVLLTNTASVALGFAMYANSLINP
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCH
QLLQLPKATGHGLGQSLLATGLWMAPVGLVMMAVSPIAGRLITARGPRTSLIAGSVVIAG
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHEECCCEEEC
GYCLALGLTSSPPGVLLVSCVISTGVALAYASMPTLIMQSVPASEGAAANGLNTLMRSIG
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
TTGASAVIGVVLANMTIPFGSTRVPSLAGLHVGYLIGAGAALIAGLLALGIPGRAASKST
CCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
VTLPEPRRTSPQAAQPAATSTSSV
EECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]