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The map label for this gene is ksdD [H]

Identifier: 158315121

GI number: 158315121

Start: 3932129

End: 3933823

Strand: Direct

Name: ksdD [H]

Synonym: Franean1_3320

Alternate gene names: 158315121

Gene position: 3932129-3933823 (Clockwise)

Preceding gene: 158315120

Following gene: 158315122

Centisome position: 43.78

GC content: 69.91

Gene sequence:

>1695_bases
GTGTCGAAGTCGGATGCCAGCTACGACCATGCCGTTGACGTCATTGTCGTGGGATCGGGCGGTGGTCTGTGCGGCGCCGT
GGCCGCGGCGGCGAGCGGCCTGGACACGCTGGTGATCGAGAAGCAGCCGATGATCGGCGGGTCCACGGCCATGTCAGGCG
GCGTGCTGTGGCTGCCGGACAACCCGCTCATGCAGGCCGACGGCGTTCCCGACTCCCTTGAGGACGCGCTGGCGTACTTC
GAGTCGGTGGTCGGGGACGTCGGACCCGCCTCGTCGCGGGAGCGGCGGCTCGCCTACATCGTCGAAGGCTCCAACATGGT
CCGCTTCCTGCAGGGCCTGGGCCTGCGTTTCGAGCGGTGCGAAGGGTACAGCGACTACTACGCGCAGGTGGCGGGAATTC
GTGGCGGCAGCGCCCGCGGCCGCTCCATCGAACCCGCGGTGACCGATGGCAGGAAGCTCGGACCGTGGTTCGCGAAGCTG
ATGCCGGGCATGACGGCCGCGCTCGGAATCGTCGTGATGACCCGCGAGGCGTCCACTCTGCAGCTGATCAAGCGGCGGCC
GAAAGCCATGCGCACCGCCCTCCGGGTGGGGATGCGGACGGCCATGGGCAGGCTCAGGAGGCAGACCCGGCTGGCCAACG
GCGCGGCACTGATCGCGCAGGCCCTGGAGGCGGCGCTGGCGGCCGGGGCGACGGTCTGGACAGACACCGGGCTGGTCGAC
CTGATCGTCGAGGACGGCCGGGTGGCCGGCGTCGTGGCCAGTCGGGACGGGCAGACCGTCCGGATCCGCGCCCGCCGCGG
CGTGCTGTTGAGCTCGGGCGGGTTCGCCCGCAACGCCGAGATGCGCAGACGCTACTCGAAGCAGCCGAACGAGGGGTCGT
GGACCATCGCCAACCCCGGGGACACGGGCGAGGCGATCGAGGCCGCCCAGCGGGTCGGCGCCGCCGTCGACTTCATGGAC
GAGGCGTTGTGGATCCCGGCCTCCATCCAGCCCGGCGGACGTCCGAGCCTGCACACCGGAGAGCGGAGCAAGCCGGGCTC
GATCATCGTCGACCGGGCCGGTCGGCGGTACTTCAACGAGGCGGTCTCCTACATGGAGGCCGGGCGGCAGATGTACGCGC
ACAACACGGCCGGTGAGTCCATTCCGAGCTGGCTGGTCATGGACTCCCGCCACCGCGGTCGTTATCTGTTCGCGTTCCGT
GCCAACACCCCCGAAGAGTGGATCACCAGCGGCTACATGAAGAAGGCCGACACGGTGGAGGAACTGGCGCGGGCGTGCGG
CATAGACCCGGCCGGTCTGGCCGCCACGGTCGAGCGGTTCAACGGGTTCGCGAAGCAGGGCACCGACCCCGACTTCCACC
GCGGCGAAGGGGCTCACGAGCGGTACCAGGGCGACTACGGCAACCAGCCGAACGCCTCGCTCGCGCCCGTCGAGAAGGCG
CCCTTCTACGCGGTCGAGCTCTACCCGGGTGACGTGGGGACGAGCGGCGGGCTGCTCTGTGACGAGTTCGCCCGTGTGCT
CGACACCAACCATGAGCCCATCCCGGGTCTGTACGCTGCCGGGAACTGCAGCGCGTCGGTGATGGGACGCACCTATCTGG
GGGCGGGCGCCAGCATCGGGAACAGCTGCGTCTTCTCCTACATCGGCATGAAGCACGCCGCGCACGTCGTCTCCGGCGAC
CCGGTGGCCACGTGA

Upstream 100 bases:

>100_bases
CGAGATGGAGCAGCTCATCAGCAACATGCACTCCGAACTCGACCGGTACCTCGCCGGCTGAGGCACCGCACCGAAACCAT
CCACTCCATGGAGGGGCACC

Downstream 100 bases:

>100_bases
CGGGGGAGGGGAGTGAGCGGTCCAGGCGGCCGCTGGTCCGGGTCGAGCCCATCGGCGCGGACCTCACGCCCGAGCCCGGT
GAGACGATCATTGAGGCGGC

Product: 3-ketosteroid-delta-1-dehydrogenase

Products: NA

Alternate protein names: 3-keto-Delta(4)-steroid Delta(1)-dehydrogenase; KSDD; 3-oxo-Delta(4)-steroid 1-dehydrogenase; KSTD [H]

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSKSDASYDHAVDVIVVGSGGGLCGAVAAAASGLDTLVIEKQPMIGGSTAMSGGVLWLPDNPLMQADGVPDSLEDALAYF
ESVVGDVGPASSRERRLAYIVEGSNMVRFLQGLGLRFERCEGYSDYYAQVAGIRGGSARGRSIEPAVTDGRKLGPWFAKL
MPGMTAALGIVVMTREASTLQLIKRRPKAMRTALRVGMRTAMGRLRRQTRLANGAALIAQALEAALAAGATVWTDTGLVD
LIVEDGRVAGVVASRDGQTVRIRARRGVLLSSGGFARNAEMRRRYSKQPNEGSWTIANPGDTGEAIEAAQRVGAAVDFMD
EALWIPASIQPGGRPSLHTGERSKPGSIIVDRAGRRYFNEAVSYMEAGRQMYAHNTAGESIPSWLVMDSRHRGRYLFAFR
ANTPEEWITSGYMKKADTVEELARACGIDPAGLAATVERFNGFAKQGTDPDFHRGEGAHERYQGDYGNQPNASLAPVEKA
PFYAVELYPGDVGTSGGLLCDEFARVLDTNHEPIPGLYAAGNCSASVMGRTYLGAGASIGNSCVFSYIGMKHAAHVVSGD
PVAT

Sequences:

>Translated_564_residues
MSKSDASYDHAVDVIVVGSGGGLCGAVAAAASGLDTLVIEKQPMIGGSTAMSGGVLWLPDNPLMQADGVPDSLEDALAYF
ESVVGDVGPASSRERRLAYIVEGSNMVRFLQGLGLRFERCEGYSDYYAQVAGIRGGSARGRSIEPAVTDGRKLGPWFAKL
MPGMTAALGIVVMTREASTLQLIKRRPKAMRTALRVGMRTAMGRLRRQTRLANGAALIAQALEAALAAGATVWTDTGLVD
LIVEDGRVAGVVASRDGQTVRIRARRGVLLSSGGFARNAEMRRRYSKQPNEGSWTIANPGDTGEAIEAAQRVGAAVDFMD
EALWIPASIQPGGRPSLHTGERSKPGSIIVDRAGRRYFNEAVSYMEAGRQMYAHNTAGESIPSWLVMDSRHRGRYLFAFR
ANTPEEWITSGYMKKADTVEELARACGIDPAGLAATVERFNGFAKQGTDPDFHRGEGAHERYQGDYGNQPNASLAPVEKA
PFYAVELYPGDVGTSGGLLCDEFARVLDTNHEPIPGLYAAGNCSASVMGRTYLGAGASIGNSCVFSYIGMKHAAHVVSGD
PVAT
>Mature_563_residues
SKSDASYDHAVDVIVVGSGGGLCGAVAAAASGLDTLVIEKQPMIGGSTAMSGGVLWLPDNPLMQADGVPDSLEDALAYFE
SVVGDVGPASSRERRLAYIVEGSNMVRFLQGLGLRFERCEGYSDYYAQVAGIRGGSARGRSIEPAVTDGRKLGPWFAKLM
PGMTAALGIVVMTREASTLQLIKRRPKAMRTALRVGMRTAMGRLRRQTRLANGAALIAQALEAALAAGATVWTDTGLVDL
IVEDGRVAGVVASRDGQTVRIRARRGVLLSSGGFARNAEMRRRYSKQPNEGSWTIANPGDTGEAIEAAQRVGAAVDFMDE
ALWIPASIQPGGRPSLHTGERSKPGSIIVDRAGRRYFNEAVSYMEAGRQMYAHNTAGESIPSWLVMDSRHRGRYLFAFRA
NTPEEWITSGYMKKADTVEELARACGIDPAGLAATVERFNGFAKQGTDPDFHRGEGAHERYQGDYGNQPNASLAPVEKAP
FYAVELYPGDVGTSGGLLCDEFARVLDTNHEPIPGLYAAGNCSASVMGRTYLGAGASIGNSCVFSYIGMKHAAHVVSGDP
VAT

Specific function: Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3- ketosteroids. Is also involved in the formation of 1,4- androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. 3-oxosteroid dehydrogenase subfamily [H]

Homologues:

Organism=Caenorhabditis elegans, GI71986328, Length=378, Percent_Identity=26.4550264550265, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =1.3.99.4 [H]

Molecular weight: Translated: 59980; Mature: 59848

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSDASYDHAVDVIVVGSGGGLCGAVAAAASGLDTLVIEKQPMIGGSTAMSGGVLWLPD
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEECCC
NPLMQADGVPDSLEDALAYFESVVGDVGPASSRERRLAYIVEGSNMVRFLQGLGLRFERC
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHCCCEEHHH
EGYSDYYAQVAGIRGGSARGRSIEPAVTDGRKLGPWFAKLMPGMTAALGIVVMTREASTL
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHEEEEEECCHHHH
QLIKRRPKAMRTALRVGMRTAMGRLRRQTRLANGAALIAQALEAALAAGATVWTDTGLVD
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEECCCEEE
LIVEDGRVAGVVASRDGQTVRIRARRGVLLSSGGFARNAEMRRRYSKQPNEGSWTIANPG
EEEECCEEEEEEEECCCCEEEEEEECCEEEECCCCCCCHHHHHHHCCCCCCCCEEECCCC
DTGEAIEAAQRVGAAVDFMDEALWIPASIQPGGRPSLHTGERSKPGSIIVDRAGRRYFNE
CCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHH
AVSYMEAGRQMYAHNTAGESIPSWLVMDSRHRGRYLFAFRANTPEEWITSGYMKKADTVE
HHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
ELARACGIDPAGLAATVERFNGFAKQGTDPDFHRGEGAHERYQGDYGNQPNASLAPVEKA
HHHHHHCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCC
PFYAVELYPGDVGTSGGLLCDEFARVLDTNHEPIPGLYAAGNCSASVMGRTYLGAGASIG
CEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCHHHHCCHHCCCCCCCC
NSCVFSYIGMKHAAHVVSGDPVAT
HHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
SKSDASYDHAVDVIVVGSGGGLCGAVAAAASGLDTLVIEKQPMIGGSTAMSGGVLWLPD
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEECCC
NPLMQADGVPDSLEDALAYFESVVGDVGPASSRERRLAYIVEGSNMVRFLQGLGLRFERC
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHCCCEEHHH
EGYSDYYAQVAGIRGGSARGRSIEPAVTDGRKLGPWFAKLMPGMTAALGIVVMTREASTL
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHEEEEEECCHHHH
QLIKRRPKAMRTALRVGMRTAMGRLRRQTRLANGAALIAQALEAALAAGATVWTDTGLVD
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEECCCEEE
LIVEDGRVAGVVASRDGQTVRIRARRGVLLSSGGFARNAEMRRRYSKQPNEGSWTIANPG
EEEECCEEEEEEEECCCCEEEEEEECCEEEECCCCCCCHHHHHHHCCCCCCCCEEECCCC
DTGEAIEAAQRVGAAVDFMDEALWIPASIQPGGRPSLHTGERSKPGSIIVDRAGRRYFNE
CCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHH
AVSYMEAGRQMYAHNTAGESIPSWLVMDSRHRGRYLFAFRANTPEEWITSGYMKKADTVE
HHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
ELARACGIDPAGLAATVERFNGFAKQGTDPDFHRGEGAHERYQGDYGNQPNASLAPVEKA
HHHHHHCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCC
PFYAVELYPGDVGTSGGLLCDEFARVLDTNHEPIPGLYAAGNCSASVMGRTYLGAGASIG
CEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCHHHHCCHHCCCCCCCC
NSCVFSYIGMKHAAHVVSGDPVAT
HHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA