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The map label for this gene is Hgd [H]

Identifier: 158315086

GI number: 158315086

Start: 3890645

End: 3891481

Strand: Direct

Name: Hgd [H]

Synonym: Franean1_3283

Alternate gene names: 158315086

Gene position: 3890645-3891481 (Clockwise)

Preceding gene: 158315085

Following gene: 158315087

Centisome position: 43.32

GC content: 73.6

Gene sequence:

>837_bases
GTGACCGTCCTGCCCCGAGTCGGTTTCGTCGGACTCGGCGCCCAGGGCGGCCCGATGGCCCGCCGCATCGCCGACGCCGG
CTTCCCGACCACTCTGTGGGCGCGTCGACCGGAAAGCCTCGCGCCCTATGCCGGGACGGCGGCCCGCGTGGCCGGAAGCC
GCAGGGAGCTCGGCGCGGCCAGTGACGTGCTCTGCGTCTGCGTGGTGGACGACGCCGGTGTCGACGAGGTGCTCCGCGGT
CCGGAGGGGGCGCTGGCCGGCATGGCGGACAGCGGCGTGGTGATCATCCACAGCACCACGCATCCGGACACCTGCCGCCG
GCTCCAGACGGACTTCCCGAACCTGCGCGTCCTCGACGCGCCCGTGAGCGGCGGCGGTGTGCGGGCCCGCGAGGGCACGC
TGCTCGTCATGGTGGGCGGCGACGCCAGCGTGCTCGAACGGGTCCGGCCGGTGCTGGACACGTTCGCGAAGCCGCTGCTG
CACATCGGCGCGCTGGGGACGGGTCAGGAAGTCAAGCTCCTCAACAACGCGCTCTTCGCCGCGCACCTCGCTCTCGCCGC
CGAGGTGTACACGCTGGCGCACGGCCGCGGACTCGATGTGGAGGGCGTCGCGACCGTCCTGAACGCGGGCAGCGGGAGGA
GCTTCGCCGCCGACGTCGTGGCGGCGGCCGTGCATCGACTCGAGCCCCTGGCCGGCCGCGCCGGGTCCCTGCTCGCCAAG
GACGTCGGCATCCTCGCCGACCTGCTCTCCCCGAACCCCTCCGAGCTCATCGCCGTGGCCGACACCGCGCTCGAAGTCAT
GGGCGTCCCCAGGCCCGGGAGAAAGGACCCCGCATGA

Upstream 100 bases:

>100_bases
ACTTCCTGGTGCTCACCGTCCCGGCGGTGCGCGACGAACTGGTCGAGCGGGCGACCGACATGGAGAAGTATCTGCAGCAG
AGGATCACGGAGCAGGCTCC

Downstream 100 bases:

>100_bases
CCGCCGACCCGACGACCGCCGACCTCTACCGGACCATCATGGCCGTAGAGCCGCCCGAGGCCGCGACACCGTTCGAGAAG
GCCAGCCAGGACTTCGTGAT

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MTVLPRVGFVGLGAQGGPMARRIADAGFPTTLWARRPESLAPYAGTAARVAGSRRELGAASDVLCVCVVDDAGVDEVLRG
PEGALAGMADSGVVIIHSTTHPDTCRRLQTDFPNLRVLDAPVSGGGVRAREGTLLVMVGGDASVLERVRPVLDTFAKPLL
HIGALGTGQEVKLLNNALFAAHLALAAEVYTLAHGRGLDVEGVATVLNAGSGRSFAADVVAAAVHRLEPLAGRAGSLLAK
DVGILADLLSPNPSELIAVADTALEVMGVPRPGRKDPA

Sequences:

>Translated_278_residues
MTVLPRVGFVGLGAQGGPMARRIADAGFPTTLWARRPESLAPYAGTAARVAGSRRELGAASDVLCVCVVDDAGVDEVLRG
PEGALAGMADSGVVIIHSTTHPDTCRRLQTDFPNLRVLDAPVSGGGVRAREGTLLVMVGGDASVLERVRPVLDTFAKPLL
HIGALGTGQEVKLLNNALFAAHLALAAEVYTLAHGRGLDVEGVATVLNAGSGRSFAADVVAAAVHRLEPLAGRAGSLLAK
DVGILADLLSPNPSELIAVADTALEVMGVPRPGRKDPA
>Mature_277_residues
TVLPRVGFVGLGAQGGPMARRIADAGFPTTLWARRPESLAPYAGTAARVAGSRRELGAASDVLCVCVVDDAGVDEVLRGP
EGALAGMADSGVVIIHSTTHPDTCRRLQTDFPNLRVLDAPVSGGGVRAREGTLLVMVGGDASVLERVRPVLDTFAKPLLH
IGALGTGQEVKLLNNALFAAHLALAAEVYTLAHGRGLDVEGVATVLNAGSGRSFAADVVAAAVHRLEPLAGRAGSLLAKD
VGILADLLSPNPSELIAVADTALEVMGVPRPGRKDPA

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=281, Percent_Identity=28.4697508896797, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI40556376, Length=208, Percent_Identity=26.4423076923077, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI145693186, Length=221, Percent_Identity=31.2217194570136, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786719, Length=198, Percent_Identity=33.8383838383838, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790315, Length=212, Percent_Identity=28.7735849056604, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789092, Length=249, Percent_Identity=31.7269076305221, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17557316, Length=247, Percent_Identity=27.5303643724696, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24655230, Length=249, Percent_Identity=30.9236947791165, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922568, Length=249, Percent_Identity=30.9236947791165, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574115, Length=211, Percent_Identity=27.0142180094787, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 28474; Mature: 28343

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLPRVGFVGLGAQGGPMARRIADAGFPTTLWARRPESLAPYAGTAARVAGSRRELGAA
CCCCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHCCCHHHCCCC
SDVLCVCVVDDAGVDEVLRGPEGALAGMADSGVVIIHSTTHPDTCRRLQTDFPNLRVLDA
CCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCEEEEC
PVSGGGVRAREGTLLVMVGGDASVLERVRPVLDTFAKPLLHIGALGTGQEVKLLNNALFA
CCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AHLALAAEVYTLAHGRGLDVEGVATVLNAGSGRSFAADVVAAAVHRLEPLAGRAGSLLAK
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
DVGILADLLSPNPSELIAVADTALEVMGVPRPGRKDPA
HHHHHHHHHCCCHHHEEEHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TVLPRVGFVGLGAQGGPMARRIADAGFPTTLWARRPESLAPYAGTAARVAGSRRELGAA
CCCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHCCCHHHCCCC
SDVLCVCVVDDAGVDEVLRGPEGALAGMADSGVVIIHSTTHPDTCRRLQTDFPNLRVLDA
CCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCEEEEC
PVSGGGVRAREGTLLVMVGGDASVLERVRPVLDTFAKPLLHIGALGTGQEVKLLNNALFA
CCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AHLALAAEVYTLAHGRGLDVEGVATVLNAGSGRSFAADVVAAAVHRLEPLAGRAGSLLAK
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
DVGILADLLSPNPSELIAVADTALEVMGVPRPGRKDPA
HHHHHHHHHCCCHHHEEEHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA