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The map label for this gene is lip2 [H]

Identifier: 158314682

GI number: 158314682

Start: 3375846

End: 3376751

Strand: Direct

Name: lip2 [H]

Synonym: Franean1_2861

Alternate gene names: 158314682

Gene position: 3375846-3376751 (Clockwise)

Preceding gene: 158314681

Following gene: 158314683

Centisome position: 37.58

GC content: 67.66

Gene sequence:

>906_bases
ATGGCGCTCGACCCCGCCGCCCTTCGATTTCTCGAGGCGGTCCGCGACATTCCGCAACCCTACGAAATGGCTCTCGCCGA
ATTTCGGCGCGCGGGCGAGGACCTGGTCAGAACTTCGGAACCGGAGCCGATCACGAAGGTTGACGAGTTCATCATCCCGG
GCGGCGATGGCCAGGAACTCAGGCTGCGCTGCTACGTTCCCGCGCACGAGGGTCCGCGCCCGGTGGTCGTCTGGCTGCAT
GGGGGCTCCTTCATCCGGGGATCGCTCGACATGTTCGACGCGATTCGCCGATCCTTCGCGAACGGGACCGGCTGCATCGT
GCTCGCGGTGGACCAGCGGCTGTCGCCGGAAGCACAGTTCCCGGCACCGCTGGAGGATGCCTACGCCGCCATCCGGTGGG
CCGCGGACAACGCGGACAGCCTCGGCGGAGATCCGAACCGGCTTGGCGTCGGCGGTGAGAGCAGCGGCGGAAACCTGGCC
ACGGCCGTCACGCTTCTCGCCCGGAAGCGGGGGGCGCCCCGGCTGGCCTTCCAGGTGCTGGTAACGCCGTTGGTCGACGC
CACGGTCGGAAGCGTCTCGGCGCGGGAGTACGGGGAAGGTTACGTGCTGACCCGGCAACAGCTCATTTGGGCCTACGAGC
AGTACGCGCCTGGTGTGAGCCGCGTCGATCCGCTGCTGTCTCCCCTGCACGAGCCGCGTCTCGATGGGCTTCCGCCGGCC
GTCGTCCTCACCGTCGAATATGACCCGGTGCGTGACGAGGGTGAGCTGTATGCGCGGCGCCTGGCGGCGGAAGGTGTGCC
GGTGTCCAGTGCTCGGATCGACGGGTTTCTGCATCACTTTCCCGGTTCGCAGGCCGTCCCGACGTTGGTTCGGCTCACGT
GTGGCCTGCTCGAGTTGCTGGAGTAA

Upstream 100 bases:

>100_bases
CCCTCGAACTGCGACGAGCCCGTTCCCAGCAGGAAGTTCCGGTGCGACCGCGGGAGTGGGAACGTCGAGTGGTCGACGCC
ACGAAGCGGAGGTTGTGAAC

Downstream 100 bases:

>100_bases
CCGGTGGTTTCATCCGGAAGGAACGCTCACCATGCCCGGTACCGTTGAGCCGGCCGCGCACCCTGGTTCGCTCCACCGGC
CCGCAACGCAGGCCGACCTG

Product: alpha/beta hydrolase domain-containing protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MALDPAALRFLEAVRDIPQPYEMALAEFRRAGEDLVRTSEPEPITKVDEFIIPGGDGQELRLRCYVPAHEGPRPVVVWLH
GGSFIRGSLDMFDAIRRSFANGTGCIVLAVDQRLSPEAQFPAPLEDAYAAIRWAADNADSLGGDPNRLGVGGESSGGNLA
TAVTLLARKRGAPRLAFQVLVTPLVDATVGSVSAREYGEGYVLTRQQLIWAYEQYAPGVSRVDPLLSPLHEPRLDGLPPA
VVLTVEYDPVRDEGELYARRLAAEGVPVSSARIDGFLHHFPGSQAVPTLVRLTCGLLELLE

Sequences:

>Translated_301_residues
MALDPAALRFLEAVRDIPQPYEMALAEFRRAGEDLVRTSEPEPITKVDEFIIPGGDGQELRLRCYVPAHEGPRPVVVWLH
GGSFIRGSLDMFDAIRRSFANGTGCIVLAVDQRLSPEAQFPAPLEDAYAAIRWAADNADSLGGDPNRLGVGGESSGGNLA
TAVTLLARKRGAPRLAFQVLVTPLVDATVGSVSAREYGEGYVLTRQQLIWAYEQYAPGVSRVDPLLSPLHEPRLDGLPPA
VVLTVEYDPVRDEGELYARRLAAEGVPVSSARIDGFLHHFPGSQAVPTLVRLTCGLLELLE
>Mature_300_residues
ALDPAALRFLEAVRDIPQPYEMALAEFRRAGEDLVRTSEPEPITKVDEFIIPGGDGQELRLRCYVPAHEGPRPVVVWLHG
GSFIRGSLDMFDAIRRSFANGTGCIVLAVDQRLSPEAQFPAPLEDAYAAIRWAADNADSLGGDPNRLGVGGESSGGNLAT
AVTLLARKRGAPRLAFQVLVTPLVDATVGSVSAREYGEGYVLTRQQLIWAYEQYAPGVSRVDPLLSPLHEPRLDGLPPAV
VLTVEYDPVRDEGELYARRLAAEGVPVSSARIDGFLHHFPGSQAVPTLVRLTCGLLELLE

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=336, Percent_Identity=27.6785714285714, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI68299767, Length=201, Percent_Identity=28.3582089552239, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI61966717, Length=343, Percent_Identity=24.4897959183673, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI7662470, Length=128, Percent_Identity=32.8125, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI21328446, Length=99, Percent_Identity=34.3434343434343, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786682, Length=245, Percent_Identity=31.4285714285714, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71996133, Length=277, Percent_Identity=27.4368231046931, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI72001146, Length=165, Percent_Identity=31.5151515151515, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540028, Length=179, Percent_Identity=31.2849162011173, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17567059, Length=214, Percent_Identity=27.5700934579439, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24656084, Length=101, Percent_Identity=34.6534653465347, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24656076, Length=101, Percent_Identity=34.6534653465347, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20130169, Length=101, Percent_Identity=34.6534653465347, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 32600; Mature: 32469

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDPAALRFLEAVRDIPQPYEMALAEFRRAGEDLVRTSEPEPITKVDEFIIPGGDGQEL
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECCCCCCEE
RLRCYVPAHEGPRPVVVWLHGGSFIRGSLDMFDAIRRSFANGTGCIVLAVDQRLSPEAQF
EEEEEECCCCCCCCEEEEEECCCEEECCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
PAPLEDAYAAIRWAADNADSLGGDPNRLGVGGESSGGNLATAVTLLARKRGAPRLAFQVL
CCCHHHHHHHHEECCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
VTPLVDATVGSVSAREYGEGYVLTRQQLIWAYEQYAPGVSRVDPLLSPLHEPRLDGLPPA
HHHHHHHHHCCCHHHHCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCE
VVLTVEYDPVRDEGELYARRLAAEGVPVSSARIDGFLHHFPGSQAVPTLVRLTCGLLELL
EEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
E
C
>Mature Secondary Structure 
ALDPAALRFLEAVRDIPQPYEMALAEFRRAGEDLVRTSEPEPITKVDEFIIPGGDGQEL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECCCCCCEE
RLRCYVPAHEGPRPVVVWLHGGSFIRGSLDMFDAIRRSFANGTGCIVLAVDQRLSPEAQF
EEEEEECCCCCCCCEEEEEECCCEEECCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
PAPLEDAYAAIRWAADNADSLGGDPNRLGVGGESSGGNLATAVTLLARKRGAPRLAFQVL
CCCHHHHHHHHEECCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
VTPLVDATVGSVSAREYGEGYVLTRQQLIWAYEQYAPGVSRVDPLLSPLHEPRLDGLPPA
HHHHHHHHHCCCHHHHCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCE
VVLTVEYDPVRDEGELYARRLAAEGVPVSSARIDGFLHHFPGSQAVPTLVRLTCGLLELL
EEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]