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The map label for this gene is zitB [H]

Identifier: 158314270

GI number: 158314270

Start: 2901455

End: 2902552

Strand: Direct

Name: zitB [H]

Synonym: Franean1_2440

Alternate gene names: 158314270

Gene position: 2901455-2902552 (Clockwise)

Preceding gene: 158314269

Following gene: 158314271

Centisome position: 32.3

GC content: 75.87

Gene sequence:

>1098_bases
GTGAACACCCCCGAAGGCCGCCACGGTGACCACGGGCACGACAACGGTCAGGGTCTCGTCCCGCCGCAGACCCGGCCCGC
CCACGGCCACGACTCCGGCCACACCCACGCCCACGGCGGGCCCTGCGCGCCGGGCGGGCACGAGCACGCGGCGGGTGGGT
CCGCTCCGCGCGGCTTCGACTCCCAGCACCGCAGGCTGGCGTTCGCGACGGGCCTGAACGTCGCGATCGTCGTCGGCCAG
GCCGCGGCCGGGCTGCTCGTCGGGTCGGTCGCCCTGCTCGCCGACGCCGCGCACAACCTCGCGGACGCGGCGGGCGTCGC
GTTCGCGCTGATGGCGATCCGGCTCGCGAGGCAGGCGCCGTCCGCCACCCGGACCTTCGGCGGGCTGCGCTGGCCGGTGC
TCGCCGCCCAGGCGAACGCGGCGAGCGTGCTGGTCGTGACCACCCTGGTCTGCGTCGAGGCCGCCGGGCGGCTCGCCCAC
CCCGAGCCGGTCGACGGCTTGGTCGTCCTGATCGTGGCGATCGCCGCGGCCGTCGGTAACGGGGTCAGCGCGCTCTTCGT
CCACGAACGGCACGGTGATCTCAACACCAGGGCGGCGGTCACCCACCTGGCCGGCGACGCGCTGGTGTCGGTCGCGGTGG
CCGGCGCCGGGCTCGTCATCTGGCTCACCGGCGGCTGGTACTGGCTCGACCCGGCGCTCTCCCTGGTCGTGGCGGCGCTG
ATCGGGATCCAGGGCGTGCGCCTGCTGGCCGAGTCGTCCCGGGTGCTGCTCGAGGCGACCCCCGTCGGGCTGGACCTGGC
GGCAGTCCAGGCGGACGTCCTTGCCGTGGAGGGCGTGACCGGGGTGCACGACGTGCACGTGTGGGGCCTGTCCGACCGGG
TCGCCGCGGCGAGCGCCCATGTCGAGGTGGCCGGCCATCCGACACTCGAGGAGGCGCGGGCGGTCTCAGACCGGGTCAAG
GCGGTGCTGGCGGAGAAGCACGGCGTCGTGCACGCCACCGTCGAGACGGAGTGCGAGCCGTGCTCGCCCGCCGGCGGCGA
CCCGTGCGACGTGCGCAGGGTGACCGTGCACCAGCTGGCCCCGGCGCACCGCCACTGA

Upstream 100 bases:

>100_bases
CCGGCGGCGATCTCGTCGCGCCCGCTGGGGAGCAGCCGGCCCGGTTCGTGCCCACCGGTGGGAGCGCCGCCGCGCGCGAC
CTCACCGACCTGGTGGACCG

Downstream 100 bases:

>100_bases
TCCCCGGCGCACCGCCTCCCCGGCGCACCGTCGCCATCGTGGACTGATCGTGTGCACCCGGTCGCGGTGGGTATGTCATG
TCGAGTCGGATCGCGGCTTC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNTPEGRHGDHGHDNGQGLVPPQTRPAHGHDSGHTHAHGGPCAPGGHEHAAGGSAPRGFDSQHRRLAFATGLNVAIVVGQ
AAAGLLVGSVALLADAAHNLADAAGVAFALMAIRLARQAPSATRTFGGLRWPVLAAQANAASVLVVTTLVCVEAAGRLAH
PEPVDGLVVLIVAIAAAVGNGVSALFVHERHGDLNTRAAVTHLAGDALVSVAVAGAGLVIWLTGGWYWLDPALSLVVAAL
IGIQGVRLLAESSRVLLEATPVGLDLAAVQADVLAVEGVTGVHDVHVWGLSDRVAAASAHVEVAGHPTLEEARAVSDRVK
AVLAEKHGVVHATVETECEPCSPAGGDPCDVRRVTVHQLAPAHRH

Sequences:

>Translated_365_residues
MNTPEGRHGDHGHDNGQGLVPPQTRPAHGHDSGHTHAHGGPCAPGGHEHAAGGSAPRGFDSQHRRLAFATGLNVAIVVGQ
AAAGLLVGSVALLADAAHNLADAAGVAFALMAIRLARQAPSATRTFGGLRWPVLAAQANAASVLVVTTLVCVEAAGRLAH
PEPVDGLVVLIVAIAAAVGNGVSALFVHERHGDLNTRAAVTHLAGDALVSVAVAGAGLVIWLTGGWYWLDPALSLVVAAL
IGIQGVRLLAESSRVLLEATPVGLDLAAVQADVLAVEGVTGVHDVHVWGLSDRVAAASAHVEVAGHPTLEEARAVSDRVK
AVLAEKHGVVHATVETECEPCSPAGGDPCDVRRVTVHQLAPAHRH
>Mature_365_residues
MNTPEGRHGDHGHDNGQGLVPPQTRPAHGHDSGHTHAHGGPCAPGGHEHAAGGSAPRGFDSQHRRLAFATGLNVAIVVGQ
AAAGLLVGSVALLADAAHNLADAAGVAFALMAIRLARQAPSATRTFGGLRWPVLAAQANAASVLVVTTLVCVEAAGRLAH
PEPVDGLVVLIVAIAAAVGNGVSALFVHERHGDLNTRAAVTHLAGDALVSVAVAGAGLVIWLTGGWYWLDPALSLVVAAL
IGIQGVRLLAESSRVLLEATPVGLDLAAVQADVLAVEGVTGVHDVHVWGLSDRVAAASAHVEVAGHPTLEEARAVSDRVK
AVLAEKHGVVHATVETECEPCSPAGGDPCDVRRVTVHQLAPAHRH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI64762489, Length=345, Percent_Identity=26.6666666666667, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI52352805, Length=330, Percent_Identity=27.8787878787879, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI289803013, Length=331, Percent_Identity=26.2839879154079, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI289803009, Length=331, Percent_Identity=26.2839879154079, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI289803007, Length=331, Percent_Identity=26.2839879154079, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI289803003, Length=331, Percent_Identity=26.2839879154079, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI21359890, Length=319, Percent_Identity=23.1974921630094, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI21361112, Length=344, Percent_Identity=25, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI14210520, Length=231, Percent_Identity=27.7056277056277, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI20070323, Length=323, Percent_Identity=23.8390092879257, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI52351208, Length=152, Percent_Identity=25, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786966, Length=285, Percent_Identity=37.1929824561403, Blast_Score=141, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI193210990, Length=370, Percent_Identity=27.027027027027, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17555794, Length=342, Percent_Identity=28.3625730994152, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17555796, Length=300, Percent_Identity=29.3333333333333, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32564488, Length=307, Percent_Identity=27.3615635179153, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17550442, Length=123, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17550440, Length=123, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=165, Percent_Identity=35.1515151515151, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=152, Percent_Identity=30.9210526315789, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583858, Length=300, Percent_Identity=26.6666666666667, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24656728, Length=162, Percent_Identity=34.5679012345679, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656724, Length=162, Percent_Identity=34.5679012345679, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656720, Length=162, Percent_Identity=34.5679012345679, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656715, Length=162, Percent_Identity=34.5679012345679, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357035, Length=162, Percent_Identity=34.5679012345679, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574430, Length=159, Percent_Identity=25.7861635220126, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24584409, Length=159, Percent_Identity=25.7861635220126, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585900, Length=161, Percent_Identity=24.8447204968944, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24585898, Length=161, Percent_Identity=24.8447204968944, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24585896, Length=161, Percent_Identity=24.8447204968944, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19921672, Length=161, Percent_Identity=24.8447204968944, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 37104; Mature: 37104

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPEGRHGDHGHDNGQGLVPPQTRPAHGHDSGHTHAHGGPCAPGGHEHAAGGSAPRGFD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SQHRRLAFATGLNVAIVVGQAAAGLLVGSVALLADAAHNLADAAGVAFALMAIRLARQAP
CHHCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SATRTFGGLRWPVLAAQANAASVLVVTTLVCVEAAGRLAHPEPVDGLVVLIVAIAAAVGN
CHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
GVSALFVHERHGDLNTRAAVTHLAGDALVSVAVAGAGLVIWLTGGWYWLDPALSLVVAAL
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECHHHHHHHHHH
IGIQGVRLLAESSRVLLEATPVGLDLAAVQADVLAVEGVTGVHDVHVWGLSDRVAAASAH
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHEEECCCCCCEEEEEECCCCHHHHCCCE
VEVAGHPTLEEARAVSDRVKAVLAEKHGVVHATVETECEPCSPAGGDPCDVRRVTVHQLA
EEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEHHHHCC
PAHRH
CCCCC
>Mature Secondary Structure
MNTPEGRHGDHGHDNGQGLVPPQTRPAHGHDSGHTHAHGGPCAPGGHEHAAGGSAPRGFD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SQHRRLAFATGLNVAIVVGQAAAGLLVGSVALLADAAHNLADAAGVAFALMAIRLARQAP
CHHCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SATRTFGGLRWPVLAAQANAASVLVVTTLVCVEAAGRLAHPEPVDGLVVLIVAIAAAVGN
CHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
GVSALFVHERHGDLNTRAAVTHLAGDALVSVAVAGAGLVIWLTGGWYWLDPALSLVVAAL
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECHHHHHHHHHH
IGIQGVRLLAESSRVLLEATPVGLDLAAVQADVLAVEGVTGVHDVHVWGLSDRVAAASAH
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHEEECCCCCCEEEEEECCCCHHHHCCCE
VEVAGHPTLEEARAVSDRVKAVLAEKHGVVHATVETECEPCSPAGGDPCDVRRVTVHQLA
EEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEHHHHCC
PAHRH
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]