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The map label for this gene is mtaD [H]

Identifier: 158314116

GI number: 158314116

Start: 2727364

End: 2728785

Strand: Direct

Name: mtaD [H]

Synonym: Franean1_2283

Alternate gene names: 158314116

Gene position: 2727364-2728785 (Clockwise)

Preceding gene: 158314115

Following gene: 158314117

Centisome position: 30.36

GC content: 75.18

Gene sequence:

>1422_bases
GTGACCCCACCACCGGCGGGTCCCGCTCCGCTGCCCGCCGACTTCGTCGTGCGGGCCCGGCACGTCCTGACCATGGGGCC
CCGCGGCCACCTGCGGGACGCCGCGGTCGCCGTCGTCGGTGGGCGGATCGCCGCCGTCGACACCGCGGCGGACGTCCGGG
CGCGGTTCGCGGACCTGCCGGTGGTCGGGGACGGCGGCGGGATCCTGATCCCGGGGCTGGTCAGCGCGCACGGGCACTTC
TCCGAGGGGCTCGTCACCGGCATCGGTGAGACGCACACGCTGTGGGAGTGGTTCGTCCGCGTCGTCGAGCCCATCGAGGG
GCACCTCACCCGGGACATGGCCTACGTCGGGACGCTGCTCAAGGCGGCCGAGCTGGCCTGTTCCGGGGTGACGACGGTCG
CAGACATGTTCTGCTCGGCGGCCGGGGCCACCCCGGTCACCCCCGGGGTGGTCGACGCCCTCGACGCCGTCGGCCTACGC
GGCGATGTGTCGTTCGGCCCGGCGGACTCGGCGAACCCCCGGCCGGTCGCGGCCGTCCTCGCCGAGCACGCGGCGCTCGC
CGACGCGGCCCGCAACTCCCGCCGGACCACCTTCCGGGTGGGCCTGGCGACCGTGCCGTCGAGCAGCGACGAGCTGCTCG
ACGAGACGGCCCGGCTGGTCGCGCAGACCGGCCGGCTGCACGTCCACCTGCACGAGATCCGCGAGGAGGTGACCGCGTCG
CGGACGACGCGCGGCACCGGGTCGATCGAGTTCGCCGCGCGGCGCGGGCTGCTCGACGCGCAGGTCGTGGCCGCGCACTG
CGTGTGGCTCGACGACACCGACGTAGAACTGCTGCGCCGGCACCGGGTCGCGGTCGCGCACTGCCCCGTCTCGAACATGA
TCCTCGCCAGCGGGGTGTGCCAGGTCCCGCGGCTGCTGCGCGACGGGTTCACCGTCGCGCTCGGCGTGGACGGCGCGGCG
AGCAACGACAGCCAGAACATGCTGGAGACGATGAAAATCGCCGCCCTGCTGCAGAAGGTGCACCACCTGCAGGCGACGGC
CCTGACGGCGCCGACGGTGCTGCGGATGGCGACCATCGAGGGTGCGCGGGCGCTCGGGCTCGCCGACGAGGTCGGCTCCC
TGGAGGTCGGCAAGGCCGCCGACCTGGTCTACCTCGCCGAGGCGAGCCCGTCGCTGGCGCTCGTGCACGACCCCTACCAG
GCGGTTGTCTACTGTGCCTCCCCGCGGGACGTCACCGGGGTGTGGGTGGCCGGTGAGCGGGTCGTCGCCGACGGGCGGCT
GGTCGCCGTCGATCTCGGGCCGGTCCTGCCGTGGGCGCGTGAGCTGGCCGTCGAGCTCGCCAGCCGGGCCGGGCTGGACT
CCGAGCTGCGCTCCGCCGCGGCCGGCCCGCCAGTGGAAGTGGTGCCCGGCGCGGCGCGGTGA

Upstream 100 bases:

>100_bases
TCGAGCCGATCTTCACCGGCCAGCGCAAGGAGCTCAAGGCCGGCCTGGCACCCGGTGACCTGTTCACGAACGAGTTCATC
AACACCTCGATCGGCCTCAA

Downstream 100 bases:

>100_bases
ACGACGGTTGGGGTCCTTTCGGACATTAGACTGCGCACTCCGGGCGGCGCGGTGCGGGAGGTGCGGTGATCGCTGGGGTT
GCGGGGCTGGCCGCGGCGGC

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTPPPAGPAPLPADFVVRARHVLTMGPRGHLRDAAVAVVGGRIAAVDTAADVRARFADLPVVGDGGGILIPGLVSAHGHF
SEGLVTGIGETHTLWEWFVRVVEPIEGHLTRDMAYVGTLLKAAELACSGVTTVADMFCSAAGATPVTPGVVDALDAVGLR
GDVSFGPADSANPRPVAAVLAEHAALADAARNSRRTTFRVGLATVPSSSDELLDETARLVAQTGRLHVHLHEIREEVTAS
RTTRGTGSIEFAARRGLLDAQVVAAHCVWLDDTDVELLRRHRVAVAHCPVSNMILASGVCQVPRLLRDGFTVALGVDGAA
SNDSQNMLETMKIAALLQKVHHLQATALTAPTVLRMATIEGARALGLADEVGSLEVGKAADLVYLAEASPSLALVHDPYQ
AVVYCASPRDVTGVWVAGERVVADGRLVAVDLGPVLPWARELAVELASRAGLDSELRSAAAGPPVEVVPGAAR

Sequences:

>Translated_473_residues
MTPPPAGPAPLPADFVVRARHVLTMGPRGHLRDAAVAVVGGRIAAVDTAADVRARFADLPVVGDGGGILIPGLVSAHGHF
SEGLVTGIGETHTLWEWFVRVVEPIEGHLTRDMAYVGTLLKAAELACSGVTTVADMFCSAAGATPVTPGVVDALDAVGLR
GDVSFGPADSANPRPVAAVLAEHAALADAARNSRRTTFRVGLATVPSSSDELLDETARLVAQTGRLHVHLHEIREEVTAS
RTTRGTGSIEFAARRGLLDAQVVAAHCVWLDDTDVELLRRHRVAVAHCPVSNMILASGVCQVPRLLRDGFTVALGVDGAA
SNDSQNMLETMKIAALLQKVHHLQATALTAPTVLRMATIEGARALGLADEVGSLEVGKAADLVYLAEASPSLALVHDPYQ
AVVYCASPRDVTGVWVAGERVVADGRLVAVDLGPVLPWARELAVELASRAGLDSELRSAAAGPPVEVVPGAAR
>Mature_472_residues
TPPPAGPAPLPADFVVRARHVLTMGPRGHLRDAAVAVVGGRIAAVDTAADVRARFADLPVVGDGGGILIPGLVSAHGHFS
EGLVTGIGETHTLWEWFVRVVEPIEGHLTRDMAYVGTLLKAAELACSGVTTVADMFCSAAGATPVTPGVVDALDAVGLRG
DVSFGPADSANPRPVAAVLAEHAALADAARNSRRTTFRVGLATVPSSSDELLDETARLVAQTGRLHVHLHEIREEVTASR
TTRGTGSIEFAARRGLLDAQVVAAHCVWLDDTDVELLRRHRVAVAHCPVSNMILASGVCQVPRLLRDGFTVALGVDGAAS
NDSQNMLETMKIAALLQKVHHLQATALTAPTVLRMATIEGARALGLADEVGSLEVGKAADLVYLAEASPSLALVHDPYQA
VVYCASPRDVTGVWVAGERVVADGRLVAVDLGPVLPWARELAVELASRAGLDSELRSAAAGPPVEVVPGAAR

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=384, Percent_Identity=26.5625, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1789249, Length=425, Percent_Identity=27.0588235294118, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082177, Length=432, Percent_Identity=27.0833333333333, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319963, Length=404, Percent_Identity=25.4950495049505, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24643849, Length=390, Percent_Identity=27.9487179487179, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 49205; Mature: 49074

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPPAGPAPLPADFVVRARHVLTMGPRGHLRDAAVAVVGGRIAAVDTAADVRARFADLP
CCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCHHHHEEECCEEEEECCHHHHHHHHHCCC
VVGDGGGILIPGLVSAHGHFSEGLVTGIGETHTLWEWFVRVVEPIEGHLTRDMAYVGTLL
EEECCCCEEECCHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAAELACSGVTTVADMFCSAAGATPVTPGVVDALDAVGLRGDVSFGPADSANPRPVAAVL
HHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
AEHAALADAARNSRRTTFRVGLATVPSSSDELLDETARLVAQTGRLHVHLHEIREEVTAS
HHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHH
RTTRGTGSIEFAARRGLLDAQVVAAHCVWLDDTDVELLRRHRVAVAHCPVSNMILASGVC
CCCCCCCCEEHHHHCCCCHHHHHEEEEEEECCCCHHHHHHCCCEEEECCHHHHHHHHHHH
QVPRLLRDGFTVALGVDGAASNDSQNMLETMKIAALLQKVHHLQATALTAPTVLRMATIE
HHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHC
GARALGLADEVGSLEVGKAADLVYLAEASPSLALVHDPYQAVVYCASPRDVTGVWVAGER
CCHHCCCHHCCCCCCCCCCCCEEEEECCCCCEEEEECCCEEEEEECCCCCCEEEEEECCE
VVADGRLVAVDLGPVLPWARELAVELASRAGLDSELRSAAAGPPVEVVPGAAR
EEECCEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPPPAGPAPLPADFVVRARHVLTMGPRGHLRDAAVAVVGGRIAAVDTAADVRARFADLP
CCCCCCCCCCCHHHHHHHHHHEEECCCCCCCHHHHEEECCEEEEECCHHHHHHHHHCCC
VVGDGGGILIPGLVSAHGHFSEGLVTGIGETHTLWEWFVRVVEPIEGHLTRDMAYVGTLL
EEECCCCEEECCHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAAELACSGVTTVADMFCSAAGATPVTPGVVDALDAVGLRGDVSFGPADSANPRPVAAVL
HHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
AEHAALADAARNSRRTTFRVGLATVPSSSDELLDETARLVAQTGRLHVHLHEIREEVTAS
HHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHH
RTTRGTGSIEFAARRGLLDAQVVAAHCVWLDDTDVELLRRHRVAVAHCPVSNMILASGVC
CCCCCCCCEEHHHHCCCCHHHHHEEEEEEECCCCHHHHHHCCCEEEECCHHHHHHHHHHH
QVPRLLRDGFTVALGVDGAASNDSQNMLETMKIAALLQKVHHLQATALTAPTVLRMATIE
HHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHC
GARALGLADEVGSLEVGKAADLVYLAEASPSLALVHDPYQAVVYCASPRDVTGVWVAGER
CCHHCCCHHCCCCCCCCCCCCEEEEECCCCCEEEEECCCEEEEEECCCCCCEEEEEECCE
VVADGRLVAVDLGPVLPWARELAVELASRAGLDSELRSAAAGPPVEVVPGAAR
EEECCEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]