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The map label for this gene is kefBC [H]

Identifier: 158314027

GI number: 158314027

Start: 2626404

End: 2627786

Strand: Direct

Name: kefBC [H]

Synonym: Franean1_2193

Alternate gene names: 158314027

Gene position: 2626404-2627786 (Clockwise)

Preceding gene: 158314026

Following gene: 158314032

Centisome position: 29.24

GC content: 72.38

Gene sequence:

>1383_bases
GTGACGGCGGCCCCGGTGGCCTCGTTGTCCCATCATTCATTGCTCATTTTTCTTCTTCAGGTGACCGTCCTGTTGTGCCT
CGCGCTGGGGCTCGGTCGTCTCGCCATCCGACTCGGGCTGCCCTCCGTGGTCGGCGAACTGCTCGCGGGCGTGGTGGTCG
GCCCGTCGCTGCTCGGGGCGGTCGCGTCCGAGTTCTCGGGCTGGCTGCTGCCCGCCGAGCCCGACCAGATGCACCTGCTC
GACGCGCTGGGGCAGATCGGCGTGATCCTCCTGGTGGGCCTCACCGGCATCGAGATGGACATGCGGATGGTCCGCCGGCG
GGGAGCCACCGCCGCGCGGATCAGCATCGCCGGCCTCGTGCTGCCGGTCGGGCTCGGGATCGGCGCGGGCCTGCTCCTGC
CGGAGTCGCTGCTGGCGGACGGCGCCGACCGCGGGGAGTTCGCGCTGTTCCTCGGGGTGGCCATGGGGGTCAGCGCGATC
CCCGTCGCGGCCAAGATCCTGCACGACATGCGGCTGCTGCACCGCAACGTCGGCCAGCTCATCCTCGCCTCCGCCACGGT
TGACGACGCGGTCGGCTGGTCGTTGCTGTCGGTGGTCTCCGCGATGGCGACAACGGGGGTGCGCGGCGGCGACATCGCGT
GGCCGGTGCTCAGCGTGATCGGTGTCGTCGCCGCGGCGTTCGTTGTCGGCCGCCCGCTCGCCCGGCTGGCCGTCGCCGCC
GGCGGCCTTGCCAGGCCGTCCGCTGAAACGGCTGAAACGGCTGACACCGGCGGCACCGGATCGGGTTCCGGTATCGCGGT
GGCGGTCGTCTTCATCCTCGCCGCGGCCGCCGGGACGCACGCTCTCAAACTGGAGGCGATCCTCGGCGCGTTCATTGCCG
GCATCCTGCTCGGGTCCACGCCGACTCTGGACATCCGGCGGCTCGAACCGCTCCGCCTGATGGTCATGGGCGTGCTCGCG
CCGATCTTCTTCGCGTCCGCCGGGCTGCGCATCGACCTGACCGCGCTGACCCGGCCGGAGGTGGCGCTCGCCGCCGTCGT
GATCCTCGGACTCGCGATCCTGGGCAAGTTCGCCGGTGCCTACATCGGTGCCCGCGCGAGCCGGCTGGGGCACTGGGAGG
CGCTCTCGCTGGGCGCGGGCCTGAACGCCCGCGGCGTCATCGAGATCGTCGTGGCCGGCACGGGCCTGCGCCTCGGCGTC
CTCTCCACCGCGACGTACACCGTGATCGTCCTGGTGGCGGTCGTGACGTCGATCATGACGCCGCCGATCCTGCGGGCGAC
CATGCGCCGGGTGGAGCAGACCGCCGAGGAGCAGCTGCGCGAGCTCGACCTGGCCGGTCGCTCCGTCGGGGCGCCCCGCG
GCCTCGACGCCGAACGCCCCTGA

Upstream 100 bases:

>100_bases
GCGCTAATCTCATCGCACCTGATTCACCCGGTGGACGGCGAGCTGAAACGACTACGTGGCGGCGGGGGCTGGCGCAGTGA
ACGCGACGGAGACGTCATTC

Downstream 100 bases:

>100_bases
GGACCGGCCAGCCCCCGGCAAGCGCCCGCTGACCTGCGGGTCAGCGGGCGCTGAGGATCTTCTCGAAGAACTCCCGGTAG
CCGCGCAGCGCCTTGCGTAG

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTAAPVASLSHHSLLIFLLQVTVLLCLALGLGRLAIRLGLPSVVGELLAGVVVGPSLLGAVASEFSGWLLPAEPDQMHLL
DALGQIGVILLVGLTGIEMDMRMVRRRGATAARISIAGLVLPVGLGIGAGLLLPESLLADGADRGEFALFLGVAMGVSAI
PVAAKILHDMRLLHRNVGQLILASATVDDAVGWSLLSVVSAMATTGVRGGDIAWPVLSVIGVVAAAFVVGRPLARLAVAA
GGLARPSAETAETADTGGTGSGSGIAVAVVFILAAAAGTHALKLEAILGAFIAGILLGSTPTLDIRRLEPLRLMVMGVLA
PIFFASAGLRIDLTALTRPEVALAAVVILGLAILGKFAGAYIGARASRLGHWEALSLGAGLNARGVIEIVVAGTGLRLGV
LSTATYTVIVLVAVVTSIMTPPILRATMRRVEQTAEEQLRELDLAGRSVGAPRGLDAERP

Sequences:

>Translated_460_residues
MTAAPVASLSHHSLLIFLLQVTVLLCLALGLGRLAIRLGLPSVVGELLAGVVVGPSLLGAVASEFSGWLLPAEPDQMHLL
DALGQIGVILLVGLTGIEMDMRMVRRRGATAARISIAGLVLPVGLGIGAGLLLPESLLADGADRGEFALFLGVAMGVSAI
PVAAKILHDMRLLHRNVGQLILASATVDDAVGWSLLSVVSAMATTGVRGGDIAWPVLSVIGVVAAAFVVGRPLARLAVAA
GGLARPSAETAETADTGGTGSGSGIAVAVVFILAAAAGTHALKLEAILGAFIAGILLGSTPTLDIRRLEPLRLMVMGVLA
PIFFASAGLRIDLTALTRPEVALAAVVILGLAILGKFAGAYIGARASRLGHWEALSLGAGLNARGVIEIVVAGTGLRLGV
LSTATYTVIVLVAVVTSIMTPPILRATMRRVEQTAEEQLRELDLAGRSVGAPRGLDAERP
>Mature_459_residues
TAAPVASLSHHSLLIFLLQVTVLLCLALGLGRLAIRLGLPSVVGELLAGVVVGPSLLGAVASEFSGWLLPAEPDQMHLLD
ALGQIGVILLVGLTGIEMDMRMVRRRGATAARISIAGLVLPVGLGIGAGLLLPESLLADGADRGEFALFLGVAMGVSAIP
VAAKILHDMRLLHRNVGQLILASATVDDAVGWSLLSVVSAMATTGVRGGDIAWPVLSVIGVVAAAFVVGRPLARLAVAAG
GLARPSAETAETADTGGTGSGSGIAVAVVFILAAAAGTHALKLEAILGAFIAGILLGSTPTLDIRRLEPLRLMVMGVLAP
IFFASAGLRIDLTALTRPEVALAAVVILGLAILGKFAGAYIGARASRLGHWEALSLGAGLNARGVIEIVVAGTGLRLGVL
STATYTVIVLVAVVTSIMTPPILRATMRRVEQTAEEQLRELDLAGRSVGAPRGLDAERP

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=439, Percent_Identity=25.7403189066059, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786685, Length=421, Percent_Identity=27.3159144893112, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322367, Length=467, Percent_Identity=26.1241970021413, Blast_Score=134, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 46815; Mature: 46684

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAPVASLSHHSLLIFLLQVTVLLCLALGLGRLAIRLGLPSVVGELLAGVVVGPSLLGA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VASEFSGWLLPAEPDQMHLLDALGQIGVILLVGLTGIEMDMRMVRRRGATAARISIAGLV
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHH
LPVGLGIGAGLLLPESLLADGADRGEFALFLGVAMGVSAIPVAAKILHDMRLLHRNVGQL
HHHHHCCCCHHHCCHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
ILASATVDDAVGWSLLSVVSAMATTGVRGGDIAWPVLSVIGVVAAAFVVGRPLARLAVAA
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
GGLARPSAETAETADTGGTGSGSGIAVAVVFILAAAAGTHALKLEAILGAFIAGILLGST
CCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PTLDIRRLEPLRLMVMGVLAPIFFASAGLRIDLTALTRPEVALAAVVILGLAILGKFAGA
CCCCHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
YIGARASRLGHWEALSLGAGLNARGVIEIVVAGTGLRLGVLSTATYTVIVLVAVVTSIMT
HHHHHHHHCCCCHHHECCCCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHC
PPILRATMRRVEQTAEEQLRELDLAGRSVGAPRGLDAERP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAAPVASLSHHSLLIFLLQVTVLLCLALGLGRLAIRLGLPSVVGELLAGVVVGPSLLGA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VASEFSGWLLPAEPDQMHLLDALGQIGVILLVGLTGIEMDMRMVRRRGATAARISIAGLV
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHH
LPVGLGIGAGLLLPESLLADGADRGEFALFLGVAMGVSAIPVAAKILHDMRLLHRNVGQL
HHHHHCCCCHHHCCHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
ILASATVDDAVGWSLLSVVSAMATTGVRGGDIAWPVLSVIGVVAAAFVVGRPLARLAVAA
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
GGLARPSAETAETADTGGTGSGSGIAVAVVFILAAAAGTHALKLEAILGAFIAGILLGST
CCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PTLDIRRLEPLRLMVMGVLAPIFFASAGLRIDLTALTRPEVALAAVVILGLAILGKFAGA
CCCCHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
YIGARASRLGHWEALSLGAGLNARGVIEIVVAGTGLRLGVLSTATYTVIVLVAVVTSIMT
HHHHHHHHCCCCHHHECCCCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHC
PPILRATMRRVEQTAEEQLRELDLAGRSVGAPRGLDAERP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]