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The map label for this gene is tpiA [H]

Identifier: 158313900

GI number: 158313900

Start: 2488987

End: 2489799

Strand: Direct

Name: tpiA [H]

Synonym: Franean1_2065

Alternate gene names: 158313900

Gene position: 2488987-2489799 (Clockwise)

Preceding gene: 158313899

Following gene: 158313901

Centisome position: 27.71

GC content: 71.71

Gene sequence:

>813_bases
GTGGCGAAGGGGGCACCCGCCCGCGGGTCGGCCGGAACCGGCCGGCGGACGCTGGTCGCCGGCAACTGGAAGATGAACCT
CAACCACCTCGAGGCCATCGCGCTGGTGCAGAAGGTCGCCTTCGACCTCAAGCCCGCCGAGCTCGAGCGGGTCGAGGTCG
TCTTCCTGCCGCCGTTCACCGACCTGCGCAGCGTCCAGACGCTGATCGACGGCGACAAGCTCGCCGTCGGCTACGGCGGC
CAGGATCTCTCCCCGCACGGCTCGGGCGCCTACACCGGCGACATCAGCGGGCCGATGCTGGCCAGGCTCGGCTGCTCGTA
CGTCGTCGTCGGGCACTCCGAGCGGCGCACGTACCACCACGAGGACGACGCGCTGGTCGCCTCGAAGGTCCTGGCGGCCT
ACAAACACGGCATCACGCCGATCCTGTGTGTCGGCGAGCACGAGGACATCCGCGCCGCGGGAACCCATGTCGAGCACGTC
CTGGCGCAGCTCGAGGGCTCGCTGGCCGGCGTGAGCGCGGAGCAGGCGGCCACGCTCGTCGTCGCCTACGAGCCGGTCTG
GGCGATCGGTACCGGGCGCACCGCATCCGCCCAGGACGCGCAGGACATGTGCGCCGCCGTCCGCGGCCAGCTGACGAAGC
TGTACGACGAGCCGATCGCGGCCGGCATCCGGGTCCTCTACGGCGGCTCGGTGAAGGCCGCCAACGCGGCCGAGCTGTTC
ACCATGCCCGACGTGGACGGCGGTCTGGTCGGCGGTGCGAGCCTGGTCGCCGAGGAGTTCGTCGGCATCATCCGCAGCGG
TCCGGCGGCGTAG

Upstream 100 bases:

>100_bases
GTACCTGGAGGGCAAGACGCTCCCGGGCCTCGCCGCGCTCGACGTCTGAGTACCACCGAGTCTGATCTTCACACTTTCAC
CGAGGAAGGGAAGCAGGGAC

Downstream 100 bases:

>100_bases
CGGGGGCTGTCCGCCACCGGTGCGCGCCCGCGGCCGGCCGCGCACGAGCCGTCCCGGGGTGTGCCACATCGGCGACCGGG
GTGGCGTCATGTACGTTTGC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MAKGAPARGSAGTGRRTLVAGNWKMNLNHLEAIALVQKVAFDLKPAELERVEVVFLPPFTDLRSVQTLIDGDKLAVGYGG
QDLSPHGSGAYTGDISGPMLARLGCSYVVVGHSERRTYHHEDDALVASKVLAAYKHGITPILCVGEHEDIRAAGTHVEHV
LAQLEGSLAGVSAEQAATLVVAYEPVWAIGTGRTASAQDAQDMCAAVRGQLTKLYDEPIAAGIRVLYGGSVKAANAAELF
TMPDVDGGLVGGASLVAEEFVGIIRSGPAA

Sequences:

>Translated_270_residues
MAKGAPARGSAGTGRRTLVAGNWKMNLNHLEAIALVQKVAFDLKPAELERVEVVFLPPFTDLRSVQTLIDGDKLAVGYGG
QDLSPHGSGAYTGDISGPMLARLGCSYVVVGHSERRTYHHEDDALVASKVLAAYKHGITPILCVGEHEDIRAAGTHVEHV
LAQLEGSLAGVSAEQAATLVVAYEPVWAIGTGRTASAQDAQDMCAAVRGQLTKLYDEPIAAGIRVLYGGSVKAANAAELF
TMPDVDGGLVGGASLVAEEFVGIIRSGPAA
>Mature_269_residues
AKGAPARGSAGTGRRTLVAGNWKMNLNHLEAIALVQKVAFDLKPAELERVEVVFLPPFTDLRSVQTLIDGDKLAVGYGGQ
DLSPHGSGAYTGDISGPMLARLGCSYVVVGHSERRTYHHEDDALVASKVLAAYKHGITPILCVGEHEDIRAAGTHVEHVL
AQLEGSLAGVSAEQAATLVVAYEPVWAIGTGRTASAQDAQDMCAAVRGQLTKLYDEPIAAGIRVLYGGSVKAANAAELFT
MPDVDGGLVGGASLVAEEFVGIIRSGPAA

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=252, Percent_Identity=40.0793650793651, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI226529917, Length=252, Percent_Identity=40.0793650793651, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1790353, Length=256, Percent_Identity=41.015625, Blast_Score=179, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17536593, Length=253, Percent_Identity=41.1067193675889, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320255, Length=252, Percent_Identity=40.8730158730159, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI28572004, Length=259, Percent_Identity=41.3127413127413, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28572008, Length=253, Percent_Identity=41.897233201581, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28572006, Length=253, Percent_Identity=41.897233201581, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 28108; Mature: 27977

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKGAPARGSAGTGRRTLVAGNWKMNLNHLEAIALVQKVAFDLKPAELERVEVVFLPPFT
CCCCCCCCCCCCCCCEEEEECCEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCH
DLRSVQTLIDGDKLAVGYGGQDLSPHGSGAYTGDISGPMLARLGCSYVVVGHSERRTYHH
HHHHHHHHHCCCEEEEEECCCCCCCCCCCCEECCCCCHHHHHCCCCEEEEECCCCCCCCC
EDDALVASKVLAAYKHGITPILCVGEHEDIRAAGTHVEHVLAQLEGSLAGVSAEQAATLV
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEE
VAYEPVWAIGTGRTASAQDAQDMCAAVRGQLTKLYDEPIAAGIRVLYGGSVKAANAAELF
EEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCEEEE
TMPDVDGGLVGGASLVAEEFVGIIRSGPAA
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKGAPARGSAGTGRRTLVAGNWKMNLNHLEAIALVQKVAFDLKPAELERVEVVFLPPFT
CCCCCCCCCCCCCCEEEEECCEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCH
DLRSVQTLIDGDKLAVGYGGQDLSPHGSGAYTGDISGPMLARLGCSYVVVGHSERRTYHH
HHHHHHHHHCCCEEEEEECCCCCCCCCCCCEECCCCCHHHHHCCCCEEEEECCCCCCCCC
EDDALVASKVLAAYKHGITPILCVGEHEDIRAAGTHVEHVLAQLEGSLAGVSAEQAATLV
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEE
VAYEPVWAIGTGRTASAQDAQDMCAAVRGQLTKLYDEPIAAGIRVLYGGSVKAANAAELF
EEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCEEEE
TMPDVDGGLVGGASLVAEEFVGIIRSGPAA
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]