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The map label for this gene is uvrC

Identifier: 158313894

GI number: 158313894

Start: 2481394

End: 2483472

Strand: Direct

Name: uvrC

Synonym: Franean1_2059

Alternate gene names: 158313894

Gene position: 2481394-2483472 (Clockwise)

Preceding gene: 158313892

Following gene: 158313895

Centisome position: 27.63

GC content: 73.02

Gene sequence:

>2079_bases
ATGGCTGATCCGGCGTCCTACCGGCCCCCGCCGGGCTCGATCCCCGAGACCCCGGGCGTGTATCGCTTCCGCGACGAACA
TGGCCGGGTCATTTACGTGGGCAAGGCCAAGAGTCTGCGTGCCCGGCTGGCCAACTACTTCGCCGACATCCACACGCTGC
ACCCCCGGACCCAGCACATGGTCACCACGGCCGGTTCCGTGGAGTGGACCGTGGTGTCCACCGAGGTCGAGGCGCTCCAG
CTCGAGTACACCTGGATCAAGGAGTTCGATCCGCGCTTCAACGTCCGCTACCGCGATGACAAGAGCTATCCGAGTCTCGC
GGTGACGCTGTACGAGGAGTTCCCGCGGCTCCAGGTGATGCGTGGGCCCAAGCGGCGCGGCGTGCGCTACTTCGGCCCCT
ACGCGCACGCGTGGGCCATCAGGGAGACCCTGGACCTGCTGCTGCGGGTCTTCCCCGCGCGCACCTGCAGCTCCGGGGTC
TTCAAGCGGGCTGGCCAGGTGGGCCGTCCCTGCCTGCTCGGGTACATCGACCGCTGCTCGGCCCCCTGCGTGGGGCGGGT
CGACGCCGATGCCCACCGCCAGATCGTCGACGACTTCTGCGACTTCATGTCCGGGCAGACCGGCCGCTACCTGCGCCGGC
TCGAGCGCGAGATGCGGGCCGCGGCCGAGGCGCAGGAGTACGAGCGCGCCGCGCGGCTGCGTGACGACATCGGGGCGCTG
CGCCGCGCGGTCGAGAAGCAGGCCGTCGTCCTGCCCGACGGCACCGACGCCGACGTGATCGCCTTCGCCCAGGACGAGCT
GGAGGCCGCGGTCCAGATCTTCTACGTGCGTGGCGGTCGGGTCCGCGGCCAGCGGGGCTGGGTCGTCGACAAGCTCGAGG
ACGTCACCACCGCCGACCTCGTCGAGCAGTTCCTGACCCAGGAGTACCTCGACGGCGTGCGTCCGGCCGGCACCGCCGGC
ACCGCCGATACCGCCGATACCGCCGATACCGCCGACCCGGCGCCGGCCGCGCAGATCCCCCGCGAGATCCTCGTGCCCGA
GCTGCCGCCGGACGCCGAGGCCGTCGCCGAGCTCCTCGAACGGGCCCGTGGGGCCCGCGTCGACCTGCGCGTCCCCCGCC
GGGGGGACAAACGCACCCTGATGGAGACCGTCGAACGCAACGCCAAGCAGGCGTTCACCCTGCACCGGACGAAGCGCGCC
GGCGACCTCACCGCGCGCAGCCGCGCGCTGGCCGACCTCCAGGAGGCGCTGGAGCTCCCTGACGCCCCGCTGCGGATCGA
GTGCTTCGACGTGTCGAACACCCAGGGCACCGACGTCGTGGCCAGCATGGTGGTCTTCGAGGACGGCCTGCCCCGCAAGT
CGGAGTACCGCCGGTTCTCCATCCGCGGGGTCGACGGCCAGGACGACGTGGCGAGCATGCGCGAGACCGTCCACCGGCGC
TTCTCCCGCTATCTGGCGGAGCGGGCCCGCACTGGCGAGCTCGAGGAGTACCCGGGCGCCCCCACCGGCGACGACGAGGC
TCCCGAGACCGGCCGGCCCCGGCGGTTCGCCTACCCGCCCAACCTCGTCGTCGTCGACGGCGGGCCGCCGCAGGTCGCCG
CCGCCGCGCGCGCGCTCGACGAGCTCGGCATCGAGTCCGGGCCCGGCGGGGTGGCACTGTGCGGGCTGGCCAAGCGCCTG
GAGGAGGTCTGGCTGCCCGACCAGGACGAGCCGGTGATCCTCCCGCGGACGAGCGAGGCCCTCTATCTGCTCCAGCGCGT
GCGGGACGAGGCACACCGGTTCGCGATCACCTACCACCGGCAGAAGCGGTCGACGTCGATGGTCGCCTCGGCGCTCGACG
ACGTCCCGGGGCTCGGGGAGACTCGACGCAAGGCGCTGCTGCGGCACTTCGGCTCGGTGGCGAAGGTGCGGGCCGCGGGC
GCCGAGGAGATCGCGCAGGTGCCGGGCATCGGCCCGCGCACGGCGGAGGCGATCGTCGCCGCTCTGGCGCGGTCGGCCCC
GGGCACGGACGCGGCGCCGGCGCCCGCCGTCGACCCGCTGACCGGTGAGATCATCGACTCGGCGGGGGTGACCCGGTGA

Upstream 100 bases:

>100_bases
TGAGCGACGGGGGCCCTCGACAGCATGGAAGCTCAGCGTGATGAAATAGCTACGTGCAGGCACTGCTCAGGCCGGATGAC
GGTCGCCGTAGGCTCGGCTC

Downstream 100 bases:

>100_bases
CAGCGGCGACGCTCGACCTTGCGATCATCACGGGGCTGTCCGGTGCCGGCCGCAGCACGGCGGCTAAGTGCCTCGAGGAC
CTCGGCTGGTTTGTCGTCGA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MADPASYRPPPGSIPETPGVYRFRDEHGRVIYVGKAKSLRARLANYFADIHTLHPRTQHMVTTAGSVEWTVVSTEVEALQ
LEYTWIKEFDPRFNVRYRDDKSYPSLAVTLYEEFPRLQVMRGPKRRGVRYFGPYAHAWAIRETLDLLLRVFPARTCSSGV
FKRAGQVGRPCLLGYIDRCSAPCVGRVDADAHRQIVDDFCDFMSGQTGRYLRRLEREMRAAAEAQEYERAARLRDDIGAL
RRAVEKQAVVLPDGTDADVIAFAQDELEAAVQIFYVRGGRVRGQRGWVVDKLEDVTTADLVEQFLTQEYLDGVRPAGTAG
TADTADTADTADPAPAAQIPREILVPELPPDAEAVAELLERARGARVDLRVPRRGDKRTLMETVERNAKQAFTLHRTKRA
GDLTARSRALADLQEALELPDAPLRIECFDVSNTQGTDVVASMVVFEDGLPRKSEYRRFSIRGVDGQDDVASMRETVHRR
FSRYLAERARTGELEEYPGAPTGDDEAPETGRPRRFAYPPNLVVVDGGPPQVAAAARALDELGIESGPGGVALCGLAKRL
EEVWLPDQDEPVILPRTSEALYLLQRVRDEAHRFAITYHRQKRSTSMVASALDDVPGLGETRRKALLRHFGSVAKVRAAG
AEEIAQVPGIGPRTAEAIVAALARSAPGTDAAPAPAVDPLTGEIIDSAGVTR

Sequences:

>Translated_692_residues
MADPASYRPPPGSIPETPGVYRFRDEHGRVIYVGKAKSLRARLANYFADIHTLHPRTQHMVTTAGSVEWTVVSTEVEALQ
LEYTWIKEFDPRFNVRYRDDKSYPSLAVTLYEEFPRLQVMRGPKRRGVRYFGPYAHAWAIRETLDLLLRVFPARTCSSGV
FKRAGQVGRPCLLGYIDRCSAPCVGRVDADAHRQIVDDFCDFMSGQTGRYLRRLEREMRAAAEAQEYERAARLRDDIGAL
RRAVEKQAVVLPDGTDADVIAFAQDELEAAVQIFYVRGGRVRGQRGWVVDKLEDVTTADLVEQFLTQEYLDGVRPAGTAG
TADTADTADTADPAPAAQIPREILVPELPPDAEAVAELLERARGARVDLRVPRRGDKRTLMETVERNAKQAFTLHRTKRA
GDLTARSRALADLQEALELPDAPLRIECFDVSNTQGTDVVASMVVFEDGLPRKSEYRRFSIRGVDGQDDVASMRETVHRR
FSRYLAERARTGELEEYPGAPTGDDEAPETGRPRRFAYPPNLVVVDGGPPQVAAAARALDELGIESGPGGVALCGLAKRL
EEVWLPDQDEPVILPRTSEALYLLQRVRDEAHRFAITYHRQKRSTSMVASALDDVPGLGETRRKALLRHFGSVAKVRAAG
AEEIAQVPGIGPRTAEAIVAALARSAPGTDAAPAPAVDPLTGEIIDSAGVTR
>Mature_691_residues
ADPASYRPPPGSIPETPGVYRFRDEHGRVIYVGKAKSLRARLANYFADIHTLHPRTQHMVTTAGSVEWTVVSTEVEALQL
EYTWIKEFDPRFNVRYRDDKSYPSLAVTLYEEFPRLQVMRGPKRRGVRYFGPYAHAWAIRETLDLLLRVFPARTCSSGVF
KRAGQVGRPCLLGYIDRCSAPCVGRVDADAHRQIVDDFCDFMSGQTGRYLRRLEREMRAAAEAQEYERAARLRDDIGALR
RAVEKQAVVLPDGTDADVIAFAQDELEAAVQIFYVRGGRVRGQRGWVVDKLEDVTTADLVEQFLTQEYLDGVRPAGTAGT
ADTADTADTADPAPAAQIPREILVPELPPDAEAVAELLERARGARVDLRVPRRGDKRTLMETVERNAKQAFTLHRTKRAG
DLTARSRALADLQEALELPDAPLRIECFDVSNTQGTDVVASMVVFEDGLPRKSEYRRFSIRGVDGQDDVASMRETVHRRF
SRYLAERARTGELEEYPGAPTGDDEAPETGRPRRFAYPPNLVVVDGGPPQVAAAARALDELGIESGPGGVALCGLAKRLE
EVWLPDQDEPVILPRTSEALYLLQRVRDEAHRFAITYHRQKRSTSMVASALDDVPGLGETRRKALLRHFGSVAKVRAAGA
EEIAQVPGIGPRTAEAIVAALARSAPGTDAAPAPAVDPLTGEIIDSAGVTR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=669, Percent_Identity=34.678624813154, Blast_Score=357, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_FRASN (A8KYR0)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001506402.1
- ProteinModelPortal:   A8KYR0
- GeneID:   5670460
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_2059
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   FSP1855:FRANEAN1_2059-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 76396; Mature: 76265

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPASYRPPPGSIPETPGVYRFRDEHGRVIYVGKAKSLRARLANYFADIHTLHPRTQHM
CCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCHHHE
VTTAGSVEWTVVSTEVEALQLEYTWIKEFDPRFNVRYRDDKSYPSLAVTLYEEFPRLQVM
EEECCCEEEEEEECEEEEEEEEEHHHHHCCCCCCEEECCCCCCCHHEEHHHHHCCHHHHH
RGPKRRGVRYFGPYAHAWAIRETLDLLLRVFPARTCSSGVFKRAGQVGRPCLLGYIDRCS
CCHHHCCCEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHCC
APCVGRVDADAHRQIVDDFCDFMSGQTGRYLRRLEREMRAAAEAQEYERAARLRDDIGAL
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRAVEKQAVVLPDGTDADVIAFAQDELEAAVQIFYVRGGRVRGQRGWVVDKLEDVTTADL
HHHHHHCEEECCCCCCCCEEEECHHHHHHHHEEEEEECCEEECCCCCCHHHHHHHHHHHH
VEQFLTQEYLDGVRPAGTAGTADTADTADTADPAPAAQIPREILVPELPPDAEAVAELLE
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCCCCCCHHHHHHHHH
RARGARVDLRVPRRGDKRTLMETVERNAKQAFTLHRTKRAGDLTARSRALADLQEALELP
HHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
DAPLRIECFDVSNTQGTDVVASMVVFEDGLPRKSEYRRFSIRGVDGQDDVASMRETVHRR
CCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHCCEEEEECCCCCHHHHHHHHHHHHH
FSRYLAERARTGELEEYPGAPTGDDEAPETGRPRRFAYPPNLVVVDGGPPQVAAAARALD
HHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCEEEECCCCCHHHHHHHHHH
ELGIESGPGGVALCGLAKRLEEVWLPDQDEPVILPRTSEALYLLQRVRDEAHRFAITYHR
HCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHEEEEEHH
QKRSTSMVASALDDVPGLGETRRKALLRHFGSVAKVRAAGAEEIAQVPGIGPRTAEAIVA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHH
ALARSAPGTDAAPAPAVDPLTGEIIDSAGVTR
HHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
ADPASYRPPPGSIPETPGVYRFRDEHGRVIYVGKAKSLRARLANYFADIHTLHPRTQHM
CCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCHHHE
VTTAGSVEWTVVSTEVEALQLEYTWIKEFDPRFNVRYRDDKSYPSLAVTLYEEFPRLQVM
EEECCCEEEEEEECEEEEEEEEEHHHHHCCCCCCEEECCCCCCCHHEEHHHHHCCHHHHH
RGPKRRGVRYFGPYAHAWAIRETLDLLLRVFPARTCSSGVFKRAGQVGRPCLLGYIDRCS
CCHHHCCCEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHCC
APCVGRVDADAHRQIVDDFCDFMSGQTGRYLRRLEREMRAAAEAQEYERAARLRDDIGAL
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRAVEKQAVVLPDGTDADVIAFAQDELEAAVQIFYVRGGRVRGQRGWVVDKLEDVTTADL
HHHHHHCEEECCCCCCCCEEEECHHHHHHHHEEEEEECCEEECCCCCCHHHHHHHHHHHH
VEQFLTQEYLDGVRPAGTAGTADTADTADTADPAPAAQIPREILVPELPPDAEAVAELLE
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCCCCCCHHHHHHHHH
RARGARVDLRVPRRGDKRTLMETVERNAKQAFTLHRTKRAGDLTARSRALADLQEALELP
HHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
DAPLRIECFDVSNTQGTDVVASMVVFEDGLPRKSEYRRFSIRGVDGQDDVASMRETVHRR
CCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHCCEEEEECCCCCHHHHHHHHHHHHH
FSRYLAERARTGELEEYPGAPTGDDEAPETGRPRRFAYPPNLVVVDGGPPQVAAAARALD
HHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCEEEECCCCCHHHHHHHHHH
ELGIESGPGGVALCGLAKRLEEVWLPDQDEPVILPRTSEALYLLQRVRDEAHRFAITYHR
HCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHEEEEEHH
QKRSTSMVASALDDVPGLGETRRKALLRHFGSVAKVRAAGAEEIAQVPGIGPRTAEAIVA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHH
ALARSAPGTDAAPAPAVDPLTGEIIDSAGVTR
HHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA