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The map label for this gene is glkA [H]

Identifier: 158313661

GI number: 158313661

Start: 2189767

End: 2190738

Strand: Direct

Name: glkA [H]

Synonym: Franean1_1825

Alternate gene names: 158313661

Gene position: 2189767-2190738 (Clockwise)

Preceding gene: 158313660

Following gene: 158313665

Centisome position: 24.38

GC content: 76.03

Gene sequence:

>972_bases
GTGACCACCGGGTCAGCGACCGCCCCCGAGGGGGACGGCGACCTGGCGATCGGAGTCGACGTCGGCGGGACGAAAGTTGC
CGCCGGTGTCGTCGACGCCCAGGGCAGGATGCTGGCCTCCGCCCGACGGCCCACCCCGAGCCATGCCCCGGCCGAGGTCG
CCGACGCCATCGCCGAGCTCGTCGCCGGGCTCCGCCAGGAGTACGACGTCCGCGCCGTGGGCATCGGCGCGGCGGGATGG
ATCGACCGCGACCGGTCGACCGTCCTCTTCGCCCCGAACCTGGCCTGGCGCGACGAGCCGCTGCGCGACGTCGTGGCGGA
GCGGGTCGGCCTGCCCGTGGTCGTCGAGAACGACGCCAACGCGATGGCCTGGGCCGAGTACCGCTTCGGCGCCGGGCGCG
GCCAGGCCGACCTCGTCTGCGTCACCGTCGGCACCGGTATCGGCGGCGGCATTGTCCTGGACGGCCGGCTGCACCGCGGC
GCGTTCGGCATCGGCGCCGAGATGGGCCACATGCAGGTGGTCCCGGGCGGCCACCTGTGCGGCTGTGGGAACCGCGGCTG
CTGGGAGCAGTACGCCAGCGGACGGGCCCTCGTCCGGGTCGCCCAGGAGATGGCCACCGCGTCCCCGGAGGCCGCCCGCA
CGATGCTGGCCGGTCGCTCCGTCGAGGAGCTGAGCGGGCCGGACGTCACCACCGCCGCCCAGGACGGCGACCCGGCCGCG
GTGAAGTGCTTCGAGGAGATCGGCCACTGGCTCGGCCAGGGCCTGGCGAGCCTGACGGCGATCCTCGACCCGGGCCGGTT
CGTCATCGGTGGCGGCGTATCGGACGCGGGGGAGCTGCTGGTCGGGCCCGCCCGCGCCCAGTACCGGGCGGGGCTGTCGG
GCCGCGGGCACCGGCCGGAGGCCGACGTGGTGGTGGCCACCCTCGGCTCCTCCGCCGGCATCGTCGGCGCCGCCGACCTC
GCCCGCATGTAG

Upstream 100 bases:

>100_bases
CCACCACCAGGCCGGGGCCGTGAGACGGGCGCCGGCCTTACAACGTCCGCGGGGTCGCCCCGACCCCGCGTCCAGAAGAT
CGATGTGAGGTGAGCGCACA

Downstream 100 bases:

>100_bases
ACGTCGGAGCTCCCGTCTGGTGCGTTTCGCCGCGGATCAGGTCTTGTAGTCGGGGACGAGCTCGGTCGCCAGCTGCTCGA
GAAAGAGGCCGGCGTCGGCG

Product: ROK family glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTTGSATAPEGDGDLAIGVDVGGTKVAAGVVDAQGRMLASARRPTPSHAPAEVADAIAELVAGLRQEYDVRAVGIGAAGW
IDRDRSTVLFAPNLAWRDEPLRDVVAERVGLPVVVENDANAMAWAEYRFGAGRGQADLVCVTVGTGIGGGIVLDGRLHRG
AFGIGAEMGHMQVVPGGHLCGCGNRGCWEQYASGRALVRVAQEMATASPEAARTMLAGRSVEELSGPDVTTAAQDGDPAA
VKCFEEIGHWLGQGLASLTAILDPGRFVIGGGVSDAGELLVGPARAQYRAGLSGRGHRPEADVVVATLGSSAGIVGAADL
ARM

Sequences:

>Translated_323_residues
MTTGSATAPEGDGDLAIGVDVGGTKVAAGVVDAQGRMLASARRPTPSHAPAEVADAIAELVAGLRQEYDVRAVGIGAAGW
IDRDRSTVLFAPNLAWRDEPLRDVVAERVGLPVVVENDANAMAWAEYRFGAGRGQADLVCVTVGTGIGGGIVLDGRLHRG
AFGIGAEMGHMQVVPGGHLCGCGNRGCWEQYASGRALVRVAQEMATASPEAARTMLAGRSVEELSGPDVTTAAQDGDPAA
VKCFEEIGHWLGQGLASLTAILDPGRFVIGGGVSDAGELLVGPARAQYRAGLSGRGHRPEADVVVATLGSSAGIVGAADL
ARM
>Mature_322_residues
TTGSATAPEGDGDLAIGVDVGGTKVAAGVVDAQGRMLASARRPTPSHAPAEVADAIAELVAGLRQEYDVRAVGIGAAGWI
DRDRSTVLFAPNLAWRDEPLRDVVAERVGLPVVVENDANAMAWAEYRFGAGRGQADLVCVTVGTGIGGGIVLDGRLHRGA
FGIGAEMGHMQVVPGGHLCGCGNRGCWEQYASGRALVRVAQEMATASPEAARTMLAGRSVEELSGPDVTTAAQDGDPAAV
KCFEEIGHWLGQGLASLTAILDPGRFVIGGGVSDAGELLVGPARAQYRAGLSGRGHRPEADVVVATLGSSAGIVGAADLA
RM

Specific function: Required for glucose repression of many different genes [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=266, Percent_Identity=30.0751879699248, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI298566325, Length=266, Percent_Identity=30.0751879699248, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4885285, Length=266, Percent_Identity=30.0751879699248, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI190014632, Length=266, Percent_Identity=30.0751879699248, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1786891, Length=271, Percent_Identity=26.9372693726937, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787363, Length=273, Percent_Identity=30.7692307692308, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787878, Length=211, Percent_Identity=31.7535545023697, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI87081733, Length=322, Percent_Identity=29.5031055900621, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082230, Length=263, Percent_Identity=33.8403041825095, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790522, Length=325, Percent_Identity=24, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082127, Length=277, Percent_Identity=24.187725631769, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 32910; Mature: 32778

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTGSATAPEGDGDLAIGVDVGGTKVAAGVVDAQGRMLASARRPTPSHAPAEVADAIAEL
CCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHCCCCCCCCCHHHHHHHHHHH
VAGLRQEYDVRAVGIGAAGWIDRDRSTVLFAPNLAWRDEPLRDVVAERVGLPVVVENDAN
HHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCC
AMAWAEYRFGAGRGQADLVCVTVGTGIGGGIVLDGRLHRGAFGIGAEMGHMQVVPGGHLC
EEEEEEEECCCCCCCCCEEEEEECCCCCCCEEECCEECCCEEECCCCCCCEEECCCCCEE
GCGNRGCWEQYASGRALVRVAQEMATASPEAARTMLAGRSVEELSGPDVTTAAQDGDPAA
CCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCCEECCCCCCHHH
VKCFEEIGHWLGQGLASLTAILDPGRFVIGGGVSDAGELLVGPARAQYRAGLSGRGHRPE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEECCCHHHHHCCCCCCCCCCC
ADVVVATLGSSAGIVGAADLARM
CCEEEEECCCCCCCEECHHHHCC
>Mature Secondary Structure 
TTGSATAPEGDGDLAIGVDVGGTKVAAGVVDAQGRMLASARRPTPSHAPAEVADAIAEL
CCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHCCCCCCCCCHHHHHHHHHHH
VAGLRQEYDVRAVGIGAAGWIDRDRSTVLFAPNLAWRDEPLRDVVAERVGLPVVVENDAN
HHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCC
AMAWAEYRFGAGRGQADLVCVTVGTGIGGGIVLDGRLHRGAFGIGAEMGHMQVVPGGHLC
EEEEEEEECCCCCCCCCEEEEEECCCCCCCEEECCEECCCEEECCCCCCCEEECCCCCEE
GCGNRGCWEQYASGRALVRVAQEMATASPEAARTMLAGRSVEELSGPDVTTAAQDGDPAA
CCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCCEECCCCCCHHH
VKCFEEIGHWLGQGLASLTAILDPGRFVIGGGVSDAGELLVGPARAQYRAGLSGRGHRPE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEECCCHHHHHCCCCCCCCCCC
ADVVVATLGSSAGIVGAADLARM
CCEEEEECCCCCCCEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1435260; 12000953 [H]