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The map label for this gene is Hgd [H]

Identifier: 158313467

GI number: 158313467

Start: 1948304

End: 1949206

Strand: Direct

Name: Hgd [H]

Synonym: Franean1_1631

Alternate gene names: 158313467

Gene position: 1948304-1949206 (Clockwise)

Preceding gene: 158313465

Following gene: 158313468

Centisome position: 21.69

GC content: 73.98

Gene sequence:

>903_bases
ATGGCGGGCACGAGGGCGACGGTCGGATTCGTGGGCCTGGGGAGCATGGGCGGCGCCCTGGCCGCGAACCTGGTCGCGGC
CGGGTTCGACGTCGTCGCCCACGACGCGGCCGGCCCGGATCGGGTCCCGGTGGGAGCAGCCGGCGCGGTCGACGTCGCCG
AGGTCGCCGGCCGGGCCGACACCGTCGTGTTCAGCCTGCCCGACGGGGCGGCGTCCGAGCAGGTCGCCGGTGAGATCGTC
GCGCTGGCCGGCCGGCGGGCGGCGTACGTCGTCGACACCTCGACGGTCGGGGTGGCCGCCGCGCGCCGGATCGCCGGCCG
GCTGGCCGGCGCCGGTGTCGGCTACGTCGACGCGCCGGTGTCGGGTGGTGTGGCGGGCGCCCGGGCGCGCACGATCGCGG
TGATGTTCGCCGGGTCCGACGCCGACTGCGCGGCGGTCACGCCCGTCCTGGCCGGCCTGAGCGACCGCCGGACCAGAGTG
GGCGACGAGCCGGGCCTGGCCCAGGCGCTGAAGCTGGCGAACAACTTCCTCTCCGCGACGGCGCTGGCGGCGACCAGCGA
GGCGATCGCCTTCGGCACCGCGGCCGGGCTCGACATGGCCACGATGCTCGACGTGCTGAACGGCGCGAGCGGCCGGAGCT
CGGCGACCGGCGACAAGTTCCCCAACCACGTACTCACCGAACGCTACGCGGCTGGTTTCACCAACTCGTTGATGGCGAAG
GACGTCGCGCTCTATCTGGCGGCCGTCCAGGAGCACGACGGTGCCGTGCGAAGCCCACAGAATTCACCGAACTCACCGAA
CTCGCGGATCGGGGCGGTCACGGCGTCGGTGTGGGAGCGGTTCGCGGCCGCGGCACCCGGTGCCGACTTCACCCGGATCT
ATCCCTTCGTGAAGGGCACCTGA

Upstream 100 bases:

>100_bases
GTTCGTGGCGGCGCCGGAGGAAGGTCCCGGCCCGACCGGGCCGCCGCCGCCCGAGCGCCGTCGCCCGGGCGAGGCGGTCG
CGGCGACGAGGATGGGCGTG

Downstream 100 bases:

>100_bases
CTGCCCGCCGGACGCCTGCTCCGAGTATCTCCGCACTGTCTCCCGGCCGGGGAGCCTCCTGGGGTCGGGGTCTTGATAAA
TCGGGTGTTCAGAAACTAAT

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MAGTRATVGFVGLGSMGGALAANLVAAGFDVVAHDAAGPDRVPVGAAGAVDVAEVAGRADTVVFSLPDGAASEQVAGEIV
ALAGRRAAYVVDTSTVGVAAARRIAGRLAGAGVGYVDAPVSGGVAGARARTIAVMFAGSDADCAAVTPVLAGLSDRRTRV
GDEPGLAQALKLANNFLSATALAATSEAIAFGTAAGLDMATMLDVLNGASGRSSATGDKFPNHVLTERYAAGFTNSLMAK
DVALYLAAVQEHDGAVRSPQNSPNSPNSRIGAVTASVWERFAAAAPGADFTRIYPFVKGT

Sequences:

>Translated_300_residues
MAGTRATVGFVGLGSMGGALAANLVAAGFDVVAHDAAGPDRVPVGAAGAVDVAEVAGRADTVVFSLPDGAASEQVAGEIV
ALAGRRAAYVVDTSTVGVAAARRIAGRLAGAGVGYVDAPVSGGVAGARARTIAVMFAGSDADCAAVTPVLAGLSDRRTRV
GDEPGLAQALKLANNFLSATALAATSEAIAFGTAAGLDMATMLDVLNGASGRSSATGDKFPNHVLTERYAAGFTNSLMAK
DVALYLAAVQEHDGAVRSPQNSPNSPNSRIGAVTASVWERFAAAAPGADFTRIYPFVKGT
>Mature_299_residues
AGTRATVGFVGLGSMGGALAANLVAAGFDVVAHDAAGPDRVPVGAAGAVDVAEVAGRADTVVFSLPDGAASEQVAGEIVA
LAGRRAAYVVDTSTVGVAAARRIAGRLAGAGVGYVDAPVSGGVAGARARTIAVMFAGSDADCAAVTPVLAGLSDRRTRVG
DEPGLAQALKLANNFLSATALAATSEAIAFGTAAGLDMATMLDVLNGASGRSSATGDKFPNHVLTERYAAGFTNSLMAKD
VALYLAAVQEHDGAVRSPQNSPNSPNSRIGAVTASVWERFAAAAPGADFTRIYPFVKGT

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=307, Percent_Identity=28.9902280130293, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1786719, Length=246, Percent_Identity=32.1138211382114, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI145693186, Length=241, Percent_Identity=31.5352697095436, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1789092, Length=248, Percent_Identity=32.6612903225806, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790315, Length=255, Percent_Identity=28.6274509803922, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17557316, Length=306, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24655230, Length=302, Percent_Identity=29.4701986754967, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922568, Length=302, Percent_Identity=29.4701986754967, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 29747; Mature: 29615

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGTRATVGFVGLGSMGGALAANLVAAGFDVVAHDAAGPDRVPVGAAGAVDVAEVAGRAD
CCCCCCEEEEEECCCCCHHHHHHHHHHCCHHEEECCCCCCCCCCCCCCCHHHHHHCCCCC
TVVFSLPDGAASEQVAGEIVALAGRRAAYVVDTSTVGVAAARRIAGRLAGAGVGYVDAPV
EEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEECCCC
SGGVAGARARTIAVMFAGSDADCAAVTPVLAGLSDRRTRVGDEPGLAQALKLANNFLSAT
CCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHH
ALAATSEAIAFGTAAGLDMATMLDVLNGASGRSSATGDKFPNHVLTERYAAGFTNSLMAK
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
DVALYLAAVQEHDGAVRSPQNSPNSPNSRIGAVTASVWERFAAAAPGADFTRIYPFVKGT
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHEECCEECCC
>Mature Secondary Structure 
AGTRATVGFVGLGSMGGALAANLVAAGFDVVAHDAAGPDRVPVGAAGAVDVAEVAGRAD
CCCCCEEEEEECCCCCHHHHHHHHHHCCHHEEECCCCCCCCCCCCCCCHHHHHHCCCCC
TVVFSLPDGAASEQVAGEIVALAGRRAAYVVDTSTVGVAAARRIAGRLAGAGVGYVDAPV
EEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEECCCC
SGGVAGARARTIAVMFAGSDADCAAVTPVLAGLSDRRTRVGDEPGLAQALKLANNFLSAT
CCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHH
ALAATSEAIAFGTAAGLDMATMLDVLNGASGRSSATGDKFPNHVLTERYAAGFTNSLMAK
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
DVALYLAAVQEHDGAVRSPQNSPNSPNSRIGAVTASVWERFAAAAPGADFTRIYPFVKGT
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA