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The map label for this gene is vraR [H]

Identifier: 158313275

GI number: 158313275

Start: 1731069

End: 1731725

Strand: Direct

Name: vraR [H]

Synonym: Franean1_1435

Alternate gene names: 158313275

Gene position: 1731069-1731725 (Clockwise)

Preceding gene: 158313274

Following gene: 158313276

Centisome position: 19.27

GC content: 70.47

Gene sequence:

>657_bases
GTGACCGAACCCCCCGCCACCATTCGGGTGCTCCTCGCCGACGACCACCGCCTCGTGCTGGACGGCCTGTCCGCGCTGAT
CGACTCCGTCGACGGCCTCACCGTCGTCGGGGAGGCGACCTCCGGCGAGCAGGCCGTCGACCTCGCCGGCACGGAGCACC
CCGACGTCGTGCTCATGGACATCGAGATGCCCGGGATCGGCGGGGTCGAGGCAACCCGCCGGATCACCACCGCACAGCCG
ACGATCGCGGTCGTGATGCTCACGATGTACGGCGAGGACGAGTTCGTCTTCGCCGCCCTACGCGCCGGCGCCCGCGGCTA
CCTGCTCAAAGGCGCCCAGCAGAAGGACGTCGTACGCACCATCGGGGCCGTGGCCCGCGGCGACGCCGTGTTCGGACCGG
ACGTCGCGCACCGCGTACTGCGCACCTTCACCAGCCCACCTGCGGAGAACGCCCCGTTCCCCGAGCTCACCGAACGGGAA
CGCGAAGTACTCAGCCTGCTGGCGAACGGCTGGCCGAACAGCCGCATCGCGCGCCATCTCCAGCTCACCCCGAAGACCGT
CGCCAACAACGTCTCCAACATCCTCGCCAAACTGCACGCCCCGGACCGCACGGCGGCAATCCTGCGAGCCCGCCGCGCCG
GCCTGGGTGAACCATGA

Upstream 100 bases:

>100_bases
CGATACCCCGGTCCGCCGCCGTGGTCGCTCCAGAAAGGGATCACGGATCTTCTTCATCCGCGCACACCGACGTCACCGGA
ATGCTCACGAGGAGCCAGCA

Downstream 100 bases:

>100_bases
CCCACCCTCCCGACGGCCCGAACGGGCGGGTGAGGAGGGTGCGCATGGCCTGGCGCAACCAGCCCGCAACAGGACGCCGT
TAATGTCCAGCCATGACCTT

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MTEPPATIRVLLADDHRLVLDGLSALIDSVDGLTVVGEATSGEQAVDLAGTEHPDVVLMDIEMPGIGGVEATRRITTAQP
TIAVVMLTMYGEDEFVFAALRAGARGYLLKGAQQKDVVRTIGAVARGDAVFGPDVAHRVLRTFTSPPAENAPFPELTERE
REVLSLLANGWPNSRIARHLQLTPKTVANNVSNILAKLHAPDRTAAILRARRAGLGEP

Sequences:

>Translated_218_residues
MTEPPATIRVLLADDHRLVLDGLSALIDSVDGLTVVGEATSGEQAVDLAGTEHPDVVLMDIEMPGIGGVEATRRITTAQP
TIAVVMLTMYGEDEFVFAALRAGARGYLLKGAQQKDVVRTIGAVARGDAVFGPDVAHRVLRTFTSPPAENAPFPELTERE
REVLSLLANGWPNSRIARHLQLTPKTVANNVSNILAKLHAPDRTAAILRARRAGLGEP
>Mature_217_residues
TEPPATIRVLLADDHRLVLDGLSALIDSVDGLTVVGEATSGEQAVDLAGTEHPDVVLMDIEMPGIGGVEATRRITTAQPT
IAVVMLTMYGEDEFVFAALRAGARGYLLKGAQQKDVVRTIGAVARGDAVFGPDVAHRVLRTFTSPPAENAPFPELTERER
EVLSLLANGWPNSRIARHLQLTPKTVANNVSNILAKLHAPDRTAAILRARRAGLGEP

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=192, Percent_Identity=39.0625, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=37.378640776699, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787473, Length=191, Percent_Identity=35.6020942408377, Blast_Score=100, Evalue=5e-23,
Organism=Escherichia coli, GI1790102, Length=191, Percent_Identity=34.0314136125654, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1786747, Length=189, Percent_Identity=27.5132275132275, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788712, Length=206, Percent_Identity=23.7864077669903, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788546, Length=195, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23267; Mature: 23136

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPPATIRVLLADDHRLVLDGLSALIDSVDGLTVVGEATSGEQAVDLAGTEHPDVVLMD
CCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCCCCCEEEEE
IEMPGIGGVEATRRITTAQPTIAVVMLTMYGEDEFVFAALRAGARGYLLKGAQQKDVVRT
ECCCCCCCCHHHHEECCCCCCEEEEEEEHCCCCHHHHHHHHCCCCCEEECCCCHHHHHHH
IGAVARGDAVFGPDVAHRVLRTFTSPPAENAPFPELTEREREVLSLLANGWPNSRIARHL
HHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
QLTPKTVANNVSNILAKLHAPDRTAAILRARRAGLGEP
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TEPPATIRVLLADDHRLVLDGLSALIDSVDGLTVVGEATSGEQAVDLAGTEHPDVVLMD
CCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCCCCCEEEEE
IEMPGIGGVEATRRITTAQPTIAVVMLTMYGEDEFVFAALRAGARGYLLKGAQQKDVVRT
ECCCCCCCCHHHHEECCCCCCEEEEEEEHCCCCHHHHHHHHCCCCCEEECCCCHHHHHHH
IGAVARGDAVFGPDVAHRVLRTFTSPPAENAPFPELTEREREVLSLLANGWPNSRIARHL
HHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
QLTPKTVANNVSNILAKLHAPDRTAAILRARRAGLGEP
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]