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The map label for this gene is iscS [H]

Identifier: 158312933

GI number: 158312933

Start: 1284901

End: 1286160

Strand: Direct

Name: iscS [H]

Synonym: Franean1_1079

Alternate gene names: 158312933

Gene position: 1284901-1286160 (Clockwise)

Preceding gene: 158312932

Following gene: 158312934

Centisome position: 14.31

GC content: 75.56

Gene sequence:

>1260_bases
GTGTGCGGCCGGGTTCGGGCGGTCGTCCCGAGGCCGGGTGGGGCGCCCGAGTGGCGGCTACCCTCTACAGACGTGACCTA
CCTCGACCACGCGGCGACCACGCCGATGCGCCCGGAGGCCGTCGCGGCGTTCACCGCTGTGTTGACGGACGCCGGGAACG
CCTCATCGCTGCACGCCGGCGGTCGGCGCGCCCGCCGGATCGTCGAGGAGTCGAGGGAGTCCCTGGCCGAGGTGCTGGGC
GCGCGGCCGTCCGACCTGATCTTCACTGCGGGCGGCACGGAGAGCGACAATCTGGCGATCAAGGGGCTGTACTGGTCGCG
CCGCGCCGCCGACCCGCGCCGGCGCCGGATCCTGGTCAGCGCGGTGGAGCACCCGGCGGTGCTGGACACCGCGTCCTGGC
TGGCCCGGCGGCAGGGGGCGGTGCTGGAGACACTGCCGGTGGACGAGACCGGCCTGGTCGCCCCCGAGGTGCTGCGCGCC
GCGGTGGAGTCCGACCCGGCCTCGGTCGCGCTCGTCTCGGTGATGTGGGCGAACAGCGAGGTGGGCACCATCCAGCCGGT
CGCCGAGCTGGCCCGGGTCGCCCACGCTCACGACATCCCGTTCCACACCGACGCCGTCCAGGCGTTCGGGCAGATCGAGA
CGTCGTTCGCCACCAGCGAGGCGGACGCGCTGACGATCAGCGCACACAAGATCGGCGGCCCGGTGGGGGTGGGCGCGCTG
CTCGTGCGGCGTGGGGTCGAGGTGGAGCCGCTGGCGCACGGCGGCGGGCAGGAGCGCGATGTCCGCTCCGGGACGCTCAA
CACCCCGGGAGTGGCCGCCTTCGCCGCGGCGGCGGCCGCCGTCACCGCGGAACTGCCCGCCGAGCGGGTCCGGCTGGCCT
CGCTGCGCGACGACCTCGTGCGCCGGGTGCTGGCCGAGGTGCCCGGGGCGACGCTCAACGGTGCCGCCCCCGGCCCCGGC
CGGCTGCCCGGAAACGCACACCTGACCTTCCCCGGCTGCGAGGGCGACTCGCTGCTGATGCTGCTCGACGCGCACGGGGT
GGAATGCTCGACGGGCTCGGCCTGCTCGGCGGGAGTGGCGCGGCCCTCGCACGTGTTGTTGGCGATGGGCGCCGGTGAGG
CCCACGCCCGTGGGTCGCTGCGGTTCTCACTCGGGCACGGCTCGTCGGCGGCGGACGTCGACGCGCTGGTCGCCGTGATC
GGTCCGGTGGTGGCGCGCGCCAGCCGCGCCGGTGAGCTCGCGGGTCTGAGCGCGGGGTGA

Upstream 100 bases:

>100_bases
TGTGCGGGACCTCGTCGAGCTGCTCACCGACCTGCGGCGCGGTGCCGGCGACTTCTGACCCGCCCGGACCCGGACCCGGG
CCAGCCGGTGCCCCGACCCG

Downstream 100 bases:

>100_bases
GTCGATGAGCCGGCGGCGGGAGCGCCCGCCGAGCCGGCGGTGTGGACGAGGGGTGGGATCGTGAGCCGGATGAGGGTGCT
CGCGGCCATGTCGGGCGGCG

Product: class V aminotransferase

Products: NA

Alternate protein names: NifS protein homolog [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MCGRVRAVVPRPGGAPEWRLPSTDVTYLDHAATTPMRPEAVAAFTAVLTDAGNASSLHAGGRRARRIVEESRESLAEVLG
ARPSDLIFTAGGTESDNLAIKGLYWSRRAADPRRRRILVSAVEHPAVLDTASWLARRQGAVLETLPVDETGLVAPEVLRA
AVESDPASVALVSVMWANSEVGTIQPVAELARVAHAHDIPFHTDAVQAFGQIETSFATSEADALTISAHKIGGPVGVGAL
LVRRGVEVEPLAHGGGQERDVRSGTLNTPGVAAFAAAAAAVTAELPAERVRLASLRDDLVRRVLAEVPGATLNGAAPGPG
RLPGNAHLTFPGCEGDSLLMLLDAHGVECSTGSACSAGVARPSHVLLAMGAGEAHARGSLRFSLGHGSSAADVDALVAVI
GPVVARASRAGELAGLSAG

Sequences:

>Translated_419_residues
MCGRVRAVVPRPGGAPEWRLPSTDVTYLDHAATTPMRPEAVAAFTAVLTDAGNASSLHAGGRRARRIVEESRESLAEVLG
ARPSDLIFTAGGTESDNLAIKGLYWSRRAADPRRRRILVSAVEHPAVLDTASWLARRQGAVLETLPVDETGLVAPEVLRA
AVESDPASVALVSVMWANSEVGTIQPVAELARVAHAHDIPFHTDAVQAFGQIETSFATSEADALTISAHKIGGPVGVGAL
LVRRGVEVEPLAHGGGQERDVRSGTLNTPGVAAFAAAAAAVTAELPAERVRLASLRDDLVRRVLAEVPGATLNGAAPGPG
RLPGNAHLTFPGCEGDSLLMLLDAHGVECSTGSACSAGVARPSHVLLAMGAGEAHARGSLRFSLGHGSSAADVDALVAVI
GPVVARASRAGELAGLSAG
>Mature_419_residues
MCGRVRAVVPRPGGAPEWRLPSTDVTYLDHAATTPMRPEAVAAFTAVLTDAGNASSLHAGGRRARRIVEESRESLAEVLG
ARPSDLIFTAGGTESDNLAIKGLYWSRRAADPRRRRILVSAVEHPAVLDTASWLARRQGAVLETLPVDETGLVAPEVLRA
AVESDPASVALVSVMWANSEVGTIQPVAELARVAHAHDIPFHTDAVQAFGQIETSFATSEADALTISAHKIGGPVGVGAL
LVRRGVEVEPLAHGGGQERDVRSGTLNTPGVAAFAAAAAAVTAELPAERVRLASLRDDLVRRVLAEVPGATLNGAAPGPG
RLPGNAHLTFPGCEGDSLLMLLDAHGVECSTGSACSAGVARPSHVLLAMGAGEAHARGSLRFSLGHGSSAADVDALVAVI
GPVVARASRAGELAGLSAG

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=375, Percent_Identity=38.4, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI156713448, Length=431, Percent_Identity=34.1067285382831, Blast_Score=195, Evalue=5e-50,
Organism=Escherichia coli, GI48994898, Length=388, Percent_Identity=35.3092783505155, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1787970, Length=359, Percent_Identity=26.1838440111421, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789175, Length=404, Percent_Identity=27.2277227722772, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25143064, Length=371, Percent_Identity=38.2749326145553, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17533177, Length=337, Percent_Identity=31.1572700296736, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319831, Length=378, Percent_Identity=38.6243386243386, Blast_Score=239, Evalue=7e-64,
Organism=Drosophila melanogaster, GI20129463, Length=372, Percent_Identity=38.4408602150538, Blast_Score=228, Evalue=7e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42991; Mature: 42991

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGRVRAVVPRPGGAPEWRLPSTDVTYLDHAATTPMRPEAVAAFTAVLTDAGNASSLHAG
CCCCEEEEECCCCCCCCCCCCCCCCEEHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GRRARRIVEESRESLAEVLGARPSDLIFTAGGTESDNLAIKGLYWSRRAADPRRRRILVS
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEEEECCCCCCHHHHEEEEH
AVEHPAVLDTASWLARRQGAVLETLPVDETGLVAPEVLRAAVESDPASVALVSVMWANSE
HHCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCC
VGTIQPVAELARVAHAHDIPFHTDAVQAFGQIETSFATSEADALTISAHKIGGPVGVGAL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCHHHHHH
LVRRGVEVEPLAHGGGQERDVRSGTLNTPGVAAFAAAAAAVTAELPAERVRLASLRDDLV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RRVLAEVPGATLNGAAPGPGRLPGNAHLTFPGCEGDSLLMLLDAHGVECSTGSACSAGVA
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCC
RPSHVLLAMGAGEAHARGSLRFSLGHGSSAADVDALVAVIGPVVARASRAGELAGLSAG
CCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MCGRVRAVVPRPGGAPEWRLPSTDVTYLDHAATTPMRPEAVAAFTAVLTDAGNASSLHAG
CCCCEEEEECCCCCCCCCCCCCCCCEEHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GRRARRIVEESRESLAEVLGARPSDLIFTAGGTESDNLAIKGLYWSRRAADPRRRRILVS
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEEEECCCCCCHHHHEEEEH
AVEHPAVLDTASWLARRQGAVLETLPVDETGLVAPEVLRAAVESDPASVALVSVMWANSE
HHCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCC
VGTIQPVAELARVAHAHDIPFHTDAVQAFGQIETSFATSEADALTISAHKIGGPVGVGAL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCHHHHHH
LVRRGVEVEPLAHGGGQERDVRSGTLNTPGVAAFAAAAAAVTAELPAERVRLASLRDDLV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RRVLAEVPGATLNGAAPGPGRLPGNAHLTFPGCEGDSLLMLLDAHGVECSTGSACSAGVA
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCC
RPSHVLLAMGAGEAHARGSLRFSLGHGSSAADVDALVAVIGPVVARASRAGELAGLSAG
CCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10930739 [H]