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The map label for this gene is atpB

Identifier: 158312872

GI number: 158312872

Start: 1199121

End: 1200008

Strand: Direct

Name: atpB

Synonym: Franean1_1018

Alternate gene names: 158312872

Gene position: 1199121-1200008 (Clockwise)

Preceding gene: 158312870

Following gene: 158312873

Centisome position: 13.35

GC content: 64.98

Gene sequence:

>888_bases
GTGCCGAGCGGATCGGTGCTCATGGCGGCCGATGACGGCTTCCACGGGCCGACTCCCGATGTCTTCAAGCCGAAGAGCTG
GTTCGAGTTCGACCTGGGCCCGATCGACTTCTACTTCAACAAGTGGTCCGCGCTGACTCTGTTCGTCGCGCTGTTCGTCG
GCGGCTTCCTCTGGCTGGGGTTCCGCAAGGCGACGCTGGTGCCGCGCGGGCTCCAGAACTTCTGCGAGTCGATCTACGAC
TTCGTCGATCTCCAGATCGCTCAGAACGTCATCGGCGAGCGAGGCAGGACGTTCTCCCCGTACCTGACAATTCTCTTCTG
CTTCATCCTGGTCTCCAACGTCATGGCGGTCATTCCGGTCGCGCAGTTCCCGACGACGTCGCGAATCGCGCTGCCGATGA
TCCTCGCCGCGGTGAGCTGGTTCATCTTCAACATCGTCGGTATCCGCGAGCACGGGGCCGGTACCTACTTCAAGGACATG
CTGGTGCCGGCGCCGACCGCGCCGCTGTTCGTGAAGGTCATCCTGGCTCCGATCGAGTTCGTCTCGACGATGATCGCCCG
CCCCGCCACCCTCGCCATCCGGCTGTTCGCCAACATGTTCGCCGGCCACATGCTGCTGCTGGTCTTCGCGTTGGGCGCCG
ACTACCTGCTGCCGAAGCCCCAGTTCGTGTTCGGGCTGGTCTCCGGCCTGATGGCGATCGCTCTCACGCTGTTCGAGCTG
ATGATCGACGTGCTGCAGGCCTACATCTTCACGGTCCTCACGGCCGCCTACATCGGCGGCGCGATCTCCTCGCACGGCGG
CGGAGACCACGCGGCGGACCACTCCCCGATCCACGGCCACGAAACAAGTGCGCCGGTCACCGCCGCTGGCGCGGTGGCGC
GGGCCTGA

Upstream 100 bases:

>100_bases
ATTGCCCGGAGCGGCGGCCCATCCCGTATAGGGTGAGGTCGATCCGACCCCGGGGGGATCGCGAACTTTGTCAGCATGAA
TGATCTTGGAGGTATCGGAA

Downstream 100 bases:

>100_bases
ACCTGAATCGACCCACGCGCACCGTGGGAGAGCCCCGGTGCACCGACCACAGAAGGACGGATCCCTACGATGTCTCTTTC
CGCGGCCACGTTGCTCGCCG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MPSGSVLMAADDGFHGPTPDVFKPKSWFEFDLGPIDFYFNKWSALTLFVALFVGGFLWLGFRKATLVPRGLQNFCESIYD
FVDLQIAQNVIGERGRTFSPYLTILFCFILVSNVMAVIPVAQFPTTSRIALPMILAAVSWFIFNIVGIREHGAGTYFKDM
LVPAPTAPLFVKVILAPIEFVSTMIARPATLAIRLFANMFAGHMLLLVFALGADYLLPKPQFVFGLVSGLMAIALTLFEL
MIDVLQAYIFTVLTAAYIGGAISSHGGGDHAADHSPIHGHETSAPVTAAGAVARA

Sequences:

>Translated_295_residues
MPSGSVLMAADDGFHGPTPDVFKPKSWFEFDLGPIDFYFNKWSALTLFVALFVGGFLWLGFRKATLVPRGLQNFCESIYD
FVDLQIAQNVIGERGRTFSPYLTILFCFILVSNVMAVIPVAQFPTTSRIALPMILAAVSWFIFNIVGIREHGAGTYFKDM
LVPAPTAPLFVKVILAPIEFVSTMIARPATLAIRLFANMFAGHMLLLVFALGADYLLPKPQFVFGLVSGLMAIALTLFEL
MIDVLQAYIFTVLTAAYIGGAISSHGGGDHAADHSPIHGHETSAPVTAAGAVARA
>Mature_294_residues
PSGSVLMAADDGFHGPTPDVFKPKSWFEFDLGPIDFYFNKWSALTLFVALFVGGFLWLGFRKATLVPRGLQNFCESIYDF
VDLQIAQNVIGERGRTFSPYLTILFCFILVSNVMAVIPVAQFPTTSRIALPMILAAVSWFIFNIVGIREHGAGTYFKDML
VPAPTAPLFVKVILAPIEFVSTMIARPATLAIRLFANMFAGHMLLLVFALGADYLLPKPQFVFGLVSGLMAIALTLFELM
IDVLQAYIFTVLTAAYIGGAISSHGGGDHAADHSPIHGHETSAPVTAAGAVARA

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Saccharomyces cerevisiae, GI6226527, Length=192, Percent_Identity=31.7708333333333, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_FRASN (A8L3V9)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001505380.1
- ProteinModelPortal:   A8L3V9
- GeneID:   5669432
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_1018
- HOGENOM:   HBG734175
- OMA:   HGHETSA
- ProtClustDB:   PRK05815
- BioCyc:   FSP1855:FRANEAN1_1018-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 31983; Mature: 31852

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1380bbc4)-; HASH(0x187d80c0)-; HASH(0x18795954)-; HASH(0x18a366c4)-; HASH(0x180cd838)-; HASH(0x17870754)-; HASH(0x18668ca8)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSGSVLMAADDGFHGPTPDVFKPKSWFEFDLGPIDFYFNKWSALTLFVALFVGGFLWLG
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FRKATLVPRGLQNFCESIYDFVDLQIAQNVIGERGRTFSPYLTILFCFILVSNVMAVIPV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AQFPTTSRIALPMILAAVSWFIFNIVGIREHGAGTYFKDMLVPAPTAPLFVKVILAPIEF
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
VSTMIARPATLAIRLFANMFAGHMLLLVFALGADYLLPKPQFVFGLVSGLMAIALTLFEL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MIDVLQAYIFTVLTAAYIGGAISSHGGGDHAADHSPIHGHETSAPVTAAGAVARA
HHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCH
>Mature Secondary Structure 
PSGSVLMAADDGFHGPTPDVFKPKSWFEFDLGPIDFYFNKWSALTLFVALFVGGFLWLG
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FRKATLVPRGLQNFCESIYDFVDLQIAQNVIGERGRTFSPYLTILFCFILVSNVMAVIPV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AQFPTTSRIALPMILAAVSWFIFNIVGIREHGAGTYFKDMLVPAPTAPLFVKVILAPIEF
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
VSTMIARPATLAIRLFANMFAGHMLLLVFALGADYLLPKPQFVFGLVSGLMAIALTLFEL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MIDVLQAYIFTVLTAAYIGGAISSHGGGDHAADHSPIHGHETSAPVTAAGAVARA
HHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA