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The map label for this gene is hom [H]

Identifier: 158312859

GI number: 158312859

Start: 1185522

End: 1186841

Strand: Direct

Name: hom [H]

Synonym: Franean1_1005

Alternate gene names: 158312859

Gene position: 1185522-1186841 (Clockwise)

Preceding gene: 158312858

Following gene: 158312860

Centisome position: 13.2

GC content: 72.58

Gene sequence:

>1320_bases
ATGACGATCGACGGCGGGCGCGGTTTCGGGCGCCCGATGAGGATCGCGATGCTCGGCTGCGGGGTCGTCGGAACCGAGGT
GGTGCGGCTGCTGGGCACGCACACCGAGGATCTGGGCGCCCGGGTGGGAGCGCCGCTGGAGATCGTCGGGATCGCGGTCC
GCGATCCCGACCGGATTCGTTCCGCAGCGGTGGATCGGGAGCTGCTCACCACCGACGCGGGCGCACTGGTCGCCCGCGAC
GACGTCGACATCGTGATCGAGGTCGTCGGCGGGATCGAGCCGGTGCGGAGCTGGCTGCTGTCGGCGCTGCGGTCGGGCAA
GTCGGTGGTCAGTGCGAACAAGGCCCTGCTGGCCAGCCACGGCTCCACGCTGCACGACGCCGCGGCGGCCGCCGGCGTCG
ACCTGTACTACGAGGCGGCGGTGGCGGGCGCGATCCCGTTGCTGCGCCCGCTGCGCGAGAGCCTCGCCGGGGATCGGATC
CGCCGCGTCCTCGGCATCGTGAACGGGACGACGAACTACATCCTGACCCGCATGGACGAGACCGGGGCCTCGTTCGCCGA
GGCGTTGGCCGAGGCCGGTGAGCTCGGGTACGCCGAGGCCGACCCCTCCGCCGACATCGACGGGTTCGACGCGGCGGCCA
AGGCGGCGATCATCGCCCAGCTCGCCTTCCACACCCGGGTGACGATCGATGACGTCTACCGGGAGGGGATCGGCGCGGTC
ACCGCCGCCGACATCGCCAGTGCCCGCGAGCTCGGGTGCACGATCAAGGCGCTGGCCATCGCCGAGCGTGCCGGTGACCG
GCCCGGCGTGAGCGTGCGGGTCCATCCGGCGATGATCCCGCGCTCGCATCCGCTGGCCGGGGTGCGCGAGGCGTTCAACG
CGGTCTTCGTCGAGGCCGAGGCCGCCGGGCAGCTCATGTTCTACGGTCGTGGTGCCGGCGGCGCGCCGACCGCCTCGGCC
GTTCTCGGTGACGTGGTCGCGGTGGCCCGCAACCGGATCGCGGGCCGGCAGGGGCCGGGTGAGTCCGCCTACGCGGCCCT
GCCGATCCTGCCGATGGGCCCCACGATCACGAGCTACCACGTGCAGCTGGACGTCACGGACAAGGCCGGGGTACTCGCCG
CGGTGGCCGGCGCGTTCGCCCGGCACGATGTGTCCATCAGAAGCGTCCGTCAGGACGGCCGCGGCGACGACGCCAGCCTC
GTCCTGGTCACCCATCCGGCCGCGGATGCGGCGCTGTCCACGACCGTCGAGGACCTGCGGGTTCTCGACGGGGTGCGTGC
GGTGTCGGGCGTGGTACGGGTCGAGGGAGTTGAGTCATGA

Upstream 100 bases:

>100_bases
ACCGCGGCTCGACTGCTGCTGGCCGAGGCCACCCGGACCGTCCTGGCGAACGGCCTTCGGCTGCTGGGCGTCAGCGCGCC
GGAACGGATGTGAGAGGCGA

Downstream 100 bases:

>100_bases
CCACGATGTCGTCGATGCCGGTTTCGAGCGACCCGGCCGGCAGCAGTGCCCCCGAGCGCGCGTCGCGGGCCTGGCGGGGG
ATCATCGAGGAGTACCGGGA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTIDGGRGFGRPMRIAMLGCGVVGTEVVRLLGTHTEDLGARVGAPLEIVGIAVRDPDRIRSAAVDRELLTTDAGALVARD
DVDIVIEVVGGIEPVRSWLLSALRSGKSVVSANKALLASHGSTLHDAAAAAGVDLYYEAAVAGAIPLLRPLRESLAGDRI
RRVLGIVNGTTNYILTRMDETGASFAEALAEAGELGYAEADPSADIDGFDAAAKAAIIAQLAFHTRVTIDDVYREGIGAV
TAADIASARELGCTIKALAIAERAGDRPGVSVRVHPAMIPRSHPLAGVREAFNAVFVEAEAAGQLMFYGRGAGGAPTASA
VLGDVVAVARNRIAGRQGPGESAYAALPILPMGPTITSYHVQLDVTDKAGVLAAVAGAFARHDVSIRSVRQDGRGDDASL
VLVTHPAADAALSTTVEDLRVLDGVRAVSGVVRVEGVES

Sequences:

>Translated_439_residues
MTIDGGRGFGRPMRIAMLGCGVVGTEVVRLLGTHTEDLGARVGAPLEIVGIAVRDPDRIRSAAVDRELLTTDAGALVARD
DVDIVIEVVGGIEPVRSWLLSALRSGKSVVSANKALLASHGSTLHDAAAAAGVDLYYEAAVAGAIPLLRPLRESLAGDRI
RRVLGIVNGTTNYILTRMDETGASFAEALAEAGELGYAEADPSADIDGFDAAAKAAIIAQLAFHTRVTIDDVYREGIGAV
TAADIASARELGCTIKALAIAERAGDRPGVSVRVHPAMIPRSHPLAGVREAFNAVFVEAEAAGQLMFYGRGAGGAPTASA
VLGDVVAVARNRIAGRQGPGESAYAALPILPMGPTITSYHVQLDVTDKAGVLAAVAGAFARHDVSIRSVRQDGRGDDASL
VLVTHPAADAALSTTVEDLRVLDGVRAVSGVVRVEGVES
>Mature_438_residues
TIDGGRGFGRPMRIAMLGCGVVGTEVVRLLGTHTEDLGARVGAPLEIVGIAVRDPDRIRSAAVDRELLTTDAGALVARDD
VDIVIEVVGGIEPVRSWLLSALRSGKSVVSANKALLASHGSTLHDAAAAAGVDLYYEAAVAGAIPLLRPLRESLAGDRIR
RVLGIVNGTTNYILTRMDETGASFAEALAEAGELGYAEADPSADIDGFDAAAKAAIIAQLAFHTRVTIDDVYREGIGAVT
AADIASARELGCTIKALAIAERAGDRPGVSVRVHPAMIPRSHPLAGVREAFNAVFVEAEAAGQLMFYGRGAGGAPTASAV
LGDVVAVARNRIAGRQGPGESAYAALPILPMGPTITSYHVQLDVTDKAGVLAAVAGAFARHDVSIRSVRQDGRGDDASLV
LVTHPAADAALSTTVEDLRVLDGVRAVSGVVRVEGVES

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=258, Percent_Identity=29.0697674418605, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790376, Length=362, Percent_Identity=25.1381215469613, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322599, Length=126, Percent_Identity=29.3650793650794, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45220; Mature: 45089

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDGGRGFGRPMRIAMLGCGVVGTEVVRLLGTHTEDLGARVGAPLEIVGIAVRDPDRIR
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHCCCCEEEEEEEECCHHHHH
SAAVDRELLTTDAGALVARDDVDIVIEVVGGIEPVRSWLLSALRSGKSVVSANKALLASH
HHHHHHHHHHCCCCCEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCHHHHHCC
GSTLHDAAAAAGVDLYYEAAVAGAIPLLRPLRESLAGDRIRRVLGIVNGTTNYILTRMDE
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
TGASFAEALAEAGELGYAEADPSADIDGFDAAAKAAIIAQLAFHTRVTIDDVYREGIGAV
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCH
TAADIASARELGCTIKALAIAERAGDRPGVSVRVHPAMIPRSHPLAGVREAFNAVFVEAE
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHEEEEEC
AAGQLMFYGRGAGGAPTASAVLGDVVAVARNRIAGRQGPGESAYAALPILPMGPTITSYH
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEE
VQLDVTDKAGVLAAVAGAFARHDVSIRSVRQDGRGDDASLVLVTHPAADAALSTTVEDLR
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHH
VLDGVRAVSGVVRVEGVES
HHHHHHHHHCEEEEECCCC
>Mature Secondary Structure 
TIDGGRGFGRPMRIAMLGCGVVGTEVVRLLGTHTEDLGARVGAPLEIVGIAVRDPDRIR
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHCCCCEEEEEEEECCHHHHH
SAAVDRELLTTDAGALVARDDVDIVIEVVGGIEPVRSWLLSALRSGKSVVSANKALLASH
HHHHHHHHHHCCCCCEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCHHHHHCC
GSTLHDAAAAAGVDLYYEAAVAGAIPLLRPLRESLAGDRIRRVLGIVNGTTNYILTRMDE
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
TGASFAEALAEAGELGYAEADPSADIDGFDAAAKAAIIAQLAFHTRVTIDDVYREGIGAV
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCH
TAADIASARELGCTIKALAIAERAGDRPGVSVRVHPAMIPRSHPLAGVREAFNAVFVEAE
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHEEEEEC
AAGQLMFYGRGAGGAPTASAVLGDVVAVARNRIAGRQGPGESAYAALPILPMGPTITSYH
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEE
VQLDVTDKAGVLAAVAGAFARHDVSIRSVRQDGRGDDASLVLVTHPAADAALSTTVEDLR
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHH
VLDGVRAVSGVVRVEGVES
HHHHHHHHHCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2835591; 3320973; 9362124; 12948626; 1902466 [H]