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The map label for this gene is pepA [H]

Identifier: 158312734

GI number: 158312734

Start: 1024411

End: 1026261

Strand: Direct

Name: pepA [H]

Synonym: Franean1_0880

Alternate gene names: 158312734

Gene position: 1024411-1026261 (Clockwise)

Preceding gene: 158312733

Following gene: 158312738

Centisome position: 11.41

GC content: 74.55

Gene sequence:

>1851_bases
GTGACGACCGCCGCTCCCACCCAGGACGCCGACCTCATCGACTCGAGGTACCGCGCCCCCCTCGTCATCCTCACATCCAC
CGAGCACCCGCCGTCAGTTGGTGGACCCGAGCCGGGCGAGCCGCCGGTCCGGGACGATACCGGCGGGGCGCCGGGCGAAC
CGGCGCCGCCGGCCGGCTCCGTTGGCGCGCCCGGTAGTGCCGGAGCGGTCGGTACTGCCGGCGCTGGTGGTGCTGCCGGT
GAGGGGTCTGCCGCCGAGGGTACGGCCGGCGCCGCGGTCGGCTGGGACTGTTCCGTGCTCGCCGTCGTGGTCACCAGTGT
CGATGGTGCCGCGGTCGTCGGCGAGCAGGGCCGGAGCGCCTGCGCGCGCGTCGGCGCGGACCCGGACCGCCTGATCGAGA
ACGAGGCCTTCCGGGGGGACGCGGGCGGTGTCCTCGTCGTGCCGCTGTCGCGCTCCGAGCGGCCGTGGCGGTTGTTCCTG
CTCGGCGTGGGCGCCGGTGGGACCGCCGACTGGCGTTCGGCCGGCGCGGCTCTCGCGCGGCGCGGGGGAACGCGTGGGCG
GCCCTTCGTCGTCGCCGAACCCGACGCCGAGCAGATCTACGCGTTCGTCGAGGGCTTCGTGCTGGGCTCCTACCGCCCGG
CAGACGCCGTCACCGGTGCCACCCCGGAGGACGCCGTCACCGGTACGACCCGCGAGGCGGGCACCGAGCCGGCTCCCGAG
TTCGCGGAGTCCGCCGAGTCCACTCCCGACGAGCCGCCGGCCGGTCCGCGAGCCGAGCGGATCCTCGTCCTGCACACGGA
GCGCGCCGAGAACCCGGCGCTGATCGAGGCGGTGCGCCGGGCGCGCGCCGTGGCGGACGGCGTGTGCCTCGCCCGTGATC
TGATCAACATGCCGAGCCTCGTGAAGACGCCACGCTGGCTGGCGGACCAGGCGGTGCGAGCCGCGTCCCAGGCCGGCCTG
GGCGTCACCGTGCTCGACCACTCCGACCTGGTCAGCCAGGGCTTCGGTGGGCTGGTCGCGGTGGGCGGGGGCTCCCCGCG
CCCGCCCTGTCTGGTGACGTTGACCTACGACGGCCCGTCCACGCCCGGCGGGAGGACTCCCGGCCACCGGGTGCTGGTCG
GCAAGGGGATCACCTTCGACTCCGGCGGGCTGTCGCTCAAGCCGTCGGTCTCCATGGCCAGTATGAAGACCGACATGTCC
GGCGCGGCTGCCGTGCTCGGCGCCATGGTCACGCTGGCCGAGCTGGAAGTTCCCGGCAAGGTCACCGCGCTGCTCTGCCT
CGCCGAGAACATGATCGGCGCGTCCGCCGTCCGGCCCGGAGACGTGATCACCTGCTGGGGTGGAACGACGGTCGAGGTAC
TCAACACCGACGCCGAGGGCCGGTTGGTGCTCGCCGACGGCCTGGCCTACGCCGCCGCCACCCTCGCCCCCGACCAGATC
GTCGACCTGGCCACGCTCACCGGCGCGATCACCGTCGCGCTCGGTCGGCGCACCGCTGGCCTGTTCTCCTCCGACGACAC
GCTGGCCGGCGAGCTCGCCGGCGCGGCCGGCCGCGCGGGGGAGCGGGTCTGGCGGCTGCCGCTGACCGAGGAGTACCGGC
CGGCCATCGACTCGCCGGTCGCCGACCTGGCGAACATCGGCCGTGCGCTGGACGTCAACGGCGGGTCGATCACCGCCGCG
CTGTTCCTCAGGGAGTTCACCGCGGGTCTGCCCTGGGCGCACTTCGACATCGCCGGCACGGCCCGTGCGGACTCCGACGA
CGGCGAGATCAGCCGCGGCGGTACCGGGTGGGGAGTGCGCACCCTGATCGCCTACCTCGCCGGAGCCCCGGCAGGCGAAC
AGCCCACCTGA

Upstream 100 bases:

>100_bases
GCGAGCGCGCTGGGAGACGCTCTCAAGATCGCGGTCGGTTAGGCTCGGTGGTCACCTACCCCCGGCCCGGCGGACGGGTC
CGCGGGGCGGAGGCGTCCGC

Downstream 100 bases:

>100_bases
CGGAGCGCGTCCGGAGGCACGCGGCTGCCGGCCCTGCGGCAGGCCTCCGGACGCGCGTCAGCTGGCCTGTGGTGGCGGGT
TGTTCGGCGGCGGGCTCCGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MTTAAPTQDADLIDSRYRAPLVILTSTEHPPSVGGPEPGEPPVRDDTGGAPGEPAPPAGSVGAPGSAGAVGTAGAGGAAG
EGSAAEGTAGAAVGWDCSVLAVVVTSVDGAAVVGEQGRSACARVGADPDRLIENEAFRGDAGGVLVVPLSRSERPWRLFL
LGVGAGGTADWRSAGAALARRGGTRGRPFVVAEPDAEQIYAFVEGFVLGSYRPADAVTGATPEDAVTGTTREAGTEPAPE
FAESAESTPDEPPAGPRAERILVLHTERAENPALIEAVRRARAVADGVCLARDLINMPSLVKTPRWLADQAVRAASQAGL
GVTVLDHSDLVSQGFGGLVAVGGGSPRPPCLVTLTYDGPSTPGGRTPGHRVLVGKGITFDSGGLSLKPSVSMASMKTDMS
GAAAVLGAMVTLAELEVPGKVTALLCLAENMIGASAVRPGDVITCWGGTTVEVLNTDAEGRLVLADGLAYAAATLAPDQI
VDLATLTGAITVALGRRTAGLFSSDDTLAGELAGAAGRAGERVWRLPLTEEYRPAIDSPVADLANIGRALDVNGGSITAA
LFLREFTAGLPWAHFDIAGTARADSDDGEISRGGTGWGVRTLIAYLAGAPAGEQPT

Sequences:

>Translated_616_residues
MTTAAPTQDADLIDSRYRAPLVILTSTEHPPSVGGPEPGEPPVRDDTGGAPGEPAPPAGSVGAPGSAGAVGTAGAGGAAG
EGSAAEGTAGAAVGWDCSVLAVVVTSVDGAAVVGEQGRSACARVGADPDRLIENEAFRGDAGGVLVVPLSRSERPWRLFL
LGVGAGGTADWRSAGAALARRGGTRGRPFVVAEPDAEQIYAFVEGFVLGSYRPADAVTGATPEDAVTGTTREAGTEPAPE
FAESAESTPDEPPAGPRAERILVLHTERAENPALIEAVRRARAVADGVCLARDLINMPSLVKTPRWLADQAVRAASQAGL
GVTVLDHSDLVSQGFGGLVAVGGGSPRPPCLVTLTYDGPSTPGGRTPGHRVLVGKGITFDSGGLSLKPSVSMASMKTDMS
GAAAVLGAMVTLAELEVPGKVTALLCLAENMIGASAVRPGDVITCWGGTTVEVLNTDAEGRLVLADGLAYAAATLAPDQI
VDLATLTGAITVALGRRTAGLFSSDDTLAGELAGAAGRAGERVWRLPLTEEYRPAIDSPVADLANIGRALDVNGGSITAA
LFLREFTAGLPWAHFDIAGTARADSDDGEISRGGTGWGVRTLIAYLAGAPAGEQPT
>Mature_615_residues
TTAAPTQDADLIDSRYRAPLVILTSTEHPPSVGGPEPGEPPVRDDTGGAPGEPAPPAGSVGAPGSAGAVGTAGAGGAAGE
GSAAEGTAGAAVGWDCSVLAVVVTSVDGAAVVGEQGRSACARVGADPDRLIENEAFRGDAGGVLVVPLSRSERPWRLFLL
GVGAGGTADWRSAGAALARRGGTRGRPFVVAEPDAEQIYAFVEGFVLGSYRPADAVTGATPEDAVTGTTREAGTEPAPEF
AESAESTPDEPPAGPRAERILVLHTERAENPALIEAVRRARAVADGVCLARDLINMPSLVKTPRWLADQAVRAASQAGLG
VTVLDHSDLVSQGFGGLVAVGGGSPRPPCLVTLTYDGPSTPGGRTPGHRVLVGKGITFDSGGLSLKPSVSMASMKTDMSG
AAAVLGAMVTLAELEVPGKVTALLCLAENMIGASAVRPGDVITCWGGTTVEVLNTDAEGRLVLADGLAYAAATLAPDQIV
DLATLTGAITVALGRRTAGLFSSDDTLAGELAGAAGRAGERVWRLPLTEEYRPAIDSPVADLANIGRALDVNGGSITAAL
FLREFTAGLPWAHFDIAGTARADSDDGEISRGGTGWGVRTLIAYLAGAPAGEQPT

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=335, Percent_Identity=41.1940298507463, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI47155554, Length=325, Percent_Identity=36.9230769230769, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1790710, Length=291, Percent_Identity=47.0790378006873, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=45.9375, Blast_Score=215, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17556903, Length=328, Percent_Identity=36.280487804878, Blast_Score=174, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17565172, Length=195, Percent_Identity=31.2820512820513, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355725, Length=322, Percent_Identity=36.6459627329193, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24661038, Length=322, Percent_Identity=36.0248447204969, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI20129969, Length=292, Percent_Identity=35.6164383561644, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24662227, Length=335, Percent_Identity=33.134328358209, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI161077148, Length=321, Percent_Identity=33.0218068535826, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI20130057, Length=321, Percent_Identity=33.0218068535826, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379063, Length=284, Percent_Identity=37.6760563380282, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI221379062, Length=284, Percent_Identity=37.6760563380282, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21357381, Length=284, Percent_Identity=37.6760563380282, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21355645, Length=352, Percent_Identity=30.3977272727273, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24662223, Length=352, Percent_Identity=30.3977272727273, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI20129963, Length=338, Percent_Identity=32.8402366863905, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19922386, Length=295, Percent_Identity=32.8813559322034, Blast_Score=139, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646701, Length=151, Percent_Identity=36.4238410596026, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646703, Length=151, Percent_Identity=36.4238410596026, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358201, Length=151, Percent_Identity=36.4238410596026, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 62010; Mature: 61879

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAAPTQDADLIDSRYRAPLVILTSTEHPPSVGGPEPGEPPVRDDTGGAPGEPAPPAGS
CCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VGAPGSAGAVGTAGAGGAAGEGSAAEGTAGAAVGWDCSVLAVVVTSVDGAAVVGEQGRSA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEHHHHCCCCCEEECCCCHHH
CARVGADPDRLIENEAFRGDAGGVLVVPLSRSERPWRLFLLGVGAGGTADWRSAGAALAR
HHHCCCCHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
RGGTRGRPFVVAEPDAEQIYAFVEGFVLGSYRPADAVTGATPEDAVTGTTREAGTEPAPE
CCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCHH
FAESAESTPDEPPAGPRAERILVLHTERAENPALIEAVRRARAVADGVCLARDLINMPSL
HHHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VKTPRWLADQAVRAASQAGLGVTVLDHSDLVSQGFGGLVAVGGGSPRPPCLVTLTYDGPS
HCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCC
TPGGRTPGHRVLVGKGITFDSGGLSLKPSVSMASMKTDMSGAAAVLGAMVTLAELEVPGK
CCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCH
VTALLCLAENMIGASAVRPGDVITCWGGTTVEVLNTDAEGRLVLADGLAYAAATLAPDQI
HHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEECCHHHHHHHCCHHHH
VDLATLTGAITVALGRRTAGLFSSDDTLAGELAGAAGRAGERVWRLPLTEEYRPAIDSPV
HHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCEEEECCCCHHHCCCCCCHH
ADLANIGRALDVNGGSITAALFLREFTAGLPWAHFDIAGTARADSDDGEISRGGTGWGVR
HHHHHCCCEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHH
TLIAYLAGAPAGEQPT
HHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TTAAPTQDADLIDSRYRAPLVILTSTEHPPSVGGPEPGEPPVRDDTGGAPGEPAPPAGS
CCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VGAPGSAGAVGTAGAGGAAGEGSAAEGTAGAAVGWDCSVLAVVVTSVDGAAVVGEQGRSA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEHHHHCCCCCEEECCCCHHH
CARVGADPDRLIENEAFRGDAGGVLVVPLSRSERPWRLFLLGVGAGGTADWRSAGAALAR
HHHCCCCHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
RGGTRGRPFVVAEPDAEQIYAFVEGFVLGSYRPADAVTGATPEDAVTGTTREAGTEPAPE
CCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCHH
FAESAESTPDEPPAGPRAERILVLHTERAENPALIEAVRRARAVADGVCLARDLINMPSL
HHHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VKTPRWLADQAVRAASQAGLGVTVLDHSDLVSQGFGGLVAVGGGSPRPPCLVTLTYDGPS
HCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCC
TPGGRTPGHRVLVGKGITFDSGGLSLKPSVSMASMKTDMSGAAAVLGAMVTLAELEVPGK
CCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCH
VTALLCLAENMIGASAVRPGDVITCWGGTTVEVLNTDAEGRLVLADGLAYAAATLAPDQI
HHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEECCHHHHHHHCCHHHH
VDLATLTGAITVALGRRTAGLFSSDDTLAGELAGAAGRAGERVWRLPLTEEYRPAIDSPV
HHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCEEEECCCCHHHCCCCCCHH
ADLANIGRALDVNGGSITAALFLREFTAGLPWAHFDIAGTARADSDDGEISRGGTGWGVR
HHHHHCCCEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHH
TLIAYLAGAPAGEQPT
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA