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The map label for this gene is msrA

Identifier: 158312691

GI number: 158312691

Start: 978445

End: 979110

Strand: Direct

Name: msrA

Synonym: Franean1_0835

Alternate gene names: 158312691

Gene position: 978445-979110 (Clockwise)

Preceding gene: 158312690

Following gene: 158312693

Centisome position: 10.89

GC content: 71.02

Gene sequence:

>666_bases
ATGTTCTTCGGTCGCCACAAGACGACCCTCCCGACTGCCGACCAGGCCCTGCCCGGCCGCGGCACGCCGATCTTCACCGG
CCCCGACCGTCACACCGTCCTCGGCGCGTCCTTGCTCGGCCCCTTCCCGGAGGGGCTGCGTACGGCGGTGTTCGGGATGG
GCTGTTTCTGGGGTGCGGAGCGCAAGTTCTGGCAGGTCCCTGGGGTGTACTCGACCGCGGTCGGCTACGCCGGCGGGATC
ACGCCCAACCCGACCTACGAGGAGGCCTGCTCCGGCCTGACCGGCCACACCGAGGCCGTGCTCGTCGTCTTCGACCCGGC
GAAGGTCAGCTTCGCCGAGCTGCTGCGGGTCTTCTGGGAGGCGCACGACCCGACACAGGGCATGCGCCAGGGCAACGACG
TCGGCACCCAGTACCGGTCGGCGGTCTACACGACCGGCGAGGACCAGGCCGCGGCCGCGCTGGCGAGCCGGGACGCTTTC
CAGCGCGTCCTCACCGCCGCCGGCTACCCGGAGATCACCACGGAGATCGCGCCCGCCGGCCCGTTCTACTACGCCGAGGA
GTACCACCAGCAGTACCTGTCGGACGCCAAGAATCCCCACGGCTACTGCGGCCTGGGCGGAACCGGAGTCAGCTGCCCCG
TCGGCCTCGCGTCAGCGGAGTCCTGA

Upstream 100 bases:

>100_bases
TGCGGGGCGTCGGGAACGGGACAGGGGCCTGCGGGGGGTCGGGAACTTGGGGAAGTCCGCGGTGGTTGTGTCTGTCGGAA
CTCCCCGGAGGTGGTTCGCG

Downstream 100 bases:

>100_bases
GCGATCGCCAGCCGGTTGGACCAAGCGCTCCGACCGGCTGGCGGCCAGTGTGTCCAGACCCGTGGCCGGTGTCCGAGGGG
CTGCGTGCCGCCAGCAGGGC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MFFGRHKTTLPTADQALPGRGTPIFTGPDRHTVLGASLLGPFPEGLRTAVFGMGCFWGAERKFWQVPGVYSTAVGYAGGI
TPNPTYEEACSGLTGHTEAVLVVFDPAKVSFAELLRVFWEAHDPTQGMRQGNDVGTQYRSAVYTTGEDQAAAALASRDAF
QRVLTAAGYPEITTEIAPAGPFYYAEEYHQQYLSDAKNPHGYCGLGGTGVSCPVGLASAES

Sequences:

>Translated_221_residues
MFFGRHKTTLPTADQALPGRGTPIFTGPDRHTVLGASLLGPFPEGLRTAVFGMGCFWGAERKFWQVPGVYSTAVGYAGGI
TPNPTYEEACSGLTGHTEAVLVVFDPAKVSFAELLRVFWEAHDPTQGMRQGNDVGTQYRSAVYTTGEDQAAAALASRDAF
QRVLTAAGYPEITTEIAPAGPFYYAEEYHQQYLSDAKNPHGYCGLGGTGVSCPVGLASAES
>Mature_221_residues
MFFGRHKTTLPTADQALPGRGTPIFTGPDRHTVLGASLLGPFPEGLRTAVFGMGCFWGAERKFWQVPGVYSTAVGYAGGI
TPNPTYEEACSGLTGHTEAVLVVFDPAKVSFAELLRVFWEAHDPTQGMRQGNDVGTQYRSAVYTTGEDQAAAALASRDAF
QRVLTAAGYPEITTEIAPAGPFYYAEEYHQQYLSDAKNPHGYCGLGGTGVSCPVGLASAES

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=218, Percent_Identity=60.091743119266, Blast_Score=267, Evalue=6e-72,
Organism=Homo sapiens, GI208609995, Length=189, Percent_Identity=65.0793650793651, Blast_Score=260, Evalue=7e-70,
Organism=Homo sapiens, GI208609993, Length=218, Percent_Identity=45.8715596330275, Blast_Score=179, Evalue=1e-45,
Organism=Escherichia coli, GI1790665, Length=194, Percent_Identity=59.2783505154639, Blast_Score=221, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=36.9127516778523, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=169, Percent_Identity=34.3195266272189, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=43.1506849315069, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24664631, Length=146, Percent_Identity=42.4657534246575, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=41.8439716312057, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_FRASN (A8L177)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001505199.1
- ProteinModelPortal:   A8L177
- SMR:   A8L177
- GeneID:   5669251
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_0835
- HOGENOM:   HBG748152
- OMA:   SAIYCTT
- ProtClustDB:   CLSK948906
- BioCyc:   FSP1855:FRANEAN1_0835-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 23536; Mature: 23536

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: ACT_SITE 55-55

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFGRHKTTLPTADQALPGRGTPIFTGPDRHTVLGASLLGPFPEGLRTAVFGMGCFWGAE
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEHHHHHCCCHHHHHHHHHHHHHHCCCC
RKFWQVPGVYSTAVGYAGGITPNPTYEEACSGLTGHTEAVLVVFDPAKVSFAELLRVFWE
CCEEECCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
AHDPTQGMRQGNDVGTQYRSAVYTTGEDQAAAALASRDAFQRVLTAAGYPEITTEIAPAG
CCCCHHHHHCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCC
PFYYAEEYHQQYLSDAKNPHGYCGLGGTGVSCPVGLASAES
CCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFFGRHKTTLPTADQALPGRGTPIFTGPDRHTVLGASLLGPFPEGLRTAVFGMGCFWGAE
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEHHHHHCCCHHHHHHHHHHHHHHCCCC
RKFWQVPGVYSTAVGYAGGITPNPTYEEACSGLTGHTEAVLVVFDPAKVSFAELLRVFWE
CCEEECCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
AHDPTQGMRQGNDVGTQYRSAVYTTGEDQAAAALASRDAFQRVLTAAGYPEITTEIAPAG
CCCCHHHHHCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCC
PFYYAEEYHQQYLSDAKNPHGYCGLGGTGVSCPVGLASAES
CCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA