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The map label for this gene is sppA [H]

Identifier: 158312662

GI number: 158312662

Start: 943502

End: 945457

Strand: Direct

Name: sppA [H]

Synonym: Franean1_0806

Alternate gene names: 158312662

Gene position: 943502-945457 (Clockwise)

Preceding gene: 158312661

Following gene: 158312663

Centisome position: 10.5

GC content: 74.74

Gene sequence:

>1956_bases
ATGGTTGGAACGCCCAGACAGGTGGTCGCCGACGTCCAGCGGATCGCGCGGCGGCGCAACGCCCCGATCGTGCTCGAGCT
CGACCTGACGTCCGATCCGGTCGAGGGCGTGCCCACGGACCCGCTGACGGCGGCGGTCTCGCACCGGCGGACCGGCCTGC
GGGAGATCGTCGACGGGCTGCGCCGAGCGGCTCGGGACGAGCGCGCGAGCGTCGTCGTGGCGCACGTCGCCGCCTGCGGG
ATGCCGCTGGCGCGGGTGCAGGAGATCCGGGACGCCGTCGCCGAGTTCCGGGCCTCCGGCGGGGCCGCCTACGCCTACGC
GGACACCTTCGGCGAGTTCGGCGGCGGCACCGTCGCCTACTACCTGGCCTGCGCGTTCGACGAGATCTGGCTCGCGCCGC
CCGGTGACCTGGGCCTGACCGGCGTCGCGATGGAGACCCCGTTCGTGCGCGACGCGCTCGACCGGCTCGGTGTCACCGTT
GAGATCGGCCAGCGCCACGAGTACAAGAACGCGGTGAACACGCTGGTGGAGCGGGACTTCACCCCCGCCCACCGGGAGGC
GCTGGCCCGCATCGTCGACTCCAGCGCCGAGCAGATCGTCGCCGGGATCGCGCAGAGCCGGGGCCTGTCGGCCGACCAGG
TCCGGCGCATGATCGACATCGCGCCGCTGGCCGGCCACGTGGCGCTCTCCGCCGGCCTCGTCGACCGCATCGGCTACCGC
GACGAGATCTATGAGTACGCCCGGGAGCGAGCCCGCGCGCTGGCCGGCCGGGACCCGGGCGATGACGCCGGGGAGACGGT
CGAACCGGTTCTGAGGTACGTCTCCGCCTACCGGCGGGCGGCCGTCCGCAAGGCCGAGTCGCCGGTGCGCCGCGCCGGGT
CGTTCGCCTCGTCGCTGCCGGCGACGATCTTCCTGCGCGAGTCCGGCCGTTCCCGCACGGGAACGGCCGGTGGTCCCGGG
GACGAGAGACCGGCCGGCGCGGCGGGCCCGTCGCGGGCGGGCGCGGACGTGGTGCCGCCGGAGATCGATCCGCACACGTC
GGTGGTGGCGCTCGTGCACGGCACCGGGCCGGTGGTCCTCGGCGGAGCCACGATGCCCTTCTCGGGGCCGGTGTTGGCCG
CCGACGCCGTCACGGCAGCGTTCCGCGCCGCCGCACGTGATCCTTCTGTGGCCGCCGCGGTCTTTCGGGTGGAGAGCCCT
GGAGGCTCCTATGTGGCCTCGGACGTGGTCCGTCGGGAGATCGAACGGTTCCGATCCACAGGCCGTCCAGTAGTGGTCTC
GATGGGCTCGGTGGCCGCGTCGGGCGGGTACTTCGTCGCGCTCGCGGGGGACGTGATCGTCGCGAACCCGGGAACGCTGA
CCGGGTCCATCGGTGTCTTCGGTGGCAAGCAGGTCGTGCGCGACCTGTTCGACAAGGTCGGCATCGGCTTCGGCGCCGTC
GCCGCCGGCGAGAACGCGCTGATGATGTCCCCGCGCCAGCCGTTCACCCAGGCCGGGCGGGCGAAGCTGGACGAGTTCCT
CGACCGCGTCTACGCCGACTTCGTGGACAAGGTCGCCCAGGCCCGCCGCATGTCGCACGGCGACGCCCACGAGCTCGCCC
GCGGCCGGGTCTGGACGGGCGCCGACGCCCACCGTCACGGTCTGGTGGACGAGCTGGGCGGGCTGGCCCACGCGATCGAC
CTCGCCTGGGCCCGGGCCGGCCTGCCGGCAGGGGAGACGCCCAGGGTGCGGCTCACGCCGAAGTCGTCGGTGTTCGACCG
GCTGCGCGCGCCGAAGTCCAGCGAGGAGCCGGCCGCGGCGTCCGCGCTGGCACCCGGGCTGGGCGCCGGGCTCGCCGGCC
TCGGGCTGCGCGGCGCGCTGCTCGTCGGCGAGCGGCTCCTGGGGGCTGGCCTGGCCCGGGCGGGCCTGCCGGGTGCCGGC
CCCCTGGTGATGCCGCCGGTCGGCGAGATCCGTTAG

Upstream 100 bases:

>100_bases
GTCCGCGAGCGTTCCCCCGGGTGGGCCGGCAGCCACGGACGGGCCTGTGCACGGGGCCTGATCGGCAGTCGCCCGCGGGG
CGCTCGTCTAGCCTCTGAGC

Downstream 100 bases:

>100_bases
TCCCGCGGGGCCCGGCCGGGCAGAACGCGCGCTGGTTGCGCGACCCCGGAGCGTGATCGGGGTGCCACGCTGGCGGCGGG
ACGTCCCCGCGTGGCGCGAC

Product: signal peptide peptidase SppA, 36K type

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MVGTPRQVVADVQRIARRRNAPIVLELDLTSDPVEGVPTDPLTAAVSHRRTGLREIVDGLRRAARDERASVVVAHVAACG
MPLARVQEIRDAVAEFRASGGAAYAYADTFGEFGGGTVAYYLACAFDEIWLAPPGDLGLTGVAMETPFVRDALDRLGVTV
EIGQRHEYKNAVNTLVERDFTPAHREALARIVDSSAEQIVAGIAQSRGLSADQVRRMIDIAPLAGHVALSAGLVDRIGYR
DEIYEYARERARALAGRDPGDDAGETVEPVLRYVSAYRRAAVRKAESPVRRAGSFASSLPATIFLRESGRSRTGTAGGPG
DERPAGAAGPSRAGADVVPPEIDPHTSVVALVHGTGPVVLGGATMPFSGPVLAADAVTAAFRAAARDPSVAAAVFRVESP
GGSYVASDVVRREIERFRSTGRPVVVSMGSVAASGGYFVALAGDVIVANPGTLTGSIGVFGGKQVVRDLFDKVGIGFGAV
AAGENALMMSPRQPFTQAGRAKLDEFLDRVYADFVDKVAQARRMSHGDAHELARGRVWTGADAHRHGLVDELGGLAHAID
LAWARAGLPAGETPRVRLTPKSSVFDRLRAPKSSEEPAAASALAPGLGAGLAGLGLRGALLVGERLLGAGLARAGLPGAG
PLVMPPVGEIR

Sequences:

>Translated_651_residues
MVGTPRQVVADVQRIARRRNAPIVLELDLTSDPVEGVPTDPLTAAVSHRRTGLREIVDGLRRAARDERASVVVAHVAACG
MPLARVQEIRDAVAEFRASGGAAYAYADTFGEFGGGTVAYYLACAFDEIWLAPPGDLGLTGVAMETPFVRDALDRLGVTV
EIGQRHEYKNAVNTLVERDFTPAHREALARIVDSSAEQIVAGIAQSRGLSADQVRRMIDIAPLAGHVALSAGLVDRIGYR
DEIYEYARERARALAGRDPGDDAGETVEPVLRYVSAYRRAAVRKAESPVRRAGSFASSLPATIFLRESGRSRTGTAGGPG
DERPAGAAGPSRAGADVVPPEIDPHTSVVALVHGTGPVVLGGATMPFSGPVLAADAVTAAFRAAARDPSVAAAVFRVESP
GGSYVASDVVRREIERFRSTGRPVVVSMGSVAASGGYFVALAGDVIVANPGTLTGSIGVFGGKQVVRDLFDKVGIGFGAV
AAGENALMMSPRQPFTQAGRAKLDEFLDRVYADFVDKVAQARRMSHGDAHELARGRVWTGADAHRHGLVDELGGLAHAID
LAWARAGLPAGETPRVRLTPKSSVFDRLRAPKSSEEPAAASALAPGLGAGLAGLGLRGALLVGERLLGAGLARAGLPGAG
PLVMPPVGEIR
>Mature_651_residues
MVGTPRQVVADVQRIARRRNAPIVLELDLTSDPVEGVPTDPLTAAVSHRRTGLREIVDGLRRAARDERASVVVAHVAACG
MPLARVQEIRDAVAEFRASGGAAYAYADTFGEFGGGTVAYYLACAFDEIWLAPPGDLGLTGVAMETPFVRDALDRLGVTV
EIGQRHEYKNAVNTLVERDFTPAHREALARIVDSSAEQIVAGIAQSRGLSADQVRRMIDIAPLAGHVALSAGLVDRIGYR
DEIYEYARERARALAGRDPGDDAGETVEPVLRYVSAYRRAAVRKAESPVRRAGSFASSLPATIFLRESGRSRTGTAGGPG
DERPAGAAGPSRAGADVVPPEIDPHTSVVALVHGTGPVVLGGATMPFSGPVLAADAVTAAFRAAARDPSVAAAVFRVESP
GGSYVASDVVRREIERFRSTGRPVVVSMGSVAASGGYFVALAGDVIVANPGTLTGSIGVFGGKQVVRDLFDKVGIGFGAV
AAGENALMMSPRQPFTQAGRAKLDEFLDRVYADFVDKVAQARRMSHGDAHELARGRVWTGADAHRHGLVDELGGLAHAID
LAWARAGLPAGETPRVRLTPKSSVFDRLRAPKSSEEPAAASALAPGLGAGLAGLGLRGALLVGERLLGAGLARAGLPGAG
PLVMPPVGEIR

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=185, Percent_Identity=41.6216216216216, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1787527, Length=213, Percent_Identity=29.5774647887324, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 67917; Mature: 67917

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGTPRQVVADVQRIARRRNAPIVLELDLTSDPVEGVPTDPLTAAVSHRRTGLREIVDGL
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHH
RRAARDERASVVVAHVAACGMPLARVQEIRDAVAEFRASGGAAYAYADTFGEFGGGTVAY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCHHHH
YLACAFDEIWLAPPGDLGLTGVAMETPFVRDALDRLGVTVEIGQRHEYKNAVNTLVERDF
HHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCC
TPAHREALARIVDSSAEQIVAGIAQSRGLSADQVRRMIDIAPLAGHVALSAGLVDRIGYR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DEIYEYARERARALAGRDPGDDAGETVEPVLRYVSAYRRAAVRKAESPVRRAGSFASSLP
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATIFLRESGRSRTGTAGGPGDERPAGAAGPSRAGADVVPPEIDPHTSVVALVHGTGPVVL
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEE
GGATMPFSGPVLAADAVTAAFRAAARDPSVAAAVFRVESPGGSYVASDVVRREIERFRST
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHC
GRPVVVSMGSVAASGGYFVALAGDVIVANPGTLTGSIGVFGGKQVVRDLFDKVGIGFGAV
CCCEEEECCCEECCCCEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHH
AAGENALMMSPRQPFTQAGRAKLDEFLDRVYADFVDKVAQARRMSHGDAHELARGRVWTG
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEECC
ADAHRHGLVDELGGLAHAIDLAWARAGLPAGETPRVRLTPKSSVFDRLRAPKSSEEPAAA
CCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCCCHH
SALAPGLGAGLAGLGLRGALLVGERLLGAGLARAGLPGAGPLVMPPVGEIR
HHHCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVGTPRQVVADVQRIARRRNAPIVLELDLTSDPVEGVPTDPLTAAVSHRRTGLREIVDGL
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHH
RRAARDERASVVVAHVAACGMPLARVQEIRDAVAEFRASGGAAYAYADTFGEFGGGTVAY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCHHHH
YLACAFDEIWLAPPGDLGLTGVAMETPFVRDALDRLGVTVEIGQRHEYKNAVNTLVERDF
HHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCC
TPAHREALARIVDSSAEQIVAGIAQSRGLSADQVRRMIDIAPLAGHVALSAGLVDRIGYR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DEIYEYARERARALAGRDPGDDAGETVEPVLRYVSAYRRAAVRKAESPVRRAGSFASSLP
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATIFLRESGRSRTGTAGGPGDERPAGAAGPSRAGADVVPPEIDPHTSVVALVHGTGPVVL
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEE
GGATMPFSGPVLAADAVTAAFRAAARDPSVAAAVFRVESPGGSYVASDVVRREIERFRST
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHC
GRPVVVSMGSVAASGGYFVALAGDVIVANPGTLTGSIGVFGGKQVVRDLFDKVGIGFGAV
CCCEEEECCCEECCCCEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHH
AAGENALMMSPRQPFTQAGRAKLDEFLDRVYADFVDKVAQARRMSHGDAHELARGRVWTG
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEECC
ADAHRHGLVDELGGLAHAIDLAWARAGLPAGETPRVRLTPKSSVFDRLRAPKSSEEPAAA
CCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCCCHH
SALAPGLGAGLAGLGLRGALLVGERLLGAGLARAGLPGAGPLVMPPVGEIR
HHHCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]