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The map label for this gene is cmcT [H]

Identifier: 158312587

GI number: 158312587

Start: 849344

End: 851635

Strand: Direct

Name: cmcT [H]

Synonym: Franean1_0731

Alternate gene names: 158312587

Gene position: 849344-851635 (Clockwise)

Preceding gene: 158312584

Following gene: 158312588

Centisome position: 9.46

GC content: 72.08

Gene sequence:

>2292_bases
ATGGCGAAGAGCAGGGGCAAGCCGAGAGCGAGGTCCGCGGGATCCGGGGGTGCAGGGGCGCCCGCGCGCAGGGGGACCGG
CCCGGCAACGCCGGCCGCGGCGAGCGAGGCGGCGACATCCGAAGCCATACCCGAAGCCACGGCGGATGCCGCCGGAGGCG
CTGGCGACCTCGGACCCACCGGCGGCAACGGCGCCGAGGCTGACGTTGCTGCTGAGGCTGCTGACGTTGCGGCTGGTGAG
GTTGCCGCTGACGAGATTGCAGGCGGCGAGGCTGCTGACGGCGAGGCTGGCGATGCGGCGGCTGCGGGCGCCGGGGTGGC
GCACGAAGAGGCTGACCGCGAAGAGGCTGACGTGGTGGCCCCGGCCGGCGAGGTGTCTGCCGAAGAGGCTGGGGTGGCGG
CCGGGACGGTGGCTACCGGCGAGGCGGTGGCCGAGAAGGCCGAAGCGGTGGCCGCTGGCGCGGGCGTGGCCGAGGAGATG
GCTGAGCGGCAGAGCCTGCCAGCCGAGACCAAGCCCGAGGTCGTGGTCGTGCCCGAGGGTGAGGCCAAGCCCGAGGTTGC
AGCTGAGCCCGAGGTTGAGGCCAAGGTCGGATCCGAAACCGAGGTCGGATCCGGCGTCGAGGCGCAGGCCGCGGTCGCGG
ATGAGAACGCGCTGGTCTCGGCGGAGCCGGAGGCCGGTGCGGAGCCGGTCGAGATCGTCATTCCTGAGCAGGTGACCGCT
GCCGCGAGCATGGTCGCGCCGGCCGGAGCCGCGGAGAAGGAGACGGTCGCGCCGGGCCAGGTCGCCGCGGAGAAGACCGA
GGAGAAGACGGCCGCCCCGGCCGGCCGGGGTCGGCGGGTGCCGGCCTGGGCGGTGCTGGCCGTGTGCTGCTTCGCCCAGT
TCATGGTCGTCCTGGACGTCTCGATCGTGAACGTCGCGCTGCCGTCCATGCAGACCGAACTGGGTCTGAGCTCGTCCGGT
CTGCAGTGGGTGGTCAACTCCTACACGCTGGCCTTCGCCGGGCTGCTGCTGTTCGGTGGGCGGGCGGCGGACCTGTTCGG
GCGGCGCCGGGTGTTCATCACCGGGCTCACCCTGTTCACCGCGGCGAGTCTTGCCGGCGGGCTCGCCAACGACCAGACGA
TGCTGATCGTCGCCCGCGCCGTGCAGGGGCTCGGTGGCGCGGTGCTCGCGCCCGCGACGCTGAGCATGCTGATGACCTCC
TTCCCGGATCCGCGTGAGCGTGCCCGGGCGCTCGGAATGTGGGGTGCGACCGCCGCCGGTGGAGGTGCGATGGGCGCGCT
CGCCGGAGGTGTGCTGACCGAGATCGCCGACTGGCGCTGGGTGCTGTTCGTCAACGTGCCGATCGGACTGGTGCTGATCG
TTGGCGCGCGGGCGGCGTTGATCGAATCCCGCGGTCAGGCTCGCGGAGTGCGCGATCTCGACATTCCCGGCACTGTCACC
GTCACGGCCGGGCTGACGGCGCTGGTCTACGGCATCGTGCGGACGGAGTCCAGCAGTTGGGGCTCGCCGGTGACCATCGC
GTGGCTGGCCGGCGCGGTCGTGTTGCTCGCGGCCTTCCTGATCATCGAGTCGCGTACCGCGAACCCACTGGTGCCACTGG
CCATCTTCCGGCGCCGGGCGCTGCGGTACGCGAACACGATCGGCGTGGTGATGGGCTCGATCATGTTCGGGCTGTTCTTC
TTCCTGACCCTGTACCTGCAGCAGGTCAAGGGCCAGGGGCCGCTCGAGGCCGGCCTGGCGCTGGTGCCCATGCCGATTAT
GATCATTGTCGGGTCGCAGGTCAGTTCCCGGACGGTCGGCCGGTTCGGCCCCCGTCCGCTGATCATCGGCGCGTCGGTGA
TCGTGGCGTCGAGCGTCGGCTGGCTCAGTGCCCTGAGCGCGCACGGCTCCTACTGGGCCGAGGTTTTCGGGCCGCTCGCG
CTGCTGGGCTTCGGGATGGGCATCAACATGGTCGCGGTGACGACCGCCGCCACCGCCGGTGTGCCGCCGCAGTTGGCCGG
GCTGGCGTCCGGTCTACTCAACACCGCGCGGCAGATCGGCGCCGCCGTCGGCCTGGCCGTCCTGGCGATCATCGCGGACA
CGCACACCGACAACGAGCTGGCCGCGGGAGCGGACCGGGCCGACGCGCTGACCTCGGGGTACTCGCTGGGATTCCTGGTG
TGCGCGGCGCTCATGCTCGGGGCCGCCGTGCTGGCGGTGTTCATGCCGCGCAAGGAGGTGCTCGTCGCCCAGGCGGGTGC
CGCCCAGGCCCGCCCGGAACCGGAGCGGGTGGAGGCGCTCGCCGAAGCCTGA

Upstream 100 bases:

>100_bases
CGACGTAGGGTCGGTCGGACGTCCGTACGGTGTACGGGGACCTGGTCGCGGGCCGGCGCGGCCGCCAGATCGACGACCGG
TGCGGCTGTGGGAGGACGCG

Downstream 100 bases:

>100_bases
CCGCCTGCCGGGGCGGAAGGCGGCCGCCCGTCCCGAGATCCGGTGCCGTGTCCTGAGAATCGAATAGCCAGAACCGCGAC
CCGTCACCAATGGTGACGGG

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 763; Mature: 762

Protein sequence:

>763_residues
MAKSRGKPRARSAGSGGAGAPARRGTGPATPAAASEAATSEAIPEATADAAGGAGDLGPTGGNGAEADVAAEAADVAAGE
VAADEIAGGEAADGEAGDAAAAGAGVAHEEADREEADVVAPAGEVSAEEAGVAAGTVATGEAVAEKAEAVAAGAGVAEEM
AERQSLPAETKPEVVVVPEGEAKPEVAAEPEVEAKVGSETEVGSGVEAQAAVADENALVSAEPEAGAEPVEIVIPEQVTA
AASMVAPAGAAEKETVAPGQVAAEKTEEKTAAPAGRGRRVPAWAVLAVCCFAQFMVVLDVSIVNVALPSMQTELGLSSSG
LQWVVNSYTLAFAGLLLFGGRAADLFGRRRVFITGLTLFTAASLAGGLANDQTMLIVARAVQGLGGAVLAPATLSMLMTS
FPDPRERARALGMWGATAAGGGAMGALAGGVLTEIADWRWVLFVNVPIGLVLIVGARAALIESRGQARGVRDLDIPGTVT
VTAGLTALVYGIVRTESSSWGSPVTIAWLAGAVVLLAAFLIIESRTANPLVPLAIFRRRALRYANTIGVVMGSIMFGLFF
FLTLYLQQVKGQGPLEAGLALVPMPIMIIVGSQVSSRTVGRFGPRPLIIGASVIVASSVGWLSALSAHGSYWAEVFGPLA
LLGFGMGINMVAVTTAATAGVPPQLAGLASGLLNTARQIGAAVGLAVLAIIADTHTDNELAAGADRADALTSGYSLGFLV
CAALMLGAAVLAVFMPRKEVLVAQAGAAQARPEPERVEALAEA

Sequences:

>Translated_763_residues
MAKSRGKPRARSAGSGGAGAPARRGTGPATPAAASEAATSEAIPEATADAAGGAGDLGPTGGNGAEADVAAEAADVAAGE
VAADEIAGGEAADGEAGDAAAAGAGVAHEEADREEADVVAPAGEVSAEEAGVAAGTVATGEAVAEKAEAVAAGAGVAEEM
AERQSLPAETKPEVVVVPEGEAKPEVAAEPEVEAKVGSETEVGSGVEAQAAVADENALVSAEPEAGAEPVEIVIPEQVTA
AASMVAPAGAAEKETVAPGQVAAEKTEEKTAAPAGRGRRVPAWAVLAVCCFAQFMVVLDVSIVNVALPSMQTELGLSSSG
LQWVVNSYTLAFAGLLLFGGRAADLFGRRRVFITGLTLFTAASLAGGLANDQTMLIVARAVQGLGGAVLAPATLSMLMTS
FPDPRERARALGMWGATAAGGGAMGALAGGVLTEIADWRWVLFVNVPIGLVLIVGARAALIESRGQARGVRDLDIPGTVT
VTAGLTALVYGIVRTESSSWGSPVTIAWLAGAVVLLAAFLIIESRTANPLVPLAIFRRRALRYANTIGVVMGSIMFGLFF
FLTLYLQQVKGQGPLEAGLALVPMPIMIIVGSQVSSRTVGRFGPRPLIIGASVIVASSVGWLSALSAHGSYWAEVFGPLA
LLGFGMGINMVAVTTAATAGVPPQLAGLASGLLNTARQIGAAVGLAVLAIIADTHTDNELAAGADRADALTSGYSLGFLV
CAALMLGAAVLAVFMPRKEVLVAQAGAAQARPEPERVEALAEA
>Mature_762_residues
AKSRGKPRARSAGSGGAGAPARRGTGPATPAAASEAATSEAIPEATADAAGGAGDLGPTGGNGAEADVAAEAADVAAGEV
AADEIAGGEAADGEAGDAAAAGAGVAHEEADREEADVVAPAGEVSAEEAGVAAGTVATGEAVAEKAEAVAAGAGVAEEMA
ERQSLPAETKPEVVVVPEGEAKPEVAAEPEVEAKVGSETEVGSGVEAQAAVADENALVSAEPEAGAEPVEIVIPEQVTAA
ASMVAPAGAAEKETVAPGQVAAEKTEEKTAAPAGRGRRVPAWAVLAVCCFAQFMVVLDVSIVNVALPSMQTELGLSSSGL
QWVVNSYTLAFAGLLLFGGRAADLFGRRRVFITGLTLFTAASLAGGLANDQTMLIVARAVQGLGGAVLAPATLSMLMTSF
PDPRERARALGMWGATAAGGGAMGALAGGVLTEIADWRWVLFVNVPIGLVLIVGARAALIESRGQARGVRDLDIPGTVTV
TAGLTALVYGIVRTESSSWGSPVTIAWLAGAVVLLAAFLIIESRTANPLVPLAIFRRRALRYANTIGVVMGSIMFGLFFF
LTLYLQQVKGQGPLEAGLALVPMPIMIIVGSQVSSRTVGRFGPRPLIIGASVIVASSVGWLSALSAHGSYWAEVFGPLAL
LGFGMGINMVAVTTAATAGVPPQLAGLASGLLNTARQIGAAVGLAVLAIIADTHTDNELAAGADRADALTSGYSLGFLVC
AALMLGAAVLAVFMPRKEVLVAQAGAAQARPEPERVEALAEA

Specific function: Involved in cephamycin export [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=481, Percent_Identity=28.4823284823285, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1789042, Length=401, Percent_Identity=29.426433915212, Blast_Score=140, Evalue=4e-34,
Organism=Escherichia coli, GI1788710, Length=451, Percent_Identity=27.0509977827051, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI87081983, Length=408, Percent_Identity=28.4313725490196, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1788392, Length=410, Percent_Identity=30.7317073170732, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6324954, Length=422, Percent_Identity=26.0663507109005, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6323520, Length=437, Percent_Identity=24.7139588100687, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323935, Length=518, Percent_Identity=24.3243243243243, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322958, Length=411, Percent_Identity=23.8442822384428, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321663, Length=152, Percent_Identity=30.2631578947368, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319770, Length=311, Percent_Identity=24.4372990353698, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 76197; Mature: 76065

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSRGKPRARSAGSGGAGAPARRGTGPATPAAASEAATSEAIPEATADAAGGAGDLGPT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCC
GGNGAEADVAAEAADVAAGEVAADEIAGGEAADGEAGDAAAAGAGVAHEEADREEADVVA
CCCCCCCHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCEEC
PAGEVSAEEAGVAAGTVATGEAVAEKAEAVAAGAGVAEEMAERQSLPAETKPEVVVVPEG
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCC
EAKPEVAAEPEVEAKVGSETEVGSGVEAQAAVADENALVSAEPEAGAEPVEIVIPEQVTA
CCCCCCCCCCCCHHHCCCCCCCCCCCCCHHEECCCCCEEECCCCCCCCCEEEECCCHHHH
AASMVAPAGAAEKETVAPGQVAAEKTEEKTAAPAGRGRRVPAWAVLAVCCFAQFMVVLDV
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SIVNVALPSMQTELGLSSSGLQWVVNSYTLAFAGLLLFGGRAADLFGRRRVFITGLTLFT
HHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEHHHHHH
AASLAGGLANDQTMLIVARAVQGLGGAVLAPATLSMLMTSFPDPRERARALGMWGATAAG
HHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
GGAMGALAGGVLTEIADWRWVLFVNVPIGLVLIVGARAALIESRGQARGVRDLDIPGTVT
CCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEE
VTAGLTALVYGIVRTESSSWGSPVTIAWLAGAVVLLAAFLIIESRTANPLVPLAIFRRRA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LRYANTIGVVMGSIMFGLFFFLTLYLQQVKGQGPLEAGLALVPMPIMIIVGSQVSSRTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHCCCEEEEECCCHHHCCHH
RFGPRPLIIGASVIVASSVGWLSALSAHGSYWAEVFGPLALLGFGMGINMVAVTTAATAG
CCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCC
VPPQLAGLASGLLNTARQIGAAVGLAVLAIIADTHTDNELAAGADRADALTSGYSLGFLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHCCCHHHHHH
CAALMLGAAVLAVFMPRKEVLVAQAGAAQARPEPERVEALAEA
HHHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
AKSRGKPRARSAGSGGAGAPARRGTGPATPAAASEAATSEAIPEATADAAGGAGDLGPT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCC
GGNGAEADVAAEAADVAAGEVAADEIAGGEAADGEAGDAAAAGAGVAHEEADREEADVVA
CCCCCCCHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCEEC
PAGEVSAEEAGVAAGTVATGEAVAEKAEAVAAGAGVAEEMAERQSLPAETKPEVVVVPEG
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCC
EAKPEVAAEPEVEAKVGSETEVGSGVEAQAAVADENALVSAEPEAGAEPVEIVIPEQVTA
CCCCCCCCCCCCHHHCCCCCCCCCCCCCHHEECCCCCEEECCCCCCCCCEEEECCCHHHH
AASMVAPAGAAEKETVAPGQVAAEKTEEKTAAPAGRGRRVPAWAVLAVCCFAQFMVVLDV
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SIVNVALPSMQTELGLSSSGLQWVVNSYTLAFAGLLLFGGRAADLFGRRRVFITGLTLFT
HHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEHHHHHH
AASLAGGLANDQTMLIVARAVQGLGGAVLAPATLSMLMTSFPDPRERARALGMWGATAAG
HHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
GGAMGALAGGVLTEIADWRWVLFVNVPIGLVLIVGARAALIESRGQARGVRDLDIPGTVT
CCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEE
VTAGLTALVYGIVRTESSSWGSPVTIAWLAGAVVLLAAFLIIESRTANPLVPLAIFRRRA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LRYANTIGVVMGSIMFGLFFFLTLYLQQVKGQGPLEAGLALVPMPIMIIVGSQVSSRTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHCCCEEEEECCCHHHCCHH
RFGPRPLIIGASVIVASSVGWLSALSAHGSYWAEVFGPLALLGFGMGINMVAVTTAATAG
CCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCC
VPPQLAGLASGLLNTARQIGAAVGLAVLAIIADTHTDNELAAGADRADALTSGYSLGFLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHCCCHHHHHH
CAALMLGAAVLAVFMPRKEVLVAQAGAAQARPEPERVEALAEA
HHHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]