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The map label for this gene is moaE2 [H]

Identifier: 158312546

GI number: 158312546

Start: 808552

End: 809826

Strand: Direct

Name: moaE2 [H]

Synonym: Franean1_0689

Alternate gene names: 158312546

Gene position: 808552-809826 (Clockwise)

Preceding gene: 158312545

Following gene: 158312547

Centisome position: 9.0

GC content: 73.8

Gene sequence:

>1275_bases
GTGAAAACGGTAGACCAGCACGCATCGGACATTATGGCCGCAATCCACCCCATGTCGCCGCGGCGGACGGCGCTGCGCGA
GGCGCACGGCTGCGTGCTCGCGGCGCACGTGCGGGCGACGGTGGCCGTCCCGGGCTTCGACAACTCCGCGATGGACGGCT
ACGCCGCCCGCGCCGCGGACGTCGCCGAGGCCAGCGAGGACAACCCTGTGACGCTCCCCGTGGCCGGCGAGATCATGGCC
GGCCCGGTGTCACCCGCGCCACTCGCCCCGGGCACCGTCGTACGGATCATGACCGGTGCCCCGCTCCCGAAGGGCGCCGA
CACGATCGTCCAGCTCGAGTGGACGGACGGCGGCATCGAGACGGTCCGGATCAACCAGGCGCCGCGCCGCGGGCTGCACA
TCCGCCGTGCCGGGGAGGACATCGCGCCCGGCAACCTCGTGCTCGCCGCGGGCACCGTGCTCGGCGCCGCGCAGATCGGC
CTGCTGGCGGCCGTCAACGTCGCCCGGCCGGCGGTCCACCCGCGTCCGCGGGTGGCGGTTCTGTCCACCGGCAGCGAGCT
TGTCGAGGTCGGCACCCCGCTCGGGCCGGGCCAGATCGTCGACTCGAACAGCCACGCCATCGCCGCCGCGGTGCACGAGG
CGGGGGCGCTCGTCCGCCGGGTCGACGGGGTGTCGGACGACCCCGACGAGTTCGGCGCGACCTTCGACGAGCTGCTGCGC
AGCAACGACGTCGTGATCACCACCGGCGGGATCAGTGTCGGCGCGAGGGACGTCGTCAAGCAGGTCCTGAGCAAGTCCGA
CGAGATCCGGTTCGAGCGCATCGCCATGCAGCCCGGCAAGCCGCAGGGCTTCGGTGTCGTCGGTGGCGTGCCCGTCTTCA
CCCTTCCGGGTAACCCGGTGAGCGCCCTGGTGTCGTTTGAGCTGTTCGTCCGGCCGGCGCTGCGGCGGATGCGCGGCCTG
CCGGCGGGCCCGGGGGGCGCGAGCTGGCGGCAGCCGGCCACCGGCACCGTCACCGTCCGGGTGAGCGAGACTATGCAGTC
CGCGGCCGGAAGGCGTACCTTTCCCCGGGTCCGTCTCGAACGTGACGACACCGGGGAGCTGGTCGCGACGTCCGCCGGGG
GGCAGGGCGCCCACCAGATGTCCGGGCTGGCCTCGGCCCACGCGCTGCTCGTCGTCCCCGAGGAGGTCACCGAGGTGCCC
GCAGGCACGAAGCTTCCCGCGGTGCTGCTGCCCGAGCCCGAGTGGGCCGGCCCGTTCGGTGAGGCCCGCGGGTGA

Upstream 100 bases:

>100_bases
GAGAGCTCACTCGCCGGCCGTCATGGCCTGCTGCCCGGCACACCGCTGACACGAAGGCTATACGGCCTGAACAGAAGTGT
AAAGAACGGGACGGGTGCCT

Downstream 100 bases:

>100_bases
CCGGTCCCGGGCGGTTCACCCACGTCGACGACCGGGGCGCGGCGCGGATGGTCGACGTCTCGGCCAAGGAGGTCACGGCG
CGCACGGCGACCGCCGCCGG

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase 2 [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKTVDQHASDIMAAIHPMSPRRTALREAHGCVLAAHVRATVAVPGFDNSAMDGYAARAADVAEASEDNPVTLPVAGEIMA
GPVSPAPLAPGTVVRIMTGAPLPKGADTIVQLEWTDGGIETVRINQAPRRGLHIRRAGEDIAPGNLVLAAGTVLGAAQIG
LLAAVNVARPAVHPRPRVAVLSTGSELVEVGTPLGPGQIVDSNSHAIAAAVHEAGALVRRVDGVSDDPDEFGATFDELLR
SNDVVITTGGISVGARDVVKQVLSKSDEIRFERIAMQPGKPQGFGVVGGVPVFTLPGNPVSALVSFELFVRPALRRMRGL
PAGPGGASWRQPATGTVTVRVSETMQSAAGRRTFPRVRLERDDTGELVATSAGGQGAHQMSGLASAHALLVVPEEVTEVP
AGTKLPAVLLPEPEWAGPFGEARG

Sequences:

>Translated_424_residues
MKTVDQHASDIMAAIHPMSPRRTALREAHGCVLAAHVRATVAVPGFDNSAMDGYAARAADVAEASEDNPVTLPVAGEIMA
GPVSPAPLAPGTVVRIMTGAPLPKGADTIVQLEWTDGGIETVRINQAPRRGLHIRRAGEDIAPGNLVLAAGTVLGAAQIG
LLAAVNVARPAVHPRPRVAVLSTGSELVEVGTPLGPGQIVDSNSHAIAAAVHEAGALVRRVDGVSDDPDEFGATFDELLR
SNDVVITTGGISVGARDVVKQVLSKSDEIRFERIAMQPGKPQGFGVVGGVPVFTLPGNPVSALVSFELFVRPALRRMRGL
PAGPGGASWRQPATGTVTVRVSETMQSAAGRRTFPRVRLERDDTGELVATSAGGQGAHQMSGLASAHALLVVPEEVTEVP
AGTKLPAVLLPEPEWAGPFGEARG
>Mature_424_residues
MKTVDQHASDIMAAIHPMSPRRTALREAHGCVLAAHVRATVAVPGFDNSAMDGYAARAADVAEASEDNPVTLPVAGEIMA
GPVSPAPLAPGTVVRIMTGAPLPKGADTIVQLEWTDGGIETVRINQAPRRGLHIRRAGEDIAPGNLVLAAGTVLGAAQIG
LLAAVNVARPAVHPRPRVAVLSTGSELVEVGTPLGPGQIVDSNSHAIAAAVHEAGALVRRVDGVSDDPDEFGATFDELLR
SNDVVITTGGISVGARDVVKQVLSKSDEIRFERIAMQPGKPQGFGVVGGVPVFTLPGNPVSALVSFELFVRPALRRMRGL
PAGPGGASWRQPATGTVTVRVSETMQSAAGRRTFPRVRLERDDTGELVATSAGGQGAHQMSGLASAHALLVVPEEVTEVP
AGTKLPAVLLPEPEWAGPFGEARG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=395, Percent_Identity=38.4810126582278, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI66932975, Length=395, Percent_Identity=38.4810126582278, Blast_Score=200, Evalue=2e-51,
Organism=Escherichia coli, GI1787049, Length=396, Percent_Identity=37.8787878787879, Blast_Score=242, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI25147659, Length=385, Percent_Identity=31.9480519480519, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=358, Percent_Identity=25.4189944134078, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136978, Length=419, Percent_Identity=30.3102625298329, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24638841, Length=419, Percent_Identity=30.3102625298329, Blast_Score=144, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43793; Mature: 43793

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVDQHASDIMAAIHPMSPRRTALREAHGCVLAAHVRATVAVPGFDNSAMDGYAARAAD
CCCHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEEEEEEEEEECCCCCCCCCCHHHHHHH
VAEASEDNPVTLPVAGEIMAGPVSPAPLAPGTVVRIMTGAPLPKGADTIVQLEWTDGGIE
HHHCCCCCCEEEEECCCEEECCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCEE
TVRINQAPRRGLHIRRAGEDIAPGNLVLAAGTVLGAAQIGLLAAVNVARPAVHPRPRVAV
EEEECCCCCCCCEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LSTGSELVEVGTPLGPGQIVDSNSHAIAAAVHEAGALVRRVDGVSDDPDEFGATFDELLR
EECCCHHHHHCCCCCCCCEEECCCCEEEHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHC
SNDVVITTGGISVGARDVVKQVLSKSDEIRFERIAMQPGKPQGFGVVGGVPVFTLPGNPV
CCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCCEEEEECCCHH
SALVSFELFVRPALRRMRGLPAGPGGASWRQPATGTVTVRVSETMQSAAGRRTFPRVRLE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCCCCEEEEC
RDDTGELVATSAGGQGAHQMSGLASAHALLVVPEEVTEVPAGTKLPAVLLPEPEWAGPFG
CCCCCCEEEECCCCCCHHHHHHHHHCCEEEEECHHHHCCCCCCCCCEEEECCCCCCCCCC
EARG
CCCC
>Mature Secondary Structure
MKTVDQHASDIMAAIHPMSPRRTALREAHGCVLAAHVRATVAVPGFDNSAMDGYAARAAD
CCCHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEEEEEEEEEECCCCCCCCCCHHHHHHH
VAEASEDNPVTLPVAGEIMAGPVSPAPLAPGTVVRIMTGAPLPKGADTIVQLEWTDGGIE
HHHCCCCCCEEEEECCCEEECCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCEE
TVRINQAPRRGLHIRRAGEDIAPGNLVLAAGTVLGAAQIGLLAAVNVARPAVHPRPRVAV
EEEECCCCCCCCEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LSTGSELVEVGTPLGPGQIVDSNSHAIAAAVHEAGALVRRVDGVSDDPDEFGATFDELLR
EECCCHHHHHCCCCCCCCEEECCCCEEEHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHC
SNDVVITTGGISVGARDVVKQVLSKSDEIRFERIAMQPGKPQGFGVVGGVPVFTLPGNPV
CCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCCEEEEECCCHH
SALVSFELFVRPALRRMRGLPAGPGGASWRQPATGTVTVRVSETMQSAAGRRTFPRVRLE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCCCCEEEEC
RDDTGELVATSAGGQGAHQMSGLASAHALLVVPEEVTEVPAGTKLPAVLLPEPEWAGPFG
CCCCCCEEEECCCCCCHHHHHHHHHCCEEEEECHHHHCCCCCCCCCEEEECCCCCCCCCC
EARG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]