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The map label for this gene is ydgK [H]

Identifier: 158312300

GI number: 158312300

Start: 518334

End: 519530

Strand: Direct

Name: ydgK [H]

Synonym: Franean1_0437

Alternate gene names: 158312300

Gene position: 518334-519530 (Clockwise)

Preceding gene: 158312299

Following gene: 158312302

Centisome position: 5.77

GC content: 72.1

Gene sequence:

>1197_bases
GTGAATTCCGCACGCCGCACCCTGCTCGTGCTCGGCTTCCTCGTCGCGCTCGGGCCGTTCACGGTCGACTTCTACATTCC
GGCGTTCCCGCTCGTCCAAGCCGACTTCGGCACGAGCGCAGCCGCCGTGCAGCTCACGCTGACGGCCACCACCATCGGCT
TCGCGCTGGGCCAGCTGGCCATCGGCCCGTGGAGCGACAGCATCGGGCGGCGCCGGCCCCTGCTGGTGGCCACCGCCCTG
CACGTGGCCGGCAGCCTGGGCGTCGCCGCGGCGCCCACCGTCGAAGTCATGCTCGTCTTCCGGCTGCTGCAGGGCGCCGG
AGCCGCCGGCAGCGGCGTCGTGGCCCTGGCCATGGTGCGCGACCTCTTCGACGGTGCCCTGTTCGTGCGGATGGCAGCCC
GGCTCGCCGTGGTGACCGGGCTCGCGCCGGTTGTCGCACCTTTCGCCGGTTCGCTGATGCTGAGCCACATGTCCTGGCGA
GGCTTGTTCGTCTGCATCGCGCTCTACGGCTTGGCGGTGCTCGCCGTCGCGGCGTTCCTGGTCCGGGAGACGGCCCCGTT
GGTGCGGCGAGCGGGGGCGCCGCTCGGGCGTTACCGCGTGCTGGTGACGGATCGCGGCTTCGTCGGCGCCGCCCTCGCCG
GTGGTCTGCTGGTCTCCAGCGTCTTCACCTACATGAGTTCGTCGTCGTTCCTCTTCCAGGAGACGTACGGCCTCTCCGCC
CAGCGGTACAGCCTGGTCTTCGCGGCGAACGCGGTGGGCTTCGTGATCGGGGCGCAGACGTCAGCGCGGCTCGTCACCCG
GATCGGGCCGCGGCGGCTGCTCCGATACGTACTGCCCTCGCTCGGCTTCCTCGGCTTCACCCTGCTGCTCGCGGCATTCG
CCGGCGAGAACGTGGTGGTGGTGACCTTCGTGACGGCGCTCTACTTCCTCCTGGCAGGCGCCGTCGGGCCCTGCCTGCAG
GTGATCGGCATGGCCCCGCACGGGGAGAGGGCCGGAACCGCCGCCGCGCTGATGGGCGCCGCGAACTTCGGCCTGGCCGG
CGCGACCGCGCCGGTGGCCGGACTACTCGGCGTCGGCTCGATCGGCCCGATCGGCCTCGTCATGGGGCTGACCATGACGG
TCGCGGTGGTTGTCTTCCGGGTGTTGGCCCGCGACCGGCGCGAAGCGCGGGCCGGGGCGCCTTCGCCGGTCCCTTGA

Upstream 100 bases:

>100_bases
GCCTACGCTGTTTTGTAGAACGTTGCACGGACTGGCCGGCAACGACCCTCCGGGGGCAGTGCGCAGCCGTTGACCGGCTG
CCCGATCGACAAGGGCCCCC

Downstream 100 bases:

>100_bases
CGCGCGATCGGTCGCGTCCGATGGGCGAGCGGGTCGACCTGCTGCTCGCCGAGATGACCCTCGACGAGAACCTGGGCCGG
TGTTGGGGATCTACGACGTC

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNSARRTLLVLGFLVALGPFTVDFYIPAFPLVQADFGTSAAAVQLTLTATTIGFALGQLAIGPWSDSIGRRRPLLVATAL
HVAGSLGVAAAPTVEVMLVFRLLQGAGAAGSGVVALAMVRDLFDGALFVRMAARLAVVTGLAPVVAPFAGSLMLSHMSWR
GLFVCIALYGLAVLAVAAFLVRETAPLVRRAGAPLGRYRVLVTDRGFVGAALAGGLLVSSVFTYMSSSSFLFQETYGLSA
QRYSLVFAANAVGFVIGAQTSARLVTRIGPRRLLRYVLPSLGFLGFTLLLAAFAGENVVVVTFVTALYFLLAGAVGPCLQ
VIGMAPHGERAGTAAALMGAANFGLAGATAPVAGLLGVGSIGPIGLVMGLTMTVAVVVFRVLARDRREARAGAPSPVP

Sequences:

>Translated_398_residues
MNSARRTLLVLGFLVALGPFTVDFYIPAFPLVQADFGTSAAAVQLTLTATTIGFALGQLAIGPWSDSIGRRRPLLVATAL
HVAGSLGVAAAPTVEVMLVFRLLQGAGAAGSGVVALAMVRDLFDGALFVRMAARLAVVTGLAPVVAPFAGSLMLSHMSWR
GLFVCIALYGLAVLAVAAFLVRETAPLVRRAGAPLGRYRVLVTDRGFVGAALAGGLLVSSVFTYMSSSSFLFQETYGLSA
QRYSLVFAANAVGFVIGAQTSARLVTRIGPRRLLRYVLPSLGFLGFTLLLAAFAGENVVVVTFVTALYFLLAGAVGPCLQ
VIGMAPHGERAGTAAALMGAANFGLAGATAPVAGLLGVGSIGPIGLVMGLTMTVAVVVFRVLARDRREARAGAPSPVP
>Mature_398_residues
MNSARRTLLVLGFLVALGPFTVDFYIPAFPLVQADFGTSAAAVQLTLTATTIGFALGQLAIGPWSDSIGRRRPLLVATAL
HVAGSLGVAAAPTVEVMLVFRLLQGAGAAGSGVVALAMVRDLFDGALFVRMAARLAVVTGLAPVVAPFAGSLMLSHMSWR
GLFVCIALYGLAVLAVAAFLVRETAPLVRRAGAPLGRYRVLVTDRGFVGAALAGGLLVSSVFTYMSSSSFLFQETYGLSA
QRYSLVFAANAVGFVIGAQTSARLVTRIGPRRLLRYVLPSLGFLGFTLLLAAFAGENVVVVTFVTALYFLLAGAVGPCLQ
VIGMAPHGERAGTAAALMGAANFGLAGATAPVAGLLGVGSIGPIGLVMGLTMTVAVVVFRVLARDRREARAGAPSPVP

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=406, Percent_Identity=28.0788177339901, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI48994889, Length=351, Percent_Identity=28.2051282051282, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1790146, Length=238, Percent_Identity=29.8319327731092, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787065, Length=256, Percent_Identity=26.953125, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082312, Length=329, Percent_Identity=27.0516717325228, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40909; Mature: 40909

Theoretical pI: Translated: 11.74; Mature: 11.74

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSARRTLLVLGFLVALGPFTVDFYIPAFPLVQADFGTSAAAVQLTLTATTIGFALGQLA
CCCHHHHHHHHHHHHHHCCCEEEEECCCCHHEECCCCCCCEEEEEEEHHHHHHHHHHHHC
IGPWSDSIGRRRPLLVATALHVAGSLGVAAAPTVEVMLVFRLLQGAGAAGSGVVALAMVR
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DLFDGALFVRMAARLAVVTGLAPVVAPFAGSLMLSHMSWRGLFVCIALYGLAVLAVAAFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRETAPLVRRAGAPLGRYRVLVTDRGFVGAALAGGLLVSSVFTYMSSSSFLFQETYGLSA
HHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCH
QRYSLVFAANAVGFVIGAQTSARLVTRIGPRRLLRYVLPSLGFLGFTLLLAAFAGENVVV
HHEEEEEEECHHEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VTFVTALYFLLAGAVGPCLQVIGMAPHGERAGTAAALMGAANFGLAGATAPVAGLLGVGS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCC
IGPIGLVMGLTMTVAVVVFRVLARDRREARAGAPSPVP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNSARRTLLVLGFLVALGPFTVDFYIPAFPLVQADFGTSAAAVQLTLTATTIGFALGQLA
CCCHHHHHHHHHHHHHHCCCEEEEECCCCHHEECCCCCCCEEEEEEEHHHHHHHHHHHHC
IGPWSDSIGRRRPLLVATALHVAGSLGVAAAPTVEVMLVFRLLQGAGAAGSGVVALAMVR
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DLFDGALFVRMAARLAVVTGLAPVVAPFAGSLMLSHMSWRGLFVCIALYGLAVLAVAAFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRETAPLVRRAGAPLGRYRVLVTDRGFVGAALAGGLLVSSVFTYMSSSSFLFQETYGLSA
HHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCH
QRYSLVFAANAVGFVIGAQTSARLVTRIGPRRLLRYVLPSLGFLGFTLLLAAFAGENVVV
HHEEEEEEECHHEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VTFVTALYFLLAGAVGPCLQVIGMAPHGERAGTAAALMGAANFGLAGATAPVAGLLGVGS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCC
IGPIGLVMGLTMTVAVVVFRVLARDRREARAGAPSPVP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]