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The map label for this gene is ltrA [H]

Identifier: 158312283

GI number: 158312283

Start: 494865

End: 495920

Strand: Direct

Name: ltrA [H]

Synonym: Franean1_0420

Alternate gene names: 158312283

Gene position: 494865-495920 (Clockwise)

Preceding gene: 158312282

Following gene: 158312287

Centisome position: 5.51

GC content: 63.54

Gene sequence:

>1056_bases
ATGTCGACAGGGCGAAGGGGAACAGGTGGCCGGATACTCAACGGACGGAAGGCATGCGTAATGCAGAGCGCCGAAATGGT
CCTTGGTGTCCTCCGTGAACGTGGAAGGAGAGGACTGCCGCTGGAGCGGGTGTATCGACAGTTGTTCAACGCGGCGCTGT
ACCTGGTGGCCTACGGGCGTCTGTACTCCAACAAGGGTGCGATGACGCCCGGGGAGACCGTGGACGGCATGTCGCTGGCT
ACCATCGACCGCATCATCGATGCGATGCGCCACGAGCGCTACCGATGGAAACCGGTGAAGCGGGTGCACATCCCGAAGAA
GAACGGGAAGAAACGCCCGCTGGGCCTGCCGACCTGGTCGGACAAGCTGGTCGCCGAGGTGGTGCGCCTGCTGTTGGAGG
CGTACTACGAGCCGACCTTCTCCGACCACTCCCACGGGTTCCGCCCAGGCAGAGCCTGCCACACCGCACTCGGTGAGGTG
GTCGATGTCTGGAAGGGGACGCACTGGTTCATTGAGGGCGACATCGCCCGCTGTTTCGAGGAGCTCGACCATCAGGTCAT
GCTCGACACGGTGGGCGAGAGAATCCACGACAACCGGTTCCTGGGGCTCCTGAAGGCCATGCTGCGCGCGGGGTATCTGG
AGGACTGGAAATGGGGAGCGACACTGTCCGGAACGGTACAGGGCGGTCCGGCGTCCCCGATCCTTTCCAATATATATCTC
GACCGGCTGGACAGCTTCGTCGTGACACACCTGCTCCCGGACTACAACCGGGGCGAACGCAGGGCATCCAACCCTGCCTA
CCAGAAAATCGAATATGCGATCGCGCGTGCCCGACGGCACGGCGACCGGCCAGCATTACGCCGGCTTCGCCAGCAACGCC
GCCAGCTGCCCAGCCAGGATCCCCACGATCCCAGCTATCGGCGGCTACGGTACGTAAGGTACGCCGACTTATGCCGACGT
CGGCATAAGTCCGCTTATGCCGAGGGCCGGGTTATGCCGACCGGACTGCTGGAGGGTCTGCGTGTCAGGCAGGTCCTCGT
CGTGGGGGCGGCATAA

Upstream 100 bases:

>100_bases
AGGGACGTACCGCGGGATCGCCTAAGGGGCGCGAGCCCTAAGGTGACGGAGTTTCCATAGTAGTCGTGGGAGTAACGCCC
CACCGGGGACGGCATGAAAG

Downstream 100 bases:

>100_bases
CCCGGTGGGTGCTGGCGGTAGCTAGAGGTTGTCGAGGAAGGTGAGCAGGCTGTCGGGTGGCCGGTAGCGGCCGGGGCTGG
TGCCGGGCTGCTGGACGCGG

Product: RNA-directed DNA polymerase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSTGRRGTGGRILNGRKACVMQSAEMVLGVLRERGRRGLPLERVYRQLFNAALYLVAYGRLYSNKGAMTPGETVDGMSLA
TIDRIIDAMRHERYRWKPVKRVHIPKKNGKKRPLGLPTWSDKLVAEVVRLLLEAYYEPTFSDHSHGFRPGRACHTALGEV
VDVWKGTHWFIEGDIARCFEELDHQVMLDTVGERIHDNRFLGLLKAMLRAGYLEDWKWGATLSGTVQGGPASPILSNIYL
DRLDSFVVTHLLPDYNRGERRASNPAYQKIEYAIARARRHGDRPALRRLRQQRRQLPSQDPHDPSYRRLRYVRYADLCRR
RHKSAYAEGRVMPTGLLEGLRVRQVLVVGAA

Sequences:

>Translated_351_residues
MSTGRRGTGGRILNGRKACVMQSAEMVLGVLRERGRRGLPLERVYRQLFNAALYLVAYGRLYSNKGAMTPGETVDGMSLA
TIDRIIDAMRHERYRWKPVKRVHIPKKNGKKRPLGLPTWSDKLVAEVVRLLLEAYYEPTFSDHSHGFRPGRACHTALGEV
VDVWKGTHWFIEGDIARCFEELDHQVMLDTVGERIHDNRFLGLLKAMLRAGYLEDWKWGATLSGTVQGGPASPILSNIYL
DRLDSFVVTHLLPDYNRGERRASNPAYQKIEYAIARARRHGDRPALRRLRQQRRQLPSQDPHDPSYRRLRYVRYADLCRR
RHKSAYAEGRVMPTGLLEGLRVRQVLVVGAA
>Mature_350_residues
STGRRGTGGRILNGRKACVMQSAEMVLGVLRERGRRGLPLERVYRQLFNAALYLVAYGRLYSNKGAMTPGETVDGMSLAT
IDRIIDAMRHERYRWKPVKRVHIPKKNGKKRPLGLPTWSDKLVAEVVRLLLEAYYEPTFSDHSHGFRPGRACHTALGEVV
DVWKGTHWFIEGDIARCFEELDHQVMLDTVGERIHDNRFLGLLKAMLRAGYLEDWKWGATLSGTVQGGPASPILSNIYLD
RLDSFVVTHLLPDYNRGERRASNPAYQKIEYAIARARRHGDRPALRRLRQQRRQLPSQDPHDPSYRRLRYVRYADLCRRR
HKSAYAEGRVMPTGLLEGLRVRQVLVVGAA

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226520, Length=271, Percent_Identity=35.0553505535055, Blast_Score=195, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6226521, Length=281, Percent_Identity=34.1637010676157, Blast_Score=189, Evalue=6e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 40179; Mature: 40048

Theoretical pI: Translated: 10.72; Mature: 10.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGRRGTGGRILNGRKACVMQSAEMVLGVLRERGRRGLPLERVYRQLFNAALYLVAYGR
CCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LYSNKGAMTPGETVDGMSLATIDRIIDAMRHERYRWKPVKRVHIPKKNGKKRPLGLPTWS
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCC
DKLVAEVVRLLLEAYYEPTFSDHSHGFRPGRACHTALGEVVDVWKGTHWFIEGDIARCFE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHH
ELDHQVMLDTVGERIHDNRFLGLLKAMLRAGYLEDWKWGATLSGTVQGGPASPILSNIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
DRLDSFVVTHLLPDYNRGERRASNPAYQKIEYAIARARRHGDRPALRRLRQQRRQLPSQD
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
PHDPSYRRLRYVRYADLCRRRHKSAYAEGRVMPTGLLEGLRVRQVLVVGAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
STGRRGTGGRILNGRKACVMQSAEMVLGVLRERGRRGLPLERVYRQLFNAALYLVAYGR
CCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LYSNKGAMTPGETVDGMSLATIDRIIDAMRHERYRWKPVKRVHIPKKNGKKRPLGLPTWS
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCC
DKLVAEVVRLLLEAYYEPTFSDHSHGFRPGRACHTALGEVVDVWKGTHWFIEGDIARCFE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHH
ELDHQVMLDTVGERIHDNRFLGLLKAMLRAGYLEDWKWGATLSGTVQGGPASPILSNIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
DRLDSFVVTHLLPDYNRGERRASNPAYQKIEYAIARARRHGDRPALRRLRQQRRQLPSQD
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
PHDPSYRRLRYVRYADLCRRRHKSAYAEGRVMPTGLLEGLRVRQVLVVGAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]