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The map label for this gene is mtnC

Identifier: 157963991

GI number: 157963991

Start: 5076055

End: 5076735

Strand: Direct

Name: mtnC

Synonym: Spea_4180

Alternate gene names: 157963991

Gene position: 5076055-5076735 (Clockwise)

Preceding gene: 157963989

Following gene: 157963994

Centisome position: 98.1

GC content: 45.81

Gene sequence:

>681_bases
ATGGGTATCAGAGCCATCGTCGTTGATACAGCCGGTACGACTACCGACCTTAACTTTATTGAGGATGTACTTTTTCCTTA
TTCAGCTAAGGCCTTACCCGCTTTTCTTGAAGAAAATCAAAATAATGTACTCGTAGACAACTGCATTTGCGATGTGCAAG
ATATTGCCCTCGAGCCAGATGCCAGCCTTGCTCGCGTGACTGAAATTTTACTGCAGTGGATTGAAGAAGATCGCAAAGCC
ACACCACTGAAGACCATCCAAGGTTTGATCTGGAAACAGGGCTATGCCAATGGCGAGTTTACCGGGCATATCTTCCCTGA
CTTTATCGAAGCACTCGATGGCTACAAGCAACAAGGTCTGCGGGTTTATAGCTTCTCTTCAGGTTCTGTTGAGGCGCAAA
AACTGTTGTTTAGCCACAGCGATGCAGGCGATCTAAACGATAAGTTTAATGGCCACTTCGACACTCGCACCGGTAACAAG
CGTTTCAAACAGGCTTACAGCAATATCGTCAACACCATCAGCCTAAGCCCGAAGCAGATCCTATTTGTTTCTGATGTGCT
AGAAGAGCTAAAAGCGGCCAACGAAGCTGGATTACATGTGGTACAGATGGTTCGCGATGACAGTCAGCGTACTGGCGATT
TTAAAACCATTGCTAGCTTTGACGAGCTAAAGATAGATTAA

Upstream 100 bases:

>100_bases
GATGCAATTACACTAGCCAAAGCAGGCAATTCAGCTTAGGATCTGAGCAATAAATCGATCTCGAATACAAGTAATCCACA
TTGCGGAGTAACCAAACATT

Downstream 100 bases:

>100_bases
GTTAATGCTAAGTAACAAAAGGGCCTTAAAGGCTCTTTTGTTACTTTTGCTGTCAACTGTCGCTTGGAAAAGCGGGCGAG
ATACACTTTTTAACCTCGAA

Product: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Products: NA

Alternate protein names: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MGIRAIVVDTAGTTTDLNFIEDVLFPYSAKALPAFLEENQNNVLVDNCICDVQDIALEPDASLARVTEILLQWIEEDRKA
TPLKTIQGLIWKQGYANGEFTGHIFPDFIEALDGYKQQGLRVYSFSSGSVEAQKLLFSHSDAGDLNDKFNGHFDTRTGNK
RFKQAYSNIVNTISLSPKQILFVSDVLEELKAANEAGLHVVQMVRDDSQRTGDFKTIASFDELKID

Sequences:

>Translated_226_residues
MGIRAIVVDTAGTTTDLNFIEDVLFPYSAKALPAFLEENQNNVLVDNCICDVQDIALEPDASLARVTEILLQWIEEDRKA
TPLKTIQGLIWKQGYANGEFTGHIFPDFIEALDGYKQQGLRVYSFSSGSVEAQKLLFSHSDAGDLNDKFNGHFDTRTGNK
RFKQAYSNIVNTISLSPKQILFVSDVLEELKAANEAGLHVVQMVRDDSQRTGDFKTIASFDELKID
>Mature_225_residues
GIRAIVVDTAGTTTDLNFIEDVLFPYSAKALPAFLEENQNNVLVDNCICDVQDIALEPDASLARVTEILLQWIEEDRKAT
PLKTIQGLIWKQGYANGEFTGHIFPDFIEALDGYKQQGLRVYSFSSGSVEAQKLLFSHSDAGDLNDKFNGHFDTRTGNKR
FKQAYSNIVNTISLSPKQILFVSDVLEELKAANEAGLHVVQMVRDDSQRTGDFKTIASFDELKID

Specific function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone

COG id: COG4229

COG function: function code C; Predicted enolase-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family

Homologues:

Organism=Homo sapiens, GI10864017, Length=252, Percent_Identity=36.1111111111111, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI115533232, Length=215, Percent_Identity=37.2093023255814, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320797, Length=201, Percent_Identity=31.3432835820896, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360080, Length=237, Percent_Identity=38.3966244725738, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24644163, Length=237, Percent_Identity=38.3966244725738, Blast_Score=167, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNC_SHEPA (A8HAA3)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001504025.1
- ProteinModelPortal:   A8HAA3
- SMR:   A8HAA3
- STRING:   A8HAA3
- GeneID:   5664564
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_4180
- NMPDR:   fig|398579.3.peg.3630
- eggNOG:   COG4229
- HOGENOM:   HBG294242
- OMA:   TTDLNFI
- ProtClustDB:   CLSK866737
- BioCyc:   SPEA398579:SPEA_4180-MONOMER
- HAMAP:   MF_01681
- InterPro:   IPR010041
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR005833
- Gene3D:   G3DSA:3.40.50.1000
- PANTHER:   PTHR20371
- PRINTS:   PR00413
- TIGRFAMs:   TIGR01691
- TIGRFAMs:   TIGR01549

Pfam domain/function: SSF56784 SSF56784

EC number: =3.1.3.77

Molecular weight: Translated: 25198; Mature: 25066

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIRAIVVDTAGTTTDLNFIEDVLFPYSAKALPAFLEENQNNVLVDNCICDVQDIALEPD
CCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEHHHCCHHHHCCCCC
ASLARVTEILLQWIEEDRKATPLKTIQGLIWKQGYANGEFTGHIFPDFIEALDGYKQQGL
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHCCC
RVYSFSSGSVEAQKLLFSHSDAGDLNDKFNGHFDTRTGNKRFKQAYSNIVNTISLSPKQI
EEEEECCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCHHH
LFVSDVLEELKAANEAGLHVVQMVRDDSQRTGDFKTIASFDELKID
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHCHHHHCCC
>Mature Secondary Structure 
GIRAIVVDTAGTTTDLNFIEDVLFPYSAKALPAFLEENQNNVLVDNCICDVQDIALEPD
CCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEHHHCCHHHHCCCCC
ASLARVTEILLQWIEEDRKATPLKTIQGLIWKQGYANGEFTGHIFPDFIEALDGYKQQGL
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHCCC
RVYSFSSGSVEAQKLLFSHSDAGDLNDKFNGHFDTRTGNKRFKQAYSNIVNTISLSPKQI
EEEEECCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCHHH
LFVSDVLEELKAANEAGLHVVQMVRDDSQRTGDFKTIASFDELKID
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA