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The map label for this gene is cusR [H]

Identifier: 157963921

GI number: 157963921

Start: 4997234

End: 4997911

Strand: Reverse

Name: cusR [H]

Synonym: Spea_4110

Alternate gene names: 157963921

Gene position: 4997911-4997234 (Counterclockwise)

Preceding gene: 157963922

Following gene: 157963920

Centisome position: 96.59

GC content: 46.17

Gene sequence:

>678_bases
ATGAAAATACTCATGGTTGAAGATGACGCGACTACCATCGAATATGTCGTAAAGGGATTTGTTGAGCAAGGGCACAATAT
AGAAACTGCGACAGACGGCCATCAAGGTTTGTTGCTTGCAACCAGCATGAAGTACGACTTAATCATTTTAGATCGTATGT
TGCCACAGCTAGATGGCTTGAAGTTGTTAGCGGCGCTACGCGCTACTGGCAGTCAAACGCCAGTATTGATCTTATCTGCG
TTAAGCCATGTCGATGAGCGAGTAAAAGGACTACGTGCGGGTGGTGATGACTACATGACCAAGCCTTTCGCCTTCTCTGA
GCTGTTGGTTCGTGCCGAGAAGTTGATGCAGCGTGGTGAATCACAGCCAGCGGTTACCGACCTTAATGTGGGTCCGTTAA
CTATAGAGTTGTTGACTCGTAAAGTGACTCTCGATGGGCAAGAAATCTTACTGCAGCCAAAAGAGTTTCAGCTACTTAAA
TACCTGATGGAACATGTTAATCAGGTAATTAGTCGCACCCTGCTTTTTGAAGCTGTGTGGGATTATCACTTCGATCCTCG
TACCAATGTCATCGATGTGCATATCGCCAAACTGAGACGTAAGTTTGAAGAGCTAGGCCACGGTGAATTAATCGAAACTG
TTCGAGGTGCTGGGTATCGGTTACGCCAAGGGCATTAA

Upstream 100 bases:

>100_bases
TTATATAGAATTAGAAATCCTTGATATTGATGGTAAACGTCAGTTGGCCTTCGATATTGAAAACAAACAATTATTACCAC
TGCTCAAATGGGACTAAAAC

Downstream 100 bases:

>100_bases
GCCCTATCAGAGTAGTGCCTGGCGCATTACCATCATATTCTCGGCCCTGGTAACTGTCATCATTGGCACATTGTTACTGG
GAATGTATCGCCAGCTGATC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGLKLLAALRATGSQTPVLILSA
LSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGESQPAVTDLNVGPLTIELLTRKVTLDGQEILLQPKEFQLLK
YLMEHVNQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQGH

Sequences:

>Translated_225_residues
MKILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGLKLLAALRATGSQTPVLILSA
LSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGESQPAVTDLNVGPLTIELLTRKVTLDGQEILLQPKEFQLLK
YLMEHVNQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQGH
>Mature_225_residues
MKILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGLKLLAALRATGSQTPVLILSA
LSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGESQPAVTDLNVGPLTIELLTRKVTLDGQEILLQPKEFQLLK
YLMEHVNQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQGH

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=44.3438914027149, Blast_Score=192, Evalue=1e-50,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=42.0091324200913, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=39.3665158371041, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=36.6515837104072, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=32.8828828828829, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=31.5555555555556, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=30.1369863013699, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=34.5132743362832, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=31.0810810810811, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=31.6742081447964, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=28.9473684210526, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=31.390134529148, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=29.4372294372294, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=28.82096069869, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=31.0344827586207, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790437, Length=138, Percent_Identity=31.8840579710145, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=133, Percent_Identity=30.0751879699248, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=37.6237623762376, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=29.4117647058824, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790299, Length=135, Percent_Identity=30.3703703703704, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25401; Mature: 25401

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGL
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCHHCHH
KLLAALRATGSQTPVLILSALSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
SQPAVTDLNVGPLTIELLTRKVTLDGQEILLQPKEFQLLKYLMEHVNQVISRTLLFEAVW
CCCCEEECCCCCEEHEEHHHHHCCCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQGH
HCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGL
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCHHCHH
KLLAALRATGSQTPVLILSALSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
SQPAVTDLNVGPLTIELLTRKVTLDGQEILLQPKEFQLLKYLMEHVNQVISRTLLFEAVW
CCCCEEECCCCCEEHEEHHHHHCCCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQGH
HCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]