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The map label for this gene is fixC [H]

Identifier: 157963852

GI number: 157963852

Start: 4908089

End: 4909378

Strand: Direct

Name: fixC [H]

Synonym: Spea_4041

Alternate gene names: 157963852

Gene position: 4908089-4909378 (Clockwise)

Preceding gene: 157963851

Following gene: 157963853

Centisome position: 94.85

GC content: 43.41

Gene sequence:

>1290_bases
ATGTCAGAAGAATCATTTGACGCCATTATCGTAGGCGCAGGGCTTGCAGGTTGTGTTGCGGCGTACGTTCTTGCAAAAGA
GGGAGCCGACGTTCTGGTAATTGAACGTGGTAACTATGCTGGTAGCAAGAATATGACCGGCGGTCGTTTATACGCTCACA
GCCTAGAAAAAATTATTCCTGGTTTTGCCAAAGAAGCGCCAATAGAAAGAAAAGTCACTAAAGAAAAAGTCACCTTTCTA
ACTGATGATACAGGCGTCACTCTCGACTACCACAACGGTCGGGATCAAACTGCAGTTGAAGAATCTTATACCCTATTAAG
AGGGGATTTTGACCAGTGGTTAATGGGCAAGGCCGAAGAGGTTGGTGCGCAATTCATTACTGGTATTCGTGTTGAGGAGA
TCTTAACCCAAGACGGTAAAGTCATTGGTGTGAAAGCTGATGGTGATGAGCTAACTGCCAAATCAGTAATTCTGGCAGAA
GGAGTTAACCCGGTTCTTGGTGAACAACTTGGAATGGTTAAACGTGTTAAATCAGATGCTATGGCCGTTGGAGCAAAAGA
GTTAATCGAGCTACCACAAAAGGTTATTCAGGATCGTTTTAACCTTAATGATGACGAAGGTTGTGCTTGGTTATTTGCAG
GCTCCCCCGCCAACGGTTTGATGGGCGGTGGATTCATTTATACCAATAAAAGCTCAGTTTCATTGGGTATCGTCTGTGGT
TTACATGATATTGGCAGTTCAGATAAAACTGTACCGCAAATGCTTGAAGACTTTAAAAACCACGCCATGATCAAGCCCCT
TATAGAAGGCGGTAAACTGATTGAATACTCAGGTCACGTTGTGCCTGAAGCCGGTATTCATATGGTGCCAAAACTTGTTG
ATGACGGCGTATTAATTACCGGAGATGCTGCAGGCTTTTGCTTAAATATCGGCTACACAGTCCGCGGCATGGATCTGGCT
ATTGCCTCGGGTGAAGCAGCAGCCAAAGCAGTATTGGCCGCACGAGAGAAAAACGATTTTAGTGCGCAAGGTTTATCTTC
TTATCAAACATTACTAGAAGATAGCTTCATCATGAAAGATCTCAAGTTGTACAAAGAGTTACCTAAGTTCATGGAGAACC
CTCGCATCTTTAATGAATATCCAAAAATGGTGGCCGACATAATGCAAAGCATGTTCACCGTCGACGGCACTCCATCACAA
CCAATAAGAAAAACTCTCATGAAGCACTGTAAAGAAGTGGGTTACATGAATCTGATTAAAGATGGAATTAAAGGAGTGAC
TTCAATATGA

Upstream 100 bases:

>100_bases
AAAGCCTAACGGAAACACAATTTTTATTGTTATTTCAATCGCCTTGAATCTCTGTAGAGACTAGAGGCGAATAGATAAAT
ATACCTAGAGAGTGACGAGT

Downstream 100 bases:

>100_bases
GTGAAGTAGTTAACGTCGATGTCAAATTAGGCGTCAATAAGTTTCATGTCGATGAGGGGCATCCTCATATTATCTTAAAA
GACAATCCCGATATGAACGA

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSEESFDAIIVGAGLAGCVAAYVLAKEGADVLVIERGNYAGSKNMTGGRLYAHSLEKIIPGFAKEAPIERKVTKEKVTFL
TDDTGVTLDYHNGRDQTAVEESYTLLRGDFDQWLMGKAEEVGAQFITGIRVEEILTQDGKVIGVKADGDELTAKSVILAE
GVNPVLGEQLGMVKRVKSDAMAVGAKELIELPQKVIQDRFNLNDDEGCAWLFAGSPANGLMGGGFIYTNKSSVSLGIVCG
LHDIGSSDKTVPQMLEDFKNHAMIKPLIEGGKLIEYSGHVVPEAGIHMVPKLVDDGVLITGDAAGFCLNIGYTVRGMDLA
IASGEAAAKAVLAAREKNDFSAQGLSSYQTLLEDSFIMKDLKLYKELPKFMENPRIFNEYPKMVADIMQSMFTVDGTPSQ
PIRKTLMKHCKEVGYMNLIKDGIKGVTSI

Sequences:

>Translated_429_residues
MSEESFDAIIVGAGLAGCVAAYVLAKEGADVLVIERGNYAGSKNMTGGRLYAHSLEKIIPGFAKEAPIERKVTKEKVTFL
TDDTGVTLDYHNGRDQTAVEESYTLLRGDFDQWLMGKAEEVGAQFITGIRVEEILTQDGKVIGVKADGDELTAKSVILAE
GVNPVLGEQLGMVKRVKSDAMAVGAKELIELPQKVIQDRFNLNDDEGCAWLFAGSPANGLMGGGFIYTNKSSVSLGIVCG
LHDIGSSDKTVPQMLEDFKNHAMIKPLIEGGKLIEYSGHVVPEAGIHMVPKLVDDGVLITGDAAGFCLNIGYTVRGMDLA
IASGEAAAKAVLAAREKNDFSAQGLSSYQTLLEDSFIMKDLKLYKELPKFMENPRIFNEYPKMVADIMQSMFTVDGTPSQ
PIRKTLMKHCKEVGYMNLIKDGIKGVTSI
>Mature_428_residues
SEESFDAIIVGAGLAGCVAAYVLAKEGADVLVIERGNYAGSKNMTGGRLYAHSLEKIIPGFAKEAPIERKVTKEKVTFLT
DDTGVTLDYHNGRDQTAVEESYTLLRGDFDQWLMGKAEEVGAQFITGIRVEEILTQDGKVIGVKADGDELTAKSVILAEG
VNPVLGEQLGMVKRVKSDAMAVGAKELIELPQKVIQDRFNLNDDEGCAWLFAGSPANGLMGGGFIYTNKSSVSLGIVCGL
HDIGSSDKTVPQMLEDFKNHAMIKPLIEGGKLIEYSGHVVPEAGIHMVPKLVDDGVLITGDAAGFCLNIGYTVRGMDLAI
ASGEAAAKAVLAAREKNDFSAQGLSSYQTLLEDSFIMKDLKLYKELPKFMENPRIFNEYPKMVADIMQSMFTVDGTPSQP
IRKTLMKHCKEVGYMNLIKDGIKGVTSI

Specific function: Could be part of an electron transfer system required for anaerobic carnitine reduction [H]

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF-QO/fixC family [H]

Homologues:

Organism=Homo sapiens, GI119703746, Length=396, Percent_Identity=26.7676767676768, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786227, Length=427, Percent_Identity=61.3583138173302, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1787991, Length=429, Percent_Identity=60.3729603729604, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI87082155, Length=414, Percent_Identity=35.9903381642512, Blast_Score=295, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI25144720, Length=400, Percent_Identity=27.75, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324932, Length=413, Percent_Identity=25.90799031477, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24652256, Length=407, Percent_Identity=27.5184275184275, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: 1.5.5.-

Molecular weight: Translated: 46344; Mature: 46213

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEESFDAIIVGAGLAGCVAAYVLAKEGADVLVIERGNYAGSKNMTGGRLYAHSLEKIIP
CCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
GFAKEAPIERKVTKEKVTFLTDDTGVTLDYHNGRDQTAVEESYTLLRGDFDQWLMGKAEE
CHHHCCCCHHHHHHHHEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCHHH
VGAQFITGIRVEEILTQDGKVIGVKADGDELTAKSVILAEGVNPVLGEQLGMVKRVKSDA
HHHHHHHCCHHHHHHCCCCCEEEEECCCCCHHHHHHHEECCCCHHHHHHHHHHHHHHHHH
MAVGAKELIELPQKVIQDRFNLNDDEGCAWLFAGSPANGLMGGGFIYTNKSSVSLGIVCG
HHHCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCEEEEEEE
LHDIGSSDKTVPQMLEDFKNHAMIKPLIEGGKLIEYSGHVVPEAGIHMVPKLVDDGVLIT
HHHCCCCCCHHHHHHHHHHCCCEEHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEE
GDAAGFCLNIGYTVRGMDLAIASGEAAAKAVLAAREKNDFSAQGLSSYQTLLEDSFIMKD
ECCCCEEEECCEEEECCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LKLYKELPKFMENPRIFNEYPKMVADIMQSMFTVDGTPSQPIRKTLMKHCKEVGYMNLIK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHH
DGIKGVTSI
HHHHHHCCC
>Mature Secondary Structure 
SEESFDAIIVGAGLAGCVAAYVLAKEGADVLVIERGNYAGSKNMTGGRLYAHSLEKIIP
CCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
GFAKEAPIERKVTKEKVTFLTDDTGVTLDYHNGRDQTAVEESYTLLRGDFDQWLMGKAEE
CHHHCCCCHHHHHHHHEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCHHH
VGAQFITGIRVEEILTQDGKVIGVKADGDELTAKSVILAEGVNPVLGEQLGMVKRVKSDA
HHHHHHHCCHHHHHHCCCCCEEEEECCCCCHHHHHHHEECCCCHHHHHHHHHHHHHHHHH
MAVGAKELIELPQKVIQDRFNLNDDEGCAWLFAGSPANGLMGGGFIYTNKSSVSLGIVCG
HHHCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCEEEEEEE
LHDIGSSDKTVPQMLEDFKNHAMIKPLIEGGKLIEYSGHVVPEAGIHMVPKLVDDGVLIT
HHHCCCCCCHHHHHHHHHHCCCEEHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEE
GDAAGFCLNIGYTVRGMDLAIASGEAAAKAVLAAREKNDFSAQGLSSYQTLLEDSFIMKD
ECCCCEEEECCEEEECCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LKLYKELPKFMENPRIFNEYPKMVADIMQSMFTVDGTPSQPIRKTLMKHCKEVGYMNLIK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHH
DGIKGVTSI
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]