Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 157963829

GI number: 157963829

Start: 4880530

End: 4881852

Strand: Direct

Name: envZ [H]

Synonym: Spea_4018

Alternate gene names: 157963829

Gene position: 4880530-4881852 (Clockwise)

Preceding gene: 157963828

Following gene: 157963830

Centisome position: 94.32

GC content: 48.53

Gene sequence:

>1323_bases
GTGGCTATAAATAAACGATGGTGGCAACGCTTTTTGCCACGCAGCTCCTTCAGCCAAACCGTAATGCTAATTGGCTGTTT
GCTGCTCACCAATCAGCTAGTGTCCTACATCTCTGTTGCCGTTTACTTCATTAAACCCAGCTATCAGCAGATAAACCAGC
TGATAGCGAGACAAGTGAAACTGCTTTTCGTCGATGGGGTCGATATCGGCCGCGAACACCTCACCATAGTCGATGCCCTT
AACGCTAAAGTGCGCGATGACACCATGCAGTTTTATAACCAGAAGCAAGCTCGCCAAGCTGGCATCGAGCGTACCACTTA
CTACAGCTTCTTATCTTCCCAAATGTCTGAATATCTAGGTGGCGAGGCTGAAGTGCGCATCGCTCAGGGAGAAGAGTTTG
AGATCTGGATCCGCCCACCTCAAGCCCCCTCTATCTGGATTAGAGTGCCACTGACTGGACTCAACGAAAAAAATCTATCG
CCGCTAACACTATATTTGATGGTCATTGGCGCGTTAAGTGTGGCCGGAGGATGGTGGTTTGCTCGCCAGCAAAATCGTCC
GCTTAGACGACTGCAAAAAGCGGCCATCGCCGTGTCTCGTGGTGACTACCCTAAGCCGCTACCATTAAGTGGCTCGACAG
AAATTGTCGAAGTGACCAACACCTTTAACCAGATGTCTCACAGCATGAAGCAACTGGAGCAAGACAGAGCCCTGCTGATG
GCCGGGATCTCTCACGATCTGCGCACGCCTCTGACCCGTATCCGACTCGCATCAGAGATGATGGTGGAGGAAGATCAATA
TCTGAAAGATGGCATAGTTAACGATATCGAAGATATGGACGCCATCATCAATCAGTTTATCTCTTACATCAGGCAAGATC
AGGAAGGCACACGGGAACTTGAGCAAATTAACATTCTAATTCAGGATGTTATTCAGGCAGAGTCTAACCGTGAAGGCGAT
ATTGAATCAGAGTTAGTAACCTGCCCTATCGTGCCAATGCAAGCTATTGCCGTCAAACGTGTGATCAGTAATTTAGTCGA
GAATGCCTACCGTTATGGTAACGGCTGGGTGCGCATTAACTCACAATTTAATGGGAAGTATGTTGGCTTTAGCGTCGAAG
ATAACGGCCCAGGTATTGACGAAGAGCAGATCCCCAAGTTATTTCAACCTTTCACCCAAGGCGATACGGCTCGCGGCAGT
GTTGGGTCAGGTTTAGGCTTAGCAATCATCAAACGAATTGTCGATAGACACCAAGGCAAGGTGATCCTCACTAATCGCAG
CGAGGGCGGATTACATGCTCAAGTCTGGTTGCCAATAGAATAG

Upstream 100 bases:

>100_bases
TAATGACTAAGTGATAATGACTAAGAGATAATGACTAAGTGACAATGACTAAGTGACAATAGTTAAGTGACTATAAACAA
ACGATGGTGGCAATAGTTAA

Downstream 100 bases:

>100_bases
CCATTAATGTAATCGTCATAATCAGAATCGATTTTGTTCAAGTCATTTAAAATAAAGACTAATCTGTAATTTATTTGTAA
CGAAAAAGCCATATTCTAGC

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MAINKRWWQRFLPRSSFSQTVMLIGCLLLTNQLVSYISVAVYFIKPSYQQINQLIARQVKLLFVDGVDIGREHLTIVDAL
NAKVRDDTMQFYNQKQARQAGIERTTYYSFLSSQMSEYLGGEAEVRIAQGEEFEIWIRPPQAPSIWIRVPLTGLNEKNLS
PLTLYLMVIGALSVAGGWWFARQQNRPLRRLQKAAIAVSRGDYPKPLPLSGSTEIVEVTNTFNQMSHSMKQLEQDRALLM
AGISHDLRTPLTRIRLASEMMVEEDQYLKDGIVNDIEDMDAIINQFISYIRQDQEGTRELEQINILIQDVIQAESNREGD
IESELVTCPIVPMQAIAVKRVISNLVENAYRYGNGWVRINSQFNGKYVGFSVEDNGPGIDEEQIPKLFQPFTQGDTARGS
VGSGLGLAIIKRIVDRHQGKVILTNRSEGGLHAQVWLPIE

Sequences:

>Translated_440_residues
MAINKRWWQRFLPRSSFSQTVMLIGCLLLTNQLVSYISVAVYFIKPSYQQINQLIARQVKLLFVDGVDIGREHLTIVDAL
NAKVRDDTMQFYNQKQARQAGIERTTYYSFLSSQMSEYLGGEAEVRIAQGEEFEIWIRPPQAPSIWIRVPLTGLNEKNLS
PLTLYLMVIGALSVAGGWWFARQQNRPLRRLQKAAIAVSRGDYPKPLPLSGSTEIVEVTNTFNQMSHSMKQLEQDRALLM
AGISHDLRTPLTRIRLASEMMVEEDQYLKDGIVNDIEDMDAIINQFISYIRQDQEGTRELEQINILIQDVIQAESNREGD
IESELVTCPIVPMQAIAVKRVISNLVENAYRYGNGWVRINSQFNGKYVGFSVEDNGPGIDEEQIPKLFQPFTQGDTARGS
VGSGLGLAIIKRIVDRHQGKVILTNRSEGGLHAQVWLPIE
>Mature_439_residues
AINKRWWQRFLPRSSFSQTVMLIGCLLLTNQLVSYISVAVYFIKPSYQQINQLIARQVKLLFVDGVDIGREHLTIVDALN
AKVRDDTMQFYNQKQARQAGIERTTYYSFLSSQMSEYLGGEAEVRIAQGEEFEIWIRPPQAPSIWIRVPLTGLNEKNLSP
LTLYLMVIGALSVAGGWWFARQQNRPLRRLQKAAIAVSRGDYPKPLPLSGSTEIVEVTNTFNQMSHSMKQLEQDRALLMA
GISHDLRTPLTRIRLASEMMVEEDQYLKDGIVNDIEDMDAIINQFISYIRQDQEGTRELEQINILIQDVIQAESNREGDI
ESELVTCPIVPMQAIAVKRVISNLVENAYRYGNGWVRINSQFNGKYVGFSVEDNGPGIDEEQIPKLFQPFTQGDTARGSV
GSGLGLAIIKRIVDRHQGKVILTNRSEGGLHAQVWLPIE

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=434, Percent_Identity=44.4700460829493, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=30.0751879699248, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788393, Length=289, Percent_Identity=26.643598615917, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787894, Length=344, Percent_Identity=25.5813953488372, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1790551, Length=270, Percent_Identity=28.1481481481481, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87082128, Length=250, Percent_Identity=27.6, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=32.2869955156951, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786600, Length=246, Percent_Identity=30.0813008130081, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790861, Length=286, Percent_Identity=25.8741258741259, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=30.1310043668122, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994928, Length=227, Percent_Identity=26.8722466960352, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081816, Length=246, Percent_Identity=26.8292682926829, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=25.2, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=288, Percent_Identity=25.6944444444444, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=25.2212389380531, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788279, Length=254, Percent_Identity=25.1968503937008, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=272, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789403, Length=279, Percent_Identity=26.5232974910394, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787374, Length=283, Percent_Identity=25.0883392226148, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790300, Length=248, Percent_Identity=26.6129032258064, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49860; Mature: 49729

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAINKRWWQRFLPRSSFSQTVMLIGCLLLTNQLVSYISVAVYFIKPSYQQINQLIARQVK
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHH
LLFVDGVDIGREHLTIVDALNAKVRDDTMQFYNQKQARQAGIERTTYYSFLSSQMSEYLG
EEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
GEAEVRIAQGEEFEIWIRPPQAPSIWIRVPLTGLNEKNLSPLTLYLMVIGALSVAGGWWF
CCEEEEEECCCEEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEE
ARQQNRPLRRLQKAAIAVSRGDYPKPLPLSGSTEIVEVTNTFNQMSHSMKQLEQDRALLM
ECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
AGISHDLRTPLTRIRLASEMMVEEDQYLKDGIVNDIEDMDAIINQFISYIRQDQEGTREL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHH
EQINILIQDVIQAESNREGDIESELVTCPIVPMQAIAVKRVISNLVENAYRYGNGWVRIN
HHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
SQFNGKYVGFSVEDNGPGIDEEQIPKLFQPFTQGDTARGSVGSGLGLAIIKRIVDRHQGK
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCE
VILTNRSEGGLHAQVWLPIE
EEEEECCCCCEEEEEEEECC
>Mature Secondary Structure 
AINKRWWQRFLPRSSFSQTVMLIGCLLLTNQLVSYISVAVYFIKPSYQQINQLIARQVK
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHH
LLFVDGVDIGREHLTIVDALNAKVRDDTMQFYNQKQARQAGIERTTYYSFLSSQMSEYLG
EEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
GEAEVRIAQGEEFEIWIRPPQAPSIWIRVPLTGLNEKNLSPLTLYLMVIGALSVAGGWWF
CCEEEEEECCCEEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEE
ARQQNRPLRRLQKAAIAVSRGDYPKPLPLSGSTEIVEVTNTFNQMSHSMKQLEQDRALLM
ECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
AGISHDLRTPLTRIRLASEMMVEEDQYLKDGIVNDIEDMDAIINQFISYIRQDQEGTREL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHH
EQINILIQDVIQAESNREGDIESELVTCPIVPMQAIAVKRVISNLVENAYRYGNGWVRIN
HHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
SQFNGKYVGFSVEDNGPGIDEEQIPKLFQPFTQGDTARGSVGSGLGLAIIKRIVDRHQGK
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCE
VILTNRSEGGLHAQVWLPIE
EEEEECCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]