Click here to switch to the map view.

The map label for this gene is cyoE [H]

Identifier: 157963817

GI number: 157963817

Start: 4866661

End: 4867566

Strand: Direct

Name: cyoE [H]

Synonym: Spea_4006

Alternate gene names: 157963817

Gene position: 4866661-4867566 (Clockwise)

Preceding gene: 157963816

Following gene: 157963818

Centisome position: 94.05

GC content: 48.12

Gene sequence:

>906_bases
ATGGCAAAACAGATCGCATTACCAAGAAGCCAAACAAGCCCGCTATTTCAATGGCGCGCCTATTATGAAATGACTAAGCC
TAAAGTCGTCGCACTTATGCTGCTCACAGTTTTAGTGGGTATGTGTTTAGCCGTCCCGGGGACCGTTCCACTCGTGCCAT
TAATTGCTGGCATGGCAGGGATTGGCATGATGGCAGGCTCTGCCGCTGCCTTTAATCATTTAATCGATCGCCGCATCGAC
GGATTAATGGCTCGAACCTACAACCGCCCACTGCCTAAAGGGCGGATCTCGATAATCAAGGCGATTAGCTTTGCCTCTAT
TCTAGGGACATTAGGTTTCATCATCCTCTATGCCTTAGTAAATCCACTCACCGCCTGGCTCACCTTTGCCAGCTTAATCG
GTTATGCCGTGGTTTATACCGCTTACTTGAAACGAGCGACGCCGCAAAACATTGTGGTTGGGGGCTTGGCTGGAGCCATG
CCCCCACTGCTAGGTTGGACTGCAGTAACGGGAGAGTTTCATGGTAATGCACTGCTGCTGGTGATCATCATCTTTGCATG
GACGCCGCCTCATTTCTGGGCGCTAGCGATTCACCGTAAGGCCGAATATGCCAAGGTGGATATTCCTATGTTGCCGGTTA
CTCACGGCGTTGAATTCACCAAAACCTGCATCTTTCTCTATACGGTATTGTTAGCCATAGCCTGTTTATTACCAGTATTA
GTCGGCATGTGCGGCCCGGTTTATCTAGTAAGTTCAACCCTGCTCAGTGCTGGCTTTATCTATAAAGCTTGGCAGCTCAA
GTTCCATGAAACCCCTGGGCTTGCGATGAATGTATTTAAGTTTTCTATCTATCACTTAATGCTGCTATTTATCGCTTTAC
TGGTCGATCATTATTTATGGGTGTAA

Upstream 100 bases:

>100_bases
ATTTATCAACTACGCCTTATGGCGCAAAGCATAGAGGGCCTTAAATGACAACGACTAACGCCCTGATCTTACCGCACCAA
TACATCGCGAGGTTTCACTA

Downstream 100 bases:

>100_bases
CGAGAACAAGCCCGTTACCGAGCGAGGATAAACCATGAAACTCACCTGGATAATTGCGGCCGTGTTAATGGTAGCAGCGG
GCGTATACGCAAGCATACAG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MAKQIALPRSQTSPLFQWRAYYEMTKPKVVALMLLTVLVGMCLAVPGTVPLVPLIAGMAGIGMMAGSAAAFNHLIDRRID
GLMARTYNRPLPKGRISIIKAISFASILGTLGFIILYALVNPLTAWLTFASLIGYAVVYTAYLKRATPQNIVVGGLAGAM
PPLLGWTAVTGEFHGNALLLVIIIFAWTPPHFWALAIHRKAEYAKVDIPMLPVTHGVEFTKTCIFLYTVLLAIACLLPVL
VGMCGPVYLVSSTLLSAGFIYKAWQLKFHETPGLAMNVFKFSIYHLMLLFIALLVDHYLWV

Sequences:

>Translated_301_residues
MAKQIALPRSQTSPLFQWRAYYEMTKPKVVALMLLTVLVGMCLAVPGTVPLVPLIAGMAGIGMMAGSAAAFNHLIDRRID
GLMARTYNRPLPKGRISIIKAISFASILGTLGFIILYALVNPLTAWLTFASLIGYAVVYTAYLKRATPQNIVVGGLAGAM
PPLLGWTAVTGEFHGNALLLVIIIFAWTPPHFWALAIHRKAEYAKVDIPMLPVTHGVEFTKTCIFLYTVLLAIACLLPVL
VGMCGPVYLVSSTLLSAGFIYKAWQLKFHETPGLAMNVFKFSIYHLMLLFIALLVDHYLWV
>Mature_300_residues
AKQIALPRSQTSPLFQWRAYYEMTKPKVVALMLLTVLVGMCLAVPGTVPLVPLIAGMAGIGMMAGSAAAFNHLIDRRIDG
LMARTYNRPLPKGRISIIKAISFASILGTLGFIILYALVNPLTAWLTFASLIGYAVVYTAYLKRATPQNIVVGGLAGAMP
PLLGWTAVTGEFHGNALLLVIIIFAWTPPHFWALAIHRKAEYAKVDIPMLPVTHGVEFTKTCIFLYTVLLAIACLLPVLV
GMCGPVYLVSSTLLSAGFIYKAWQLKFHETPGLAMNVFKFSIYHLMLLFIALLVDHYLWV

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=193, Percent_Identity=37.3056994818653, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1786631, Length=280, Percent_Identity=36.0714285714286, Blast_Score=168, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71998235, Length=264, Percent_Identity=29.9242424242424, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325085, Length=249, Percent_Identity=29.718875502008, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19921064, Length=296, Percent_Identity=29.3918918918919, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32994; Mature: 32863

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQIALPRSQTSPLFQWRAYYEMTKPKVVALMLLTVLVGMCLAVPGTVPLVPLIAGMAG
CCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IGMMAGSAAAFNHLIDRRIDGLMARTYNRPLPKGRISIIKAISFASILGTLGFIILYALV
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NPLTAWLTFASLIGYAVVYTAYLKRATPQNIVVGGLAGAMPPLLGWTAVTGEFHGNALLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCHHHHHHHHCCCCCCCCHHHH
VIIIFAWTPPHFWALAIHRKAEYAKVDIPMLPVTHGVEFTKTCIFLYTVLLAIACLLPVL
HHHHHHCCCCHHHHHHHHHCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VGMCGPVYLVSSTLLSAGFIYKAWQLKFHETPGLAMNVFKFSIYHLMLLFIALLVDHYLW
HHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
V
C
>Mature Secondary Structure 
AKQIALPRSQTSPLFQWRAYYEMTKPKVVALMLLTVLVGMCLAVPGTVPLVPLIAGMAG
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IGMMAGSAAAFNHLIDRRIDGLMARTYNRPLPKGRISIIKAISFASILGTLGFIILYALV
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NPLTAWLTFASLIGYAVVYTAYLKRATPQNIVVGGLAGAMPPLLGWTAVTGEFHGNALLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCHHHHHHHHCCCCCCCCHHHH
VIIIFAWTPPHFWALAIHRKAEYAKVDIPMLPVTHGVEFTKTCIFLYTVLLAIACLLPVL
HHHHHHCCCCHHHHHHHHHCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VGMCGPVYLVSSTLLSAGFIYKAWQLKFHETPGLAMNVFKFSIYHLMLLFIALLVDHYLW
HHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA