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The map label for this gene is dctA [H]

Identifier: 157963728

GI number: 157963728

Start: 4766310

End: 4767572

Strand: Direct

Name: dctA [H]

Synonym: Spea_3917

Alternate gene names: 157963728

Gene position: 4766310-4767572 (Clockwise)

Preceding gene: 157963727

Following gene: 157963729

Centisome position: 92.11

GC content: 46.0

Gene sequence:

>1263_bases
ATGGGTATAGCTCACAAATGGAATGACTTTATGTGGCAAAAAATTAAGCCCTATCGCTCCTCTATTATCTTACTTTCGGC
CCTAATGCTGGGTGGGTTGATAGGGATCCTCTTTCCAGTGTTTGCTCTTAAGCTAAAGCCCTTGGGCCAGATATTTCTAA
ACTTACTCTTTATGATTATCGTCCCTTTAGTCGCCATCAGTGTTACCTCCTCTATTGCCCACATGACGGATCTAAAAAAA
CTCGGAGCCATCTTAGCCACTATTTTTCTCGTATCCATCATCATGGCGATTATTCCAACCTTAGGCATCATAGGACTCGC
TTCTATTTACGATCCAGCCCAAGGGGTAACCTTAGATCTGCACCAAGGAGTCAGTACAGGCTCCGGAGATATGGATTTTG
TTAACCTGCTGACCACCAATGACTTTGTTGGATTACTGTCTAAGTCCAACATTCTGGCGTTGATTATCATGTCAGTCATT
TCAGGCATAGCCATAGGTCAATCAGGCAAGGAAGGCGAAAAAGTCTCGGCTATGCTCGATAGCTTAAATACCGTGATCAT
GAAAATCGTATCTATTTTAATGCTTGTCGCTCCGGTAGGGCTTGGCGCCTACTTTGCGTCAACCATGGCCAGCCAAGATA
CCGAATTATTAAGTACCTTTGCCCGCGCTATTGGCCTGTTTCTTATCGCCGCAGCACTCTACTACACCCTTGGTAGCACG
CTGTATGCTTGGTTAGGCGGTGGTATTAATGGTGTGAAGCAGTTTTGGCGTAATGCCATTGAGCCCTCGGCAACCGCATT
AGGCACCAGCTCCTCGCTAGCATCACTGCCGGTGAATATCCGAGCCGCTAACAAGATGGGGATAAAAGAGGAAATTGCCG
ACATCTGCCTACCCTTACTGGTTAACCTAAACAAGGGTGGCGCGGCCATGACCACGGCGCTAAAAATTGTGTTTATCTAC
TCGATTCTCGGCTTAGATTTTACTGCCGATGTGTTTGCTCTCACTGTACTGATTTCTGTACTTTCAGCCTTTGTTATTGG
TGGCGTACCAGGTGGGGCTTTCCTTGGCGAAATATTTATCGTTACCACCTTAGGCTTACCGATAGAGGTGATCCCTATCT
TGGTGATTATCGGTGCAGTCACCGATGCACCAGCTACCGTAATCAACGTGATTCACGACCTCAACGCCACCCAAATTATC
GAACGGATTAACGGTAAGCGTTATGCAAAATCTAAAGTTCTAGATACAAAAGCGAATACCTGA

Upstream 100 bases:

>100_bases
TTGCCTTGTCTGCCCGCCACTCCCCTGTTGACCTATAGTTTAACTATCCCTATTCGCTTTCGTCTGCGAAATAGCTAATA
CCAACCGATATAAGCCTTCT

Downstream 100 bases:

>100_bases
GCTCACTCGTCACCTCCTCTTCCATTGAGATGTGCAAAACAAAATAAACCTATGATTACAGCATGTTAAGCATGTGACAC
ATTAAGTGTCATATGCCTTT

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MGIAHKWNDFMWQKIKPYRSSIILLSALMLGGLIGILFPVFALKLKPLGQIFLNLLFMIIVPLVAISVTSSIAHMTDLKK
LGAILATIFLVSIIMAIIPTLGIIGLASIYDPAQGVTLDLHQGVSTGSGDMDFVNLLTTNDFVGLLSKSNILALIIMSVI
SGIAIGQSGKEGEKVSAMLDSLNTVIMKIVSILMLVAPVGLGAYFASTMASQDTELLSTFARAIGLFLIAAALYYTLGST
LYAWLGGGINGVKQFWRNAIEPSATALGTSSSLASLPVNIRAANKMGIKEEIADICLPLLVNLNKGGAAMTTALKIVFIY
SILGLDFTADVFALTVLISVLSAFVIGGVPGGAFLGEIFIVTTLGLPIEVIPILVIIGAVTDAPATVINVIHDLNATQII
ERINGKRYAKSKVLDTKANT

Sequences:

>Translated_420_residues
MGIAHKWNDFMWQKIKPYRSSIILLSALMLGGLIGILFPVFALKLKPLGQIFLNLLFMIIVPLVAISVTSSIAHMTDLKK
LGAILATIFLVSIIMAIIPTLGIIGLASIYDPAQGVTLDLHQGVSTGSGDMDFVNLLTTNDFVGLLSKSNILALIIMSVI
SGIAIGQSGKEGEKVSAMLDSLNTVIMKIVSILMLVAPVGLGAYFASTMASQDTELLSTFARAIGLFLIAAALYYTLGST
LYAWLGGGINGVKQFWRNAIEPSATALGTSSSLASLPVNIRAANKMGIKEEIADICLPLLVNLNKGGAAMTTALKIVFIY
SILGLDFTADVFALTVLISVLSAFVIGGVPGGAFLGEIFIVTTLGLPIEVIPILVIIGAVTDAPATVINVIHDLNATQII
ERINGKRYAKSKVLDTKANT
>Mature_419_residues
GIAHKWNDFMWQKIKPYRSSIILLSALMLGGLIGILFPVFALKLKPLGQIFLNLLFMIIVPLVAISVTSSIAHMTDLKKL
GAILATIFLVSIIMAIIPTLGIIGLASIYDPAQGVTLDLHQGVSTGSGDMDFVNLLTTNDFVGLLSKSNILALIIMSVIS
GIAIGQSGKEGEKVSAMLDSLNTVIMKIVSILMLVAPVGLGAYFASTMASQDTELLSTFARAIGLFLIAAALYYTLGSTL
YAWLGGGINGVKQFWRNAIEPSATALGTSSSLASLPVNIRAANKMGIKEEIADICLPLLVNLNKGGAAMTTALKIVFIYS
ILGLDFTADVFALTVLISVLSAFVIGGVPGGAFLGEIFIVTTLGLPIEVIPILVIIGAVTDAPATVINVIHDLNATQIIE
RINGKRYAKSKVLDTKANT

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468564, Length=268, Percent_Identity=29.1044776119403, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI223468566, Length=250, Percent_Identity=30.8, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI5032093, Length=253, Percent_Identity=30.8300395256917, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI21314632, Length=268, Percent_Identity=27.2388059701493, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4827012, Length=271, Percent_Identity=26.5682656826568, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI66773030, Length=278, Percent_Identity=28.0575539568345, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI40254478, Length=249, Percent_Identity=26.1044176706827, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI169790839, Length=278, Percent_Identity=26.2589928057554, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI194239697, Length=274, Percent_Identity=25.9124087591241, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1789947, Length=348, Percent_Identity=26.7241379310345, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790514, Length=388, Percent_Identity=26.0309278350515, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788024, Length=380, Percent_Identity=23.9473684210526, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17537407, Length=386, Percent_Identity=24.8704663212435, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193206505, Length=411, Percent_Identity=24.0875912408759, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71983106, Length=438, Percent_Identity=22.8310502283105, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71983099, Length=438, Percent_Identity=22.8310502283105, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71996953, Length=280, Percent_Identity=26.7857142857143, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193206654, Length=422, Percent_Identity=23.2227488151659, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541374, Length=396, Percent_Identity=24.2424242424242, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583025, Length=418, Percent_Identity=24.1626794258373, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137668, Length=418, Percent_Identity=24.1626794258373, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583023, Length=418, Percent_Identity=24.1626794258373, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44320; Mature: 44188

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIAHKWNDFMWQKIKPYRSSIILLSALMLGGLIGILFPVFALKLKPLGQIFLNLLFMII
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPLVAISVTSSIAHMTDLKKLGAILATIFLVSIIMAIIPTLGIIGLASIYDPAQGVTLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
HQGVSTGSGDMDFVNLLTTNDFVGLLSKSNILALIIMSVISGIAIGQSGKEGEKVSAMLD
CCCCCCCCCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SLNTVIMKIVSILMLVAPVGLGAYFASTMASQDTELLSTFARAIGLFLIAAALYYTLGST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYAWLGGGINGVKQFWRNAIEPSATALGTSSSLASLPVNIRAANKMGIKEEIADICLPLL
HHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHCCCEEEECCCCCHHHHHHHHHHHHH
VNLNKGGAAMTTALKIVFIYSILGLDFTADVFALTVLISVLSAFVIGGVPGGAFLGEIFI
HCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VTTLGLPIEVIPILVIIGAVTDAPATVINVIHDLNATQIIERINGKRYAKSKVLDTKANT
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
GIAHKWNDFMWQKIKPYRSSIILLSALMLGGLIGILFPVFALKLKPLGQIFLNLLFMII
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPLVAISVTSSIAHMTDLKKLGAILATIFLVSIIMAIIPTLGIIGLASIYDPAQGVTLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
HQGVSTGSGDMDFVNLLTTNDFVGLLSKSNILALIIMSVISGIAIGQSGKEGEKVSAMLD
CCCCCCCCCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SLNTVIMKIVSILMLVAPVGLGAYFASTMASQDTELLSTFARAIGLFLIAAALYYTLGST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYAWLGGGINGVKQFWRNAIEPSATALGTSSSLASLPVNIRAANKMGIKEEIADICLPLL
HHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHCCCEEEECCCCCHHHHHHHHHHHHH
VNLNKGGAAMTTALKIVFIYSILGLDFTADVFALTVLISVLSAFVIGGVPGGAFLGEIFI
HCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VTTLGLPIEVIPILVIIGAVTDAPATVINVIHDLNATQIIERINGKRYAKSKVLDTKANT
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA