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The map label for this gene is fabF [H]

Identifier: 157963711

GI number: 157963711

Start: 4747371

End: 4748669

Strand: Direct

Name: fabF [H]

Synonym: Spea_3900

Alternate gene names: 157963711

Gene position: 4747371-4748669 (Clockwise)

Preceding gene: 157963710

Following gene: 157963712

Centisome position: 91.74

GC content: 50.96

Gene sequence:

>1299_bases
GTGAATTCAACGACCCCAATTGCGATAACTCATTTAGGTTTATGCACTCCTTTAGGGCTGACGCCTCAAGCTGTGCTCGA
CAACTTAATCGCGGGCAGTATCAATGGCATGCAGTGGCGAGATGATCTATTGTTTGAGCGTGCCGTGTTGGTTGGTCAAG
TCGATGTCCAATTGCCCGCTATTCCAGCAACTTTAAAGCGGTTTGATACCCGTAATAATCAGCTGACTCTGCTCATTGCC
CAGCAAATTGAACCAGCCGTCGAGCAGGCCAAGCGCCAATATGGCAACCAGCGGATTGGCCTAGTTATCGGCACCAGTAC
ATCGGGCATTGCCACAGGTGAAGCTGCGCTTGCAGTGCAACAGCGTTCAGGGGAGTTTCCTCAGGATTACGACTATGCCA
AGCAGGAGTTAGGCGACACCAGCCAGTTTCTACAGGCCTACTTTAATTTGAGCGGCCCATGCTATACCGTCTCGACCGCT
TGCTCATCAAGCGCTAAAGTCTTTGCCAGTGCCAAGCGCCTTATCGATGCCGGCATCTGCGATATGGTGATTGTCGGCGG
CATCGACACCCTGTGCCAGCTCACCCTTAACGGCTTCTACTCCCTCGAATCTATCTCTAGCGGGCACTGCCAACCCTTTA
GCGCCAATCGTGACGGTATCAATATTGGTGAAGGCGGTGCACTCTTTACCCTAGAAAAAGCAGTCCACAAGGGTGACAAA
AAGGCGATAATTCTCAGTGGTATAGGCGAGTCGAGCGACGCCCACCATATCTCGGCGCCGCATCCTGAAGGACAAGGCGC
CATCACTGCCATGCAAGCAGCACTTAATATGGCAGGTTTACAGCCAGAGCAGATCGATTACCTTAACCTGCATGGCACAG
CGACCCCAAAAAATGACGCCATGGAGAGCCGCGCAGTGCAGCAAGTGTTTAGCAATAGCTTGCCAGCATGCAGCTCAACT
AAGCCACTAACAGGGCACACCTTAGGCGCTACAGGTGCAATCGAAGCGGCGTTTTGTTATCTACTACTCAGTGATTACAA
TAAGCAGCAATATTTACCGCCACAGATTTGGGATCAAGAGCAAGATCCTAATGACCCTAGCCTGCCGCTGGTCGCAAAAG
GCCAGCAGGCCAACATTCGCCACGTGATGAGCAACTCTTTTGCCTTTGGCGGCAGCAATGCCAGCCTGATCTTGAGCCGA
AGCGGATCAAATAACGAAGCGCTAAAGAATACAGCACTAAAAATTAAAGCCTTAAAAAATATAGTCAGTGACGCAACAGA
GACAAGCCAAGATGTTTGA

Upstream 100 bases:

>100_bases
GAGTTAGACAAGTGGCAAGCCGATGTTAATCTCAACATTCCTGCGGCCAACTTCAAGTTAGCCATTAGCCCGTTATAAAC
CTGACTGAGTGGATATTTAA

Downstream 100 bases:

>100_bases
TATTACAAAGCTTGCAGAGCAAGAGGTGGAAAAGTTTATCCCCCATCGCCAGCCGATGATCTTAATCAGCCAGCTACTTA
AGCATAGCCATGATAGCTTG

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNSTTPIAITHLGLCTPLGLTPQAVLDNLIAGSINGMQWRDDLLFERAVLVGQVDVQLPAIPATLKRFDTRNNQLTLLIA
QQIEPAVEQAKRQYGNQRIGLVIGTSTSGIATGEAALAVQQRSGEFPQDYDYAKQELGDTSQFLQAYFNLSGPCYTVSTA
CSSSAKVFASAKRLIDAGICDMVIVGGIDTLCQLTLNGFYSLESISSGHCQPFSANRDGINIGEGGALFTLEKAVHKGDK
KAIILSGIGESSDAHHISAPHPEGQGAITAMQAALNMAGLQPEQIDYLNLHGTATPKNDAMESRAVQQVFSNSLPACSST
KPLTGHTLGATGAIEAAFCYLLLSDYNKQQYLPPQIWDQEQDPNDPSLPLVAKGQQANIRHVMSNSFAFGGSNASLILSR
SGSNNEALKNTALKIKALKNIVSDATETSQDV

Sequences:

>Translated_432_residues
MNSTTPIAITHLGLCTPLGLTPQAVLDNLIAGSINGMQWRDDLLFERAVLVGQVDVQLPAIPATLKRFDTRNNQLTLLIA
QQIEPAVEQAKRQYGNQRIGLVIGTSTSGIATGEAALAVQQRSGEFPQDYDYAKQELGDTSQFLQAYFNLSGPCYTVSTA
CSSSAKVFASAKRLIDAGICDMVIVGGIDTLCQLTLNGFYSLESISSGHCQPFSANRDGINIGEGGALFTLEKAVHKGDK
KAIILSGIGESSDAHHISAPHPEGQGAITAMQAALNMAGLQPEQIDYLNLHGTATPKNDAMESRAVQQVFSNSLPACSST
KPLTGHTLGATGAIEAAFCYLLLSDYNKQQYLPPQIWDQEQDPNDPSLPLVAKGQQANIRHVMSNSFAFGGSNASLILSR
SGSNNEALKNTALKIKALKNIVSDATETSQDV
>Mature_432_residues
MNSTTPIAITHLGLCTPLGLTPQAVLDNLIAGSINGMQWRDDLLFERAVLVGQVDVQLPAIPATLKRFDTRNNQLTLLIA
QQIEPAVEQAKRQYGNQRIGLVIGTSTSGIATGEAALAVQQRSGEFPQDYDYAKQELGDTSQFLQAYFNLSGPCYTVSTA
CSSSAKVFASAKRLIDAGICDMVIVGGIDTLCQLTLNGFYSLESISSGHCQPFSANRDGINIGEGGALFTLEKAVHKGDK
KAIILSGIGESSDAHHISAPHPEGQGAITAMQAALNMAGLQPEQIDYLNLHGTATPKNDAMESRAVQQVFSNSLPACSST
KPLTGHTLGATGAIEAAFCYLLLSDYNKQQYLPPQIWDQEQDPNDPSLPLVAKGQQANIRHVMSNSFAFGGSNASLILSR
SGSNNEALKNTALKIKALKNIVSDATETSQDV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=438, Percent_Identity=31.9634703196347, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI223972627, Length=159, Percent_Identity=44.0251572327044, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI41872631, Length=407, Percent_Identity=28.2555282555283, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1788663, Length=410, Percent_Identity=30.4878048780488, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1787337, Length=270, Percent_Identity=35.5555555555556, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=29.3269230769231, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=33.4600760456274, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI212642053, Length=268, Percent_Identity=28.7313432835821, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17550940, Length=393, Percent_Identity=23.9185750636132, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=272, Percent_Identity=35.6617647058824, Blast_Score=136, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24644341, Length=395, Percent_Identity=31.1392405063291, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24581345, Length=269, Percent_Identity=26.0223048327138, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221330659, Length=280, Percent_Identity=25.3571428571429, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19920632, Length=280, Percent_Identity=25.3571428571429, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45964; Mature: 45964

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTTPIAITHLGLCTPLGLTPQAVLDNLIAGSINGMQWRDDLLFERAVLVGQVDVQLPA
CCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEEEECCC
IPATLKRFDTRNNQLTLLIAQQIEPAVEQAKRQYGNQRIGLVIGTSTSGIATGEAALAVQ
CHHHHHHHCCCCCEEEEEEHHHCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHEEEH
QRSGEFPQDYDYAKQELGDTSQFLQAYFNLSGPCYTVSTACSSSAKVFASAKRLIDAGIC
HHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHHCCHH
DMVIVGGIDTLCQLTLNGFYSLESISSGHCQPFSANRDGINIGEGGALFTLEKAVHKGDK
HEEECCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCEECCCCCEEEEHHHHHCCCC
KAIILSGIGESSDAHHISAPHPEGQGAITAMQAALNMAGLQPEQIDYLNLHGTATPKNDA
CEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHH
MESRAVQQVFSNSLPACSSTKPLTGHTLGATGAIEAAFCYLLLSDYNKQQYLPPQIWDQE
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCC
QDPNDPSLPLVAKGQQANIRHVMSNSFAFGGSNASLILSRSGSNNEALKNTALKIKALKN
CCCCCCCCCEEECCCCCHHHHHHHCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
IVSDATETSQDV
HHHHHHHHCCCC
>Mature Secondary Structure
MNSTTPIAITHLGLCTPLGLTPQAVLDNLIAGSINGMQWRDDLLFERAVLVGQVDVQLPA
CCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEEEECCC
IPATLKRFDTRNNQLTLLIAQQIEPAVEQAKRQYGNQRIGLVIGTSTSGIATGEAALAVQ
CHHHHHHHCCCCCEEEEEEHHHCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHEEEH
QRSGEFPQDYDYAKQELGDTSQFLQAYFNLSGPCYTVSTACSSSAKVFASAKRLIDAGIC
HHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHHCCHH
DMVIVGGIDTLCQLTLNGFYSLESISSGHCQPFSANRDGINIGEGGALFTLEKAVHKGDK
HEEECCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCEECCCCCEEEEHHHHHCCCC
KAIILSGIGESSDAHHISAPHPEGQGAITAMQAALNMAGLQPEQIDYLNLHGTATPKNDA
CEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHH
MESRAVQQVFSNSLPACSSTKPLTGHTLGATGAIEAAFCYLLLSDYNKQQYLPPQIWDQE
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCC
QDPNDPSLPLVAKGQQANIRHVMSNSFAFGGSNASLILSRSGSNNEALKNTALKIKALKN
CCCCCCCCCEEECCCCCHHHHHHHCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
IVSDATETSQDV
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]