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The map label for this gene is ftsW [H]

Identifier: 157963623

GI number: 157963623

Start: 4635004

End: 4636221

Strand: Reverse

Name: ftsW [H]

Synonym: Spea_3812

Alternate gene names: 157963623

Gene position: 4636221-4635004 (Counterclockwise)

Preceding gene: 157963624

Following gene: 157963622

Centisome position: 89.6

GC content: 47.54

Gene sequence:

>1218_bases
ATGGCGAGTAGCGAGAAGCAGTTAAGTTTATTTGGCAACCGCTTAAAATGGTCGTTGCCGAATCTGTTTAGCGACAACTC
AGCCCCTGGGATGCAGCTGTACGATAGAGCATTGTTATTTGCTGTTTTGTCGTTGATCTGTTTTGGCTTTGTTATGGTGA
TGTCAGCCTCTATGCCTGAGGCGCAAACTTTAACGGGAAACCCGTTTCATTTTGTATGGCGTCATGGTGCTTACCTTGTG
GGCTGTGTAATCATTGCCGCAGTGGTATTACAGGTTGAGGTAAGCATTTGGCAGAGATATAGCGTGCTATTGCTATTTGT
GGTCGGGGCAATGCTCGTAGCAGTACTCTTTGTGGGGACTACGGTAAACGGGGCGACCCGTTGGCTGTCTATAGGGCCTA
TTCGTATTCAGGTGGCCGAGATAGCTAAGTTTGCTTTTGCCATCTATATGGCGGGTTACTTGGTACGTCGTCACCAAGAG
ATTAGGGAAAATGCCAAAGGTTTCTATAAGCCGATTGGTGTTTTTGCCGTATACGCTTTTTTAATTTTGATGCAGCCTGA
CTTAGGTACGGTTGTGGTGCTATTTGTTGGTACGGTAGGCTTGCTGTTTTTAGCGGGGGCGCGATTACTGGATTTCTTCG
CGCTGATCTTAACCGGGATCTTGGCATTCGTAGCGCTTGTACTGCTTGAGCCGTACCGTATGCGACGAGTGACCTCGTTT
CTTGACCCATGGCAAGATCCATTTGGTAGTGGTTACCAGCTGACGCAGTCATTGATGGCCTATGGTCGCGGTGATTGGTT
TGGCCAAGGTTTAGGCAACAGCATTCAGAAGTTAGAGTATCTGCCTGAGGCGCATACCGACTTTATCTTTGCGGTGATTG
GTGAAGAACTCGGATTTATCGGCATTATTGCGGTATTAGCCGTGCTGCTATTTGTGGCACTGCGGGCGATAAAGTTGGGC
AACATGTGTTTAGCACTTGAGCGTGCATTCGAAGGCTATTTAGCCTACGGCATTGGCATTTGGATCTGTTTCCAAACTGT
GGTCAATGTCGGCGCGAGTATCGGTATGTTGCCAACCAAAGGATTAACCCTGCCATTTATTAGTTATGGCGGTAGTAGTT
TATGGGTGATGACGGCGGCAGCAATGATGCTTATCCGAATTGACCATGAAAGAAGATTGAGTGTTATCCAGGCCATCGAA
GGCCGGACAAACAAATAA

Upstream 100 bases:

>100_bases
GGTGATATTGTTATTCTGTCACCGGCTTGTTCAAGCTTAGATATGTACCCCAACTTTATGGCTCGTGGAGATGAATTCCG
TAGCCTGGTTGAAGCGCTTC

Downstream 100 bases:

>100_bases
TGAGTGAGATAATGACTAACCAAGCTGAAGAGAAACGCATTTTAATTATGGCTGGCGGTACCGGCGGTCATGTGTTTCCT
GCGTTAGCGGTAGCTAAGTA

Product: cell division protein FtsW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MASSEKQLSLFGNRLKWSLPNLFSDNSAPGMQLYDRALLFAVLSLICFGFVMVMSASMPEAQTLTGNPFHFVWRHGAYLV
GCVIIAAVVLQVEVSIWQRYSVLLLFVVGAMLVAVLFVGTTVNGATRWLSIGPIRIQVAEIAKFAFAIYMAGYLVRRHQE
IRENAKGFYKPIGVFAVYAFLILMQPDLGTVVVLFVGTVGLLFLAGARLLDFFALILTGILAFVALVLLEPYRMRRVTSF
LDPWQDPFGSGYQLTQSLMAYGRGDWFGQGLGNSIQKLEYLPEAHTDFIFAVIGEELGFIGIIAVLAVLLFVALRAIKLG
NMCLALERAFEGYLAYGIGIWICFQTVVNVGASIGMLPTKGLTLPFISYGGSSLWVMTAAAMMLIRIDHERRLSVIQAIE
GRTNK

Sequences:

>Translated_405_residues
MASSEKQLSLFGNRLKWSLPNLFSDNSAPGMQLYDRALLFAVLSLICFGFVMVMSASMPEAQTLTGNPFHFVWRHGAYLV
GCVIIAAVVLQVEVSIWQRYSVLLLFVVGAMLVAVLFVGTTVNGATRWLSIGPIRIQVAEIAKFAFAIYMAGYLVRRHQE
IRENAKGFYKPIGVFAVYAFLILMQPDLGTVVVLFVGTVGLLFLAGARLLDFFALILTGILAFVALVLLEPYRMRRVTSF
LDPWQDPFGSGYQLTQSLMAYGRGDWFGQGLGNSIQKLEYLPEAHTDFIFAVIGEELGFIGIIAVLAVLLFVALRAIKLG
NMCLALERAFEGYLAYGIGIWICFQTVVNVGASIGMLPTKGLTLPFISYGGSSLWVMTAAAMMLIRIDHERRLSVIQAIE
GRTNK
>Mature_404_residues
ASSEKQLSLFGNRLKWSLPNLFSDNSAPGMQLYDRALLFAVLSLICFGFVMVMSASMPEAQTLTGNPFHFVWRHGAYLVG
CVIIAAVVLQVEVSIWQRYSVLLLFVVGAMLVAVLFVGTTVNGATRWLSIGPIRIQVAEIAKFAFAIYMAGYLVRRHQEI
RENAKGFYKPIGVFAVYAFLILMQPDLGTVVVLFVGTVGLLFLAGARLLDFFALILTGILAFVALVLLEPYRMRRVTSFL
DPWQDPFGSGYQLTQSLMAYGRGDWFGQGLGNSIQKLEYLPEAHTDFIFAVIGEELGFIGIIAVLAVLLFVALRAIKLGN
MCLALERAFEGYLAYGIGIWICFQTVVNVGASIGMLPTKGLTLPFISYGGSSLWVMTAAAMMLIRIDHERRLSVIQAIEG
RTNK

Specific function: This is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. Plays a role in the stabilization of the ftsZ ring during cell division [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786277, Length=374, Percent_Identity=56.951871657754, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1786853, Length=318, Percent_Identity=33.0188679245283, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR013437 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 44659; Mature: 44528

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ASSEKQLSLFGNRLKWSLPNLFSDNSAPGMQLYDRALLFAVLSLICFGFVMVMSASMPE
CCCHHHHHHHHCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC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CCCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]