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The map label for this gene is lpxC [H]

Identifier: 157963617

GI number: 157963617

Start: 4627998

End: 4628918

Strand: Reverse

Name: lpxC [H]

Synonym: Spea_3806

Alternate gene names: 157963617

Gene position: 4628918-4627998 (Counterclockwise)

Preceding gene: 157963618

Following gene: 157963615

Centisome position: 89.45

GC content: 43.76

Gene sequence:

>921_bases
ATGATTTTTCAAAGAACTGTCAAAGAAATGGTTAAGACTACTGGTGTTGGATTGCATTCCGGCAACAAGGTGACTTTGAT
CATTAAGCCCGCACCAGTTAATACCGGCATTAAGCTAGTTCGTACCGACTTGTCACCAGCAGTGGAAATTCCAGCTGTTG
CCGATCAAGTGCGTGAAACGACTATGTGTACAGCCTTGGTTAATGACGATGGTGTTCGTATATCAACAATTGAGCATCTA
TTCGCTGCGCTAGCCGGATTAGGTATCGATAACGCAGTTATCGAAGTTGACGCGCCTGAAATTCCAATTATGGATGGCAG
TGCGAGTCCTTTTGTTTTCCTATTGCAATCAGTAGGCATCCAAGAGCAAAACGCAGCTAAGAAATATATTAAAATCACTA
AACCAATTCGTGTTGAAGATGGTGATAAATGGGCAGAGTTGAAACCCTTTAAAGGTTTCAGAGTCGATTTCGCTATTGAC
TTTAATCACCCTGAAATTGCTCGTAGTCAGCAGCATATGGTGATGGATTTCTCATCGTCTGCTTTTATTAAAGATATCAG
CCGCGCTAGAACCTTTGGTTTTATGCGAGATATCGAATATTTAAGAGCCAATAATCTTGCACTAGGCGGCAGCATGGAAA
ATGCTGTTGTACTTGACGAATATCGCGTCCTCAACCCCGATGGCCTGCGTTATGAGGACGAGTTTGTTAAGCACAAGATT
CTTGATGCCTTTGGTGATCTGTATGTGGCGGGTCACGCGATTGTTGGTGAGTTCTGTGCATATAAAACAGGACATGCACT
TAACAACCAGTTAGTGCGTGCCATGCTTGCACAACAAGATGCTTGGGAAATCGTGAGCTTTGAAAAAGAAGCCGACGCAC
CTGTCAGCTTCTCAGTACCAGCCGGTGCTGTATTCGCTTAA

Upstream 100 bases:

>100_bases
TTTGCAAAGATATGCTAAGATATCCGACCAGCATAGCCTACGCACGACTAAAAAGTGTGTGGTTAGTGCTTTTTTGTTGA
GATAATAAACGGGTAAAAAC

Downstream 100 bases:

>100_bases
CAGCGAATTAAGATTGCCTTGAACGGCTGGCTAATGCAGCCAGCCGTTTTAGTTTTACCGCTAATGTCCCCTCAGTATGT
TCAGCTAAAGCTTCAATGTG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIFQRTVKEMVKTTGVGLHSGNKVTLIIKPAPVNTGIKLVRTDLSPAVEIPAVADQVRETTMCTALVNDDGVRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSVGIQEQNAAKKYIKITKPIRVEDGDKWAELKPFKGFRVDFAID
FNHPEIARSQQHMVMDFSSSAFIKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAIVGEFCAYKTGHALNNQLVRAMLAQQDAWEIVSFEKEADAPVSFSVPAGAVFA

Sequences:

>Translated_306_residues
MIFQRTVKEMVKTTGVGLHSGNKVTLIIKPAPVNTGIKLVRTDLSPAVEIPAVADQVRETTMCTALVNDDGVRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSVGIQEQNAAKKYIKITKPIRVEDGDKWAELKPFKGFRVDFAID
FNHPEIARSQQHMVMDFSSSAFIKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAIVGEFCAYKTGHALNNQLVRAMLAQQDAWEIVSFEKEADAPVSFSVPAGAVFA
>Mature_306_residues
MIFQRTVKEMVKTTGVGLHSGNKVTLIIKPAPVNTGIKLVRTDLSPAVEIPAVADQVRETTMCTALVNDDGVRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSVGIQEQNAAKKYIKITKPIRVEDGDKWAELKPFKGFRVDFAID
FNHPEIARSQQHMVMDFSSSAFIKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAIVGEFCAYKTGHALNNQLVRAMLAQQDAWEIVSFEKEADAPVSFSVPAGAVFA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=62.828947368421, Blast_Score=420, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 33660; Mature: 33660

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFQRTVKEMVKTTGVGLHSGNKVTLIIKPAPVNTGIKLVRTDLSPAVEIPAVADQVRET
CCHHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCCEEEEECCCCCEECCHHHHHHHHH
TMCTALVNDDGVRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSVGI
HHEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCHHHHHHHHCCC
QEQNAAKKYIKITKPIRVEDGDKWAELKPFKGFRVDFAIDFNHPEIARSQQHMVMDFSSS
CCHHHHHHHEEECCCEEECCCCCCCCCCCCCCEEEEEEEECCCCHHHCCCCEEEEECCCC
AFIKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCHHHHHHHHH
LDAFGDLYVAGHAIVGEFCAYKTGHALNNQLVRAMLAQQDAWEIVSFEKEADAPVSFSVP
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHEEECCCCCCCEEEECC
AGAVFA
CCCCCC
>Mature Secondary Structure
MIFQRTVKEMVKTTGVGLHSGNKVTLIIKPAPVNTGIKLVRTDLSPAVEIPAVADQVRET
CCHHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCCEEEEECCCCCEECCHHHHHHHHH
TMCTALVNDDGVRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSVGI
HHEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCHHHHHHHHCCC
QEQNAAKKYIKITKPIRVEDGDKWAELKPFKGFRVDFAIDFNHPEIARSQQHMVMDFSSS
CCHHHHHHHEEECCCEEECCCCCCCCCCCCCCEEEEEEEECCCCHHHCCCCEEEEECCCC
AFIKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCHHHHHHHHH
LDAFGDLYVAGHAIVGEFCAYKTGHALNNQLVRAMLAQQDAWEIVSFEKEADAPVSFSVP
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHEEECCCCCCCEEEECC
AGAVFA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA