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The map label for this gene is ubiB [H]

Identifier: 157963606

GI number: 157963606

Start: 4608548

End: 4610197

Strand: Direct

Name: ubiB [H]

Synonym: Spea_3794

Alternate gene names: 157963606

Gene position: 4608548-4610197 (Clockwise)

Preceding gene: 157963605

Following gene: 157963607

Centisome position: 89.06

GC content: 46.0

Gene sequence:

>1650_bases
ATGACAGTAAAAAGTATCAGGCGCGCTTATCACGTTATTCGTACTGCATTGCATTACGGACTGGATGATTTACTTCCCCC
TAAGTTAACGCCTTGGTACTTCAAACTCTTAAGGTACTGCTTCTTTTGGCTACGAAATCAACACAAAGATAAAGTCGGTG
GTGAGCGGTTAAAGCTTGCGATGCAAGAGCTTGGGCCTGTCTACATCAAGTTTGGACAGATGCTGTCGACTCGTCGTGAC
CTGTTATCTGATGAGTGGGCCGAAGAACTTGCCATGTTGCAAGATAGGGTGCCACCGTTTGACTCAGCAATTGCAAGGGA
ATCTATCGAGAAGGAACTCAATGCTCCAATCGAACGCTACTTTAACGACTTTGACGACACCCCGCTGGCTTCGGCCTCTA
TCTCTCAAGTTCATACTGCCACGCTGAAATCTAATGGCGCAGCTGTCGTCCTCAAAGTATTACGCCCAGATGTTGAGAAG
AAGGTTCATGCAGATTTACTGCTGATGTCACAAGCTGCCGATTTTCTAGAGAGGCTGCTAGGTGCAAATAATCGCTTACG
TCCTGCTGAAGTGGTTGAAGACTACCGTACGACCATAGAGGGCGAGCTCAACCTCAAACTCGAAGCGCTCAATGCCATAA
AGTTACGCAATAACTTTATCGACTCCAATGCACTCTACATCCCCTATATGTATGAAGAGTTATGCTTCACGCGACTAATT
GTTATGGAGCGTATCGACGGCATTCCAGTATCAGATAAAGTAGCACTAGAAGCCCAAGGCACTAACTTAAAGCTGCTTGC
TGAGCGTGGTGTAGAGCTGTTCTTCACTCAAGTATTCCGTGATAACTTTTTCCACGCAGACATGCACCCAGGCAATGTAT
TCGTCAGTAGAGAGCATCCTAACGACCCTTTCTATATCGGTTTAGATTGCGGCATCATGGGTACGCTTACCGATGAGGAT
AAACGCTACTTGGCCGAGAATTTCTTAGCCTTCTTCAATCGCGACTATCGCCGCATTGCTCAGCTTTATATTGAGTCGGG
CTGGGTCTCAGCCGATACCGATGTGGGTGCCTTCGAACAAGCGGTAAAAGTGGTTTGTGAGCCGATGTTTAACAAACCAC
TAGATGAGATATCATTTGGCCATGTGCTGCTTGAGCTATTTAGAACCGCACGTCGCTTCGACATGGTGGTGCAACCACAG
CTGGTTTTACTCGAAAAAACCCTACTGTATATCGAAGGGCTTGGGCGTCAACTGTATCCGCAACTGGATTTATGGCAAAC
GGCTAAACCTTTCTTAGAGCAGTGGATGGCCGAGCAGGTTGGTCCTAAAGCCATGGCAGCAAAAGTTAAGCAGCAGTTAC
CTTATTGGGCCGAACACTTGCCTGAACTGCCAGAACTTATCTATGACAACTTGAAAATAGGTCGCGACCTATCTAAAAAT
CAAAACAAATTGTTAGATCGGTATCTCAAACATCAGCAAAAAGCTCATAAAAGTAACTATCTGTTGATTACATCGGCCAT
TTTAGTGATCTGTGGCACTATTTTGTTAAACCAAGACGCTACACTATGGCCCTCTTATGGCAGTATTGGCATAGGCATCA
CTCTGTGGGTGCTGGGATGGCGATCGAGACCAAAGAATCGCAAAATTTAG

Upstream 100 bases:

>100_bases
AATATATCTATTTAAGTGATAGAATCGATGACTTAGCCGCCGATGTCGAGGCGACAGCTACACGGATTGACCAGCTTATC
AACAGGGTAAAAACACAACC

Downstream 100 bases:

>100_bases
CTAGACCTAAATAACCAAAGGTTCATAATAGAACCAGTATCTAATCAAGAGGATTCATCCATGGGTGGCATTAGTATTTG
GCAACTTCTTATCATTGCTT

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MTVKSIRRAYHVIRTALHYGLDDLLPPKLTPWYFKLLRYCFFWLRNQHKDKVGGERLKLAMQELGPVYIKFGQMLSTRRD
LLSDEWAEELAMLQDRVPPFDSAIARESIEKELNAPIERYFNDFDDTPLASASISQVHTATLKSNGAAVVLKVLRPDVEK
KVHADLLLMSQAADFLERLLGANNRLRPAEVVEDYRTTIEGELNLKLEALNAIKLRNNFIDSNALYIPYMYEELCFTRLI
VMERIDGIPVSDKVALEAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNVFVSREHPNDPFYIGLDCGIMGTLTDED
KRYLAENFLAFFNRDYRRIAQLYIESGWVSADTDVGAFEQAVKVVCEPMFNKPLDEISFGHVLLELFRTARRFDMVVQPQ
LVLLEKTLLYIEGLGRQLYPQLDLWQTAKPFLEQWMAEQVGPKAMAAKVKQQLPYWAEHLPELPELIYDNLKIGRDLSKN
QNKLLDRYLKHQQKAHKSNYLLITSAILVICGTILLNQDATLWPSYGSIGIGITLWVLGWRSRPKNRKI

Sequences:

>Translated_549_residues
MTVKSIRRAYHVIRTALHYGLDDLLPPKLTPWYFKLLRYCFFWLRNQHKDKVGGERLKLAMQELGPVYIKFGQMLSTRRD
LLSDEWAEELAMLQDRVPPFDSAIARESIEKELNAPIERYFNDFDDTPLASASISQVHTATLKSNGAAVVLKVLRPDVEK
KVHADLLLMSQAADFLERLLGANNRLRPAEVVEDYRTTIEGELNLKLEALNAIKLRNNFIDSNALYIPYMYEELCFTRLI
VMERIDGIPVSDKVALEAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNVFVSREHPNDPFYIGLDCGIMGTLTDED
KRYLAENFLAFFNRDYRRIAQLYIESGWVSADTDVGAFEQAVKVVCEPMFNKPLDEISFGHVLLELFRTARRFDMVVQPQ
LVLLEKTLLYIEGLGRQLYPQLDLWQTAKPFLEQWMAEQVGPKAMAAKVKQQLPYWAEHLPELPELIYDNLKIGRDLSKN
QNKLLDRYLKHQQKAHKSNYLLITSAILVICGTILLNQDATLWPSYGSIGIGITLWVLGWRSRPKNRKI
>Mature_548_residues
TVKSIRRAYHVIRTALHYGLDDLLPPKLTPWYFKLLRYCFFWLRNQHKDKVGGERLKLAMQELGPVYIKFGQMLSTRRDL
LSDEWAEELAMLQDRVPPFDSAIARESIEKELNAPIERYFNDFDDTPLASASISQVHTATLKSNGAAVVLKVLRPDVEKK
VHADLLLMSQAADFLERLLGANNRLRPAEVVEDYRTTIEGELNLKLEALNAIKLRNNFIDSNALYIPYMYEELCFTRLIV
MERIDGIPVSDKVALEAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNVFVSREHPNDPFYIGLDCGIMGTLTDEDK
RYLAENFLAFFNRDYRRIAQLYIESGWVSADTDVGAFEQAVKVVCEPMFNKPLDEISFGHVLLELFRTARRFDMVVQPQL
VLLEKTLLYIEGLGRQLYPQLDLWQTAKPFLEQWMAEQVGPKAMAAKVKQQLPYWAEHLPELPELIYDNLKIGRDLSKNQ
NKLLDRYLKHQQKAHKSNYLLITSAILVICGTILLNQDATLWPSYGSIGIGITLWVLGWRSRPKNRKI

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=281, Percent_Identity=29.5373665480427, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI41393593, Length=271, Percent_Identity=26.9372693726937, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI32261307, Length=320, Percent_Identity=26.25, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI217035081, Length=236, Percent_Identity=29.6610169491525, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI2367309, Length=545, Percent_Identity=57.7981651376147, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=284, Percent_Identity=27.112676056338, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI32565180, Length=279, Percent_Identity=25.8064516129032, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6325148, Length=440, Percent_Identity=25, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6323282, Length=249, Percent_Identity=28.5140562248996, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=200, Percent_Identity=28, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24662575, Length=251, Percent_Identity=31.0756972111554, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI22024280, Length=291, Percent_Identity=28.5223367697594, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63329; Mature: 63198

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKSIRRAYHVIRTALHYGLDDLLPPKLTPWYFKLLRYCFFWLRNQHKDKVGGERLKLA
CCHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MQELGPVYIKFGQMLSTRRDLLSDEWAEELAMLQDRVPPFDSAIARESIEKELNAPIERY
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHH
FNDFDDTPLASASISQVHTATLKSNGAAVVLKVLRPDVEKKVHADLLLMSQAADFLERLL
HCCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GANNRLRPAEVVEDYRTTIEGELNLKLEALNAIKLRNNFIDSNALYIPYMYEELCFTRLI
CCCCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHH
VMERIDGIPVSDKVALEAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNVFVSREHP
HHHHCCCCCCCCCEEEEECCCCEEEHHHCCHHHHHHHHHHCCCEECCCCCCCEEEECCCC
NDPFYIGLDCGIMGTLTDEDKRYLAENFLAFFNRDYRRIAQLYIESGWVSADTDVGAFEQ
CCCEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
AVKVVCEPMFNKPLDEISFGHVLLELFRTARRFDMVVQPQLVLLEKTLLYIEGLGRQLYP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHCCHHHCC
QLDLWQTAKPFLEQWMAEQVGPKAMAAKVKQQLPYWAEHLPELPELIYDNLKIGRDLSKN
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCCCCC
QNKLLDRYLKHQQKAHKSNYLLITSAILVICGTILLNQDATLWPSYGSIGIGITLWVLGW
HHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEEC
RSRPKNRKI
CCCCCCCCC
>Mature Secondary Structure 
TVKSIRRAYHVIRTALHYGLDDLLPPKLTPWYFKLLRYCFFWLRNQHKDKVGGERLKLA
CHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MQELGPVYIKFGQMLSTRRDLLSDEWAEELAMLQDRVPPFDSAIARESIEKELNAPIERY
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHH
FNDFDDTPLASASISQVHTATLKSNGAAVVLKVLRPDVEKKVHADLLLMSQAADFLERLL
HCCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GANNRLRPAEVVEDYRTTIEGELNLKLEALNAIKLRNNFIDSNALYIPYMYEELCFTRLI
CCCCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHH
VMERIDGIPVSDKVALEAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNVFVSREHP
HHHHCCCCCCCCCEEEEECCCCEEEHHHCCHHHHHHHHHHCCCEECCCCCCCEEEECCCC
NDPFYIGLDCGIMGTLTDEDKRYLAENFLAFFNRDYRRIAQLYIESGWVSADTDVGAFEQ
CCCEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
AVKVVCEPMFNKPLDEISFGHVLLELFRTARRFDMVVQPQLVLLEKTLLYIEGLGRQLYP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHCCHHHCC
QLDLWQTAKPFLEQWMAEQVGPKAMAAKVKQQLPYWAEHLPELPELIYDNLKIGRDLSKN
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCCCCC
QNKLLDRYLKHQQKAHKSNYLLITSAILVICGTILLNQDATLWPSYGSIGIGITLWVLGW
HHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEEC
RSRPKNRKI
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA