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The map label for this gene is ubiE [H]

Identifier: 157963604

GI number: 157963604

Start: 4607161

End: 4607916

Strand: Direct

Name: ubiE [H]

Synonym: Spea_3792

Alternate gene names: 157963604

Gene position: 4607161-4607916 (Clockwise)

Preceding gene: 157963603

Following gene: 157963605

Centisome position: 89.03

GC content: 41.53

Gene sequence:

>756_bases
ATGTCAGACGACTCTTCAAACAGCACTCACTTCGGTTATAAAACTGTCGAAGCTGAAAAGAAAGCCGACATGGTTGCTGG
CGTATTTCATTCTGTCGCAGCAAAATACGACATTATGAATGACGTTATGTCTTTCGGTATCCACCGCATGTGGAAACGCT
TCACTATCGAAAGTGCAGGTGCACGTCCAGGCATGAAAGTATTAGATCTTGCAGGTGGTACTGGTGATTTAACCGCGAAG
TTTTCTCGTATCGTCGGTGAAACAGGCCAAGTAACCCTAGCCGATATTAACGACTCTATGCTTAAAGTTGGTCGTGAAAA
GCTACGTGACAAAGGTATTGTTGGTAACGTTAACTACGTCCAAGCTAATGCCGAAGCCTTGCCTTTCCCTGATAATCATT
TTGATATTATCACCATCGCTTTTGGTCTACGAAATGTGACCAACAAAGATGCTGCAATCGCTTCTATGTTGCGCGTACTT
AAGCCTGGTGGAAAGCTATTAGTACTTGAGTTTTCAAAGCCTCAGCATGAGATTATGCGTAAAATCTATGACATCTATAG
CTTTAAAGTACTACCAAAAATGGGTTCTTTAATCACTAAAGATGCAGACAGCTATGAATACCTTGCTGAGTCAATTCGTA
TGCACCCAGATCAAGATACCTTAAAGCAGATGATGGAAGATGCAGGCTTTGAACAAGTCAATTATACCAATATGACTGAC
GGTATCGTTGCCTTACACAAGGGTTATAAATTCTGA

Upstream 100 bases:

>100_bases
AGTTAACATTCGTCACAGACTGATAGATGAAAGATTCAGCAATCCGCTTCGATGGCTTACAATCGCACCAATTTAATTGC
TAATGTATAGGAACAGATAG

Downstream 100 bases:

>100_bases
TAGGGCTCACTATGTCTCGTGACTTGTCACTACTGACCTGTGCCGCGATTGAGATCAGCTTAAACAAGCTGATCTCTCAA
TCTCCTGAAGATTACGCTAA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSDDSSNSTHFGYKTVEAEKKADMVAGVFHSVAAKYDIMNDVMSFGIHRMWKRFTIESAGARPGMKVLDLAGGTGDLTAK
FSRIVGETGQVTLADINDSMLKVGREKLRDKGIVGNVNYVQANAEALPFPDNHFDIITIAFGLRNVTNKDAAIASMLRVL
KPGGKLLVLEFSKPQHEIMRKIYDIYSFKVLPKMGSLITKDADSYEYLAESIRMHPDQDTLKQMMEDAGFEQVNYTNMTD
GIVALHKGYKF

Sequences:

>Translated_251_residues
MSDDSSNSTHFGYKTVEAEKKADMVAGVFHSVAAKYDIMNDVMSFGIHRMWKRFTIESAGARPGMKVLDLAGGTGDLTAK
FSRIVGETGQVTLADINDSMLKVGREKLRDKGIVGNVNYVQANAEALPFPDNHFDIITIAFGLRNVTNKDAAIASMLRVL
KPGGKLLVLEFSKPQHEIMRKIYDIYSFKVLPKMGSLITKDADSYEYLAESIRMHPDQDTLKQMMEDAGFEQVNYTNMTD
GIVALHKGYKF
>Mature_250_residues
SDDSSNSTHFGYKTVEAEKKADMVAGVFHSVAAKYDIMNDVMSFGIHRMWKRFTIESAGARPGMKVLDLAGGTGDLTAKF
SRIVGETGQVTLADINDSMLKVGREKLRDKGIVGNVNYVQANAEALPFPDNHFDIITIAFGLRNVTNKDAAIASMLRVLK
PGGKLLVLEFSKPQHEIMRKIYDIYSFKVLPKMGSLITKDADSYEYLAESIRMHPDQDTLKQMMEDAGFEQVNYTNMTDG
IVALHKGYKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=276, Percent_Identity=44.2028985507246, Blast_Score=243, Evalue=8e-65,
Organism=Escherichia coli, GI48994983, Length=251, Percent_Identity=74.5019920318725, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17557039, Length=245, Percent_Identity=43.6734693877551, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323526, Length=257, Percent_Identity=42.8015564202335, Blast_Score=188, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24641702, Length=257, Percent_Identity=45.5252918287938, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27930; Mature: 27799

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDSSNSTHFGYKTVEAEKKADMVAGVFHSVAAKYDIMNDVMSFGIHRMWKRFTIESAG
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ARPGMKVLDLAGGTGDLTAKFSRIVGETGQVTLADINDSMLKVGREKLRDKGIVGNVNYV
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCEEE
QANAEALPFPDNHFDIITIAFGLRNVTNKDAAIASMLRVLKPGGKLLVLEFSKPQHEIMR
EECCCCCCCCCCCEEEEEEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
KIYDIYSFKVLPKMGSLITKDADSYEYLAESIRMHPDQDTLKQMMEDAGFEQVNYTNMTD
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEECCCCCCC
GIVALHKGYKF
HHHHHCCCCCC
>Mature Secondary Structure 
SDDSSNSTHFGYKTVEAEKKADMVAGVFHSVAAKYDIMNDVMSFGIHRMWKRFTIESAG
CCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ARPGMKVLDLAGGTGDLTAKFSRIVGETGQVTLADINDSMLKVGREKLRDKGIVGNVNYV
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCEEE
QANAEALPFPDNHFDIITIAFGLRNVTNKDAAIASMLRVLKPGGKLLVLEFSKPQHEIMR
EECCCCCCCCCCCEEEEEEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
KIYDIYSFKVLPKMGSLITKDADSYEYLAESIRMHPDQDTLKQMMEDAGFEQVNYTNMTD
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEECCCCCCC
GIVALHKGYKF
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA