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The map label for this gene is fhs [H]

Identifier: 157963532

GI number: 157963532

Start: 4525807

End: 4527519

Strand: Reverse

Name: fhs [H]

Synonym: Spea_3720

Alternate gene names: 157963532

Gene position: 4527519-4525807 (Counterclockwise)

Preceding gene: 157963533

Following gene: 157963530

Centisome position: 87.5

GC content: 49.74

Gene sequence:

>1713_bases
ATGCATTCAGATATTGAAATTTCGCGCCAACACACCTGTTTACCTATCACTGATATCGCTAATAATTTAGGCCTTGAGCC
TGATGAACTCTCTCTTTGTGGTGCCAATAAGGCCAAGATTTCGCTGTCGGTCGCTAAACGACTCGCAGACAGAGAAAATG
CCAAACTGGTGATTGTCACTGCGGTGACGCCAACGCCATTCGGCGAAGGAAAAACCGTAACAACTATCGGCTTAACCCAA
GCCATGAACCTCAACGGCATTAAAGCCTGCGCCTGTATTCGTCAGCCTAGTATGGGGCCTGTATTTGGCACTAAGGGCGG
CGCCGCGGGTGGCGGTTATGCGCAAGTCGTGCCGATGGAAGAGCTGAACCTACACTTGACCGGTGATATTCACGCGGTTA
GCAGTGCCCATAATTTAGCGGCAGCCGCAATCGACGCACGTCTATTCCATGAAACACGTTTAGGCGCCGAAGCTTTTACT
CAAGAATCAGGTTTAACTGCGCTTAATATCGATGCTGAAAATATCCTTTGGCGCCGAGTGGTTGACCATAACGAACGCAG
CCTAAGACAGATTAAAGTCGGCTTTGGTGCGGTTAATGGCCCTGTACATGAGTCGGGTTTCGACATCACTGCAGCGTCTG
AATTGATGGCGATTCTAGCGCTGAGCCAAGACTTAAAAGATCTTAGACAGCGTATTGGTCGCCTCGTATTGGCGCTCAAT
AATCAAGGTGAGCCGATCACAGCCGAAACGCTAGGCGTTGCAGGTGCGATGACGGTGATTATGGCCGATGCGATTGAGCC
AACCTTGATGCAGACTCTGTCTGGTGATCCATGCTTTATTCATGCTGGCCCCTTTGCCAATATAGCGCATGGTAACTCTT
CGATTATTGCCGATACCATCGCGGCTAAGCTTGCCGACGTTGTCGTGACAGAAGCGGGATTTGGCTCAGATATGGGCTTT
GAAAAGTTCAGTAACATCAAGGTGAGAGAATCGGGCTACGCTCCGAGCGCATCTGTAGTGGTAGTGACACTGAAGGCTCT
GAAAGCCAATAGTGGCATCGAATCTGACCAAGATATTAACCAGCCAGATACGCAGCGTCTAAAGGTCGGCTTTGCTAACC
TTGAATGGCATATCAACAACGTCAGCCAATATGGCGTGCCAGTTGTGGTCGCAATTAACCGTTTCCCGACCGATACCGAC
GAGGAACTTGAGTGGCTGAAGCAGGCTATTGAGCAAACTAAGGCCTTCGGCAGTGAGATAAGCGAAGCCTTTGGTAAAGG
CGCAGAAGGAGCGACTAAGCTTGCGGATATGGTTTACCGTGCGACGCAGACGCCATCTGACTTTAACTTGCTGTACGAGA
GCAATACTAGCCTTGAGTCTAAGCTGATGACGCTTGCAGAGGTGGGTTATGGCGCATCGAGCGTCACTCTATCTGATAAA
GCTAAGTCACAATTAAACTGGCTGGCTAAGCATAACTATGGCGAGCTACCTATCTGTGTCGCTAAGACGCCGATGTCGAT
AAGCCACGATCCAGATATTAAAGGGATCCCGACAGGTTTTGAACTGCCTATTACTGAGCTAAGGCTTAATGCTGGGGCAG
GCTTTGTCACGGCGCTTGTGGGCAAAGTGATGACTATGCCAGGGCTGGGGATTAAGCCTGGCTATCTCAATGTCGATATC
AACGATGATGGCGAGATTGTTGGATTAGCCTAA

Upstream 100 bases:

>100_bases
AAAGCTAAAATAACAATGCATTTGTGTTTTCTCGCTATCTGATATCACCTATATTGCAGCGGCAACTACCCTACATAAAA
ATAAAACGTGGAAAATCCGA

Downstream 100 bases:

>100_bases
AAGTATTAGCTATCGAATCTAATAAAAAGCCCCGACAACCTTAGGTTGTCGGGGCTTTTTTCATTTTATCTTTAAGAGTT
ACTTCTCTATAGCCGTTTGA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MHSDIEISRQHTCLPITDIANNLGLEPDELSLCGANKAKISLSVAKRLADRENAKLVIVTAVTPTPFGEGKTVTTIGLTQ
AMNLNGIKACACIRQPSMGPVFGTKGGAAGGGYAQVVPMEELNLHLTGDIHAVSSAHNLAAAAIDARLFHETRLGAEAFT
QESGLTALNIDAENILWRRVVDHNERSLRQIKVGFGAVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALN
NQGEPITAETLGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTIAAKLADVVVTEAGFGSDMGF
EKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDQDINQPDTQRLKVGFANLEWHINNVSQYGVPVVVAINRFPTDTD
EELEWLKQAIEQTKAFGSEISEAFGKGAEGATKLADMVYRATQTPSDFNLLYESNTSLESKLMTLAEVGYGASSVTLSDK
AKSQLNWLAKHNYGELPICVAKTPMSISHDPDIKGIPTGFELPITELRLNAGAGFVTALVGKVMTMPGLGIKPGYLNVDI
NDDGEIVGLA

Sequences:

>Translated_570_residues
MHSDIEISRQHTCLPITDIANNLGLEPDELSLCGANKAKISLSVAKRLADRENAKLVIVTAVTPTPFGEGKTVTTIGLTQ
AMNLNGIKACACIRQPSMGPVFGTKGGAAGGGYAQVVPMEELNLHLTGDIHAVSSAHNLAAAAIDARLFHETRLGAEAFT
QESGLTALNIDAENILWRRVVDHNERSLRQIKVGFGAVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALN
NQGEPITAETLGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTIAAKLADVVVTEAGFGSDMGF
EKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDQDINQPDTQRLKVGFANLEWHINNVSQYGVPVVVAINRFPTDTD
EELEWLKQAIEQTKAFGSEISEAFGKGAEGATKLADMVYRATQTPSDFNLLYESNTSLESKLMTLAEVGYGASSVTLSDK
AKSQLNWLAKHNYGELPICVAKTPMSISHDPDIKGIPTGFELPITELRLNAGAGFVTALVGKVMTMPGLGIKPGYLNVDI
NDDGEIVGLA
>Mature_570_residues
MHSDIEISRQHTCLPITDIANNLGLEPDELSLCGANKAKISLSVAKRLADRENAKLVIVTAVTPTPFGEGKTVTTIGLTQ
AMNLNGIKACACIRQPSMGPVFGTKGGAAGGGYAQVVPMEELNLHLTGDIHAVSSAHNLAAAAIDARLFHETRLGAEAFT
QESGLTALNIDAENILWRRVVDHNERSLRQIKVGFGAVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALN
NQGEPITAETLGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTIAAKLADVVVTEAGFGSDMGF
EKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDQDINQPDTQRLKVGFANLEWHINNVSQYGVPVVVAINRFPTDTD
EELEWLKQAIEQTKAFGSEISEAFGKGAEGATKLADMVYRATQTPSDFNLLYESNTSLESKLMTLAEVGYGASSVTLSDK
AKSQLNWLAKHNYGELPICVAKTPMSISHDPDIKGIPTGFELPITELRLNAGAGFVTALVGKVMTMPGLGIKPGYLNVDI
NDDGEIVGLA

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=615, Percent_Identity=46.8292682926829, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI36796743, Length=615, Percent_Identity=45.0406504065041, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI310124614, Length=81, Percent_Identity=44.4444444444444, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17568737, Length=618, Percent_Identity=46.4401294498382, Blast_Score=500, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17568739, Length=618, Percent_Identity=46.4401294498382, Blast_Score=500, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=45.44, Blast_Score=490, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6319558, Length=629, Percent_Identity=44.9920508744038, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24645718, Length=617, Percent_Identity=45.0567260940032, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=617, Percent_Identity=45.0567260940032, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=617, Percent_Identity=45.0567260940032, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=617, Percent_Identity=45.0567260940032, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60497; Mature: 60497

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSDIEISRQHTCLPITDIANNLGLEPDELSLCGANKAKISLSVAKRLADRENAKLVIVT
CCCCCEECCCCCEEEHHHHHHHCCCCCCCEEEECCCCCEEEHHHHHHHHCCCCCEEEEEE
AVTPTPFGEGKTVTTIGLTQAMNLNGIKACACIRQPSMGPVFGTKGGAAGGGYAQVVPME
EECCCCCCCCCEEEEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHH
ELNLHLTGDIHAVSSAHNLAAAAIDARLFHETRLGAEAFTQESGLTALNIDAENILWRRV
HCCEEEECCEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECCHHHHHHHHH
VDHNERSLRQIKVGFGAVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALN
HCCCHHHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEC
NQGEPITAETLGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTI
CCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCEECCCCCCHHHHHH
AAKLADVVVTEAGFGSDMGFEKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDQDIN
HHHHHHHHEECCCCCCCCCHHHHCCEEEEECCCCCCCCEEEEEEEHHHCCCCCCCCCCCC
QPDTQRLKVGFANLEWHINNVSQYGVPVVVAINRFPTDTDEELEWLKQAIEQTKAFGSEI
CCCCCEEEEEEEEEEEEECCHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
SEAFGKGAEGATKLADMVYRATQTPSDFNLLYESNTSLESKLMTLAEVGYGASSVTLSDK
HHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECHH
AKSQLNWLAKHNYGELPICVAKTPMSISHDPDIKGIPTGFELPITELRLNAGAGFVTALV
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCHHHHHHH
GKVMTMPGLGIKPGYLNVDINDDGEIVGLA
HHHHHCCCCCCCCCEEEEEECCCCCEEEEC
>Mature Secondary Structure
MHSDIEISRQHTCLPITDIANNLGLEPDELSLCGANKAKISLSVAKRLADRENAKLVIVT
CCCCCEECCCCCEEEHHHHHHHCCCCCCCEEEECCCCCEEEHHHHHHHHCCCCCEEEEEE
AVTPTPFGEGKTVTTIGLTQAMNLNGIKACACIRQPSMGPVFGTKGGAAGGGYAQVVPME
EECCCCCCCCCEEEEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHH
ELNLHLTGDIHAVSSAHNLAAAAIDARLFHETRLGAEAFTQESGLTALNIDAENILWRRV
HCCEEEECCEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECCHHHHHHHHH
VDHNERSLRQIKVGFGAVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALN
HCCCHHHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEC
NQGEPITAETLGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTI
CCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCEECCCCCCHHHHHH
AAKLADVVVTEAGFGSDMGFEKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDQDIN
HHHHHHHHEECCCCCCCCCHHHHCCEEEEECCCCCCCCEEEEEEEHHHCCCCCCCCCCCC
QPDTQRLKVGFANLEWHINNVSQYGVPVVVAINRFPTDTDEELEWLKQAIEQTKAFGSEI
CCCCCEEEEEEEEEEEEECCHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
SEAFGKGAEGATKLADMVYRATQTPSDFNLLYESNTSLESKLMTLAEVGYGASSVTLSDK
HHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECHH
AKSQLNWLAKHNYGELPICVAKTPMSISHDPDIKGIPTGFELPITELRLNAGAGFVTALV
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCHHHHHHH
GKVMTMPGLGIKPGYLNVDINDDGEIVGLA
HHHHHCCCCCCCCCEEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA