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The map label for this gene is rnr [H]

Identifier: 157963404

GI number: 157963404

Start: 4382163

End: 4384622

Strand: Reverse

Name: rnr [H]

Synonym: Spea_3590

Alternate gene names: 157963404

Gene position: 4384622-4382163 (Counterclockwise)

Preceding gene: 157963405

Following gene: 157963403

Centisome position: 84.73

GC content: 47.72

Gene sequence:

>2460_bases
ATGATACAAGATCCGCATATTAAGCGTGAGCAAGAAAAATACGAAAACCCAATTCCAAGTCGTGAGTACATTTTAGATTA
CTTGCGCTCACAAACGTCACCATTAACTCGTGAACATATTGCTACAGCCCTAAAAATTGAAGGCGAAGAGCAGCTAGAAG
CAATTCGTCGTCGCCTGCGTGCGATGGAGCGTGACGGTGAACTAGTGTTTACCCGTGGTCAGTCATATGGCTTGCCTGAG
AGAATGGACCTGTTAACCGGTACCGTGATTGGTCACCGTGATGGCTTTGGTTTCTTGAAATTAGAAGAGGGCGGCGACGA
CCTTTATATCAATAACCGTGACATGTTGATGTATTTCCACGGTGACAGAGTCCTTGCGCAAAAAGCGGGTGTAGACCGTA
AGGGTCGCCGTGAAGCGCGTATTGTACGTTTGGTTGAAGAGCGTAGCGCCGCATTAGTGGGCCGTTTTCACCTAGACGCT
GGCATGGGTTTTGTGATTGCCGATGACCGCCGCATCACCCAAGAGATTTTAGTTCCCGAAGAAGATCGCAAGGGCGCGCG
TCAAGGCGATATCGTGGTACTTGAGCTAACACGCCGTCCAGGTCGTTACGTCAAAGCCGCTGGTAAAGTGACTGAAGTGC
TAGGTAAAGAGATGGCACCGGGCATGGAGATTGAGATTGCGCTGCGCAATTACGATCTGCCGCACACATGGTCAGGCCTG
ATTGAGAAGAAGCTGCGTAAAATCCCTGACGAAGTTACCGAAGCTGACAAAGAAGGTCGCGTTGACTTACGTAATTTGCC
ATTAGTGACTATCGATGGTGAAGATGCACGAGATTTTGATGATGCAGTTTACGCCGAGAAGAAAAAGTCTGGCGGCTGGC
GCTTATGGGTAGCCATTGCGGACGTGAGTCATTACGTACGCACAGAATCTGCACTCGATAAAGAAGCGCGCGCTCGTGGT
AACTCGGTGTATTTCCCATCGCAAGTTATCCCTATGCTGCCTGAGAAGATCTCTAATGGTCTGTGCTCTTTAATGCCTAA
GGTCGATCGTCTATGCATGGTTGCAGAGATGACCATCTCTGCAGTAGGAAAATTGTCGGGTTATAAGTTCTACCCTGCAG
TAATGCACTCGCATGCGCGTTTAACTTATACCCAAGTGGCTGACATGCTTGAGGGCGGAGAGGTGAGTGATGAGCTTAAG
CCTATATTCCCGCACCTACAGACATTGCAATCGCTATATCTGACATTAGAAGAGACCCGCGCAGAGCGTGGTGCAATTGC
ATTTGAAACTACTGAAACGCAATTTATCTTCAATGAGCAGCGTAAGATCGACAAGATTGTGCCGCGTAACCGTAACCAGG
CACACAAGATCATCGAAGAGTGTATGATTTTGGCTAACGTTGCGTCTGCTAAATTTGTTAAAAAGCACAAAGGTGAAGTG
TTATACCGTGTGCATGAGGCGCCTTCAGAGCAAAAGCTAACCAACTTTAAGGATTTCCTTAAAGAGCGTGGCTTAACGAT
GGAAGGTGGCTTAGAGCCAGAGCCTAAAGATTACCAAGCGGTGATGGAGCAAATTGCTGACAGAGCCGATGCAGAGCTTA
TTCAGGTAATGTTGCTACGCTCTATGCGTCAAGCAACCTATACCCCAGATAATGAAGGTCACTTTGGTTTGGCACTTGAG
GAGTATTCTCACTTTACCTCGCCAATTCGTCGTTATCCAGATTTGATCTTGCACCGCGTGATCCGTTATTTACTTGCTAA
GCAAGAAGGTAACTTAACTGATCAATGGACTGCAGATGGCGGTTTTAATTATAAGATTGAAGAGTTGGATCTGTTAGGTG
AAGAGTGTTCGACTACCGAGCGTCGCGCCGATGAAGCAACTCGAGATGTGAGTGACTGGCTTAAGTGTGAGTTTATGCAA
GATCATGTCGGTGACACTTTCGAAGCTGTGATCGCTTCGGTGACACATTTTGGCATGTTTGTTCGCCTAAACGATCTGTT
TATCGATGGTCTCGTGCATATCTCAAGCCTAGGTAGTGATTATTATCAGTATGATAATATGCGCCAGCGTTTAGTGGGGG
AAGCCTCGGGACAGGTTTATCAGATTGGTGATACGGTTACGGTCAAAGTTGCTGGGGTTAATCTTGATGACCGTCAGATT
GACTTGATGATGGAAGGCGACTCTGCAGGCGGTAAACGTCGTAGGCCAACCAAACCATTAACCGCGCGTGAGCGAGTGAA
CCGTGAAGGTGCAAAGCTTGGTGCTAAGCGTGAGTCTTCTAGAGGCAAAGGCGCAGAGGGTGACTCTGAGGCTAAGTCAG
GGGCAAAGCGTAAGTCGAGCGGCGGTAAATATAAGAGCGGCAGCAGCGCTGCAGCTAAAAAGACTAAGACAAAAGCTTCG
GCAAAAAAATCTTCAGCGAGTAAAGCTAAGTCAGCCAAGCGTAAAGCGAGTAAGAAATAG

Upstream 100 bases:

>100_bases
AATGCCGCCCAGCGCAGTTGCTAGGGCAAAGAAAGAGCACCTTAGAACGCAACAATAAGCATGCCCTAGAAAGAGGTCAT
GTCAATAATTTGGAAAATGA

Downstream 100 bases:

>100_bases
ATGAAAAAGCAAGATATGACCTTTGGATTGCATGCTGTTGAAGCAGTACTAAAAAACAGCCCTGAGCGTGTAATTGAAAT
GTGGGTACTACAAGGTCGTG

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R [H]

Number of amino acids: Translated: 819; Mature: 819

Protein sequence:

>819_residues
MIQDPHIKREQEKYENPIPSREYILDYLRSQTSPLTREHIATALKIEGEEQLEAIRRRLRAMERDGELVFTRGQSYGLPE
RMDLLTGTVIGHRDGFGFLKLEEGGDDLYINNRDMLMYFHGDRVLAQKAGVDRKGRREARIVRLVEERSAALVGRFHLDA
GMGFVIADDRRITQEILVPEEDRKGARQGDIVVLELTRRPGRYVKAAGKVTEVLGKEMAPGMEIEIALRNYDLPHTWSGL
IEKKLRKIPDEVTEADKEGRVDLRNLPLVTIDGEDARDFDDAVYAEKKKSGGWRLWVAIADVSHYVRTESALDKEARARG
NSVYFPSQVIPMLPEKISNGLCSLMPKVDRLCMVAEMTISAVGKLSGYKFYPAVMHSHARLTYTQVADMLEGGEVSDELK
PIFPHLQTLQSLYLTLEETRAERGAIAFETTETQFIFNEQRKIDKIVPRNRNQAHKIIEECMILANVASAKFVKKHKGEV
LYRVHEAPSEQKLTNFKDFLKERGLTMEGGLEPEPKDYQAVMEQIADRADAELIQVMLLRSMRQATYTPDNEGHFGLALE
EYSHFTSPIRRYPDLILHRVIRYLLAKQEGNLTDQWTADGGFNYKIEELDLLGEECSTTERRADEATRDVSDWLKCEFMQ
DHVGDTFEAVIASVTHFGMFVRLNDLFIDGLVHISSLGSDYYQYDNMRQRLVGEASGQVYQIGDTVTVKVAGVNLDDRQI
DLMMEGDSAGGKRRRPTKPLTARERVNREGAKLGAKRESSRGKGAEGDSEAKSGAKRKSSGGKYKSGSSAAAKKTKTKAS
AKKSSASKAKSAKRKASKK

Sequences:

>Translated_819_residues
MIQDPHIKREQEKYENPIPSREYILDYLRSQTSPLTREHIATALKIEGEEQLEAIRRRLRAMERDGELVFTRGQSYGLPE
RMDLLTGTVIGHRDGFGFLKLEEGGDDLYINNRDMLMYFHGDRVLAQKAGVDRKGRREARIVRLVEERSAALVGRFHLDA
GMGFVIADDRRITQEILVPEEDRKGARQGDIVVLELTRRPGRYVKAAGKVTEVLGKEMAPGMEIEIALRNYDLPHTWSGL
IEKKLRKIPDEVTEADKEGRVDLRNLPLVTIDGEDARDFDDAVYAEKKKSGGWRLWVAIADVSHYVRTESALDKEARARG
NSVYFPSQVIPMLPEKISNGLCSLMPKVDRLCMVAEMTISAVGKLSGYKFYPAVMHSHARLTYTQVADMLEGGEVSDELK
PIFPHLQTLQSLYLTLEETRAERGAIAFETTETQFIFNEQRKIDKIVPRNRNQAHKIIEECMILANVASAKFVKKHKGEV
LYRVHEAPSEQKLTNFKDFLKERGLTMEGGLEPEPKDYQAVMEQIADRADAELIQVMLLRSMRQATYTPDNEGHFGLALE
EYSHFTSPIRRYPDLILHRVIRYLLAKQEGNLTDQWTADGGFNYKIEELDLLGEECSTTERRADEATRDVSDWLKCEFMQ
DHVGDTFEAVIASVTHFGMFVRLNDLFIDGLVHISSLGSDYYQYDNMRQRLVGEASGQVYQIGDTVTVKVAGVNLDDRQI
DLMMEGDSAGGKRRRPTKPLTARERVNREGAKLGAKRESSRGKGAEGDSEAKSGAKRKSSGGKYKSGSSAAAKKTKTKAS
AKKSSASKAKSAKRKASKK
>Mature_819_residues
MIQDPHIKREQEKYENPIPSREYILDYLRSQTSPLTREHIATALKIEGEEQLEAIRRRLRAMERDGELVFTRGQSYGLPE
RMDLLTGTVIGHRDGFGFLKLEEGGDDLYINNRDMLMYFHGDRVLAQKAGVDRKGRREARIVRLVEERSAALVGRFHLDA
GMGFVIADDRRITQEILVPEEDRKGARQGDIVVLELTRRPGRYVKAAGKVTEVLGKEMAPGMEIEIALRNYDLPHTWSGL
IEKKLRKIPDEVTEADKEGRVDLRNLPLVTIDGEDARDFDDAVYAEKKKSGGWRLWVAIADVSHYVRTESALDKEARARG
NSVYFPSQVIPMLPEKISNGLCSLMPKVDRLCMVAEMTISAVGKLSGYKFYPAVMHSHARLTYTQVADMLEGGEVSDELK
PIFPHLQTLQSLYLTLEETRAERGAIAFETTETQFIFNEQRKIDKIVPRNRNQAHKIIEECMILANVASAKFVKKHKGEV
LYRVHEAPSEQKLTNFKDFLKERGLTMEGGLEPEPKDYQAVMEQIADRADAELIQVMLLRSMRQATYTPDNEGHFGLALE
EYSHFTSPIRRYPDLILHRVIRYLLAKQEGNLTDQWTADGGFNYKIEELDLLGEECSTTERRADEATRDVSDWLKCEFMQ
DHVGDTFEAVIASVTHFGMFVRLNDLFIDGLVHISSLGSDYYQYDNMRQRLVGEASGQVYQIGDTVTVKVAGVNLDDRQI
DLMMEGDSAGGKRRRPTKPLTARERVNREGAKLGAKRESSRGKGAEGDSEAKSGAKRKSSGGKYKSGSSAAAKKTKTKAS
AKKSSASKAKSAKRKASKK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=401, Percent_Identity=32.1695760598504, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI190014623, Length=401, Percent_Identity=32.1695760598504, Blast_Score=182, Evalue=2e-45,
Organism=Homo sapiens, GI134288890, Length=415, Percent_Identity=28.6746987951807, Blast_Score=151, Evalue=3e-36,
Organism=Homo sapiens, GI19115966, Length=561, Percent_Identity=24.4206773618538, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI219521928, Length=561, Percent_Identity=24.4206773618538, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI156105693, Length=308, Percent_Identity=26.2987012987013, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI156105695, Length=308, Percent_Identity=26.2987012987013, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI87082383, Length=725, Percent_Identity=59.7241379310345, Blast_Score=930, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=650, Percent_Identity=29.3846153846154, Blast_Score=188, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17553506, Length=510, Percent_Identity=28.6274509803922, Blast_Score=164, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI212645896, Length=401, Percent_Identity=29.925187032419, Blast_Score=163, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324552, Length=438, Percent_Identity=28.0821917808219, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320499, Length=510, Percent_Identity=20.7843137254902, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24649634, Length=444, Percent_Identity=29.5045045045045, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19922976, Length=363, Percent_Identity=27.8236914600551, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24654597, Length=363, Percent_Identity=27.8236914600551, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24654592, Length=363, Percent_Identity=27.8236914600551, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 92433; Mature: 92433

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II ; PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQDPHIKREQEKYENPIPSREYILDYLRSQTSPLTREHIATALKIEGEEQLEAIRRRLR
CCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHEECCHHHHHHHHHHHH
AMERDGELVFTRGQSYGLPERMDLLTGTVIGHRDGFGFLKLEEGGDDLYINNRDMLMYFH
HHCCCCCEEEECCCCCCCCHHHHHHHHHEEECCCCCEEEEEECCCCEEEECCCCEEEEEE
GDRVLAQKAGVDRKGRREARIVRLVEERSAALVGRFHLDAGMGFVIADDRRITQEILVPE
CCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCEEEEECCCHHHHHHCCCC
EDRKGARQGDIVVLELTRRPGRYVKAAGKVTEVLGKEMAPGMEIEIALRNYDLPHTWSGL
HHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHH
IEKKLRKIPDEVTEADKEGRVDLRNLPLVTIDGEDARDFDDAVYAEKKKSGGWRLWVAIA
HHHHHHHCCHHHHCCCCCCCCEECCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEE
DVSHYVRTESALDKEARARGNSVYFPSQVIPMLPEKISNGLCSLMPKVDRLCMVAEMTIS
HHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHH
AVGKLSGYKFYPAVMHSHARLTYTQVADMLEGGEVSDELKPIFPHLQTLQSLYLTLEETR
HHHHCCCCEECHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AERGAIAFETTETQFIFNEQRKIDKIVPRNRNQAHKIIEECMILANVASAKFVKKHKGEV
HHCCCEEEECCCCEEEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LYRVHEAPSEQKLTNFKDFLKERGLTMEGGLEPEPKDYQAVMEQIADRADAELIQVMLLR
EEEECCCCCHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SMRQATYTPDNEGHFGLALEEYSHFTSPIRRYPDLILHRVIRYLLAKQEGNLTDQWTADG
HHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCC
GFNYKIEELDLLGEECSTTERRADEATRDVSDWLKCEFMQDHVGDTFEAVIASVTHFGMF
CCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VRLNDLFIDGLVHISSLGSDYYQYDNMRQRLVGEASGQVYQIGDTVTVKVAGVNLDDRQI
EEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCEEEEEEEECCCCCCEE
DLMMEGDSAGGKRRRPTKPLTARERVNREGAKLGAKRESSRGKGAEGDSEAKSGAKRKSS
EEEEECCCCCCCCCCCCCCCHHHHHHCHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCC
GGKYKSGSSAAAKKTKTKASAKKSSASKAKSAKRKASKK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIQDPHIKREQEKYENPIPSREYILDYLRSQTSPLTREHIATALKIEGEEQLEAIRRRLR
CCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHEECCHHHHHHHHHHHH
AMERDGELVFTRGQSYGLPERMDLLTGTVIGHRDGFGFLKLEEGGDDLYINNRDMLMYFH
HHCCCCCEEEECCCCCCCCHHHHHHHHHEEECCCCCEEEEEECCCCEEEECCCCEEEEEE
GDRVLAQKAGVDRKGRREARIVRLVEERSAALVGRFHLDAGMGFVIADDRRITQEILVPE
CCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCEEEEECCCHHHHHHCCCC
EDRKGARQGDIVVLELTRRPGRYVKAAGKVTEVLGKEMAPGMEIEIALRNYDLPHTWSGL
HHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHH
IEKKLRKIPDEVTEADKEGRVDLRNLPLVTIDGEDARDFDDAVYAEKKKSGGWRLWVAIA
HHHHHHHCCHHHHCCCCCCCCEECCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEE
DVSHYVRTESALDKEARARGNSVYFPSQVIPMLPEKISNGLCSLMPKVDRLCMVAEMTIS
HHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHH
AVGKLSGYKFYPAVMHSHARLTYTQVADMLEGGEVSDELKPIFPHLQTLQSLYLTLEETR
HHHHCCCCEECHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AERGAIAFETTETQFIFNEQRKIDKIVPRNRNQAHKIIEECMILANVASAKFVKKHKGEV
HHCCCEEEECCCCEEEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LYRVHEAPSEQKLTNFKDFLKERGLTMEGGLEPEPKDYQAVMEQIADRADAELIQVMLLR
EEEECCCCCHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SMRQATYTPDNEGHFGLALEEYSHFTSPIRRYPDLILHRVIRYLLAKQEGNLTDQWTADG
HHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCC
GFNYKIEELDLLGEECSTTERRADEATRDVSDWLKCEFMQDHVGDTFEAVIASVTHFGMF
CCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VRLNDLFIDGLVHISSLGSDYYQYDNMRQRLVGEASGQVYQIGDTVTVKVAGVNLDDRQI
EEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCEEEEEEEECCCCCCEE
DLMMEGDSAGGKRRRPTKPLTARERVNREGAKLGAKRESSRGKGAEGDSEAKSGAKRKSS
EEEEECCCCCCCCCCCCCCCHHHHHHCHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCC
GGKYKSGSSAAAKKTKTKASAKKSSASKAKSAKRKASKK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]