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The map label for this gene is folP [H]

Identifier: 157962884

GI number: 157962884

Start: 3761117

End: 3761959

Strand: Reverse

Name: folP [H]

Synonym: Spea_3066

Alternate gene names: 157962884

Gene position: 3761959-3761117 (Counterclockwise)

Preceding gene: 157962885

Following gene: 157962883

Centisome position: 72.7

GC content: 45.2

Gene sequence:

>843_bases
TTGTCTATTTTAACTAGTCGTCACACATCTCTCGATTTGAGCTCTCCCGTTGTGATGGGGATCCTCAATGTCACGCCAGA
TTCATTTTCTGATGGTGGCGAATATTCATCGATTCAAGCGGCTTGCAGACAAGCCGATTTAATGGTGGCTCAAGGCGCCA
AAATTATCGATATTGGTGGTGAGTCAACCCGACCTGGTGCTAAGGACGTATCTATTGAAGATGAGCTAAAGCGTGTGCTC
CCTTTAATTGAGTATGTTAGTCGTAATCATGATGTGTGGGTCTCAATTGATACCAGTAAAGCGGTTGTTATGCAGGCGGC
AGTTGAAGCCGGTGCACAGCTGATTAATGATGTTAGAGCGTTACAGGAACCCGGTGCATTATCTACCGCGGCTAAGTTAG
ATGTGCCGGTTTGTTTAATGCATATGCAAGGTCAGCCGAGGACCATGCAAGATGCGCCACAGTATGACGATATCATTAGT
GATATTAGTCAGTTCTTCTGTGAGCGGATCGAAGTCTGTATTGACGCGGGAATTAAACGTGAGCAGATAGTGCTCGATCC
TGGTTTTGGTTTTGGTAAATCGCTAGCCCACAATTACGAGTTACTCAATCGGATGGCTGAGTTTTCGAGCTTCGATTTAC
CCGTGCTTGCAGGTTTATCGCGTAAGAGTATGTTTGGACAGTTACTCGGACGTGAGGTATCACAAAGATTAAGTGCCACA
CTTGCTGGTAATATGCTGGCAATACAAGCGGGCGCAAAGATAGTGCGTGTGCATGATGTACAAGAGACCAGTGACATGAT
AGCAGTGATAGAAGCTGCAAAGAATTTTAAAACTTTGGCTTAA

Upstream 100 bases:

>100_bases
AAGCCCGATGTTAGCGATGCTGACGAATCACCGGCTAAGTAATCTTTAGTTTGATAAAGAAAACCCCTTCTAGGGGTTTT
CTTGTTTACGGAACTTTATT

Downstream 100 bases:

>100_bases
TATTTTGGCTTTACACGCCAGTTGTTCAGTTAGGGTTAGTATTTTTTACGGTAGAATCGATGGATTTAGATCTACCTGAT
TATTGAGTTTGGAGTTCAAG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSILTSRHTSLDLSSPVVMGILNVTPDSFSDGGEYSSIQAACRQADLMVAQGAKIIDIGGESTRPGAKDVSIEDELKRVL
PLIEYVSRNHDVWVSIDTSKAVVMQAAVEAGAQLINDVRALQEPGALSTAAKLDVPVCLMHMQGQPRTMQDAPQYDDIIS
DISQFFCERIEVCIDAGIKREQIVLDPGFGFGKSLAHNYELLNRMAEFSSFDLPVLAGLSRKSMFGQLLGREVSQRLSAT
LAGNMLAIQAGAKIVRVHDVQETSDMIAVIEAAKNFKTLA

Sequences:

>Translated_280_residues
MSILTSRHTSLDLSSPVVMGILNVTPDSFSDGGEYSSIQAACRQADLMVAQGAKIIDIGGESTRPGAKDVSIEDELKRVL
PLIEYVSRNHDVWVSIDTSKAVVMQAAVEAGAQLINDVRALQEPGALSTAAKLDVPVCLMHMQGQPRTMQDAPQYDDIIS
DISQFFCERIEVCIDAGIKREQIVLDPGFGFGKSLAHNYELLNRMAEFSSFDLPVLAGLSRKSMFGQLLGREVSQRLSAT
LAGNMLAIQAGAKIVRVHDVQETSDMIAVIEAAKNFKTLA
>Mature_279_residues
SILTSRHTSLDLSSPVVMGILNVTPDSFSDGGEYSSIQAACRQADLMVAQGAKIIDIGGESTRPGAKDVSIEDELKRVLP
LIEYVSRNHDVWVSIDTSKAVVMQAAVEAGAQLINDVRALQEPGALSTAAKLDVPVCLMHMQGQPRTMQDAPQYDDIISD
ISQFFCERIEVCIDAGIKREQIVLDPGFGFGKSLAHNYELLNRMAEFSSFDLPVLAGLSRKSMFGQLLGREVSQRLSATL
AGNMLAIQAGAKIVRVHDVQETSDMIAVIEAAKNFKTLA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=274, Percent_Identity=56.2043795620438, Blast_Score=340, Evalue=8e-95,
Organism=Saccharomyces cerevisiae, GI6324073, Length=330, Percent_Identity=30, Blast_Score=126, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30310; Mature: 30179

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILTSRHTSLDLSSPVVMGILNVTPDSFSDGGEYSSIQAACRQADLMVAQGAKIIDIGG
CCCCCCCCCCCCCCCCHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECC
ESTRPGAKDVSIEDELKRVLPLIEYVSRNHDVWVSIDTSKAVVMQAAVEAGAQLINDVRA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LQEPGALSTAAKLDVPVCLMHMQGQPRTMQDAPQYDDIISDISQFFCERIEVCIDAGIKR
HHCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
EQIVLDPGFGFGKSLAHNYELLNRMAEFSSFDLPVLAGLSRKSMFGQLLGREVSQRLSAT
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHH
LAGNMLAIQAGAKIVRVHDVQETSDMIAVIEAAKNFKTLA
HHCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SILTSRHTSLDLSSPVVMGILNVTPDSFSDGGEYSSIQAACRQADLMVAQGAKIIDIGG
CCCCCCCCCCCCCCCHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECC
ESTRPGAKDVSIEDELKRVLPLIEYVSRNHDVWVSIDTSKAVVMQAAVEAGAQLINDVRA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LQEPGALSTAAKLDVPVCLMHMQGQPRTMQDAPQYDDIISDISQFFCERIEVCIDAGIKR
HHCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
EQIVLDPGFGFGKSLAHNYELLNRMAEFSSFDLPVLAGLSRKSMFGQLLGREVSQRLSAT
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHH
LAGNMLAIQAGAKIVRVHDVQETSDMIAVIEAAKNFKTLA
HHCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]