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The map label for this gene is dxr [H]

Identifier: 157962698

GI number: 157962698

Start: 3517781

End: 3518971

Strand: Reverse

Name: dxr [H]

Synonym: Spea_2879

Alternate gene names: 157962698

Gene position: 3518971-3517781 (Counterclockwise)

Preceding gene: 157962699

Following gene: 157962697

Centisome position: 68.0

GC content: 44.25

Gene sequence:

>1191_bases
ATGCAAAATATGGTGATTTTAGGCGCAACAGGCTCCATTGGTGCAAGCACCTTGAATGTTGTGGCGTGTAATCCTGAGCA
GTACAAGGTTTTTGCGTTAGTGGCAAATACTAATGTCGCCAAAATGCTAGAGATCTGTATTGCGCATCAGCCTAAGATTG
CCCATATGGTCGATGCAAAAGCGGCTCAAGCGCTCAAGCAGCAACTTCCAAGTCATCTCAAAATTGAAGTGACTACTGGT
GAAGATGAGCTGTTGTCTCTTGTGAGCTGCAGTGAGGTTGATACCGTGATGGCGGCCATTGTCGGCGCCGCGGGTCTACC
TTCAACTCTCGCCGCGGTTAATGCGGGTAAACGAGTATTGCTGGCTAACAAAGAATCGTTAGTCATGTCTGGCCAGCTGT
TTATTGAAGCGATGCAAAACTCTGGCGCACAAGTATTGCCGGTAGATAGTGAACACAACGCTATTTTCCAGTGTTTATCT
GAGCGTTCACAGCTTGAGATAGGTCGTTGTGACCTAACTGGTGCAGGGGTTTCTCATATTTTGCTGACAGGTTCTGGTGG
TCCGTTTTTAACCTCAGATTTATCGTCACTGGTAAATATGACGCCTGATCAGGCCTGTAAACACCCTAATTGGTCTATGG
GGCGTAAGATCTCGGTTGATTCTGCGACCATGATGAATAAAGGTCTCGAATATATTGAGGCGCGTTGGTTGTTTAATGCA
AGTAGCGACCAGTTAAAGGTTGTGATTCACCCTCAAAGTGTGATTCATTCTATGGTGCAATACCGTGATGGCTCAGTGTT
AGCGCAATTGGGGAATCCAGATATGCGTACACCGATTGCCCATTGTATGTCATTTCCACAAAGAATTAGCTCGGGAGTTG
AACCTTTAGACTTTTTTAAAGTCGGACAGTTAAGCTTCTTAGAACCTGATTTTAATAGGTTCCCCTGTTTAGCATTGGCG
ATAGAAGCATGTAAGCAAGGGCAAGAAGCGACAACCGTATTAAACGCCGCCAATGAAATCTCTGTGCAGGCATTTTTAGA
TGGCAAGATCCGCTTTACCGATATAGCAAAAATAAACGAACAAAGCTTAATGAATACGGCGACGCATCCATTAAACTGTA
TTGATGATATCTTGGCTTTAGACTTTCAAAGTCGTCAATACACATTAAACGCTATTACTAAGCTGAATTAG

Upstream 100 bases:

>100_bases
ATTCTTCCAGGTCATGGTGGCGTGTTAGATCGCATCGATAGCTTAACGGCTGCCCTACCAGTATTCACATTAATCTATAT
AGCTTTTTGGATGTAACTAA

Downstream 100 bases:

>100_bases
TTCAGAGGAAAGGAATGATCGATTTTTTATGGAACTTAGGTTCTTTTATTGTTGCTTTAGGGATTTTAATTGCTGCCCAT
GAATATGGGCACTTTTGGGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MQNMVILGATGSIGASTLNVVACNPEQYKVFALVANTNVAKMLEICIAHQPKIAHMVDAKAAQALKQQLPSHLKIEVTTG
EDELLSLVSCSEVDTVMAAIVGAAGLPSTLAAVNAGKRVLLANKESLVMSGQLFIEAMQNSGAQVLPVDSEHNAIFQCLS
ERSQLEIGRCDLTGAGVSHILLTGSGGPFLTSDLSSLVNMTPDQACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFNA
SSDQLKVVIHPQSVIHSMVQYRDGSVLAQLGNPDMRTPIAHCMSFPQRISSGVEPLDFFKVGQLSFLEPDFNRFPCLALA
IEACKQGQEATTVLNAANEISVQAFLDGKIRFTDIAKINEQSLMNTATHPLNCIDDILALDFQSRQYTLNAITKLN

Sequences:

>Translated_396_residues
MQNMVILGATGSIGASTLNVVACNPEQYKVFALVANTNVAKMLEICIAHQPKIAHMVDAKAAQALKQQLPSHLKIEVTTG
EDELLSLVSCSEVDTVMAAIVGAAGLPSTLAAVNAGKRVLLANKESLVMSGQLFIEAMQNSGAQVLPVDSEHNAIFQCLS
ERSQLEIGRCDLTGAGVSHILLTGSGGPFLTSDLSSLVNMTPDQACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFNA
SSDQLKVVIHPQSVIHSMVQYRDGSVLAQLGNPDMRTPIAHCMSFPQRISSGVEPLDFFKVGQLSFLEPDFNRFPCLALA
IEACKQGQEATTVLNAANEISVQAFLDGKIRFTDIAKINEQSLMNTATHPLNCIDDILALDFQSRQYTLNAITKLN
>Mature_396_residues
MQNMVILGATGSIGASTLNVVACNPEQYKVFALVANTNVAKMLEICIAHQPKIAHMVDAKAAQALKQQLPSHLKIEVTTG
EDELLSLVSCSEVDTVMAAIVGAAGLPSTLAAVNAGKRVLLANKESLVMSGQLFIEAMQNSGAQVLPVDSEHNAIFQCLS
ERSQLEIGRCDLTGAGVSHILLTGSGGPFLTSDLSSLVNMTPDQACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFNA
SSDQLKVVIHPQSVIHSMVQYRDGSVLAQLGNPDMRTPIAHCMSFPQRISSGVEPLDFFKVGQLSFLEPDFNRFPCLALA
IEACKQGQEATTVLNAANEISVQAFLDGKIRFTDIAKINEQSLMNTATHPLNCIDDILALDFQSRQYTLNAITKLN

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=59.0909090909091, Blast_Score=459, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42728; Mature: 42728

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNMVILGATGSIGASTLNVVACNPEQYKVFALVANTNVAKMLEICIAHQPKIAHMVDAK
CCCEEEEECCCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHH
AAQALKQQLPSHLKIEVTTGEDELLSLVSCSEVDTVMAAIVGAAGLPSTLAAVNAGKRVL
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEE
LANKESLVMSGQLFIEAMQNSGAQVLPVDSEHNAIFQCLSERSQLEIGRCDLTGAGVSHI
EECCCCEEEEHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCEECCEEECCCCCEEE
LLTGSGGPFLTSDLSSLVNMTPDQACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFNA
EEECCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHEEEECC
SSDQLKVVIHPQSVIHSMVQYRDGSVLAQLGNPDMRTPIAHCMSFPQRISSGVEPLDFFK
CCCCEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHC
VGQLSFLEPDFNRFPCLALAIEACKQGQEATTVLNAANEISVQAFLDGKIRFTDIAKINE
CCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCEEEEEEEHHCCH
QSLMNTATHPLNCIDDILALDFQSRQYTLNAITKLN
HHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MQNMVILGATGSIGASTLNVVACNPEQYKVFALVANTNVAKMLEICIAHQPKIAHMVDAK
CCCEEEEECCCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHH
AAQALKQQLPSHLKIEVTTGEDELLSLVSCSEVDTVMAAIVGAAGLPSTLAAVNAGKRVL
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEE
LANKESLVMSGQLFIEAMQNSGAQVLPVDSEHNAIFQCLSERSQLEIGRCDLTGAGVSHI
EECCCCEEEEHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCEECCEEECCCCCEEE
LLTGSGGPFLTSDLSSLVNMTPDQACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFNA
EEECCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHEEEECC
SSDQLKVVIHPQSVIHSMVQYRDGSVLAQLGNPDMRTPIAHCMSFPQRISSGVEPLDFFK
CCCCEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHC
VGQLSFLEPDFNRFPCLALAIEACKQGQEATTVLNAANEISVQAFLDGKIRFTDIAKINE
CCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCEEEEEEEHHCCH
QSLMNTATHPLNCIDDILALDFQSRQYTLNAITKLN
HHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA