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The map label for this gene is lpxD [H]

Identifier: 157962694

GI number: 157962694

Start: 3512304

End: 3513320

Strand: Reverse

Name: lpxD [H]

Synonym: Spea_2875

Alternate gene names: 157962694

Gene position: 3513320-3512304 (Counterclockwise)

Preceding gene: 157962695

Following gene: 157962693

Centisome position: 67.9

GC content: 44.94

Gene sequence:

>1017_bases
ATGAAAAGCTATACTTTAAGAGTACTGGCTGACCATTTAAATGCAGATGTTCAAGGTGATGATACAGTTGAGATCTCAGC
TGTAGGCACCTTGGACGGTGCAGGTCCAGGTCAAATCTCTTTCTTGGCAAATTCTAAATATCGCTCGCAGCTGCAAACCA
CAGCTGCGTCGGCGATCTTGATGACGCCTACAGATGCAGAAAGCTACACAGGTAATGCGATTGTATTAAAAGATCCTTAC
GTGGGTTTTGCACGCATCGCACAGTTTCTCGATACAACACCAAAGGCAGCCGATAATATTCACCCTTCAGCGCAAATAGC
TGAATCAGCTATGTTAGGCGAAGGTGTGGCGATTGGTGCTAACGCGGTCATTGGTGAGAATGTTATTCTAGGCAACAATG
TACAGATTGGTGCTGGTAGTGTTATTGGTCAAGACAGTGTTATTGGCTCAAATACTCGCTTGTGGGCAAACGTTACCGTA
TACCACAATGTCCATCTAGGCCAAGATTGTATTATCCACTCTGGCGCAGTTTTGGGGTCCGATGGCTTTGGCTATGCTAA
CGAGCGTGGTCAATGGATTAAAATTCCACAAACAGGTGGCGTTCGCATTGGTGACAGGGTTGAGATCGGTGCAAACACGA
CTGTGGATAGAGGTGCCATCGAGCATACTGAAATCCATGATGGTGTGATTATCGACAACCAAGTTCAGATCGCTCATAAC
GATATCATCGGCGCTAATACGGCTATTGCGGGCTGTACTGTTGTCGCAGGCAGCGTGACTATCGGTAAGCATTGTATTAT
TGGTGGTAATAGTGCGATTTCAGGACATTTAACTATTGCTGATGGCGTTCATATTTCTGGTGGCACCAATGTTACCAGTA
TTATCCGCGATAAAGGCGTTTATTCATCAGCCACAGTTGCGATGGATAATAAGCTTTGGCGTAAGAATACCGTGCGTTTT
AGACAGTTAGATACGCTATTCCAACGTGTGAAAACACTGGAAAATAACGTAAAGTAA

Upstream 100 bases:

>100_bases
TATGACATGGTGCTTCAACGCGGCGCCGTTATCTATGTTAAGCCTAGCGCTGACATCAGTAACAAAGTGGTTGAAGCTTT
AGGTAAAGGCAAGTAAATAG

Downstream 100 bases:

>100_bases
ATGAATGACTGCAGTGAGCAGATAAAGGAAAAATTCGTGTCAAATCAATTGAATACAATGGATATTAAAGAGATCCTAAA
ATTTTTACCTCATAGGTATC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKSYTLRVLADHLNADVQGDDTVEISAVGTLDGAGPGQISFLANSKYRSQLQTTAASAILMTPTDAESYTGNAIVLKDPY
VGFARIAQFLDTTPKAADNIHPSAQIAESAMLGEGVAIGANAVIGENVILGNNVQIGAGSVIGQDSVIGSNTRLWANVTV
YHNVHLGQDCIIHSGAVLGSDGFGYANERGQWIKIPQTGGVRIGDRVEIGANTTVDRGAIEHTEIHDGVIIDNQVQIAHN
DIIGANTAIAGCTVVAGSVTIGKHCIIGGNSAISGHLTIADGVHISGGTNVTSIIRDKGVYSSATVAMDNKLWRKNTVRF
RQLDTLFQRVKTLENNVK

Sequences:

>Translated_338_residues
MKSYTLRVLADHLNADVQGDDTVEISAVGTLDGAGPGQISFLANSKYRSQLQTTAASAILMTPTDAESYTGNAIVLKDPY
VGFARIAQFLDTTPKAADNIHPSAQIAESAMLGEGVAIGANAVIGENVILGNNVQIGAGSVIGQDSVIGSNTRLWANVTV
YHNVHLGQDCIIHSGAVLGSDGFGYANERGQWIKIPQTGGVRIGDRVEIGANTTVDRGAIEHTEIHDGVIIDNQVQIAHN
DIIGANTAIAGCTVVAGSVTIGKHCIIGGNSAISGHLTIADGVHISGGTNVTSIIRDKGVYSSATVAMDNKLWRKNTVRF
RQLDTLFQRVKTLENNVK
>Mature_338_residues
MKSYTLRVLADHLNADVQGDDTVEISAVGTLDGAGPGQISFLANSKYRSQLQTTAASAILMTPTDAESYTGNAIVLKDPY
VGFARIAQFLDTTPKAADNIHPSAQIAESAMLGEGVAIGANAVIGENVILGNNVQIGAGSVIGQDSVIGSNTRLWANVTV
YHNVHLGQDCIIHSGAVLGSDGFGYANERGQWIKIPQTGGVRIGDRVEIGANTTVDRGAIEHTEIHDGVIIDNQVQIAHN
DIIGANTAIAGCTVVAGSVTIGKHCIIGGNSAISGHLTIADGVHISGGTNVTSIIRDKGVYSSATVAMDNKLWRKNTVRF
RQLDTLFQRVKTLENNVK

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=337, Percent_Identity=51.9287833827893, Blast_Score=347, Evalue=5e-97,
Organism=Escherichia coli, GI1786378, Length=195, Percent_Identity=28.2051282051282, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35462; Mature: 35462

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSYTLRVLADHLNADVQGDDTVEISAVGTLDGAGPGQISFLANSKYRSQLQTTAASAIL
CCCEEEEEEEHHHCCCCCCCCEEEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHCCEEE
MTPTDAESYTGNAIVLKDPYVGFARIAQFLDTTPKAADNIHPSAQIAESAMLGEGVAIGA
ECCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEECC
NAVIGENVILGNNVQIGAGSVIGQDSVIGSNTRLWANVTVYHNVHLGQDCIIHSGAVLGS
CEEECCCEEECCCEEECCCCEECCCCEECCCCEEEEEEEEEEEEECCCCEEEECCEEECC
DGFGYANERGQWIKIPQTGGVRIGDRVEIGANTTVDRGAIEHTEIHDGVIIDNQVQIAHN
CCCCCCCCCCCEEECCCCCCEEECCEEEECCCCCCCCCCCEECCCCCCEEECCEEEEEEC
DIIGANTAIAGCTVVAGSVTIGKHCIIGGNSAISGHLTIADGVHISGGTNVTSIIRDKGV
CEECCCCHHCEEEEEECCEEECCEEEEECCCEEEEEEEEECCEEECCCCCHHHHHHCCCC
YSSATVAMDNKLWRKNTVRFRQLDTLFQRVKTLENNVK
CCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSYTLRVLADHLNADVQGDDTVEISAVGTLDGAGPGQISFLANSKYRSQLQTTAASAIL
CCCEEEEEEEHHHCCCCCCCCEEEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHCCEEE
MTPTDAESYTGNAIVLKDPYVGFARIAQFLDTTPKAADNIHPSAQIAESAMLGEGVAIGA
ECCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEECC
NAVIGENVILGNNVQIGAGSVIGQDSVIGSNTRLWANVTVYHNVHLGQDCIIHSGAVLGS
CEEECCCEEECCCEEECCCCEECCCCEECCCCEEEEEEEEEEEEECCCCEEEECCEEECC
DGFGYANERGQWIKIPQTGGVRIGDRVEIGANTTVDRGAIEHTEIHDGVIIDNQVQIAHN
CCCCCCCCCCCEEECCCCCCEEECCEEEECCCCCCCCCCCEECCCCCCEEECCEEEEEEC
DIIGANTAIAGCTVVAGSVTIGKHCIIGGNSAISGHLTIADGVHISGGTNVTSIIRDKGV
CEECCCCHHCEEEEEECCEEECCEEEEECCCEEEEEEEEECCEEECCCCCHHHHHHCCCC
YSSATVAMDNKLWRKNTVRFRQLDTLFQRVKTLENNVK
CCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]