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The map label for this gene is dmsA [H]

Identifier: 157962638

GI number: 157962638

Start: 3438237

End: 3440759

Strand: Reverse

Name: dmsA [H]

Synonym: Spea_2818

Alternate gene names: 157962638

Gene position: 3440759-3438237 (Counterclockwise)

Preceding gene: 157962639

Following gene: 157962637

Centisome position: 66.49

GC content: 46.53

Gene sequence:

>2523_bases
ATGGAACGTAGAAGTTTCTTAAAAATGAGTGCCGCGCTGGGCTGCGCTGCAACAGTTACCGGCTGTAATTCAAGCTCTGA
TGATGCCAATGTTATTCCACCACAGCCGCCAGTGACTGACGAAGTGGTAAACTGGTCATCTTGCCTAGTTAACTGTGGTT
CTAACTGTCCAATTAAGGTCTTTACTAAAGACGGTATCGTGACCCGTGTTGAAACTGACCATGAAGTTGAAGACAACTAC
GGTCTACACCAAGTACGTGCTTGTGCTCGTGGTCGTTCACTACGTCAAAGAAACTACGCTGTTGACCGCCTAAAAACACC
AATGAAGCGTGTTGGTGAGCGTGGTAAAGCTGAATTTGTACCCATTAGCTGGGACGAAGCAACCAGCATTATCGCTGAAA
AGCTTGCTGCTGTTTACGCACAAGAAAATGGTGCTAAGTCAGTATTCCGTAGCTACGGTTCTGGTGCTTACTACGGTTTT
GCATCAAATGCCTGTTTCAACCGTCTATTTAACCTAAATGGTGGTTGCCTAAATGCTTATGGTAACTACTCTTGGGCGCA
GCAGATGGAAGCGGCTAAGCACACCTTCGGTACTGGCAGTACTAGCGGTTCGTCAACCATCACTATTGAAGACAGTGACT
TCTTCTTAGGTGTTGCTTACAACCCAAGCGAGATCCGTCAATCGGGTTCAGGCGAAGGTTACGATTACCTACAGGCATTG
CAGAAAAATAATGGCCTAGAAGTGGTAATGATCGACCCTCGTTACACTGACTCCATGCTAGGTAAAGAATCAAGCTGGTT
ACCAATCCGTCCAGGTACTGATGCTGCGTTTGCTGAAGCGGTTGCCTATGTGATGATCAACCACGCTAACTTTGTTGGTC
AATCTCTACCGTTTGTACTTGAGCATTCAGTTGGTTTCAACAAGCAGTCAATTGAAGATCAAAAAGCGATTTTTGCAGCG
AGCAGCGATGCGACTGACCAAGAATACGCTAAGGTAATGAACTCAGATGAAAACTACCAAGACTACATTCTAGGTCAAGG
TATTTACACTGACGCTAAGACACCAGAATGGGCTGAAAAAATCTGTGGTATTTCTGCAGAGAAAATCCGCTACATCGCTG
GCAAGCTAATGACAGCTAAAGCTCCTTACATCGTTGTGGGCGCAGGCGTTAACCGCCAAGCAAACGGCGAGCAAAGCATG
CGTTCTCTATACATGCTATCAGTGCTAACCGGTAAGCTAGGTACTCGCGGTGCATCAAATGGTGAACTACCGTACATGAG
CAGCATGTCTCGTGCAGGAATTCCAACAGGTACAAATAAAGTTACAGAAAGCATCTCTTTCTTCACTTGGTCTGAAGCGA
TTAATAACGGCGTTAATATGACTGCTCGTAGTCACGGCGTTCGTGGTACTGACGGTTTAGATACGCCACTTGGCGCAAAC
ATTAAGTTCATTCTGTCTGCATCAGATAGTTCGTTACTGAACCAGCACGCTGAAATCAACAATACGGCTGATATCTTCCG
TAATGCTGAAGATCTATTCATCGTATCTTGTGATTGCTGGATGACGCCTGGCGCTAAGTTTGCTGACATCATCTTACCGG
ATACTAGCTGGTTAGAGTCAAACGACTTAGTTAACGACTCATACGCTTCAGGCTCACTAGGTTACCTAACTGCCATGTCT
TCATCTGTTGAGACTATGTGGGATTGTAAGTCTATGTACGAAGCGGCTGCGATGATCGCTGACAAGATGGGCGTTGGCGC
TGGCTTTAGAGACGGCAAAAACGAAGATGAGTGGTTAGAAGAGCTTTATCAAAGCACTAAAGCTAACAGCAACAACATCG
GTGTTTCTCCAGCGTTCCCTGCAACTTACAAAGAAGCACAAGAGATTGGTTTCTTCCGTAAGAACATGAACGATAACCAC
GTTGCACTGCAAAGCTTTGTGAAAGACGGTAAAGCGCTATCAACACCAAGTGGCAAGATTGAAATCTATTCTGCTGAACT
TGCATGGCGTGCGGCTAACTGGGACCAAGAGAACAGTACTCAAAATCCTACAAACGTTAAGGGCGACACCATCACAGCTA
TTCCACAGTACACAGTAACGTGGGACGGTTATGAAGATGAAGGCACTAAAGAAGATTACCCAATTCAGCTAGCGGGTTAC
CACACTAAGGGCCGTACCCACTCAAGCTACCACAACGTTCCATGGCTGCGTGAAGCGGTAGAAGACGCTGTTTGGGTTAA
CCCAATGGACGGTGCTAAGCACGGCCTAAGCTCTGGCGACAAGATTGAGATGTACAACGAGCGTGGTTCAATTGAAGTGA
CTGTACGTATCACACCACGTGTTGCGCCAGGTGTATTTGCCCTAGGACAAGGTGCTTGGTACAACCCTGGCAACAAGCGA
GGCAGTACTGGCCATATCGTTGACGAAGGCGGCGCAATTAACTCGTTAACTCGCTACCAGCCTAGCCCTGTCGCTAAAGG
TAACCCACAGCACACTATTCGTGTTGCCATTAAAAAGATTTAA

Upstream 100 bases:

>100_bases
CCTGAACCACAATTACAACGCCCATCAACTGATGTTGACCTTCAGCTACAAGCTGAAATAAGTCGAGTCAGATATTAATA
AGTTTGAGGAAAACAAGATT

Downstream 100 bases:

>100_bases
GAGAGTAGTTAATTATGACTGAAGCAACTCAATACGGTTTTTACGTCGACAGCACTAAGTGTACTGGCTGTAAAGCGTGC
CATGTATCTTGTAAAGACCG

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 840; Mature: 840

Protein sequence:

>840_residues
MERRSFLKMSAALGCAATVTGCNSSSDDANVIPPQPPVTDEVVNWSSCLVNCGSNCPIKVFTKDGIVTRVETDHEVEDNY
GLHQVRACARGRSLRQRNYAVDRLKTPMKRVGERGKAEFVPISWDEATSIIAEKLAAVYAQENGAKSVFRSYGSGAYYGF
ASNACFNRLFNLNGGCLNAYGNYSWAQQMEAAKHTFGTGSTSGSSTITIEDSDFFLGVAYNPSEIRQSGSGEGYDYLQAL
QKNNGLEVVMIDPRYTDSMLGKESSWLPIRPGTDAAFAEAVAYVMINHANFVGQSLPFVLEHSVGFNKQSIEDQKAIFAA
SSDATDQEYAKVMNSDENYQDYILGQGIYTDAKTPEWAEKICGISAEKIRYIAGKLMTAKAPYIVVGAGVNRQANGEQSM
RSLYMLSVLTGKLGTRGASNGELPYMSSMSRAGIPTGTNKVTESISFFTWSEAINNGVNMTARSHGVRGTDGLDTPLGAN
IKFILSASDSSLLNQHAEINNTADIFRNAEDLFIVSCDCWMTPGAKFADIILPDTSWLESNDLVNDSYASGSLGYLTAMS
SSVETMWDCKSMYEAAAMIADKMGVGAGFRDGKNEDEWLEELYQSTKANSNNIGVSPAFPATYKEAQEIGFFRKNMNDNH
VALQSFVKDGKALSTPSGKIEIYSAELAWRAANWDQENSTQNPTNVKGDTITAIPQYTVTWDGYEDEGTKEDYPIQLAGY
HTKGRTHSSYHNVPWLREAVEDAVWVNPMDGAKHGLSSGDKIEMYNERGSIEVTVRITPRVAPGVFALGQGAWYNPGNKR
GSTGHIVDEGGAINSLTRYQPSPVAKGNPQHTIRVAIKKI

Sequences:

>Translated_840_residues
MERRSFLKMSAALGCAATVTGCNSSSDDANVIPPQPPVTDEVVNWSSCLVNCGSNCPIKVFTKDGIVTRVETDHEVEDNY
GLHQVRACARGRSLRQRNYAVDRLKTPMKRVGERGKAEFVPISWDEATSIIAEKLAAVYAQENGAKSVFRSYGSGAYYGF
ASNACFNRLFNLNGGCLNAYGNYSWAQQMEAAKHTFGTGSTSGSSTITIEDSDFFLGVAYNPSEIRQSGSGEGYDYLQAL
QKNNGLEVVMIDPRYTDSMLGKESSWLPIRPGTDAAFAEAVAYVMINHANFVGQSLPFVLEHSVGFNKQSIEDQKAIFAA
SSDATDQEYAKVMNSDENYQDYILGQGIYTDAKTPEWAEKICGISAEKIRYIAGKLMTAKAPYIVVGAGVNRQANGEQSM
RSLYMLSVLTGKLGTRGASNGELPYMSSMSRAGIPTGTNKVTESISFFTWSEAINNGVNMTARSHGVRGTDGLDTPLGAN
IKFILSASDSSLLNQHAEINNTADIFRNAEDLFIVSCDCWMTPGAKFADIILPDTSWLESNDLVNDSYASGSLGYLTAMS
SSVETMWDCKSMYEAAAMIADKMGVGAGFRDGKNEDEWLEELYQSTKANSNNIGVSPAFPATYKEAQEIGFFRKNMNDNH
VALQSFVKDGKALSTPSGKIEIYSAELAWRAANWDQENSTQNPTNVKGDTITAIPQYTVTWDGYEDEGTKEDYPIQLAGY
HTKGRTHSSYHNVPWLREAVEDAVWVNPMDGAKHGLSSGDKIEMYNERGSIEVTVRITPRVAPGVFALGQGAWYNPGNKR
GSTGHIVDEGGAINSLTRYQPSPVAKGNPQHTIRVAIKKI
>Mature_840_residues
MERRSFLKMSAALGCAATVTGCNSSSDDANVIPPQPPVTDEVVNWSSCLVNCGSNCPIKVFTKDGIVTRVETDHEVEDNY
GLHQVRACARGRSLRQRNYAVDRLKTPMKRVGERGKAEFVPISWDEATSIIAEKLAAVYAQENGAKSVFRSYGSGAYYGF
ASNACFNRLFNLNGGCLNAYGNYSWAQQMEAAKHTFGTGSTSGSSTITIEDSDFFLGVAYNPSEIRQSGSGEGYDYLQAL
QKNNGLEVVMIDPRYTDSMLGKESSWLPIRPGTDAAFAEAVAYVMINHANFVGQSLPFVLEHSVGFNKQSIEDQKAIFAA
SSDATDQEYAKVMNSDENYQDYILGQGIYTDAKTPEWAEKICGISAEKIRYIAGKLMTAKAPYIVVGAGVNRQANGEQSM
RSLYMLSVLTGKLGTRGASNGELPYMSSMSRAGIPTGTNKVTESISFFTWSEAINNGVNMTARSHGVRGTDGLDTPLGAN
IKFILSASDSSLLNQHAEINNTADIFRNAEDLFIVSCDCWMTPGAKFADIILPDTSWLESNDLVNDSYASGSLGYLTAMS
SSVETMWDCKSMYEAAAMIADKMGVGAGFRDGKNEDEWLEELYQSTKANSNNIGVSPAFPATYKEAQEIGFFRKNMNDNH
VALQSFVKDGKALSTPSGKIEIYSAELAWRAANWDQENSTQNPTNVKGDTITAIPQYTVTWDGYEDEGTKEDYPIQLAGY
HTKGRTHSSYHNVPWLREAVEDAVWVNPMDGAKHGLSSGDKIEMYNERGSIEVTVRITPRVAPGVFALGQGAWYNPGNKR
GSTGHIVDEGGAINSLTRYQPSPVAKGNPQHTIRVAIKKI

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=853, Percent_Identity=40.7971864009379, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1787870, Length=851, Percent_Identity=39.7179788484136, Blast_Score=576, Evalue=1e-165,
Organism=Escherichia coli, GI171474008, Length=847, Percent_Identity=39.5513577331759, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI145693196, Length=778, Percent_Identity=26.0925449871465, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87081994, Length=834, Percent_Identity=24.8201438848921, Blast_Score=177, Evalue=3e-45,
Organism=Escherichia coli, GI1787231, Length=788, Percent_Identity=24.6192893401015, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI3868721, Length=644, Percent_Identity=24.223602484472, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1788534, Length=536, Percent_Identity=23.134328358209, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 91613; Mature: 91613

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00551 MOLYBDOPTERIN_PROK_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRSFLKMSAALGCAATVTGCNSSSDDANVIPPQPPVTDEVVNWSSCLVNCGSNCPIKV
CCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCHHHHHHCCCCCCCEEE
FTKDGIVTRVETDHEVEDNYGLHQVRACARGRSLRQRNYAVDRLKTPMKRVGERGKAEFV
EECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
PISWDEATSIIAEKLAAVYAQENGAKSVFRSYGSGAYYGFASNACFNRLFNLNGGCLNAY
ECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCEEECC
GNYSWAQQMEAAKHTFGTGSTSGSSTITIEDSDFFLGVAYNPSEIRQSGSGEGYDYLQAL
CCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEEECHHHHHHCCCCCCHHHHHHH
QKNNGLEVVMIDPRYTDSMLGKESSWLPIRPGTDAAFAEAVAYVMINHANFVGQSLPFVL
HCCCCCEEEEECCCCCHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHCHHHHCCCCCHHE
EHSVGFNKQSIEDQKAIFAASSDATDQEYAKVMNSDENYQDYILGQGIYTDAKTPEWAEK
ECCCCCCHHHCCHHHEEEEECCCCCHHHHHHHHCCCCCCHHHEECCCEECCCCCHHHHHH
ICGISAEKIRYIAGKLMTAKAPYIVVGAGVNRQANGEQSMRSLYMLSVLTGKLGTRGASN
HHCCCHHHHHHHHHHHEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GELPYMSSMSRAGIPTGTNKVTESISFFTWSEAINNGVNMTARSHGVRGTDGLDTPLGAN
CCCCCHHHHHHCCCCCCCHHHHHHHHHEEEHHHHCCCCEEEECCCCCCCCCCCCCCCCCC
IKFILSASDSSLLNQHAEINNTADIFRNAEDLFIVSCDCWMTPGAKFADIILPDTSWLES
EEEEEECCCHHHHHHHHCCCCHHHHHCCCCCEEEEEECCEECCCCCEEEEEECCCCCCCC
NDLVNDSYASGSLGYLTAMSSSVETMWDCKSMYEAAAMIADKMGVGAGFRDGKNEDEWLE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ELYQSTKANSNNIGVSPAFPATYKEAQEIGFFRKNMNDNHVALQSFVKDGKALSTPSGKI
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEECCCCCCE
EIYSAELAWRAANWDQENSTQNPTNVKGDTITAIPQYTVTWDGYEDEGTKEDYPIQLAGY
EEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCEEEEEE
HTKGRTHSSYHNVPWLREAVEDAVWVNPMDGAKHGLSSGDKIEMYNERGSIEVTVRITPR
ECCCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHCCCCCCEEEEECCCCCEEEEEEECCC
VAPGVFALGQGAWYNPGNKRGSTGHIVDEGGAINSLTRYQPSPVAKGNPQHTIRVAIKKI
CCCCEEEECCCCEECCCCCCCCCCCEEECCCCCCHHHCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MERRSFLKMSAALGCAATVTGCNSSSDDANVIPPQPPVTDEVVNWSSCLVNCGSNCPIKV
CCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCHHHHHHCCCCCCCEEE
FTKDGIVTRVETDHEVEDNYGLHQVRACARGRSLRQRNYAVDRLKTPMKRVGERGKAEFV
EECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
PISWDEATSIIAEKLAAVYAQENGAKSVFRSYGSGAYYGFASNACFNRLFNLNGGCLNAY
ECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCEEECC
GNYSWAQQMEAAKHTFGTGSTSGSSTITIEDSDFFLGVAYNPSEIRQSGSGEGYDYLQAL
CCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEEECHHHHHHCCCCCCHHHHHHH
QKNNGLEVVMIDPRYTDSMLGKESSWLPIRPGTDAAFAEAVAYVMINHANFVGQSLPFVL
HCCCCCEEEEECCCCCHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHCHHHHCCCCCHHE
EHSVGFNKQSIEDQKAIFAASSDATDQEYAKVMNSDENYQDYILGQGIYTDAKTPEWAEK
ECCCCCCHHHCCHHHEEEEECCCCCHHHHHHHHCCCCCCHHHEECCCEECCCCCHHHHHH
ICGISAEKIRYIAGKLMTAKAPYIVVGAGVNRQANGEQSMRSLYMLSVLTGKLGTRGASN
HHCCCHHHHHHHHHHHEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GELPYMSSMSRAGIPTGTNKVTESISFFTWSEAINNGVNMTARSHGVRGTDGLDTPLGAN
CCCCCHHHHHHCCCCCCCHHHHHHHHHEEEHHHHCCCCEEEECCCCCCCCCCCCCCCCCC
IKFILSASDSSLLNQHAEINNTADIFRNAEDLFIVSCDCWMTPGAKFADIILPDTSWLES
EEEEEECCCHHHHHHHHCCCCHHHHHCCCCCEEEEEECCEECCCCCEEEEEECCCCCCCC
NDLVNDSYASGSLGYLTAMSSSVETMWDCKSMYEAAAMIADKMGVGAGFRDGKNEDEWLE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ELYQSTKANSNNIGVSPAFPATYKEAQEIGFFRKNMNDNHVALQSFVKDGKALSTPSGKI
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEECCCCCCE
EIYSAELAWRAANWDQENSTQNPTNVKGDTITAIPQYTVTWDGYEDEGTKEDYPIQLAGY
EEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCEEEEEE
HTKGRTHSSYHNVPWLREAVEDAVWVNPMDGAKHGLSSGDKIEMYNERGSIEVTVRITPR
ECCCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHCCCCCCEEEEECCCCCEEEEEEECCC
VAPGVFALGQGAWYNPGNKRGSTGHIVDEGGAINSLTRYQPSPVAKGNPQHTIRVAIKKI
CCCCEEEECCCCEECCCCCCCCCCCEEECCCCCCHHHCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]