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The map label for this gene is tesB [H]

Identifier: 157962612

GI number: 157962612

Start: 3407670

End: 3408536

Strand: Reverse

Name: tesB [H]

Synonym: Spea_2791

Alternate gene names: 157962612

Gene position: 3408536-3407670 (Counterclockwise)

Preceding gene: 157962613

Following gene: 157962611

Centisome position: 65.87

GC content: 48.67

Gene sequence:

>867_bases
ATGAGCCAAGTATTAGATGATCTTCTAGCGTTACTTTCTTTAGAACAGATCGAAGAGGGGCTGTTTCGTGGCCAAAGCCA
AGATCTTGGTTTTGGGCATGTCTTTGGCGGTCAAGTCATGGGGCAAGCGCTTAGCGCGGCTAAGCGTACTGTGAGTCCTG
ATCGCAAAGTGCACTCTTTACACTCCTATTTTTTACGTGCGGGTGATGAGAAGCTACCCATCGTTTATGATGTTGAAATC
ATGCGAGATGGCGGCAGTTTTAGTGCGAGAAGAGTCAAAGCTATCCAGAAAGGTCGTCCTATATTCTATATGACCTGCTC
TTTTCAAACGAGCGAGGAAGGTTATGAGCATCAAGCGACTATGCCTGATGTGCCGGGGCCTGAAGGTCTGCTTAACCAAC
AAGAACTGGCGATGACACTGAGAGACAAGGTGCCGTCTAAAGTGCTTGAGAAGTTTATGGCTGACACGCCGATTGAGATG
CGTCTAGTCAATCCAAGTGATCCCATCGCACCTAAAGCCTGCGAGCCTATTCGTTATGTATGGATCCGGGCCAATGGCAA
GTTGCCAGATAATTTCTCTGTGCACGACTATTTGCTCGCCTATGCGTCAGACTTTAACTTTCTGGTGACGGCTGCGCAGC
CTCATGGGGTGTCATTTTTGACCCCAGGTATGCGAATGGCGACGATCGATCACGCTATGTGGTTCCACCGTCCGTTCGAT
TTCAGTCAGTGGCTTTTGTATAGCATCGATAGCCCTAATGCCTGTGGTGGTAGAGGTTTTGTAAGAGGGCAATTCTTTAA
TCAACAAGGTGAGCTGGTGGCGTCTGCAACCCAGGAAGGCCTCATCCGTATGACAAAGAAAGCATAG

Upstream 100 bases:

>100_bases
GTCGGCAAATCAGCGTCACATCAATATAGAGTAAAACTGGCGAGGTTGGGGGATCTTGAGTTAAGCTTATGGCCATAATT
AGCTGATTTTTTAGGTTGTA

Downstream 100 bases:

>100_bases
TCAATGTTAGTAAAGTTTATATTAGATACTCAGGATTAGAATCATGATCTCATTAATGAAGAAAAGCATCGTACTTTTAT
GTGTCTTGGTATTGACGGCG

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSQVLDDLLALLSLEQIEEGLFRGQSQDLGFGHVFGGQVMGQALSAAKRTVSPDRKVHSLHSYFLRAGDEKLPIVYDVEI
MRDGGSFSARRVKAIQKGRPIFYMTCSFQTSEEGYEHQATMPDVPGPEGLLNQQELAMTLRDKVPSKVLEKFMADTPIEM
RLVNPSDPIAPKACEPIRYVWIRANGKLPDNFSVHDYLLAYASDFNFLVTAAQPHGVSFLTPGMRMATIDHAMWFHRPFD
FSQWLLYSIDSPNACGGRGFVRGQFFNQQGELVASATQEGLIRMTKKA

Sequences:

>Translated_288_residues
MSQVLDDLLALLSLEQIEEGLFRGQSQDLGFGHVFGGQVMGQALSAAKRTVSPDRKVHSLHSYFLRAGDEKLPIVYDVEI
MRDGGSFSARRVKAIQKGRPIFYMTCSFQTSEEGYEHQATMPDVPGPEGLLNQQELAMTLRDKVPSKVLEKFMADTPIEM
RLVNPSDPIAPKACEPIRYVWIRANGKLPDNFSVHDYLLAYASDFNFLVTAAQPHGVSFLTPGMRMATIDHAMWFHRPFD
FSQWLLYSIDSPNACGGRGFVRGQFFNQQGELVASATQEGLIRMTKKA
>Mature_287_residues
SQVLDDLLALLSLEQIEEGLFRGQSQDLGFGHVFGGQVMGQALSAAKRTVSPDRKVHSLHSYFLRAGDEKLPIVYDVEIM
RDGGSFSARRVKAIQKGRPIFYMTCSFQTSEEGYEHQATMPDVPGPEGLLNQQELAMTLRDKVPSKVLEKFMADTPIEMR
LVNPSDPIAPKACEPIRYVWIRANGKLPDNFSVHDYLLAYASDFNFLVTAAQPHGVSFLTPGMRMATIDHAMWFHRPFDF
SQWLLYSIDSPNACGGRGFVRGQFFNQQGELVASATQEGLIRMTKKA

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=292, Percent_Identity=42.4657534246575, Blast_Score=219, Evalue=2e-57,
Organism=Escherichia coli, GI1786657, Length=283, Percent_Identity=60.7773851590106, Blast_Score=355, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI71988741, Length=293, Percent_Identity=36.1774744027304, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17531889, Length=278, Percent_Identity=35.6115107913669, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI115532456, Length=278, Percent_Identity=35.6115107913669, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17531885, Length=278, Percent_Identity=35.6115107913669, Blast_Score=160, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17558508, Length=319, Percent_Identity=34.7962382445141, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71982224, Length=299, Percent_Identity=28.7625418060201, Blast_Score=123, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI212645202, Length=270, Percent_Identity=31.4814814814815, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32225; Mature: 32094

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVLDDLLALLSLEQIEEGLFRGQSQDLGFGHVFGGQVMGQALSAAKRTVSPDRKVHSL
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
HSYFLRAGDEKLPIVYDVEIMRDGGSFSARRVKAIQKGRPIFYMTCSFQTSEEGYEHQAT
HHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCC
MPDVPGPEGLLNQQELAMTLRDKVPSKVLEKFMADTPIEMRLVNPSDPIAPKACEPIRYV
CCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEE
WIRANGKLPDNFSVHDYLLAYASDFNFLVTAAQPHGVSFLTPGMRMATIDHAMWFHRPFD
EEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCEEECCCCEEHHHHHHHHHCCCCC
FSQWLLYSIDSPNACGGRGFVRGQFFNQQGELVASATQEGLIRMTKKA
CCCEEEEECCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQVLDDLLALLSLEQIEEGLFRGQSQDLGFGHVFGGQVMGQALSAAKRTVSPDRKVHSL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
HSYFLRAGDEKLPIVYDVEIMRDGGSFSARRVKAIQKGRPIFYMTCSFQTSEEGYEHQAT
HHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCC
MPDVPGPEGLLNQQELAMTLRDKVPSKVLEKFMADTPIEMRLVNPSDPIAPKACEPIRYV
CCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEE
WIRANGKLPDNFSVHDYLLAYASDFNFLVTAAQPHGVSFLTPGMRMATIDHAMWFHRPFD
EEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCEEECCCCEEHHHHHHHHHCCCCC
FSQWLLYSIDSPNACGGRGFVRGQFFNQQGELVASATQEGLIRMTKKA
CCCEEEEECCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]