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The map label for this gene is metA

Identifier: 157962605

GI number: 157962605

Start: 3402046

End: 3402990

Strand: Reverse

Name: metA

Synonym: Spea_2784

Alternate gene names: 157962605

Gene position: 3402990-3402046 (Counterclockwise)

Preceding gene: 157962606

Following gene: 157962604

Centisome position: 65.76

GC content: 45.08

Gene sequence:

>945_bases
ATGCCGGTTAAAATCCCCGATGATCTGCCCGCGGCAGAGATCTTGGAGTCTGAGAATATCTTCGTAATGTCGGAGACTCG
GGCTGCGAATCAAGATATTCGTCCAATGAAGGTATTAATTCTTAATTTAATGCCCAATAAGATTGAGACCGAAACCCAGC
TGCTACGTCTTCTTGGTAATACCCCGCTGCAAGTCGATGTGGATCTGCTCAGAATTCACGATAAAGCCTCTAAGCATACT
TCTATCGATCACATGAATAACTTCTATCGCGATTTTGAGCAGATCAGGCAGAAGAACTACGATGGCTTGATTATTACCGG
AGCGCCTCTGGGCAAGATTGAGTTTGACGAAGTTTCTTATTGGGATCATATTCGTGAGATCATCGATTGGTCACAGCAAC
ATGTCACCTCGGTACTTTTTTTATGCTGGGCGGCTCATGCTGCTCTGTATCACCTTTTTGGTTTAAACCGTTCGCTGTTA
GAAATAAAGCGCGCCGGGGTATTTTCCCACAAGCGCACAAGTGTGCATTACCCTTTGTTACGTGGTTTTGACGATGAGTT
TTTCGCTCCTCATTCCCGCTTTGCCGAAATGGATATTGAAAAGTTACGCGCCCACCCAGAGCTAGAGGTGTTAACCGAGT
CTGACGAGGCGGGCGCCTACATGGTACTGAGCAAAAATAACCGTAATCTGTTTGTGATGGGACATCCTGAATATCAAAAA
TCGACATTGAAAGATGAGTATAATCGCGATATAGCTCAGGGTTTGACGCCTGAGTTACCGAAAAACTACTTTAAAAATGA
CGATCCAGATCAGGAGCCGATCTCGCGTTGGCATAGTCATGGAAGCCTATTGGTCAGCAACTGGCTTAACTATTACGTCT
ATCAGCTTACGCCCTATAATTTAGATGATATGACAGGAATTACCCCTTGGGAGTCGAAGGACTAG

Upstream 100 bases:

>100_bases
TTAGTACAGAAGGTGGCACGCTAAATAGATTAACTGTGAGTTAGTTTAGCCGGCGCGCCTCTTTCTGATAGGTTACTTAA
TTAGGAAAAAGAGGCGCGCT

Downstream 100 bases:

>100_bases
TCGTCCTCACTTCACTCTAATAAGCCGATACCGCTACAGCGTATCGGCTTTTTTGTTTTTACCTTGTCTCCAGCAGCATC
TGTACCGCACAACTAATCAA

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MPVKIPDDLPAAEILESENIFVMSETRAANQDIRPMKVLILNLMPNKIETETQLLRLLGNTPLQVDVDLLRIHDKASKHT
SIDHMNNFYRDFEQIRQKNYDGLIITGAPLGKIEFDEVSYWDHIREIIDWSQQHVTSVLFLCWAAHAALYHLFGLNRSLL
EIKRAGVFSHKRTSVHYPLLRGFDDEFFAPHSRFAEMDIEKLRAHPELEVLTESDEAGAYMVLSKNNRNLFVMGHPEYQK
STLKDEYNRDIAQGLTPELPKNYFKNDDPDQEPISRWHSHGSLLVSNWLNYYVYQLTPYNLDDMTGITPWESKD

Sequences:

>Translated_314_residues
MPVKIPDDLPAAEILESENIFVMSETRAANQDIRPMKVLILNLMPNKIETETQLLRLLGNTPLQVDVDLLRIHDKASKHT
SIDHMNNFYRDFEQIRQKNYDGLIITGAPLGKIEFDEVSYWDHIREIIDWSQQHVTSVLFLCWAAHAALYHLFGLNRSLL
EIKRAGVFSHKRTSVHYPLLRGFDDEFFAPHSRFAEMDIEKLRAHPELEVLTESDEAGAYMVLSKNNRNLFVMGHPEYQK
STLKDEYNRDIAQGLTPELPKNYFKNDDPDQEPISRWHSHGSLLVSNWLNYYVYQLTPYNLDDMTGITPWESKD
>Mature_313_residues
PVKIPDDLPAAEILESENIFVMSETRAANQDIRPMKVLILNLMPNKIETETQLLRLLGNTPLQVDVDLLRIHDKASKHTS
IDHMNNFYRDFEQIRQKNYDGLIITGAPLGKIEFDEVSYWDHIREIIDWSQQHVTSVLFLCWAAHAALYHLFGLNRSLLE
IKRAGVFSHKRTSVHYPLLRGFDDEFFAPHSRFAEMDIEKLRAHPELEVLTESDEAGAYMVLSKNNRNLFVMGHPEYQKS
TLKDEYNRDIAQGLTPELPKNYFKNDDPDQEPISRWHSHGSLLVSNWLNYYVYQLTPYNLDDMTGITPWESKD

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=304, Percent_Identity=53.2894736842105, Blast_Score=359, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_SHEPA (A8H6B7)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001502639.1
- ProteinModelPortal:   A8H6B7
- SMR:   A8H6B7
- STRING:   A8H6B7
- GeneID:   5663177
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_2784
- NMPDR:   fig|398579.3.peg.2405
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- ProtClustDB:   PRK05368
- BioCyc:   SPEA398579:SPEA_2784-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 36557; Mature: 36426

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKIPDDLPAAEILESENIFVMSETRAANQDIRPMKVLILNLMPNKIETETQLLRLLGN
CCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCC
TPLQVDVDLLRIHDKASKHTSIDHMNNFYRDFEQIRQKNYDGLIITGAPLGKIEFDEVSY
CCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHH
WDHIREIIDWSQQHVTSVLFLCWAAHAALYHLFGLNRSLLEIKRAGVFSHKRTSVHYPLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHH
RGFDDEFFAPHSRFAEMDIEKLRAHPELEVLTESDEAGAYMVLSKNNRNLFVMGHPEYQK
HCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEEEEEECCHHHH
STLKDEYNRDIAQGLTPELPKNYFKNDDPDQEPISRWHSHGSLLVSNWLNYYVYQLTPYN
HHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHCEEEEEECCCC
LDDMTGITPWESKD
CCCCCCCCCCCCCC
>Mature Secondary Structure 
PVKIPDDLPAAEILESENIFVMSETRAANQDIRPMKVLILNLMPNKIETETQLLRLLGN
CCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCC
TPLQVDVDLLRIHDKASKHTSIDHMNNFYRDFEQIRQKNYDGLIITGAPLGKIEFDEVSY
CCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHH
WDHIREIIDWSQQHVTSVLFLCWAAHAALYHLFGLNRSLLEIKRAGVFSHKRTSVHYPLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHH
RGFDDEFFAPHSRFAEMDIEKLRAHPELEVLTESDEAGAYMVLSKNNRNLFVMGHPEYQK
HCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEEEEEECCHHHH
STLKDEYNRDIAQGLTPELPKNYFKNDDPDQEPISRWHSHGSLLVSNWLNYYVYQLTPYN
HHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHCEEEEEECCCC
LDDMTGITPWESKD
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA