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The map label for this gene is bioH [C]

Identifier: 157962270

GI number: 157962270

Start: 2992633

End: 2993508

Strand: Reverse

Name: bioH [C]

Synonym: Spea_2449

Alternate gene names: 157962270

Gene position: 2993508-2992633 (Counterclockwise)

Preceding gene: 157962271

Following gene: 157962269

Centisome position: 57.85

GC content: 44.52

Gene sequence:

>876_bases
ATGAGCTTAGTACGCGAGTTTGGTGATGAAGTTAGTATCCAGTTACCCCATATTAAGTTAGCAGGACGGCTATGGGGTAG
TGCGGATAAACCACTGATATTGGCGCTGCATGGTTGGTTAGATAATGCCAACAGTTTTCAGCCTTTGAGTGAACATTTAA
CCGATTACCAAATTCTCGCTATCGATTGGCCCGGACACGGCGGCTCAGAGCATCGTCCGGGCGCATATCCCTTGCATTGG
ATTGATTATTTGTACGATCTCGATGCTTTACTCCAGAAGTTACCTAACATTCAAGCTCCAGTGGCAATTTTAGGTCACTC
TCTTGGCGGGATCATAGCATCTGCGTATGCCGCTGCATTTCCTGATAGGGTTGAAAATTTGATCTTAATAGAGGCTTTAT
CTCCGCTCTATGAAGATGAATCTAAATCTAAAAATAGATTAGATAAGAGTTTTAGTGCTCACCGCAGGTTTCTCGCATCA
ATAGATAAACCCGCCAATGTTTACCGTGATATGGCTGTTGCTGTGCTCGCACGGCACAAATTAACCGCACTAGAGCTGCA
ATGGTGCGAATTATTGACCCAGCGCAATATGCAAATCTTCGATTCTGGGGTATGCTGGCGCAGTGATCCGCGCTTAAAAT
TAGACTCTCCTTTAAGACTGACATTTTCTCAAGTCGATGCCTTAATGCAAGCCCATAAAGTCAACACTCTATTAATTTCA
GGTAACCGAGGTTTCTCTCAGTTACGTGAGGCGATCCCTATGGCAAATCGCTGGTTCAAGCGGTTACAGAGTGTAGAAAT
TGAAGGGGATCATCACCTTCATATGGGGAGCGCTGAGAAGGTGTCGAAGGTCATTAGTGTTTTCTTAAAAGGCTAA

Upstream 100 bases:

>100_bases
CTCCACGTTTAGCGCTTGAAGATCAAGACAAACAAAAGTATCTCGCTATCGGAGAAAGCGATAGAATGACGCTGAAATTT
GTTAAAAAGTAAGACTATAG

Downstream 100 bases:

>100_bases
GCAAAAAAGAGGCTAGGATTTTTGTCTCATTTATGTGATGATAATCAAAATTTAAACGACCGTATGATTTGTCGGCGTTT
CCAATAAATATAATGAATAG

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: Hydrolase; Alpha/Beta Fold Family Hydrolase; Alpha/Beta Hydrolase Fold Protein; Alpha/Beta Hydrolase; Hydrolase Alpha/Beta Fold Family; Hydrolase Protein; Hydrolase/Acyltransferase; Lipase A; Lipase; Beta-Ketoacyl Synthase; Polyketide Synthase; Alpha/Beta Fold Superfamily Hydrolase; Esterase; Hydrolases Or Acyltransferases; Hydrolase Or Acytransferase; Alpha/Beta Hydrolase Family Protein; Lipase LipA; Hydrolase Alpha/Beta Fold Family Protein; Epoxide Hydrolase; Alpha/Beta Superfamily Hydrolase; Alpha/Beta Fold Hydrolase Family Protein; Alpha/Beta Superfamily Hydrolase/Acyltransferase

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSLVREFGDEVSIQLPHIKLAGRLWGSADKPLILALHGWLDNANSFQPLSEHLTDYQILAIDWPGHGGSEHRPGAYPLHW
IDYLYDLDALLQKLPNIQAPVAILGHSLGGIIASAYAAAFPDRVENLILIEALSPLYEDESKSKNRLDKSFSAHRRFLAS
IDKPANVYRDMAVAVLARHKLTALELQWCELLTQRNMQIFDSGVCWRSDPRLKLDSPLRLTFSQVDALMQAHKVNTLLIS
GNRGFSQLREAIPMANRWFKRLQSVEIEGDHHLHMGSAEKVSKVISVFLKG

Sequences:

>Translated_291_residues
MSLVREFGDEVSIQLPHIKLAGRLWGSADKPLILALHGWLDNANSFQPLSEHLTDYQILAIDWPGHGGSEHRPGAYPLHW
IDYLYDLDALLQKLPNIQAPVAILGHSLGGIIASAYAAAFPDRVENLILIEALSPLYEDESKSKNRLDKSFSAHRRFLAS
IDKPANVYRDMAVAVLARHKLTALELQWCELLTQRNMQIFDSGVCWRSDPRLKLDSPLRLTFSQVDALMQAHKVNTLLIS
GNRGFSQLREAIPMANRWFKRLQSVEIEGDHHLHMGSAEKVSKVISVFLKG
>Mature_290_residues
SLVREFGDEVSIQLPHIKLAGRLWGSADKPLILALHGWLDNANSFQPLSEHLTDYQILAIDWPGHGGSEHRPGAYPLHWI
DYLYDLDALLQKLPNIQAPVAILGHSLGGIIASAYAAAFPDRVENLILIEALSPLYEDESKSKNRLDKSFSAHRRFLASI
DKPANVYRDMAVAVLARHKLTALELQWCELLTQRNMQIFDSGVCWRSDPRLKLDSPLRLTFSQVDALMQAHKVNTLLISG
NRGFSQLREAIPMANRWFKRLQSVEIEGDHHLHMGSAEKVSKVISVFLKG

Specific function: Not Clear. Seems To Be Implicated In The Early Steps Of Biotin Biosynthesis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI18777795, Length=305, Percent_Identity=27.5409836065574, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24655874, Length=298, Percent_Identity=29.1946308724832, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137390, Length=294, Percent_Identity=31.2925170068027, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24655886, Length=294, Percent_Identity=27.891156462585, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357291, Length=300, Percent_Identity=26.6666666666667, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356953, Length=292, Percent_Identity=26.7123287671233, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667992, Length=295, Percent_Identity=27.1186440677966, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356937, Length=294, Percent_Identity=26.1904761904762, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667999, Length=295, Percent_Identity=26.7796610169492, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 32741; Mature: 32610

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVREFGDEVSIQLPHIKLAGRLWGSADKPLILALHGWLDNANSFQPLSEHLTDYQILA
CCHHHHCCCCCEEEECCEEEEHHHCCCCCCCEEEEEECCCCCCCCCCHHHHCCCCEEEEE
IDWPGHGGSEHRPGAYPLHWIDYLYDLDALLQKLPNIQAPVAILGHSLGGIIASAYAAAF
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
PDRVENLILIEALSPLYEDESKSKNRLDKSFSAHRRFLASIDKPANVYRDMAVAVLARHK
HHHHHHEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LTALELQWCELLTQRNMQIFDSGVCWRSDPRLKLDSPLRLTFSQVDALMQAHKVNTLLIS
HHHHHHHHHHHHHHCCCCEECCCCEECCCCCEECCCCHHHHHHHHHHHHHHHCCCEEEEE
GNRGFSQLREAIPMANRWFKRLQSVEIEGDHHLHMGSAEKVSKVISVFLKG
CCCCHHHHHHHCCHHHHHHHHHHCEECCCCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLVREFGDEVSIQLPHIKLAGRLWGSADKPLILALHGWLDNANSFQPLSEHLTDYQILA
CHHHHCCCCCEEEECCEEEEHHHCCCCCCCEEEEEECCCCCCCCCCHHHHCCCCEEEEE
IDWPGHGGSEHRPGAYPLHWIDYLYDLDALLQKLPNIQAPVAILGHSLGGIIASAYAAAF
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
PDRVENLILIEALSPLYEDESKSKNRLDKSFSAHRRFLASIDKPANVYRDMAVAVLARHK
HHHHHHEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LTALELQWCELLTQRNMQIFDSGVCWRSDPRLKLDSPLRLTFSQVDALMQAHKVNTLLIS
HHHHHHHHHHHHHHCCCCEECCCCEECCCCCEECCCCHHHHHHHHHHHHHHHCCCEEEEE
GNRGFSQLREAIPMANRWFKRLQSVEIEGDHHLHMGSAEKVSKVISVFLKG
CCCCHHHHHHHCCHHHHHHHHHHCEECCCCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA