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The map label for this gene is rnd [H]

Identifier: 157962268

GI number: 157962268

Start: 2989575

End: 2990684

Strand: Reverse

Name: rnd [H]

Synonym: Spea_2447

Alternate gene names: 157962268

Gene position: 2990684-2989575 (Counterclockwise)

Preceding gene: 157962269

Following gene: 157962264

Centisome position: 57.8

GC content: 41.08

Gene sequence:

>1110_bases
TTGTTAGCGTTTCAATATATTGAAGATGATGCCAGTTTAGCGGCCCTTGTAGAGCAATACCAAGATGCTGATTTATTGGT
GCTAGACACAGAATTTGTTCGTACTCGTACCTATTATGCAAGATTGGGCCTTATTCAAGCCTATGATGGTAAGACTCTTG
CGTTAATCGATCCATTAGCTGTGAGTAACCTTGAATTATTTTGGCAACTGCTAAGCAAAGAAAGCAGCGTTAAGTTACTG
CATTCATGTAGTGAAGACTTAGAAGTGTTTGCACGCTATGGCAATTGCCAACCTACTAATCTATTCGATAGTCAAATTGC
TGCAGGTCTAGCTGGTATGGGGCATGGTCTAGGTTATGCCAAGCTTGTAGAGCAAACTCTTGAAGTAAGCTTAGATAAAG
GTGAGTCTCGCACCGACTGGCTAAAACGACCTTTGACAGAGGCGCAGCTCAACTACGCTGCCAATGATGTCTATTACCTT
TATAAGCTCTACCCACAATTGGTTAAGTTATTAGAAGAGCAGGGCAGACTAGATTGGGTCTATGAAGAAGGCGTTCGTAT
GACTCAAGGACGTTTAGATACTCCGGAACCTGAGACTGCCTATTTAAAGGTTAAAAATGCCTTTCAGCTATCCTCAAATC
AGCTGGCTGTATTGAGGGATTTATCTCAGTGGCGCCTAAAGCGAGCGTTACAGAAAGATCTGGCTTTGGGCTTTGTGGTG
AAAGATCATGCTCTGATTGCCTTAGCTAAGAAGCAGCCTAAGTCAACCAATGATCTCTTTAAAATGACGGAACTCACGGA
GCAGGAAAAGCGTATTCATGGTAAAGAGATCATTAAGATCATTACCAATGTTAGTTACGATAACCCGCCTAAGCCATTAG
ATGTTATCGCTCTTAAAACCGGTTATAAAAACGCATTTAAGAGTATTAAAAACAGCATTACAGAACAAGCAGAATCTAAG
AGTATCCCGTTAGAGTTATTAGGCTCTAAAAAGTATATACATGAATACTTACAGTGGGTTTGGGATGCTAAGAAAGGGAA
TAAACCACTTATTCTTACGGGTTGGCGAGAAGCGATAGTTGCCGAGTCTTTATCAGCACTGAAGTTATAA

Upstream 100 bases:

>100_bases
AAGTAAGACTAGCCTCGTCAGTCATTAAGTGGTGATTGCCACTTTTGATACACTAAAGCCGGCAATAGCCGGCTTTTGCA
TATTTATGGAGTAGACAACT

Downstream 100 bases:

>100_bases
TACCAATTCGTAAAACAAAAAAGCCCGCGTAAGCGGGCTTTTTATTGGGGGCTAGGCGTTTAGTTCTGCTCTGGAAGAGT
CACGTTAAGCTCAAGCACTG

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MLAFQYIEDDASLAALVEQYQDADLLVLDTEFVRTRTYYARLGLIQAYDGKTLALIDPLAVSNLELFWQLLSKESSVKLL
HSCSEDLEVFARYGNCQPTNLFDSQIAAGLAGMGHGLGYAKLVEQTLEVSLDKGESRTDWLKRPLTEAQLNYAANDVYYL
YKLYPQLVKLLEEQGRLDWVYEEGVRMTQGRLDTPEPETAYLKVKNAFQLSSNQLAVLRDLSQWRLKRALQKDLALGFVV
KDHALIALAKKQPKSTNDLFKMTELTEQEKRIHGKEIIKIITNVSYDNPPKPLDVIALKTGYKNAFKSIKNSITEQAESK
SIPLELLGSKKYIHEYLQWVWDAKKGNKPLILTGWREAIVAESLSALKL

Sequences:

>Translated_369_residues
MLAFQYIEDDASLAALVEQYQDADLLVLDTEFVRTRTYYARLGLIQAYDGKTLALIDPLAVSNLELFWQLLSKESSVKLL
HSCSEDLEVFARYGNCQPTNLFDSQIAAGLAGMGHGLGYAKLVEQTLEVSLDKGESRTDWLKRPLTEAQLNYAANDVYYL
YKLYPQLVKLLEEQGRLDWVYEEGVRMTQGRLDTPEPETAYLKVKNAFQLSSNQLAVLRDLSQWRLKRALQKDLALGFVV
KDHALIALAKKQPKSTNDLFKMTELTEQEKRIHGKEIIKIITNVSYDNPPKPLDVIALKTGYKNAFKSIKNSITEQAESK
SIPLELLGSKKYIHEYLQWVWDAKKGNKPLILTGWREAIVAESLSALKL
>Mature_369_residues
MLAFQYIEDDASLAALVEQYQDADLLVLDTEFVRTRTYYARLGLIQAYDGKTLALIDPLAVSNLELFWQLLSKESSVKLL
HSCSEDLEVFARYGNCQPTNLFDSQIAAGLAGMGHGLGYAKLVEQTLEVSLDKGESRTDWLKRPLTEAQLNYAANDVYYL
YKLYPQLVKLLEEQGRLDWVYEEGVRMTQGRLDTPEPETAYLKVKNAFQLSSNQLAVLRDLSQWRLKRALQKDLALGFVV
KDHALIALAKKQPKSTNDLFKMTELTEQEKRIHGKEIIKIITNVSYDNPPKPLDVIALKTGYKNAFKSIKNSITEQAESK
SIPLELLGSKKYIHEYLQWVWDAKKGNKPLILTGWREAIVAESLSALKL

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=260, Percent_Identity=25.7692307692308, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI50301240, Length=260, Percent_Identity=25.7692307692308, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1788105, Length=370, Percent_Identity=41.0810810810811, Blast_Score=269, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17531757, Length=260, Percent_Identity=26.1538461538462, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324574, Length=293, Percent_Identity=23.8907849829352, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161078302, Length=257, Percent_Identity=27.6264591439689, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 41910; Mature: 41910

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAFQYIEDDASLAALVEQYQDADLLVLDTEFVRTRTYYARLGLIQAYDGKTLALIDPLA
CCEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCEEEECCCCEEEEECCHH
VSNLELFWQLLSKESSVKLLHSCSEDLEVFARYGNCQPTNLFDSQIAAGLAGMGHGLGYA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHH
KLVEQTLEVSLDKGESRTDWLKRPLTEAQLNYAANDVYYLYKLYPQLVKLLEEQGRLDWV
HHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
YEEGVRMTQGRLDTPEPETAYLKVKNAFQLSSNQLAVLRDLSQWRLKRALQKDLALGFVV
HHCCCHHHCCCCCCCCCCEEEEEEECHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEE
KDHALIALAKKQPKSTNDLFKMTELTEQEKRIHGKEIIKIITNVSYDNPPKPLDVIALKT
ECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEC
GYKNAFKSIKNSITEQAESKSIPLELLGSKKYIHEYLQWVWDAKKGNKPLILTGWREAIV
CHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECHHHHHH
AESLSALKL
HHHHHHHCC
>Mature Secondary Structure
MLAFQYIEDDASLAALVEQYQDADLLVLDTEFVRTRTYYARLGLIQAYDGKTLALIDPLA
CCEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCEEEECCCCEEEEECCHH
VSNLELFWQLLSKESSVKLLHSCSEDLEVFARYGNCQPTNLFDSQIAAGLAGMGHGLGYA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHH
KLVEQTLEVSLDKGESRTDWLKRPLTEAQLNYAANDVYYLYKLYPQLVKLLEEQGRLDWV
HHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
YEEGVRMTQGRLDTPEPETAYLKVKNAFQLSSNQLAVLRDLSQWRLKRALQKDLALGFVV
HHCCCHHHCCCCCCCCCCEEEEEEECHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEE
KDHALIALAKKQPKSTNDLFKMTELTEQEKRIHGKEIIKIITNVSYDNPPKPLDVIALKT
ECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEC
GYKNAFKSIKNSITEQAESKSIPLELLGSKKYIHEYLQWVWDAKKGNKPLILTGWREAIV
CHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECHHHHHH
AESLSALKL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]