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The map label for this gene is edd [H]

Identifier: 157962154

GI number: 157962154

Start: 2841357

End: 2843183

Strand: Reverse

Name: edd [H]

Synonym: Spea_2333

Alternate gene names: 157962154

Gene position: 2843183-2841357 (Counterclockwise)

Preceding gene: 157962155

Following gene: 157962153

Centisome position: 54.95

GC content: 48.66

Gene sequence:

>1827_bases
ATGCACAGCGTTGTACAATCTGTTACTGACAGAATTATTGAACGAAGCAAAGATTCTCGCGCTAAGTATTTAGCGGCGCT
CGATGATGCTAAAAATAAAGGCGTTCACCGTAGCGCACTGAGTTGCGGTAACTTAGCTCACGGTTTTGCAGCTTGTAACC
CAAGCGACAAGTCCGACATAAAGCAGTTAAACAAAGCAAATATCGGTATTATCACTTCTTTTAACGACATGTTGTCTGCT
CACCAACCATACGGTGCGTACCCAGACTTGTTGAAACAGGCTTGTAACGAAGTCGGTAGTGTTGCACAAGTTGCAGGCGG
CGTTCCTGCTATGTGTGATGGCGTGACCCAAGGTCAGCCTGGCATGGAGCTTAGCCTGTTAAGCCGTGAAGTGATTGCCA
TGGGAACAGCGGTAGGTCTATCCCATAACATGTTCGACGGTGCTTTGCTGCTAGGTATTTGCGACAAGATTGTACCGGGT
CTGTTGATTGGTGCACTGAGCTTTGGCCATTTGCCTATGCTATTTGTACCTGCTGGCCCGATGAAGTCGGGTATTCCTAA
TAAGGAAAAGGCGCGTATTCGTCAAAAGTATGCCCAAGGCGAAATCGACAGAGCGGCATTGTTAGATGCTGAGTCTAAGT
CTTATCACAGTGCGGGTACTTGTACTTTCTACGGCACGGCCAACAGTAACCAGTTGATGCTAGAGGTGATGGGACTTCAA
TTACCTGGCTCATCTTTTGTTAATCCAGACGATCCGCTACGTGAAGTCTTGAGCAAGACAGCCGCTAAGCAGGTTTGTCG
TCTAACCGAAATGGGTACTCAATATACGCCAATCGGTAAAGTCGTATCTGAAAAATCAGTGGTTAACGGTATCGTTGCAC
TATTGGCAACGGGTGGCTCGACTAATCTGACCATGCACATAGTGGCCGCGGCTCGCGCTGCTGGCATTATCGTCAACTGG
GATGATTTCTCTGAGCTTTCAGATGCAGTGCCGCTACTAGCACGTGTGTATCCAAACGGTCACGCCGATATTAACCACTT
CCACGCTGCTGGCGGTATGGCGTTCTTAATAAAAGAACTGCTGGACGGCGGCTTACTTCATGAAGATGTCGATACAGTCG
CAGGTTTTGGTCTTAAGCGTTATACCCAAGAGCCGCAAATCCGTGATGGCGAGCTTAAATGGGTCGATGGTCCGCAAACA
AGCTTAGATAACGAAGTGCTAACGGGGCTTAACACGCCGTTCCAAAACAACGGTGGCCTAAAGCTGCTTAAAGGTAATCT
GGGCCGCGCGGTGATTAAAGTGTCTGCAGTGGCTGAGCAACATCGAGTTGTTGAAGCGCCAGCAGTGGTGATTGACGATC
AAAACAAGCTTGAAGCTATCTTTAAAGCGGGTGATTTAGATAAAGATTGCGTGGTGGTAGTAAAAGGTCAAGGACCAAAA
GCCATCGGCATGCCGGAGCTACATAAGCTCACTCCTATCCTTGGTACGCTACAAGATAGAGGCTATAAGGTCGCTCTACT
GACTGACGGCCGTATGTCAGGCGCGTCTGGCAAGGTGCCTGCAGCCATTCATTTAACGCCAGAGGCGTTAGATGGCGGTC
TAATCGCTAAGATCCACAATGGTGATTTAGTTCGAGTCGATGCGACAACGGGTGAACTGTCTCTGCTAGTCGATGAGGCC
GAGCTTAATGCAAGAGCTGCCGATAAAGTCGATCTGCAAAGAACAAGTTATGGAATGGGACGAGAGCTTTTCGGTGCACT
GCGCGCAAGCTTAAGCAGTCCAGAAACTGGTGCGCGATGCACTAGTGCTATTGATGAACACTATTAA

Upstream 100 bases:

>100_bases
AGCACTAGCAAGCGAAGACACGCGTGAAATGCCAATTCGAGCCGTTCTCGAACAGCATAAAACACCTGTTGATGTTTACT
GGAGCGCTTAAGGAGTAATT

Downstream 100 bases:

>100_bases
AGTTTAAGGAAGAGTAACGCAATGCTTGAGAATAACTGGTTAATACAGCCACAAGATATTTTTAAACGCAGCCCTATTGT
TCCTGTAATGGTGATCAATA

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MHSVVQSVTDRIIERSKDSRAKYLAALDDAKNKGVHRSALSCGNLAHGFAACNPSDKSDIKQLNKANIGIITSFNDMLSA
HQPYGAYPDLLKQACNEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMGTAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQKYAQGEIDRAALLDAESKSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREVLSKTAAKQVCRLTEMGTQYTPIGKVVSEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKELLDGGLLHEDVDTVAGFGLKRYTQEPQIRDGELKWVDGPQT
SLDNEVLTGLNTPFQNNGGLKLLKGNLGRAVIKVSAVAEQHRVVEAPAVVIDDQNKLEAIFKAGDLDKDCVVVVKGQGPK
AIGMPELHKLTPILGTLQDRGYKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKIHNGDLVRVDATTGELSLLVDEA
ELNARAADKVDLQRTSYGMGRELFGALRASLSSPETGARCTSAIDEHY

Sequences:

>Translated_608_residues
MHSVVQSVTDRIIERSKDSRAKYLAALDDAKNKGVHRSALSCGNLAHGFAACNPSDKSDIKQLNKANIGIITSFNDMLSA
HQPYGAYPDLLKQACNEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMGTAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQKYAQGEIDRAALLDAESKSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREVLSKTAAKQVCRLTEMGTQYTPIGKVVSEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKELLDGGLLHEDVDTVAGFGLKRYTQEPQIRDGELKWVDGPQT
SLDNEVLTGLNTPFQNNGGLKLLKGNLGRAVIKVSAVAEQHRVVEAPAVVIDDQNKLEAIFKAGDLDKDCVVVVKGQGPK
AIGMPELHKLTPILGTLQDRGYKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKIHNGDLVRVDATTGELSLLVDEA
ELNARAADKVDLQRTSYGMGRELFGALRASLSSPETGARCTSAIDEHY
>Mature_608_residues
MHSVVQSVTDRIIERSKDSRAKYLAALDDAKNKGVHRSALSCGNLAHGFAACNPSDKSDIKQLNKANIGIITSFNDMLSA
HQPYGAYPDLLKQACNEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMGTAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQKYAQGEIDRAALLDAESKSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREVLSKTAAKQVCRLTEMGTQYTPIGKVVSEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKELLDGGLLHEDVDTVAGFGLKRYTQEPQIRDGELKWVDGPQT
SLDNEVLTGLNTPFQNNGGLKLLKGNLGRAVIKVSAVAEQHRVVEAPAVVIDDQNKLEAIFKAGDLDKDCVVVVKGQGPK
AIGMPELHKLTPILGTLQDRGYKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKIHNGDLVRVDATTGELSLLVDEA
ELNARAADKVDLQRTSYGMGRELFGALRASLSSPETGARCTSAIDEHY

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=65.4485049833887, Blast_Score=835, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=573, Percent_Identity=29.4938917975567, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI2367371, Length=481, Percent_Identity=31.3929313929314, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1786464, Length=473, Percent_Identity=29.3868921775898, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322476, Length=476, Percent_Identity=28.9915966386555, Blast_Score=170, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64406; Mature: 64406

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSVVQSVTDRIIERSKDSRAKYLAALDDAKNKGVHRSALSCGNLAHGFAACNPSDKSDI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHCCCCCCCCCCHHHH
KQLNKANIGIITSFNDMLSAHQPYGAYPDLLKQACNEVGSVAQVAGGVPAMCDGVTQGQP
HHHHCCCEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMGTAVGLSHNMFDGALLLGICDKIVPGLLIGALSFGHLPMLFVPAGP
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MKSGIPNKEKARIRQKYAQGEIDRAALLDAESKSYHSAGTCTFYGTANSNQLMLEVMGLQ
CCCCCCCHHHHHHHHHHHCCCCCHHHEECCCCCCCCCCCCEEEEECCCCCEEEEEEECEE
LPGSSFVNPDDPLREVLSKTAAKQVCRLTEMGTQYTPIGKVVSEKSVVNGIVALLATGGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHIVAAARAAGIIVNWDDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKEL
CCEEEEEEEEHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHH
LDGGLLHEDVDTVAGFGLKRYTQEPQIRDGELKWVDGPQTSLDNEVLTGLNTPFQNNGGL
HCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCE
KLLKGNLGRAVIKVSAVAEQHRVVEAPAVVIDDQNKLEAIFKAGDLDKDCVVVVKGQGPK
EEEECCCCCCHHHHHHHHHHHHHEECCEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCC
AIGMPELHKLTPILGTLQDRGYKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKIHN
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHCCCCEEEEEEC
GDLVRVDATTGELSLLVDEAELNARAADKVDLQRTSYGMGRELFGALRASLSSPETGARC
CCEEEEECCCCCEEEEEEHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHH
TSAIDEHY
HHHHHCCC
>Mature Secondary Structure
MHSVVQSVTDRIIERSKDSRAKYLAALDDAKNKGVHRSALSCGNLAHGFAACNPSDKSDI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHCCCCCCCCCCHHHH
KQLNKANIGIITSFNDMLSAHQPYGAYPDLLKQACNEVGSVAQVAGGVPAMCDGVTQGQP
HHHHCCCEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMGTAVGLSHNMFDGALLLGICDKIVPGLLIGALSFGHLPMLFVPAGP
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MKSGIPNKEKARIRQKYAQGEIDRAALLDAESKSYHSAGTCTFYGTANSNQLMLEVMGLQ
CCCCCCCHHHHHHHHHHHCCCCCHHHEECCCCCCCCCCCCEEEEECCCCCEEEEEEECEE
LPGSSFVNPDDPLREVLSKTAAKQVCRLTEMGTQYTPIGKVVSEKSVVNGIVALLATGGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHIVAAARAAGIIVNWDDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKEL
CCEEEEEEEEHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHH
LDGGLLHEDVDTVAGFGLKRYTQEPQIRDGELKWVDGPQTSLDNEVLTGLNTPFQNNGGL
HCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCE
KLLKGNLGRAVIKVSAVAEQHRVVEAPAVVIDDQNKLEAIFKAGDLDKDCVVVVKGQGPK
EEEECCCCCCHHHHHHHHHHHHHEECCEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCC
AIGMPELHKLTPILGTLQDRGYKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKIHN
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHCCCCEEEEEEC
GDLVRVDATTGELSLLVDEAELNARAADKVDLQRTSYGMGRELFGALRASLSSPETGARC
CCEEEEECCCCCEEEEEEHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHH
TSAIDEHY
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]