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The map label for this gene is zitB [H]

Identifier: 157962149

GI number: 157962149

Start: 2837287

End: 2838264

Strand: Reverse

Name: zitB [H]

Synonym: Spea_2328

Alternate gene names: 157962149

Gene position: 2838264-2837287 (Counterclockwise)

Preceding gene: 157962151

Following gene: 157962148

Centisome position: 54.85

GC content: 42.74

Gene sequence:

>978_bases
ATGAACGATGGTGAACAGGCTGCAATTCATTGCGTAGATAAACAGAAGTTTTCAACCCAAAATAGTTCGGGTGAACGTAA
TACGTTTTATGTCTTAGTGCTTACGATAGTGACTATGCTGGCAGAGATCATTGCCGGTACCATTTATGGTTCAATGGCAT
TATTAGCTGATGGCTGGCATATGGGAACCCACGCAGCGGCTTTTATGATTACCTTGTTTGCTTACCGTTATGCACGAAAG
CATGCTAATTCTGCGGAGTTTTCATATGGGACTGGTAAGGTTAGCGTACTCGGGGGCTACACCAGTGCGATCGCCTTGGG
CTTAGTCGCCCTCGTGATGCTGGTAGAGTCGAGTGTGAGAATTTTTAATCCTCATGAGATCTATTTCAACCAGGCTATTT
TGGTGGCGATTATTGGTCTTATTGTTAATGTAGTCAGTGTTTTTTTATTGAAAGATCATCATAGCCACGATCATGGAAAT
GAGCACGGACATAAGCACGGACATAATCACGAACACAGCCATGAACATAAGCATAGCCATCATCATGGCCAAGATCATAA
TCTACGGGCTGCCTACTTTCACGTCCTTGCCGATGCGCTCACTTCGCTGTTAGCAATAGCAGCTTTATTGATGGGTAAAT
ATTTTGGTCTAACTTGGCTGGATCCTATTATGGGTATTGTGGGGGCAGTGATTATTACTCGTTGGGCATGGGGACTGCTT
AAACAAACAGGGCCAGTATTGTTGGATGCAAGTATTGAACAAAGCTACATGCAGCAGATCAGACAAACCATTGAGCAAGA
AAGCGCACAGCTTGTAGATCTGCATATTTGGAAAATCAGTGCCGACCATTATGCTGCTAGTATGATCATTCATTGTGAAC
GTACTGAAAAAGCAGGTTATTTTAAGGAAAAGCTATCACAATTTGAGCGCTTATCTCATATCACTATTGAAGTTAATCCA
GTGACTCAGGCACAATAA

Upstream 100 bases:

>100_bases
TGGTCAGACAGGCTTGTAAACAGAAGTGATAAGTCAGAAATGAACGATAGCTAAGAGGTTATGGCTAGATGTTAAAACAA
AATATTCAAGGGTGTTATTT

Downstream 100 bases:

>100_bases
GCCCCTTATAACGAGGAATGAACACAATGAAGAACCAAGATGATAGCCTAAATCATGCAATGATCGAGTTTTACGAGAAG
TTATCATCTTGGGAAATGGC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MNDGEQAAIHCVDKQKFSTQNSSGERNTFYVLVLTIVTMLAEIIAGTIYGSMALLADGWHMGTHAAAFMITLFAYRYARK
HANSAEFSYGTGKVSVLGGYTSAIALGLVALVMLVESSVRIFNPHEIYFNQAILVAIIGLIVNVVSVFLLKDHHSHDHGN
EHGHKHGHNHEHSHEHKHSHHHGQDHNLRAAYFHVLADALTSLLAIAALLMGKYFGLTWLDPIMGIVGAVIITRWAWGLL
KQTGPVLLDASIEQSYMQQIRQTIEQESAQLVDLHIWKISADHYAASMIIHCERTEKAGYFKEKLSQFERLSHITIEVNP
VTQAQ

Sequences:

>Translated_325_residues
MNDGEQAAIHCVDKQKFSTQNSSGERNTFYVLVLTIVTMLAEIIAGTIYGSMALLADGWHMGTHAAAFMITLFAYRYARK
HANSAEFSYGTGKVSVLGGYTSAIALGLVALVMLVESSVRIFNPHEIYFNQAILVAIIGLIVNVVSVFLLKDHHSHDHGN
EHGHKHGHNHEHSHEHKHSHHHGQDHNLRAAYFHVLADALTSLLAIAALLMGKYFGLTWLDPIMGIVGAVIITRWAWGLL
KQTGPVLLDASIEQSYMQQIRQTIEQESAQLVDLHIWKISADHYAASMIIHCERTEKAGYFKEKLSQFERLSHITIEVNP
VTQAQ
>Mature_325_residues
MNDGEQAAIHCVDKQKFSTQNSSGERNTFYVLVLTIVTMLAEIIAGTIYGSMALLADGWHMGTHAAAFMITLFAYRYARK
HANSAEFSYGTGKVSVLGGYTSAIALGLVALVMLVESSVRIFNPHEIYFNQAILVAIIGLIVNVVSVFLLKDHHSHDHGN
EHGHKHGHNHEHSHEHKHSHHHGQDHNLRAAYFHVLADALTSLLAIAALLMGKYFGLTWLDPIMGIVGAVIITRWAWGLL
KQTGPVLLDASIEQSYMQQIRQTIEQESAQLVDLHIWKISADHYAASMIIHCERTEKAGYFKEKLSQFERLSHITIEVNP
VTQAQ

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI222080086, Length=315, Percent_Identity=28.5714285714286, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI40255009, Length=315, Percent_Identity=28.5714285714286, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI20070323, Length=290, Percent_Identity=29.3103448275862, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI52351208, Length=125, Percent_Identity=29.6, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI52352805, Length=319, Percent_Identity=21.3166144200627, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI21359890, Length=290, Percent_Identity=24.4827586206897, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1786966, Length=257, Percent_Identity=28.0155642023346, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32564488, Length=305, Percent_Identity=26.2295081967213, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193210990, Length=288, Percent_Identity=30.9027777777778, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17555794, Length=282, Percent_Identity=27.3049645390071, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17555796, Length=287, Percent_Identity=27.5261324041812, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17550442, Length=203, Percent_Identity=25.1231527093596, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17550440, Length=203, Percent_Identity=25.1231527093596, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=334, Percent_Identity=26.9461077844311, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320411, Length=198, Percent_Identity=25.7575757575758, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324892, Length=359, Percent_Identity=22.2841225626741, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24656728, Length=313, Percent_Identity=26.1980830670927, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656724, Length=313, Percent_Identity=26.1980830670927, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656720, Length=313, Percent_Identity=26.1980830670927, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656715, Length=313, Percent_Identity=26.1980830670927, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357035, Length=313, Percent_Identity=26.1980830670927, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24645863, Length=324, Percent_Identity=25.6172839506173, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36214; Mature: 36214

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDGEQAAIHCVDKQKFSTQNSSGERNTFYVLVLTIVTMLAEIIAGTIYGSMALLADGWH
CCCCCCHHEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MGTHAAAFMITLFAYRYARKHANSAEFSYGTGKVSVLGGYTSAIALGLVALVMLVESSVR
CHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCE
IFNPHEIYFNQAILVAIIGLIVNVVSVFLLKDHHSHDHGNEHGHKHGHNHEHSHEHKHSH
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
HHGQDHNLRAAYFHVLADALTSLLAIAALLMGKYFGLTWLDPIMGIVGAVIITRWAWGLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KQTGPVLLDASIEQSYMQQIRQTIEQESAQLVDLHIWKISADHYAASMIIHCERTEKAGY
HCCCCEEEECHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCHHHHHHEEEEECCCCCHH
FKEKLSQFERLSHITIEVNPVTQAQ
HHHHHHHHHHHHEEEEEECCCCCCC
>Mature Secondary Structure
MNDGEQAAIHCVDKQKFSTQNSSGERNTFYVLVLTIVTMLAEIIAGTIYGSMALLADGWH
CCCCCCHHEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MGTHAAAFMITLFAYRYARKHANSAEFSYGTGKVSVLGGYTSAIALGLVALVMLVESSVR
CHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCE
IFNPHEIYFNQAILVAIIGLIVNVVSVFLLKDHHSHDHGNEHGHKHGHNHEHSHEHKHSH
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
HHGQDHNLRAAYFHVLADALTSLLAIAALLMGKYFGLTWLDPIMGIVGAVIITRWAWGLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KQTGPVLLDASIEQSYMQQIRQTIEQESAQLVDLHIWKISADHYAASMIIHCERTEKAGY
HCCCCEEEECHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCHHHHHHEEEEECCCCCHH
FKEKLSQFERLSHITIEVNPVTQAQ
HHHHHHHHHHHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]