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The map label for this gene is serC

Identifier: 157961890

GI number: 157961890

Start: 2508137

End: 2509228

Strand: Direct

Name: serC

Synonym: Spea_2069

Alternate gene names: 157961890

Gene position: 2508137-2509228 (Clockwise)

Preceding gene: 157961888

Following gene: 157961892

Centisome position: 48.47

GC content: 45.88

Gene sequence:

>1092_bases
GTGAGCGCGATTTTCAACTTCTGTGCAGGCCCAGCCATGCTCCCCCCTGCTGTTATGCAAAAGGCTCAGAAAGAACTGTT
AAACTGGAATGGCCTAGGTATTTCCGTTATGGAAATTAGTCATCGTAGTAAGGAGTTCATCGCGTTAACCGAGCAAGCAG
AAGCGGACTTACGCGCTCTGATGGAGATCCCATCCAATTACCATGTGCTGTTTATGCACGGTGGTGGTCGTGGCCAATTC
TCTGCTGTTGTGAATAATTTTCTTGGTAATGATGGTCGAGCCCTCTATCTTGTCGATGGAAGCTGGTCAAAGGCTGCGGC
TGAAGAGGCTGAAAAGCTAGTCGGTAAGGCAAATATTGATAGCATAGAGCTAGTCAGTGCTGTCAATTGTTTAAACCGAG
TTACCCTGCCAGATTTAAGTAAAATAGATAAAGATTATCGCTACGTTCACTACTGTCCAAATGAGACTGTTGATGGTATC
GAAATTTTTGATGATATTAACAGTCCGTGGCCTGTTATTGCCGATATGTCTTCTAACATTTTGTCGCGTAAGATTGATGT
TAGTCAGTTCGGTTTGATTTATGCGGGTGCGCAGAAGAACATCGGGCCATCGGGTTTAAGTATCGTAATCGTCCGTGATG
ATATGTTGGCCCTACCAAGTTTGCCGCAATCATCCATCATGGATTATCGCTTAGCGGTAGAAAACGACTCCATGTATAAC
ACTCCGCCGACCTTTGCATGGTACTTAGCCGCCGAAGTATTTGCTTGGCTCAAATGCGTTGGGGGAGTAACTGAGATGGA
GAAACTCAATATCGAGAAGGCTAGGCGCTTGTATGAGTGTATCGACGAGCTAGATTTCTACGTCAGCGGCGTAGCAAAAG
AGAATCGTAGCCGTATGAATATTACATTCCAGCTAACCAATTCTCAGCTAGATAGTCAGTTTTTAGCCGAGGCTCAAGCT
GCCGGGCTCGTCGCGCTAAAAGGGCATCGTAGTGTTGGTGGTATGCGAGCGAGTTTGTATAACGCTATGCCATTAGCAGG
CGTAGATGCTCTAGTCGGATTTATGAGGGCGTTTGCAGCTAAAAATGCTTAA

Upstream 100 bases:

>100_bases
TTGATTTTTTAATGTTAGCTGCCAAATAGTTGGGATATACTGATTGGTATAACGAATAGCTATACCCTAATGTTTCTACT
GATAATAGAAGGACAACACT

Downstream 100 bases:

>100_bases
ACATATGCTAGCTCCAGCTTAAAAAGAAAGCCGACACATAGAAGTGTCGGCTTTTTTAATTGCTTTATATATAAATTCTT
AACAGATGACTTTGGCAATG

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSAIFNFCAGPAMLPPAVMQKAQKELLNWNGLGISVMEISHRSKEFIALTEQAEADLRALMEIPSNYHVLFMHGGGRGQF
SAVVNNFLGNDGRALYLVDGSWSKAAAEEAEKLVGKANIDSIELVSAVNCLNRVTLPDLSKIDKDYRYVHYCPNETVDGI
EIFDDINSPWPVIADMSSNILSRKIDVSQFGLIYAGAQKNIGPSGLSIVIVRDDMLALPSLPQSSIMDYRLAVENDSMYN
TPPTFAWYLAAEVFAWLKCVGGVTEMEKLNIEKARRLYECIDELDFYVSGVAKENRSRMNITFQLTNSQLDSQFLAEAQA
AGLVALKGHRSVGGMRASLYNAMPLAGVDALVGFMRAFAAKNA

Sequences:

>Translated_363_residues
MSAIFNFCAGPAMLPPAVMQKAQKELLNWNGLGISVMEISHRSKEFIALTEQAEADLRALMEIPSNYHVLFMHGGGRGQF
SAVVNNFLGNDGRALYLVDGSWSKAAAEEAEKLVGKANIDSIELVSAVNCLNRVTLPDLSKIDKDYRYVHYCPNETVDGI
EIFDDINSPWPVIADMSSNILSRKIDVSQFGLIYAGAQKNIGPSGLSIVIVRDDMLALPSLPQSSIMDYRLAVENDSMYN
TPPTFAWYLAAEVFAWLKCVGGVTEMEKLNIEKARRLYECIDELDFYVSGVAKENRSRMNITFQLTNSQLDSQFLAEAQA
AGLVALKGHRSVGGMRASLYNAMPLAGVDALVGFMRAFAAKNA
>Mature_362_residues
SAIFNFCAGPAMLPPAVMQKAQKELLNWNGLGISVMEISHRSKEFIALTEQAEADLRALMEIPSNYHVLFMHGGGRGQFS
AVVNNFLGNDGRALYLVDGSWSKAAAEEAEKLVGKANIDSIELVSAVNCLNRVTLPDLSKIDKDYRYVHYCPNETVDGIE
IFDDINSPWPVIADMSSNILSRKIDVSQFGLIYAGAQKNIGPSGLSIVIVRDDMLALPSLPQSSIMDYRLAVENDSMYNT
PPTFAWYLAAEVFAWLKCVGGVTEMEKLNIEKARRLYECIDELDFYVSGVAKENRSRMNITFQLTNSQLDSQFLAEAQAA
GLVALKGHRSVGGMRASLYNAMPLAGVDALVGFMRAFAAKNA

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=365, Percent_Identity=45.7534246575342, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI10863955, Length=361, Percent_Identity=41.2742382271468, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI1787136, Length=368, Percent_Identity=55.4347826086957, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17506897, Length=362, Percent_Identity=41.7127071823204, Blast_Score=277, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6324758, Length=390, Percent_Identity=42.3076923076923, Blast_Score=266, Evalue=3e-72,
Organism=Drosophila melanogaster, GI21356589, Length=367, Percent_Identity=45.5040871934605, Blast_Score=315, Evalue=4e-86,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_SHEPA (A8H4A2)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001501924.1
- ProteinModelPortal:   A8H4A2
- SMR:   A8H4A2
- STRING:   A8H4A2
- GeneID:   5662462
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_2069
- NMPDR:   fig|398579.3.peg.1772
- eggNOG:   COG1932
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   SPEA398579:SPEA_2069-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 39855; Mature: 39724

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 102-102 BINDING 156-156 BINDING 175-175 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIFNFCAGPAMLPPAVMQKAQKELLNWNGLGISVMEISHRSKEFIALTEQAEADLRAL
CCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHH
MEIPSNYHVLFMHGGGRGQFSAVVNNFLGNDGRALYLVDGSWSKAAAEEAEKLVGKANID
HHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCC
SIELVSAVNCLNRVTLPDLSKIDKDYRYVHYCPNETVDGIEIFDDINSPWPVIADMSSNI
HHHHHHHHHHHHCCCCCCHHHHCCCCCEEEECCCCCCCCHHHHHCCCCCCCEEECHHHHH
LSRKIDVSQFGLIYAGAQKNIGPSGLSIVIVRDDMLALPSLPQSSIMDYRLAVENDSMYN
HHHCCCHHHCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCHHHHCEEEEEECCCCCCC
TPPTFAWYLAAEVFAWLKCVGGVTEMEKLNIEKARRLYECIDELDFYVSGVAKENRSRMN
CCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ITFQLTNSQLDSQFLAEAQAAGLVALKGHRSVGGMRASLYNAMPLAGVDALVGFMRAFAA
EEEEECCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
KNA
CCC
>Mature Secondary Structure 
SAIFNFCAGPAMLPPAVMQKAQKELLNWNGLGISVMEISHRSKEFIALTEQAEADLRAL
CCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHH
MEIPSNYHVLFMHGGGRGQFSAVVNNFLGNDGRALYLVDGSWSKAAAEEAEKLVGKANID
HHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCC
SIELVSAVNCLNRVTLPDLSKIDKDYRYVHYCPNETVDGIEIFDDINSPWPVIADMSSNI
HHHHHHHHHHHHCCCCCCHHHHCCCCCEEEECCCCCCCCHHHHHCCCCCCCEEECHHHHH
LSRKIDVSQFGLIYAGAQKNIGPSGLSIVIVRDDMLALPSLPQSSIMDYRLAVENDSMYN
HHHCCCHHHCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCHHHHCEEEEEECCCCCCC
TPPTFAWYLAAEVFAWLKCVGGVTEMEKLNIEKARRLYECIDELDFYVSGVAKENRSRMN
CCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ITFQLTNSQLDSQFLAEAQAAGLVALKGHRSVGGMRASLYNAMPLAGVDALVGFMRAFAA
EEEEECCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
KNA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA