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The map label for this gene is pyrD [H]

Identifier: 157961766

GI number: 157961766

Start: 2363054

End: 2364073

Strand: Direct

Name: pyrD [H]

Synonym: Spea_1943

Alternate gene names: 157961766

Gene position: 2363054-2364073 (Clockwise)

Preceding gene: 157961765

Following gene: 157961767

Centisome position: 45.67

GC content: 39.61

Gene sequence:

>1020_bases
ATGTTTTATAAAATCGCACAAAAGTTCATGTTTCAGATGGATCCAGAACTGGCCCATAATTTCGCTATCGGCAGTTTAAA
ATTTACTGGTAATTCACCTTTAAATTGCTTTTATGCGCAAAATATTAAGCCAGCCCCAGTGACAATGATGGGACTAACTT
TTCCAAACCCAGTGGGTCTTGCTGCTGGTATGGATAAAGAAGGTGAATGCATTGATGCATTCCATGCTATGGGTTTTGGT
CATATTGAAGTGGGCACGGTTACACCACGCCCTCAACCAGGTAATGAACAGCCACGTTGTTTTAGACTAAAACCCGCGAA
AGCGATTATTAACCGTATGGGTTTTAACAACAAAGGTGTTGATAATCTAGTTGCTAATCTTAAAGCGGTTAAGTCGAATG
CGATGGTTGGTGTCAATATTGGTAAGAATAAAGACACACCAGTAGAGCAAGGTAAGGAAGATTACCTGATCTGTATGGAT
AAGGTTTATCCTTATGCCGCTTATATAGCAGTCAATATTTCATCACCAAATACACCTGGTCTACGATCGCTTCAGTACGG
CGATCTTTTAGATGATCTACTTGGATCACTAAAGCAGAAGCAAAAAGAACTTGCTGAACAACACGGTAAGTACGTACCAA
TTGCTTTAAAAATTGCGCCAGACCTGTCAAGTGAAGAGATTGAGAAAATAGCTGACGCGTTAATTAGAAGCGAATTCGAT
GCAGCTATCGCAACCAATACTACATTAACTCGTGACGGTGTAAGTGGTTTGCTTAATGCCAATGAGGCGGGCGGACTAAG
TGGTAAGCCATTGAATTCATTGTCTACAATGGTTATCAAACAACTTGCTGATTGTTTAAAAGGACAGCTGCCAATTATCG
GTGTTGGTGGTATTAACAGCGCTGAAGACGCACTTGATAAACTAGACGCCGGTGCTGAAATGGTACAAATTTATTCTGGT
TTTATCTATCAAGGACCAAAATTAATTAAAGATATTGTAGAAGCATATCGAATTAAATAA

Upstream 100 bases:

>100_bases
AACTTAATCTTTTGATCCTTCATTGTGAAGGTCAAAAGTAATCTGATTAAAATCAGCAGCCCTGGCAATTGCCGGGGCTT
TTTTCGGTCTAGGAGAAAAC

Downstream 100 bases:

>100_bases
GCCCTATCGATCTAAAGTTATTATTTAGAGCATAAAACGATCATTGGGATCTTAATTGGATCGCAATGATCGTTTTTATT
TAATAATTCTAATACCATAT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MFYKIAQKFMFQMDPELAHNFAIGSLKFTGNSPLNCFYAQNIKPAPVTMMGLTFPNPVGLAAGMDKEGECIDAFHAMGFG
HIEVGTVTPRPQPGNEQPRCFRLKPAKAIINRMGFNNKGVDNLVANLKAVKSNAMVGVNIGKNKDTPVEQGKEDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDDLLGSLKQKQKELAEQHGKYVPIALKIAPDLSSEEIEKIADALIRSEFD
AAIATNTTLTRDGVSGLLNANEAGGLSGKPLNSLSTMVIKQLADCLKGQLPIIGVGGINSAEDALDKLDAGAEMVQIYSG
FIYQGPKLIKDIVEAYRIK

Sequences:

>Translated_339_residues
MFYKIAQKFMFQMDPELAHNFAIGSLKFTGNSPLNCFYAQNIKPAPVTMMGLTFPNPVGLAAGMDKEGECIDAFHAMGFG
HIEVGTVTPRPQPGNEQPRCFRLKPAKAIINRMGFNNKGVDNLVANLKAVKSNAMVGVNIGKNKDTPVEQGKEDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDDLLGSLKQKQKELAEQHGKYVPIALKIAPDLSSEEIEKIADALIRSEFD
AAIATNTTLTRDGVSGLLNANEAGGLSGKPLNSLSTMVIKQLADCLKGQLPIIGVGGINSAEDALDKLDAGAEMVQIYSG
FIYQGPKLIKDIVEAYRIK
>Mature_339_residues
MFYKIAQKFMFQMDPELAHNFAIGSLKFTGNSPLNCFYAQNIKPAPVTMMGLTFPNPVGLAAGMDKEGECIDAFHAMGFG
HIEVGTVTPRPQPGNEQPRCFRLKPAKAIINRMGFNNKGVDNLVANLKAVKSNAMVGVNIGKNKDTPVEQGKEDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDDLLGSLKQKQKELAEQHGKYVPIALKIAPDLSSEEIEKIADALIRSEFD
AAIATNTTLTRDGVSGLLNANEAGGLSGKPLNSLSTMVIKQLADCLKGQLPIIGVGGINSAEDALDKLDAGAEMVQIYSG
FIYQGPKLIKDIVEAYRIK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=329, Percent_Identity=43.161094224924, Blast_Score=248, Evalue=7e-66,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=60.960960960961, Blast_Score=427, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17509475, Length=353, Percent_Identity=39.6600566572238, Blast_Score=227, Evalue=6e-60,
Organism=Drosophila melanogaster, GI281361352, Length=326, Percent_Identity=41.1042944785276, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI17137316, Length=326, Percent_Identity=41.1042944785276, Blast_Score=235, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36658; Mature: 36658

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYKIAQKFMFQMDPELAHNFAIGSLKFTGNSPLNCFYAQNIKPAPVTMMGLTFPNPVGL
CHHHHHHHHHHHCCHHHHHHEEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCH
AAGMDKEGECIDAFHAMGFGHIEVGTVTPRPQPGNEQPRCFRLKPAKAIINRMGFNNKGV
HCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCCH
DNLVANLKAVKSNAMVGVNIGKNKDTPVEQGKEDYLICMDKVYPYAAYIAVNISSPNTPG
HHHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCC
LRSLQYGDLLDDLLGSLKQKQKELAEQHGKYVPIALKIAPDLSSEEIEKIADALIRSEFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
AAIATNTTLTRDGVSGLLNANEAGGLSGKPLNSLSTMVIKQLADCLKGQLPIIGVGGINS
HHHHCCCEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCH
AEDALDKLDAGAEMVQIYSGFIYQGPKLIKDIVEAYRIK
HHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFYKIAQKFMFQMDPELAHNFAIGSLKFTGNSPLNCFYAQNIKPAPVTMMGLTFPNPVGL
CHHHHHHHHHHHCCHHHHHHEEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCH
AAGMDKEGECIDAFHAMGFGHIEVGTVTPRPQPGNEQPRCFRLKPAKAIINRMGFNNKGV
HCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCCH
DNLVANLKAVKSNAMVGVNIGKNKDTPVEQGKEDYLICMDKVYPYAAYIAVNISSPNTPG
HHHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCC
LRSLQYGDLLDDLLGSLKQKQKELAEQHGKYVPIALKIAPDLSSEEIEKIADALIRSEFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
AAIATNTTLTRDGVSGLLNANEAGGLSGKPLNSLSTMVIKQLADCLKGQLPIIGVGGINS
HHHHCCCEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCH
AEDALDKLDAGAEMVQIYSGFIYQGPKLIKDIVEAYRIK
HHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA